Integrin α2 mediates selective metastasis to the liver

Cancer Research

Volumn 69, Issue 18, 2009, Pages 7320-7328

  Yoshimura, Kiyoshi ^a,b   Meckel, Kristen F ^b   Laird, Lindsay S ^b   Chia, Christina Y ^b   Park, Jang June ^b   Olino, Kelly L ^a   Tsunedomi, Ryouichi ^c   Harada, Toshio ^c   Iizuka, Norio ^c   Hazama, Shoichi ^c   Kato, Yukihiko ^b   Keller, Jesse W ^a   Thompson, John M ^b   Chang, Fumin ^b   Romer, Lewis H ^a   Jain, Ajay ^a,b   Iacobuzio Donahue, Christine ^a   Oka, Masaaki ^c   Pardoll, Drew M ^b   Schulick, Richard D ^a,b  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2 INTEGRIN; COLLAGEN TYPE 4; FOCAL ADHESION KINASE; ANTIBODY; FOCAL ADHESION KINASE 1; PTK2 PROTEIN, HUMAN; PTK2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN TISSUE; LIVER METASTASIS; LIVER SINUSOID; LUNG METASTASIS; MELANOMA B16; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; C57BL MOUSE; COLORECTAL TUMOR; EXPERIMENTAL MELANOMA; FEMALE; FLOW CYTOMETRY; IMMUNOLOGY; LIVER TUMOR; METABOLISM; METASTASIS; PATHOLOGY;

ANIMALS; ANTIBODIES; COLLAGEN TYPE IV; COLORECTAL NEOPLASMS; FEMALE; FLOW CYTOMETRY; FOCAL ADHESION KINASE 1; HUMANS; INTEGRIN ALPHA2; LIVER NEOPLASMS; LIVER NEOPLASMS, EXPERIMENTAL; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL;

EID: 70349754433     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-0315     Document Type: Article

References (41)

1. Fidler IJ. Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. Cancer Res 1990;50:6130-6138
2. Chambers AF, Groom AC, MacDonald IC. Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2002;2:563-572 (Pubitemid 37328923)
3. Koukoulis GK, Patriarca C, Gould VE. Adhesion molecules and tumor metastasis. Hum Pathol 1998;29:889-892
4. Chothia C, Jones EY. The molecular structure of cell adhesion molecules. Annu Rev Biochem 1997;66:823-862 (Pubitemid 27274676)
5. Hynes RO, Zhao Q. The evolution of cell adhesion. J Cell Biol 2000;150:F89-96.
6. Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell 2002;110:673-687
7. van der Flier A, Sonnenberg A. Function and interactions of integrins. Cell Tissue Res 2001;305:285-298
8. Danen EH. Integrins: regulators of tissue function and cancer progression. Curr Pharm Des 2005;11:881-891
9. Ridley AJ, Schwartz MA, Burridge K, et al. Cell migration: integrating signals from front to back. Science 2003;302:1704-1709 (Pubitemid 37505725)
10. Schmid BC, Rezniczek GA, Fabjani G, Yoneda T, Leodolter S, Zeillinger R. The neuronal guidance cue Slit2 induces targeted migration and may play a role in brain metastasis of breast cancer cells. Breast Cancer Res Treat 2007;106:333-342 (Pubitemid 350029681)
11. Wu WS. The signaling mechanism of ROS in tumor progression. Cancer Metastasis Rev 2006;25:695-705.
12. Rodrigo JP, Dominguez F, Suarez V, Canel M, Secades P, Chiara MD. Focal adhesion kinase and E-cadherin as markers for nodal metastasis in laryngeal cancer. Arch Otolaryngol Head Neck Surg 2007;133:145-150 (Pubitemid 46294115)
13. Weiner TM, Liu ET, Craven RJ, Cance WG. Expression of focal adhesion kinase gene and invasive cancer. Lancet 1993;342:1024-1025
14. Corbett TH, Griswold DP, Jr., Roberts BJ, Peckham JC, Schabel FM, Jr. Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure. Cancer Res 1975;35:2434-2439
15. Yoshimura K, Laird LS, Chia CY, et al. Live attenuated Listeria monocytogenes effectively treats hepatic colorectal cancer metastases and is strongly enhanced by depletion of regulatory T cells. Cancer Res 2007;67:10058-10066 (Pubitemid 47621257)
16. Jain A, Slansky JE, Matey LC, Allen HE, Pardoll DM, Schulick RD. Synergistic effect of a granulocytemacrophage colony-stimulating factor-transduced tumor vaccine and systemic interleukin-2 in the treatment of murine colorectal cancer hepatic metastases. Ann Surg Oncol 2003;10:810-820 (Pubitemid 40486882)
17. Yoshimura K, Jain A, Allen HE, et al. Selective targeting of antitumor immune responses with engineered live-attenuated Listeria monocytogenes. Cancer Res 2006;66:1096-1104 (Pubitemid 43165978)
18. Winter JM, Ting AH, Vilardell F, et al. Absence of E-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer. Clin Cancer Res 2008;14:412-418 (Pubitemid 351226108)
19. Cairns RA, Khokha R, Hill RP. Molecular mechanisms of tumor invasion and metastasis: an integrated view. Curr Mol Med 2003;3:659-671 (Pubitemid 37236408)
20. Baker JK, Elshaw SR, Mathewman GE, et al. Expression of integrins, degradative enzymes and their inhibitors in uveal melanoma: differences between in vitro and in vivo expression. Melanoma Res 2001;11:265-273
21. Santoro SA, Zutter MM. The α 2 β 1 integrin: a collagen receptor on platelets and other cells. Thromb Haemost 1995;74:813-821
22. Watt FM. Role of integrins in regulating epidermal adhesion, growth and differentiation. EMBO J 2002;21:3919-3926
23. Camper L, Hellman U, Lundgren-Akerlund E. Isolation, cloning, and sequence analysis of the integrin subunit a10, a h1-associated collagen binding integrin expressed on chondrocytes. J Biol Chem 1998;273:20383-20389 (Pubitemid 28377604)
24. Velling T, Kusche-Gullberg M, Sejersen T, Gullberg D. cDNA cloning and chromosomal localization of human α(11) integrin. A collagen-binding, I domain-containing, β(1)-associated integrin a-chain present in muscle tissues. J Biol Chem 1999;274:25735-25742
25. Eble JA. Collagen-binding integrins as pharmaceutical targets. Curr Pharm Des 2005;11:867-880
26. White DJ, Puranen S, Johnson MS, Heino J. The collagen receptor subfamily of the integrins. Int J Biochem Cell Biol 2004;36:1405-1410
27. Gelse K, Poschl E, Aigner T. Collagens-structure, function, and biosynthesis. Adv Drug Deliv Rev 2003;55:1531-1546
28. Sawai H, Funahashi H, Yamamoto M, et al. Interleukin-1a enhances integrin α(6)β(1) expression and metastatic capability of human pancreatic cancer. Oncology 2003;65:167-173
29. Yamaguchi K, Ura H, Yasoshima T, Shishido T, Denno R, Hirata K. Liver metastatic model for human gastric cancer established by orthotopic tumor cell implantation. World J Surg 2001;25:131-137 (Pubitemid 32303933)
30. Kemperman H, Driessens MH, La Riviere G, Meijne AM, Roos E. Adhesion mechanisms in liver metastasis formation. Cancer Surv 1995;24:67-79.
31. Herlevsen M, Schmidt DS, Miyazaki K, Zoller M. The association of the tetraspanin D6.1A with the α6β4 integrin supports cell motility and liver metastasis formation. J Cell Sci 2003;116:4373-4390 (Pubitemid 37369593)
32. Kikkawa H, Kaihou M, Horaguchi N, et al. Role of integrin α(v)β3 in the early phase of liver metastasis: PET and IVM analyses. Clin Exp Metastasis 2002;19:717-725
33. Nishimori H, Yasoshima T, Hata F, et al. A novel nude mouse model of liver metastasis and peritoneal dissemination from the same human pancreatic cancer line. Pancreas 2002;24:242-250 (Pubitemid 34260648)
34. Kishimoto H, Sasahara K, Yamazaki K, et al. Obstructive jaundice facilitates hepatic metastasis of B16F1 mouse melanoma cells: participation of increased VCAM-1 expression in the liver. Oncol Rep 2001;8:575-578 (Pubitemid 33758457)
35. Papadimitriou MN, Menter DG, Konstantopoulos K, Nicolson GL, McIntire LV. Integrin α4β1/VCAM-1 pathway mediates primary adhesion of RAW117 lymphoma cells to hepatic sinusoidal endothelial cells under flow. Clin Exp Metastasis 1999;17:669-676 (Pubitemid 30450189)
36. Wai PY, Mi Z, Guo H, et al. Osteopontin silencing by small interfering RNA suppresses in vitro and in vivo CT26 murine colon adenocarcinoma metastasis. Carcinogenesis 2005;26:741-751 (Pubitemid 41214336)
37. Haier J, Nasralla M, Nicolson GL. Different adhesion properties of highly and poorly metastatic HT-29 colon carcinoma cells with extracellular matrix components: role of integrin expression and cytoskeletal components. Br J Cancer 1999;80:1867-1874 (Pubitemid 29391268)
38. Yang C, Zeisberg M, Lively JC, Nyberg P, Afdhal N, Kalluri R. Integrin α1β1 and α2β1 are the key regulators of hepatocarcinoma cell invasion across the fibrotic matrix microenvironment. Cancer Res 2003;63:8312-8317 (Pubitemid 37549483)
39. Ho WC, Heinemann C, Hangan D, Uniyal S, Morris VL, Chan BM. Modulation of in vivo migratory function of α2β1 integrin in mouse liver. Mol Biol Cell 1997;8:1863-1875 (Pubitemid 27451107)
40. Steeg PS. Metastasis suppressors alter the signal transduction of cancer cells. Nat Rev Cancer 2003;3:55-63.
41. Romer LH, Birukov KG, Garcia JG. Focal adhesions: paradigm for a signaling nexus. Circ Res 2006;98:606-616