β1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts

Cancer Research

Volumn 68, Issue 11, 2008, Pages 4398-4405

  Park, Catherine C ^a,d   Zhang, Hui J ^b   Yao, Evelyn S ^a   Park, Chong J ^c   Bissell, Mina J ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^c SAN DIEGO STATE UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; PROTEIN KINASE B;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CANCER RADIOTHERAPY; CELL CULTURE; DOWN REGULATION; HUMAN; IONIZING RADIATION; PRIORITY JOURNAL; RADIATION DOSE; SIGNAL TRANSDUCTION; THERAPY EFFECT; TUMOR XENOGRAFT; WESTERN BLOTTING; BREAST; BREAST TUMOR; CELL LINE; CELL PROLIFERATION; CELL SEPARATION; CONFOCAL MICROSCOPY; DRUG EFFECT; METABOLISM; NICK END LABELING; PATHOLOGY; TREATMENT OUTCOME; XENOGRAFT;

ANTIGENS, CD29; APOPTOSIS; BLOTTING, WESTERN; BREAST; BREAST NEOPLASMS; CELL LINE; CELL PROLIFERATION; CELL SEPARATION; HUMANS; IN SITU NICK-END LABELING; MICROSCOPY, CONFOCAL; TRANSPLANTATION, HETEROLOGOUS; TREATMENT OUTCOME;

EID: 49249107671     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-6390     Document Type: Article

References (42)

1. Park CC, Mitsumori M, Nixon A, et al. Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence. J Clin Oncol 2000;18:1668-75.
2. Barcellos-Hoff MH, Park C, Wright EG. Radiation and the microenvironment - tumorigenesis and therapy. Nat Rev Cancer 2005;5:867-75.
3. Park CC, Henshall-Powell RL, Erickson AC, et al. Ionizing radiation induces heritable disruption of epithelial cell interactions. Proc Natl Acad Sci U S A 2003;100:10728-33.
4. Onoda JM, Piechocki MP, Honn KV. Radiation-induced increase in expression of the αIIβ3 integrin in melanoma cells: effects on metastatic potential. Radiat Res 1992;130:281-8.
5. Cordes N, Blaese MA, Meineke V, Van Beuningen D. Ionizing radiation induces up-regulation of functional β1-integrin in human lung tumour cell lines in vitro. Int J Radiat Biol 2002;78:347-57.
6. Damiano JS, Hazlehurst LA, Dalton WS. Cell adhesion-mediated drug resistance (CAM-DR) protects the K562 chronic myelogenous leukemia cell line from apoptosis induced by BCR/ABL inhibition, cytotoxic drugs, and γ-irradiation. Leukemia 2001;15:1232-9.
7. Damiano JS, Cress AE, Hazlehurst LA, Shtil AA, Dalton WS. Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines. Blood 1999;93:1658-67.
8. 1-integrin-mediated signaling essentially contributes to cell survival after radiation-induced genotoxic injury. Oncogene 2006;25:1378-90.
9. Cordes N, Meineke V. Cell adhesion-mediated radio-resistance (CAM-RR). Extracellular matrix-dependent improvement of cell survival in human tumor and normal cells in vitro. Strahlenther Onkol 2003;179:337-44.
10. 1 integrin-dependent activation of PI3-kinase. Cell Death Differ 2006;13:1776-88.
11. Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell 2002;110:673-87.
12. Giancotti FG, Ruoslahti E. Integrin signaling. Science 1999;285:1028-32.
13. Aoudjit F, Vuori K. Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells. Oncogene 2001;20:4995-5004.
14. 1 integrin subfamily in anchorage-dependent apoptosis of breast carcinoma cells differing in multidrug resistance. Biochemistry (Mosc) 2006;71:489-95.
15. 1 integrin is associated with decreased survival in invasive breast cancer. Cancer Res 2007;67:659-64.
16. Gupta AK, Cerniglia GJ, Mick R, et al. Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002. Int J Radiat Oncol Biol Phys 2003;56:846-53.
17. Hallahan D, Geng L, Qu S, et al. Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels. Cancer Cell 2003;3:63-74.
18. Seidler J, Durzok R, Brakebusch C, Cordes N. Interactions of the integrin subunit β1A with protein kinase B/Akt, p130Cas and paxillin contribute to regulation of radiation survival. Radiother Oncol 2005;76:129-34.
19. 1 Integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo. Cancer Res 2006;66:1526-35.
20. Briand P, Petersen OW, Van Deurs B. A new diploid nontumorigenic human breast epithelial cell line isolated and propagated in chemically defined medium. In Vitro Cell Dev Biol 1987;23:181-8.
21. Weaver VM, Petersen OW, Wang F, et al. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol 1997;137:231-45.
22. 1 integrin heterodimers mediate cell attachment to distinct sites on laminin. J Cell Biol 1990;110:2175-84.
23. Tomaselli KJ, Damsky CH, Reichardt LF. Purification and characterization of mammalian integrins expressed by a rat neuronal cell line (PC12): evidence that they function as α/β heterodimeric receptors for laminin and type IV collagen. J Cell Biol 1988;107:1241-52.
24. Werb Z, Tremble PM, Behrendtsen O, Crowley E, Damsky CH. Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression. J Cell Biol 1989;109:877-89.
25. Wang F, Weaver VM, Petersen OW, et al. Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proc Natl Acad Sci U S A 1998;95:14821-6.
26. Schafer JM, Bentrem DJ, Takei H, Gajdos C, Badve S, Jordan VC. A mechanism of drug resistance to tamoxifen in breast cancer. J Steroid Biochem Mol Biol 2002;83:75-83.
27. Edwards E, Geng L, Tan J, Onishko H, Donnelly E, Hallahan DE. Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation. Cancer Res 2002;62:4671-7.
28. Nakamura JL, Karlsson A, Arvold ND, et al. PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas. J Neurooncol 2005;71:215-22.
29. Zingg D, Riesterer O, Fabbro D, Glanzmann C, Bodis S, Pruschy M. Differential activation of the phosphatidylinositol 3′-kinase/Akt survival pathway by ionizing radiation in tumor and primary endothelial cells. Cancer Res 2004;64:5398-406.
30. Kohn AD, Barthel A, Kovacina KS, et al. Construction and characterization of a conditionally active version of the serine/threonine kinase Akt. J Biol Chem 1998;273:11937-43.
31. Liu H, Radisky DC, Wang F, Bissell MJ. Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells. J Cell Biol 2004;164:603-12.
32. Hay N. The Akt-mTOR tango and its relevance to cancer. Cancer Cell 2005;8:179-83.
33. Barcellos-Hoff MH. It takes a tissue to make a tumor: epigenetics, cancer and the microenvironment. J Mammary Gland Biol Neoplasia 2001;6:213-21.
34. 4 Integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell 2002;2:205-16.
35. 2-integrin-expressing cells in humans. Int J Radiat Oncol Biol Phys 1999;45:475-81.
36. Liang K, Jin W, Knuefermann C, et al. Targeting the phosphatidylinositol 3-kinase/Akt pathway for enhancing breast cancer cells to radiotherapy. Mol Cancer Ther 2003;2:353-60.
37. Lee CM, Fuhrman CB, Planelles V, et al. Phosphatidylinositol 3-kinase inhibition by LY294002 radiosensitizes human cervical cancer cell lines. Clin Cancer Res 2006;12:250-6.
38. Brognard J, Clark AS, Ni Y, Dennis PA. Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res 2001;61:3986-97.
39. Kim IA, Bae SS, Fernandes A, et al. Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines. Cancer Res 2005;65:7902-10.
40. Choi JA, Park MT, Kang CM, et al. Opposite effects of Ha-Ras and Ki-Ras on radiation-induced apoptosis via differential activation of PI3K/Akt and Rac/p38 mitogen-activated protein kinase signaling pathways. Oncogene 2004;23:9-20.
41. Choi SY, Kim MJ, Kang CM, et al. Activation of Bak and Bax through c-abl-protein kinase Cδ-p38 MAPK signaling in response to ionizing radiation in human non-small cell lung cancer cells. J Biol Chem 2006;281:7049-59.
42. Li TS, Ito H, Hayashi M, Furutani A, Matsuzaki M, Hamano K. Cellular expression of integrin-β1 is of critical importance for inducing therapeutic angiogenesis by cell implantation. Cardiovasc Res 2005;65:64-72.