The α2 integrin subunit-deficient mouse: A multifaceted phenotype including defects of branching morphogenesis and hemostasis

American Journal of Pathology

Volumn 161, Issue 1, 2002, Pages 337-344

  Chen, Jianchun ^a   Diacovo, Thomas G ^a   Grenache, David G ^a   Santoro, Samuel A ^a   Zutter, Mary M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; MESSENGER RNA;

ANIMAL TISSUE; ARTICLE; BRANCHING MORPHOGENESIS; ENDOTHELIUM CELL; EPITHELIUM CELL; FIBROBLAST; GASTROINTESTINAL TRACT; HEART; HEMOSTASIS; KERATINOCYTE; KIDNEY; LUNG; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SHEAR STRESS; THROMBOCYTE; WOUND HEALING;

EID: 0036314793     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64185-5     Document Type: Article

References (31)

1. The membrane glycoprotein Ia-IIa (VLA-2) complex mediates the Mg++dependent adhesion of platelets to collagen
2. The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others
3. Alpha 2 beta 1 integrins from different cell types show different binding specificities
4. The alpha 2 beta 1 integrin: A collagen receptor on platelets and other cells
5. Branching morphogenesis of human mammary epithelial cells in collagen gels
6. Loss of MDCK cell alpha 2 beta 1 integrin expression results in reduced cyst formation, failure of hepatocyte growth factor/scatter factor-induced branching morphogenesis, and increased apoptosis
7. Re-expression of the alpha 2 beta 1 integrin abrogates the malignant phenotype of breast carcinoma cells
8. Altered integrin expression and the malignant phenotype: The contribution of multiple integrated integrin receptors
9. A three-dimensional collagen lattice induces protein kinase C-zeta activity: Role in alpha2 integrin and collagenase mRNA expression
10. The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix
11. Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen
12. Complex patterns of expression suggest extensive roles for the alpha 2 beta 1 integrin in murine development
13. Glycoprotein V-deficient platelets have undiminished thrombin responsiveness and do not exhibit a Bernard-Soulier phenotype
14. Analysis of collagen receptors
15. Mapping the glycoprotein Ib-binding site in the von Willebrand factor A1 domain
16. The spatial and temporal expression of the alpha 2 beta 1 integrin and its ligands, collagen I, collagen IV, and laminin, suggest important roles in mouse mammary morphogenesis
17. Alpha 2 integrin subunit cytoplasmic domain-dependent cellular migration requires p38 MAPK
18. Mammary epithelial cell-cycle progression via the alpha(2)beta(1) integrin: Unique and synergistic roles of the alpha(2) cytoplasmic domain
19. Decreased expression of integrin adhesive protein receptors in adenocarcinoma of the breast
20. The ups and downs of alpha 2 beta 1-integrin expression: Contributions to epithelial cell differentiation and the malignant phenotype
21. Nucleotide polymorphisms in the alpha2 gene define multiple alleles that are associated with differences in platelet alpha2 beta1 density
22. Association of the platelet glycoprotein Ia C807T gene polymorphism with nonfatal myocardial infarction in younger patients
23. Association between diabetic retinopathy and genetic variations in alpha2beta1 integrin, a platelet receptor for collagen
24. The alpha2 gene coding sequence T807/A873 of the platelet collagen receptor integrin alpha2beta1 might be a genetic risk factor for the development of stroke in younger patients
25. Distinct determinants on collagen support alpha 2 beta 1 integrin-mediated platelet adhesion and platelet activation
26. Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen
27. Glycoprotein VI is a major collagen receptor for platelet activation: It recognizes the platelet activating quaternary structure of collagen, whereas CD36, glycoprotein IIb/IIIa and von Willebrand factor do not
28. Collagen-stimulated activation of syk but not c-src is severely compromised in human platelets lacking membrane glycoprotein VI
29. Human blood platelets showing no response to collagen fail to express surface glycoprotein la
30. Deficiency of platelet membrane glycoprotein Ia associated with a decreased platelet adhesion to subendothelium: A defect in platelet spreading