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Volumn 13, Issue 2, 2007, Pages 130-139

The expression of the cytoskeletal focal adhesion protein paxillin in breast cancer correlates with HER2 overexpression and may help predict response to chemotherapy: A retrospective immunohistochemical study

Author keywords

Breast cancer; Chemotherapy response; HER2; Paxillin; Prognosis

Indexed keywords

CELL ADHESION MOLECULE; CYCLOPHOSPHAMIDE; CYTOSKELETON PROTEIN; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; FLUOROURACIL; METHOTREXATE; PAXILLIN; PROGESTERONE RECEPTOR;

EID: 33847141029     PISSN: 1075122X     EISSN: 15244741     Source Type: Journal    
DOI: 10.1111/j.1524-4741.2007.00389.x     Document Type: Article
Times cited : (35)

References (50)
  • 2
    • 19944422061 scopus 로고    scopus 로고
    • A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    • Paik S, Shak S, Tang G, et al. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med 2004;351:2817-26.
    • (2004) N Engl J Med , vol.351 , pp. 2817-2826
    • Paik, S.1    Shak, S.2    Tang, G.3
  • 3
    • 11344285907 scopus 로고    scopus 로고
    • The expression of fascin, an actin-bundling motility protein, correlates with hormone receptor-negative breast cancer and a more aggressive clinical course
    • Yoder BJ, Tso E, Skacel M, et al. The expression of fascin, an actin-bundling motility protein, correlates with hormone receptor-negative breast cancer and a more aggressive clinical course. Clin Cancer Res 2005;11:186-92.
    • (2005) Clin Cancer Res , vol.11 , pp. 186-192
    • Yoder, B.J.1    Tso, E.2    Skacel, M.3
  • 4
    • 0032964123 scopus 로고    scopus 로고
    • Alterations in focal adhesion kinase activity and associated proteins during malignant conversion of mouse keratinocyte
    • Newell SW, Perchellet JP, Perchellet EM, Ulug ET. Alterations in focal adhesion kinase activity and associated proteins during malignant conversion of mouse keratinocyte. Mol Carcinog 1999;25:73-83.
    • (1999) Mol Carcinog , vol.25 , pp. 73-83
    • Newell, S.W.1    Perchellet, J.P.2    Perchellet, E.M.3    Ulug, E.T.4
  • 5
    • 0029666144 scopus 로고    scopus 로고
    • Involvement of heregulin-beta2 in the acquisition of the hormone-independent phenotype of breast cancer cells
    • Tang CK, Perez C, Grunt T, et al. Involvement of heregulin-beta2 in the acquisition of the hormone-independent phenotype of breast cancer cells. Cancer Res 1996;56:3350-58.
    • (1996) Cancer Res , vol.56 , pp. 3350-3358
    • Tang, C.K.1    Perez, C.2    Grunt, T.3
  • 6
    • 0034529411 scopus 로고    scopus 로고
    • Paxillin interactions
    • Turner CE. Paxillin interactions. J Cell Sci 2000;113:4139-40.
    • (2000) J Cell Sci , vol.113 , pp. 4139-4140
    • Turner, C.E.1
  • 7
    • 0033531243 scopus 로고    scopus 로고
    • Expression of the focal adhesion protein paxillin in lung cancer and its relation to cell motility
    • Salgia R, Li JL, Ewaniuk DS, et al. Expression of the focal adhesion protein paxillin in lung cancer and its relation to cell motility. Oncogene 1999;8:67-77.
    • (1999) Oncogene , vol.8 , pp. 67-77
    • Salgia, R.1    Li, J.L.2    Ewaniuk, D.S.3
  • 9
    • 0024337144 scopus 로고
    • Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
    • Slamon DJ, Godolphin W, Jones LA, et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 1989;244:707-12.
    • (1989) Science , vol.244 , pp. 707-712
    • Slamon, D.J.1    Godolphin, W.2    Jones, L.A.3
  • 10
    • 0033564110 scopus 로고    scopus 로고
    • Transcriptional up-regulation of paxillin expression by heregulin in human breast cancer cells
    • Vadlamudi R, Adam L, Tseng B, Costa L, Kumar R. Transcriptional up-regulation of paxillin expression by heregulin in human breast cancer cells. Cancer Res 1999;59:2843-46.
    • (1999) Cancer Res , vol.59 , pp. 2843-2846
    • Vadlamudi, R.1    Adam, L.2    Tseng, B.3    Costa, L.4    Kumar, R.5
  • 11
    • 33847148358 scopus 로고    scopus 로고
    • Paxillin overexpression: A reporter of HER-2/neu activity that predicts response to docetaxel/ herceptin™ chemotherapy
    • abstract
    • Davis W, Esteva F, Rajan R, et al. Paxillin overexpression: a reporter of HER-2/neu activity that predicts response to docetaxel/ herceptin™ chemotherapy. Lab Invest 2004;84:s28 (abstract).
    • (2004) Lab Invest , vol.84
    • Davis, W.1    Esteva, F.2    Rajan, R.3
  • 12
    • 16644396502 scopus 로고    scopus 로고
    • Novel bright field molecular morphology methods for detection of HER2 gene amplification
    • Tubbs R, Pettay J, Hicks D, et al. Novel bright field molecular morphology methods for detection of HER2 gene amplification. J. Molec. Histol 2004;35:589-94.
    • (2004) J. Molec. Histol , vol.35 , pp. 589-594
    • Tubbs, R.1    Pettay, J.2    Hicks, D.3
  • 13
    • 33847098629 scopus 로고    scopus 로고
    • Yoder B, Choueiri T, Downs-Kelly E. EnzMet GenePro, a novel bright fieldassay that simultaneously profiles HER2 genotype and phenotype, correlates with overall and disease free survival of breast cancer. Mod Pathol 2005;18:s247 (abstract).
    • Yoder B, Choueiri T, Downs-Kelly E. EnzMet GenePro, a novel bright fieldassay that simultaneously profiles HER2 genotype and phenotype, correlates with overall and disease free survival of breast cancer. Mod Pathol 2005;18:s247 (abstract).
  • 14
    • 27244440343 scopus 로고    scopus 로고
    • Analytical validation and interobserver reproducibility of enzmet genepro: A second-generation bright-field metallography assay for concomitant detection of HER2 gene status and protein expression in invasive carcinoma of the breast
    • Downs-Kelly E, Pettay J, Hicks D, et al. Analytical validation and interobserver reproducibility of enzmet genepro: a second-generation bright-field metallography assay for concomitant detection of HER2 gene status and protein expression in invasive carcinoma of the breast. Am J Surg Pathol 2005;29:1505-11.
    • (2005) Am J Surg Pathol , vol.29 , pp. 1505-1511
    • Downs-Kelly, E.1    Pettay, J.2    Hicks, D.3
  • 15
    • 0036135726 scopus 로고    scopus 로고
    • Differential regulation of components of the focal adhesion complex by heregulin: Role of phosphatase SHP-2
    • Vadlamudi RK, Adam L, Nguyen D, Santos M, Kumar R. Differential regulation of components of the focal adhesion complex by heregulin: role of phosphatase SHP-2. J Cell Physiol 2002;190:189-99.
    • (2002) J Cell Physiol , vol.190 , pp. 189-199
    • Vadlamudi, R.K.1    Adam, L.2    Nguyen, D.3    Santos, M.4    Kumar, R.5
  • 16
    • 2542638621 scopus 로고    scopus 로고
    • Targeted therapy in breast cancer: The HER-2/neu gene and protein
    • Ross JS, Fletcher JA, Bloom KJ, et al. Targeted therapy in breast cancer: the HER-2/neu gene and protein. Mol Cell Proteomics 2004;3:379-98.
    • (2004) Mol Cell Proteomics , vol.3 , pp. 379-398
    • Ross, J.S.1    Fletcher, J.A.2    Bloom, K.J.3
  • 17
    • 0035125564 scopus 로고    scopus 로고
    • c-erbB-2 positivity is a factor for poor prognosis in breast cancer and poor response to hormonal or chemotherapy treatment in advanced disease
    • Jukkola A, Bloigu R, Soini Y, et al. c-erbB-2 positivity is a factor for poor prognosis in breast cancer and poor response to hormonal or chemotherapy treatment in advanced disease. Eur J Cancer 2001;37:347-54.
    • (2001) Eur J Cancer , vol.37 , pp. 347-354
    • Jukkola, A.1    Bloigu, R.2    Soini, Y.3
  • 18
    • 0029662337 scopus 로고    scopus 로고
    • c-erb B2 overexpression decreases the benefit of adjuvant tamoxifen in early-stage breast cancer without axillary lymph node metastases
    • Carlomagno C, Perrone F, Gallo C, et al. c-erb B2 overexpression decreases the benefit of adjuvant tamoxifen in early-stage breast cancer without axillary lymph node metastases. J Clin Oncol 1996;14:2702-8.
    • (1996) J Clin Oncol , vol.14 , pp. 2702-2708
    • Carlomagno, C.1    Perrone, F.2    Gallo, C.3
  • 19
    • 0035884620 scopus 로고    scopus 로고
    • Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/ or ErbB-2-positive, estrogen receptor-positive primary breast cancer: Evidence from a phase III randomized trial
    • Ellis MJ, Coop A, Singh B, et al. Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/ or ErbB-2-positive, estrogen receptor-positive primary breast cancer: evidence from a phase III randomized trial. J Clin Oncol 2001;19:3808-16.
    • (2001) J Clin Oncol , vol.19 , pp. 3808-3816
    • Ellis, M.J.1    Coop, A.2    Singh, B.3
  • 20
    • 0034473776 scopus 로고    scopus 로고
    • The role of HER-2 expression in predicting response to therapy in breast cancer
    • Mass R. The role of HER-2 expression in predicting response to therapy in breast cancer. Semin Oncol 2000;27:92-100.
    • (2000) Semin Oncol , vol.27 , pp. 92-100
    • Mass, R.1
  • 21
    • 4043131642 scopus 로고    scopus 로고
    • HER-2/neu as a predictive marker in a population of advanced breast cancer patients randomly treated either with single-agent doxorubicin or single-agent docetaxel
    • Di Leo A, Chan S, Paesmans M, et al. HER-2/neu as a predictive marker in a population of advanced breast cancer patients randomly treated either with single-agent doxorubicin or single-agent docetaxel. Breast Cancer Res Treat 2004;86:197-206.
    • (2004) Breast Cancer Res Treat , vol.86 , pp. 197-206
    • Di Leo, A.1    Chan, S.2    Paesmans, M.3
  • 22
    • 0026650016 scopus 로고
    • Prognostic significance of HER-2 oncoprotein expression in breast cancer: A 30-year follow-up
    • Toikkanen S, Helin H, Isola J, Joensuu H. Prognostic significance of HER-2 oncoprotein expression in breast cancer: a 30-year follow-up. J Clin Oncol 1992;10:1044-48.
    • (1992) J Clin Oncol , vol.10 , pp. 1044-1048
    • Toikkanen, S.1    Helin, H.2    Isola, J.3    Joensuu, H.4
  • 23
    • 0032538040 scopus 로고    scopus 로고
    • erbb-2 and response to doxorubicin in patients with axillary lymph node-positive, hormone receptor-negative breast cancer
    • Paik S, Bryant J, Park C, et al. erbb-2 and response to doxorubicin in patients with axillary lymph node-positive, hormone receptor-negative breast cancer. J Natl. Cancer Inst 1998;90:1361-70.
    • (1998) J Natl. Cancer Inst , vol.90 , pp. 1361-1370
    • Paik, S.1    Bryant, J.2    Park, C.3
  • 24
    • 4444320915 scopus 로고    scopus 로고
    • Her-2/neu gene amplification and response to paclitaxel in patients with metastatic breast cancer
    • Konecny GE, Thomssen C, Luck HJ, et al. Her-2/neu gene amplification and response to paclitaxel in patients with metastatic breast cancer. J Natl. Cancer Inst 2004;96:1141-51.
    • (2004) J Natl. Cancer Inst , vol.96 , pp. 1141-1151
    • Konecny, G.E.1    Thomssen, C.2    Luck, H.J.3
  • 25
    • 0032538050 scopus 로고    scopus 로고
    • erbB-2, p53, and efficacy of adjuvant therapy in lymph node-positive breast cancer
    • Thor AD, Berry DA, Budman DR, et al. erbB-2, p53, and efficacy of adjuvant therapy in lymph node-positive breast cancer. J Natl. Cancer Inst 1998;90:1346-60.
    • (1998) J Natl. Cancer Inst , vol.90 , pp. 1346-1360
    • Thor, A.D.1    Berry, D.A.2    Budman, D.R.3
  • 26
    • 0036091354 scopus 로고    scopus 로고
    • HER-2 amplification and topoisomerase IIalpha gene aberrations as predictive markers in node-positive breast cancer patients randomly treated with an anthracycline-based therapy or with cyclo phosphamide, methotrexate, and 5-fluorouracil
    • Di Leo A, Gancberg D, Larsimont D, et al. HER-2 amplification and topoisomerase IIalpha gene aberrations as predictive markers in node-positive breast cancer patients randomly treated with an anthracycline-based therapy or with cyclo phosphamide, methotrexate, and 5-fluorouracil. Clin Cancer Res 2002;8:1107-16.
    • (2002) Clin Cancer Res , vol.8 , pp. 1107-1116
    • Di Leo, A.1    Gancberg, D.2    Larsimont, D.3
  • 27
    • 0033870292 scopus 로고    scopus 로고
    • Amplification and deletion of topoisomerase IIalpha associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer
    • Jarvinen TA, Tanner M, Rantanen V, et al. Amplification and deletion of topoisomerase IIalpha associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer. Am J Pathol 2000;156:839-47.
    • (2000) Am J Pathol , vol.156 , pp. 839-847
    • Jarvinen, T.A.1    Tanner, M.2    Rantanen, V.3
  • 28
    • 0031775808 scopus 로고    scopus 로고
    • Predictive value of topoisomerase II alpha and other prognostic factors for epirubicin chemotherapy in advanced breast cancer
    • Jarvinen TA, Holli K, Kuukasjarvi T, Isola JJ. Predictive value of topoisomerase II alpha and other prognostic factors for epirubicin chemotherapy in advanced breast cancer. Br J Cancer 1998;77:2267-73.
    • (1998) Br J Cancer , vol.77 , pp. 2267-2273
    • Jarvinen, T.A.1    Holli, K.2    Kuukasjarvi, T.3    Isola, J.J.4
  • 29
    • 0034694659 scopus 로고    scopus 로고
    • HER2 and choice of adjuvant chemotherapy for invasive breast cancer: National Surgical Adjuvant Breast and Bowel Project Protocol B-15
    • Paik S, Bryant J, Tan-Chiu E, et al. HER2 and choice of adjuvant chemotherapy for invasive breast cancer: National Surgical Adjuvant Breast and Bowel Project Protocol B-15. J Natl. Cancer Inst 2000; 92:1991-98.
    • (2000) J Natl. Cancer Inst , vol.92 , pp. 1991-1998
    • Paik, S.1    Bryant, J.2    Tan-Chiu, E.3
  • 30
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sorlie T, Perou CM, Tibshirani R, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl. Acad Sci USA 2001;98:10,869-74.
    • (2001) Proc Natl. Acad Sci USA , vol.98 , Issue.10 , pp. 869-874
    • Sorlie, T.1    Perou, C.M.2    Tibshirani, R.3
  • 31
    • 0029956081 scopus 로고    scopus 로고
    • Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients
    • Aas T, Borresen AL, Geisler S, et al. Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients. Nat Med 1996;2:811-14.
    • (1996) Nat Med , vol.2 , pp. 811-814
    • Aas, T.1    Borresen, A.L.2    Geisler, S.3
  • 32
    • 0027944206 scopus 로고
    • p53 status and the efficacy of cancer therapy in vivo
    • Lowe SW, Bodis S, McClatchey A, et al. p53 status and the efficacy of cancer therapy in vivo. Science 1994;266:807-10.
    • (1994) Science , vol.266 , pp. 807-810
    • Lowe, S.W.1    Bodis, S.2    McClatchey, A.3
  • 33
    • 0345701265 scopus 로고    scopus 로고
    • Expression of the LIM proteins paxillin and Hic-5 in human tissues
    • Yuminamochi T, Yatomi Y, Osada M, et al. Expression of the LIM proteins paxillin and Hic-5 in human tissues. J Histochem Cytochem 2003;51:513-21.
    • (2003) J Histochem Cytochem , vol.51 , pp. 513-521
    • Yuminamochi, T.1    Yatomi, Y.2    Osada, M.3
  • 34
    • 0035475321 scopus 로고    scopus 로고
    • Paxillin: A focal adhesion-associated adaptor protein
    • Schaller MD. Paxillin: a focal adhesion-associated adaptor protein. Oncogene 2001;20:6459-72.
    • (2001) Oncogene , vol.20 , pp. 6459-6472
    • Schaller, M.D.1
  • 35
    • 4644328892 scopus 로고    scopus 로고
    • Paxillin: Adapting to change
    • Brown MC, Turner CE. Paxillin: adapting to change. Physiol Rev 2004;84:1315-39.
    • (2004) Physiol Rev , vol.84 , pp. 1315-1339
    • Brown, M.C.1    Turner, C.E.2
  • 36
    • 0026770377 scopus 로고
    • Integrins: Versatility, modulation, and signaling in cell adhesion
    • Hynes RO. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 1992;69:11-25.
    • (1992) Cell , vol.69 , pp. 11-25
    • Hynes, R.O.1
  • 37
    • 2442606429 scopus 로고    scopus 로고
    • Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility
    • Subauste MC, Pertz O, Adamson ED, Turner CE, Junger S, Hahn KM. Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility. J Cell Biol 2004;165:371-81.
    • (2004) J Cell Biol , vol.165 , pp. 371-381
    • Subauste, M.C.1    Pertz, O.2    Adamson, E.D.3    Turner, C.E.4    Junger, S.5    Hahn, K.M.6
  • 38
    • 0026445719 scopus 로고
    • Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: A role in cytoskeletal assembly
    • Burridge K, Turner CE, Romer LH. Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly. J Cell Biol 1992;119:893-903.
    • (1992) J Cell Biol , vol.119 , pp. 893-903
    • Burridge, K.1    Turner, C.E.2    Romer, L.H.3
  • 39
    • 0036791850 scopus 로고    scopus 로고
    • Focal adhesion kinase: Protein interactions and cellular functions
    • Abbi S, Guan JL. Focal adhesion kinase: protein interactions and cellular functions. Histol Histopathol 2002;17:1163-671.
    • (2002) Histol Histopathol , vol.17 , pp. 1163-1671
    • Abbi, S.1    Guan, J.L.2
  • 40
    • 0037509990 scopus 로고    scopus 로고
    • Focal adhesion kinase: The first ten years
    • Parsons JT. Focal adhesion kinase: the first ten years. J Cell Sci 2003;116:1409-16.
    • (2003) J Cell Sci , vol.116 , pp. 1409-1416
    • Parsons, J.T.1
  • 42
    • 0029039421 scopus 로고
    • Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors
    • Owens LV, Xu L, Craven RJ, et al. Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res 1995;55:2752-55.
    • (1995) Cancer Res , vol.55 , pp. 2752-2755
    • Owens, L.V.1    Xu, L.2    Craven, R.J.3
  • 43
    • 0034044795 scopus 로고    scopus 로고
    • Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: Correlation with preinvasive and invasive phenotypes
    • Cance WG, Harris JE, Iacocca MV, et al. Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res 2000;6:2417-23.
    • (2000) Clin Cancer Res , vol.6 , pp. 2417-2423
    • Cance, W.G.1    Harris, J.E.2    Iacocca, M.V.3
  • 44
    • 0033570076 scopus 로고    scopus 로고
    • Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma
    • Judson PL, He X, Cance WG, Van Le L. Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma. Cancer 1999;86:1551-56.
    • (1999) Cancer , vol.86 , pp. 1551-1556
    • Judson, P.L.1    He, X.2    Cance, W.G.3    Van Le, L.4
  • 45
    • 1542569457 scopus 로고    scopus 로고
    • Focal adhesion kinase in cancer
    • Hecker TP, Gladson CL. Focal adhesion kinase in cancer. Front Biosci 2003;8:705-14.
    • (2003) Front Biosci , vol.8 , pp. 705-714
    • Hecker, T.P.1    Gladson, C.L.2
  • 46
    • 0033533746 scopus 로고    scopus 로고
    • Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells
    • Agochiya M, Brunton VG, Owens DW, et al. Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells. Oncogene 1999;18:5646-53.
    • (1999) Oncogene , vol.18 , pp. 5646-5653
    • Agochiya, M.1    Brunton, V.G.2    Owens, D.W.3
  • 47
    • 0031439110 scopus 로고    scopus 로고
    • The bovine papillomavirus E6 protein binds to the LD motif repeats of paxillin and blocks its interaction with vinculin and the focal adhesion kinase
    • Tong X, Salgia R, Li JL, Griffin JD, Howley PM. The bovine papillomavirus E6 protein binds to the LD motif repeats of paxillin and blocks its interaction with vinculin and the focal adhesion kinase. J Biol Chem 1997;272:33,373-76.
    • (1997) J Biol Chem , vol.272 , Issue.33 , pp. 373-376
    • Tong, X.1    Salgia, R.2    Li, J.L.3    Griffin, J.D.4    Howley, P.M.5
  • 48
    • 0032495590 scopus 로고    scopus 로고
    • Association of Bovine Papillomavirus Type 1 E6 oncoprotein with the focal adhesion protein paxillin through a conserved protein interaction motif
    • Vande Pol SB, Brown MC, Turner CE. Association of Bovine Papillomavirus Type 1 E6 oncoprotein with the focal adhesion protein paxillin through a conserved protein interaction motif. Oncogene 1998;16:43-52.
    • (1998) Oncogene , vol.16 , pp. 43-52
    • Vande Pol, S.B.1    Brown, M.C.2    Turner, C.E.3
  • 49
    • 0029795243 scopus 로고    scopus 로고
    • Focal adhesion kinase (pp125FAK) expression, activation and association with paxillin and p50CSK in human metastatic prostate carcinoma
    • Tremblay L, Hauck W, Aprikian AG, Begin LR, Chapdelaine A, Chevalier S. Focal adhesion kinase (pp125FAK) expression, activation and association with paxillin and p50CSK in human metastatic prostate carcinoma. Int J Cancer 1996;68:164-71.
    • (1996) Int J Cancer , vol.68 , pp. 164-171
    • Tremblay, L.1    Hauck, W.2    Aprikian, A.G.3    Begin, L.R.4    Chapdelaine, A.5    Chevalier, S.6
  • 50
    • 0030484288 scopus 로고    scopus 로고
    • Integrin expression on cell adhesion function and up-regulation of P125FAK and paxillin in metastatic renal carcinoma cells
    • Jenq W, Cooper DR, Ramirez G. Integrin expression on cell adhesion function and up-regulation of P125FAK and paxillin in metastatic renal carcinoma cells. Connect Tissue Res 1996;34:161-74.
    • (1996) Connect Tissue Res , vol.34 , pp. 161-174
    • Jenq, W.1    Cooper, D.R.2    Ramirez, G.3


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