Crosstalk between integrin and receptor tyrosine kinase signaling in breast carcinoma progression

BMB Reports

Volumn 43, Issue 5, 2010, Pages 311-318

  Soung, Young Hwa ^a   Clifford, John L ^a   Chung, Jun ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77953513171     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2010.43.5.311     Document Type: Review

References (71)

1. Hanahan, D. and Weinberg, R. A. (2000) The hallmarks of cancer. Cell 100, 57-70.
2. Larsen, M., Artym, V. V., Green, J. A. and Yamada, K. M. (2006) The matrix reorganized: extracellular matrix remodeling and integrin signaling. Curr. Opin. Cell Biol. 18, 463-471.
3. Giancotti, F. G. and Ruoslahti, E. (1999) Integrin signaling. Science 285, 1028-1032.
4. Perou, C. M., Sorlie, T., Eisen, M. B., van de Rijn, M., Jeffrey, S. S., Rees, C. A., Pollack, J. R., Ross, D. T., Johnsen, H., Akslen, L. A., Fluge, O., Pergamenschikov, A., Williams, C., Zhu, S. X., Lonning, P. E., Borresen-Dale, A. L., Brown, P. O. and Botstein, D. (2000) Molecular portraits of human breast tumours. Nature 406, 747-752.
5. Nielsen, T. O., Hsu, F. D., Jensen, K., Cheang, M., Karaca, G., Hu, Z., Hernandez-Boussard, T., Livasy, C., Cowan, D., Dressler, L., Akslen, L. A., Ragaz, J., Gown, A. M., Gilks, C. B., van de Rijn, M. and Perou, C. M. (2004) Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin. Cancer Res. 10, 5367-5374.
6. Byers, S., Park, M., Sommers, C. and Seslar, S. (1994) Breast carcinoma: a collective disorder. Breast Cancer Res. Treat. 31, 203-215.
7. Shaw, L. M. (1999) Integrin function in breast carcinoma progression. J. Mammary. Gland. Biol. Neoplasia. 4, 367-376.
8. Aumailley, M., Pesch, M., Tunggal, L., Gaill, F. and Fassler, R. (2000) Altered synthesis of laminin 1 and absence of basement membrane component deposition in (beta)1 integrin-deficient embryoid bodies. J. Cell Sci. 113 Pt 2, 259-268.
9. Plow, E. F., Haas, T. A., Zhang, L., Loftus, J. and Smith, J. W. (2000) Ligand binding to integrins. J. Biol. Chem. 275, 21785-21788.
10. van der Flier, A. and Sonnenberg, A. (2001) Function and interactions of integrins. Cell Tissue. Res. 305, 285-298.
11. Aplin, A. E., Howe, A. K. and Juliano, R. L. (1999) Cell adhesion molecules, signal transduction and cell growth. Curr. Opin. Cell Biol. 11, 737-744.
12. Luo, B. H., Carman, C. V. and Springer, T. A. (2007) Structural basis of integrin regulation and signaling. Annu. Rev. Immunol. 25, 619-647.
13. Bryan, B. A. and D'Amore, P. A. (2007) What tangled webs they weave: Rho-GTPase control of angiogenesis. Cell Mol. Life Sci. 64, 2053-2065.
14. Kanda, S., Kanetake, H. and Miyata, Y. (2007) Role of Src in angiopoietin 1-induced capillary morphogenesis of endothelial cells: effect of chronic hypoxia on Src inhibition by PP2. Cell Signal 19, 472-480.
15. Ridley, A. (2000) Rho GTPases. Integrating integrin signaling. J. Cell Biol. 150, F107-109.
16. Schwartz, M. A. and Shattil, S. J. (2000) Signaling networks linking integrins and rho family GTPases. Trends Biochem. Sci. 25, 388-391.
17. Bertotti, A., Comoglio, P. M. and Trusolino, L. (2006) Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth. J. Cell Biol. 175, 993-1003.
18. Klemke, R. L., Leng, J., Molander, R., Brooks, P. C., Vuori, K. and Cheresh, D. A. (1998) CAS/Crk coupling serves as a "molecular switch" for induction of cell migration. J. Cell Biol. 140, 961-972.
19. Collins, L. R., Ricketts, W. A., Yeh, L. and Cheresh, D. (1999) Bifurcation of cell migratory and proliferative signaling by the adaptor protein Shc. J. Cell Biol. 147, 1561-1568.
20. Mariotti, A., Kedeshian, P. A., Dans, M., Curatola, A. M., Gagnoux-Palacios, L. and Giancotti, F. G. (2001) EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion. J. Cell Biol. 155, 447-458.
21. Moro, L., Dolce, L., Cabodi, S., Bergatto, E., Boeri Erba, E., Smeriglio, M., Turco, E., Retta, S. F., Giuffrida, M. G., Venturino, M., Godovac-Zimmermann, J., Conti, A., Schaefer, E., Beguinot, L., Tacchetti, C., Gaggini, P., Silengo, L., Tarone, G. and Defilippi, P. (2002) Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines. J. Biol. Chem. 277, 9405-9414.
22. Mahabeleshwar, G. H., Feng, W., Reddy, K., Plow, E. F. and Byzova, T. V. (2007) Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis. Circ. Res. 101, 570-580.
23. Somanath, P. R., Kandel, E. S., Hay, N. and Byzova, T. V. (2007) Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly. J. Biol. Chem. 282, 22964-22976.
24. Schneller, M., Vuori, K. and Ruoslahti, E. (1997) Alphavbeta3 integrin associates with activated insulin and PDGF beta receptors and potentiates the biological activity of PDGF. EMBO J. 16, 5600-5607.
25. Borges, E., Jan, Y. and Ruoslahti, E. (2000) Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain. J. Biol. Chem. 275, 39867-39873.
26. Soldi, R., Mitola, S., Strasly, M., Defilippi, P., Tarone, G. and Bussolino, F. (1999) Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2. EMBO J. 18, 882-892.
27. Falcioni, R., Antonini, A., Nistico, P., Di Stefano, S., Crescenzi, M., Natali, P. G. and Sacchi, A. (1997) Alpha 6 beta 4 and alpha 6 beta 1 integrins associate with ErbB-2 in human carcinoma cell lines. Exp. Cell Res. 236, 76-85.
28. Trusolino, L., Bertotti, A. and Comoglio, P. M. (2001) A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth. Cell 107, 643-654.
29. Santoro, M. M., Gaudino, G. and Marchisio, P. C. (2003) The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration. Dev. Cell 5, 257-271.
30. Lipscomb, E. A. and Mercurio, A. M. (2005) Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression. Cancer Metastasis Rev. 24, 413-423.
31. Maile, L. A. and Clemmons, D. R. (2002) The alphaVbeta3 integrin regulates insulin-like growth factor I (IGF-I) receptor phosphorylation by altering the rate of recruitment of the Src-homology 2-containing phosphotyrosine phosphatase-2 to the activated IGF-I receptor. Endocrinology 143, 4259-4264.
32. Baron, W., Shattil, S. J. and ffrench-Constant, C. (2002) The oligodendrocyte precursor mitogen PDGF stimulates proliferation by activation of alpha(v)beta3 integrins. EMBO J. 21, 1957-1966.
33. Rabinovitz, I., Toker, A. and Mercurio, A. M. (1999) Protein kinase C-dependent mobilization of the alpha 6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells. J. Cell Biol. 146, 1147-1160.
34. Rabinovitz, I., Tsomo, L. and Mercurio, A. M. (2004) Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes. Mol. Cell Biol. 24, 4351-4360.
35. Germain, E. C., Santos, T. M. and Rabinovitz, I. (2009) Phosphorylation of a novel site on the {beta}4 integrin at the trailing edge of migrating cells promotes hemidesmosome disassembly. Mol. Biol. Cell 20, 56-67.
36. Trusolino, L. and Comoglio, P. M. (2002) Scatter-factor and semaphorin receptors: cell signalling for invasive growth. Nat. Rev. Cancer 2, 289-300.
37. Mercurio, A. M., Bachelder, R. E., Rabinovitz, I., O'Connor, K. L., Tani, T. and Shaw, L. M. (2001) The metastatic odyssey: the integrin connection. Surg. Oncol. Clin. N. Am. 10, 313-328.
38. Nguyen, B. P., Ryan, M. C., Gil, S. G. and Carter, W. G. (2000) Deposition of laminin 5 in epidermal wounds regulates integrin signaling and adhesion. Curr. Opin. Cell Biol. 12, 554-562.
39. Mercurio, A. M., Bachelder, R. E., Bates, R. C. and Chung, J. (2004) Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin. Semin. Cancer Biol. 14, 115-122.
40. Chung, J. and Mercurio, A. M. (2004) Contributions of the alpha6 integrins to breast carcinoma survival and progression. Mol. Cells 17, 203-209.
41. Mercurio, A. M. and Rabinovitz, I. (2001) Towards a mechanistic understanding of tumor invasion-lessons from the alpha6beta 4 integrin. Semin. Cancer Biol. 11, 129-141.
42. Chung, J., Bachelder, R. E., Lipscomb, E. A., Shaw, L. M. and Mercurio, A. M. (2002) Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells. J. Cell Biol. 158, 165-174.
43. Mercurio, A. M., Rabinovitz, I. and Shaw, L. M. (2001) The alpha 6 beta 4 integrin and epithelial cell migration. Curr. Opin. Cell Biol. 13, 541-545.
44. Head, B. P., Patel, H. H., Roth, D. M., Murray, F., Swaney, J. S., Niesman, I. R., Farquhar, M. G. and Insel, P. A. (2006) Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components. J. Biol. Chem. 281, 26391-26399.
45. de Laurentiis, A., Donovan, L. and Arcaro, A. (2007) Lipid rafts and caveolae in signaling by growth factor receptors. Open Biochem. J. 1, 12-32.
46. Guo, W., Pylayeva, Y., Pepe, A., Yoshioka, T., Muller, W. J., Inghirami, G. and Giancotti, F. G. (2006) Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell 126, 489-502.
47. Gambaletta, D., Marchetti, A., Benedetti, L., Mercurio, A. M., Sacchi, A. and Falcioni, R. (2000) Cooperative signaling between alpha(6)beta(4) integrin and ErbB-2 receptor is required to promote phosphatidylinositol 3-kinasedependent invasion. J. Biol. Chem. 275, 10604-10610.
48. Folgiero, V., Bachelder, R. E., Bon, G., Sacchi, A., Falcioni, R. and Mercurio, A. M. (2007) The alpha6beta4 integrin can regulate ErbB-3 expression: implications for alpha6 beta4 signaling and function. Cancer Res. 67, 1645-1652.
49. Gilcrease, M. Z., Zhou, X., Lu, X., Woodward, W. A., Hall, B. E. and Morrissey, P. J. (2009) Alpha6beta4 integrin crosslinking induces EGFR clustering and promotes EGF-mediated Rho activation in breast cancer. J. Exp. Clin. Cancer Res. 28, 67.
50. Chung, J., Yoon, S. O., Lipscomb, E. A. and Mercurio, A. M. (2004) The Met receptor and alpha 6 beta 4 integrin can function independently to promote carcinoma invasion. J. Biol. Chem. 279, 32287-32293.
51. Meyer, T., Marshall, J. F. and Hart, I. R. (1998) Expression of alphav integrins and vitronectin receptor identity in breast cancer cells. Br. J. Cancer 77, 530-536.
52. Wong, N. C., Mueller, B. M., Barbas, C. F., Ruminski, P., Quaranta, V., Lin, E. C. and Smith, J. W. (1998) Alphav integrins mediate adhesion and migration of breast carcinoma cell lines. Clin. Exp. Metastasis. 16, 50-61.
53. Brooks, P. C., Stromblad, S., Klemke, R., Visscher, D., Sarkar, F. H. and Cheresh, D. A. (1995) Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin. J. Clin. Invest. 96, 1815-1822.
54. Gramoun, A., Shorey, S., Bashutski, J. D., Dixon, S. J., Sims, S. M., Heersche, J. N. and Manolson, M. F. (2007) Effects of Vitaxin, a novel therapeutic in trial for metastatic bone tumors, on osteoclast functions in vitro. J. Cell Biochem. 102, 341-352.
55. Eliceiri, B. P. (2001) Integrin and growth factor receptor crosstalk. Circ. Res. 89, 1104-1110.
56. Tuck, A. B., Elliott, B. E., Hota, C., Tremblay, E. and Chambers, A. F. (2000) Osteopontin-induced, integrindependent migration of human mammary epithelial cells involves activation of the hepatocyte growth factor receptor (Met). J. Cell Biochem. 78, 465-475.
57. White, D. E. and Muller, W. J. (2007) Multifaceted roles of integrins in breast cancer metastasis. J. Mammary. Gland. Biol. Neoplasia. 12, 135-142.
58. Colognato, H., Baron, W., Avellana-Adalid, V., Relvas, J. B., Baron-Van Evercooren, A., Georges-Labouesse, E. and ffrench-Constant, C. (2002) CNS integrins switch growth factor signalling to promote target-dependent survival. Nat. Cell Biol. 4, 833-841.
59. Somanath, P. R., Malinin, N. L. and Byzova, T. V. (2009) Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis. Angiogenesis 12, 177-185.
60. Phillips, D. R., Prasad, K. S., Manganello, J., Bao, M. and Nannizzi-Alaimo, L. (2001) Integrin tyrosine phosphorylation in platelet signaling. Curr. Opin. Cell Biol. 13, 546-554.
61. Mori, S., Wu, C. Y., Yamaji, S., Saegusa, J., Shi, B., Ma, Z., Kuwabara, Y., Lam, K. S., Isseroff, R. R., Takada, Y. K. and Takada, Y. (2008) Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling. J. Biol. Chem. 283, 18066-18075.
62. Danen, E. H. and Yamada, K. M. (2001) Fibronectin, in tegrins, and growth control. J. Cell Physiol. 189, 1-13.
63. Nista, A., Leonetti, C., Bernardini, G., Mattioni, M. and Santoni, A. (1997) Functional role of alpha4beta1 and alpha5beta1 integrin fibronectin receptors expressed on adriamycin-resistant MCF-7 human mammary carcinoma cells. Int. J. Cancer 72, 133-141.
64. Morozevich, G., Kozlova, N., Cheglakov, I., Ushakova, N. and Berman, A. (2009) Integrin alpha5beta1 controls invasion of human breast carcinoma cells by direct and indirect modulation of MMP-2 collagenase activity. Cell Cycle 8, 2219-2225.
65. Jia, Y., Zeng, Z. Z., Markwart, S. M., Rockwood, K. F., Ignatoski, K. M., Ethier, S. P. and Livant, D. L. (2004) Integrin fibronectin receptors in matrix metalloproteinase-1-dependent invasion by breast cancer and mammary epithelial cells. Cancer Res. 64, 8674-8681.
66. Liu, Y., Pixley, R., Fusaro, M., Godoy, G., Kim, E., Bromberg, M. E. and Colman, R. W. (2009) Cleaved high-molecular-weight kininogen and its domain 5 inhibit migration and invasion of human prostate cancer cells through the epidermal growth factor receptor pathway. Oncogene 28, 2756-2765.
67. Cascone, I., Napione, L., Maniero, F., Serini, G. and Bussolino, F. (2005) Stable interaction between alpha5beta1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1. J. Cell Biol. 170, 993-1004.
68. Zhang, X., Groopman, J. E. and Wang, J. F. (2005) Extracellular matrix regulates endothelial functions through interaction of VEGFR-3 and integrin alpha5beta1. J. Cell Physiol. 202, 205-214.
69. Lee, J. W. and Juliano, R. L. (2002) The alpha5beta1 integrin selectively enhances epidermal growth factor signaling to the phosphatidylinositol-3-kinase/Akt pathway in intestinal epithelial cells. Biochim. Biophys. Acta. 1542, 23-31.
70. Rahman, S., Patel, Y., Murray, J., Patel, K. V., Sumathipala, R., Sobel, M. and Wijelath, E. S. (2005) Novel hepatocyte growth factor (HGF) binding domains on fibronectin and vitronectin coordinate a distinct and amplified Met-integrin induced signalling pathway in endothelial cells. BMC. Cell Biol. 6, 8.
71. Bell, L. N., Cai, L., Johnstone, B. H., Traktuev, D. O., March, K. L. and Considine, R. V. (2008) A central role for hepatocyte growth factor in adipose tissue angiogenesis. Am. J. Physiol. Endocrinol. Metab. 294, E336-344.