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Volumn 33, Issue 3, 2012, Pages 628.e1-628.e14

Association of ApoE and LRP mRNA levels with dementia and AD neuropathology

Author keywords

Alzheimer's disease; APOE; Dementia; Hippocampus; LRP

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MESSENGER RNA;

EID: 84855767006     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2011.04.010     Document Type: Article
Times cited : (28)

References (117)
  • 1
    • 76449103011 scopus 로고    scopus 로고
    • Increased expression of cholesterol transporter ABCA1 is highly correlated with severity of dementia in AD hippocampus
    • Akram A., Schmeidler J., Katsel P., Hof P.R., Haroutunian V. Increased expression of cholesterol transporter ABCA1 is highly correlated with severity of dementia in AD hippocampus. Brain Res 2010, 1318:167-177.
    • (2010) Brain Res , vol.1318 , pp. 167-177
    • Akram, A.1    Schmeidler, J.2    Katsel, P.3    Hof, P.R.4    Haroutunian, V.5
  • 6
    • 0032829336 scopus 로고    scopus 로고
    • Apolipoprotein E and beta-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein E genotype dependent
    • Beffert U., Cohn J.S., Petit-Turcotte C., Tremblay M., Aumont N., Ramassamy C., Davignon J., Poirier J. Apolipoprotein E and beta-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein E genotype dependent. Brain Res 1999, 843:87-94.
    • (1999) Brain Res , vol.843 , pp. 87-94
    • Beffert, U.1    Cohn, J.S.2    Petit-Turcotte, C.3    Tremblay, M.4    Aumont, N.5    Ramassamy, C.6    Davignon, J.7    Poirier, J.8
  • 7
    • 1542409285 scopus 로고    scopus 로고
    • Functions of lipoprotein receptors in neurons
    • Beffert U., Stolt P.C., Herz J. Functions of lipoprotein receptors in neurons. J. Lipid Res 2004, 45:403-409.
    • (2004) J. Lipid Res , vol.45 , pp. 403-409
    • Beffert, U.1    Stolt, P.C.2    Herz, J.3
  • 8
    • 34247506244 scopus 로고    scopus 로고
    • Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system
    • Bell R.D., Sagare A.P., Friedman A.E., Bedi G.S., Holtzman D.M., Deane R., Zlokovic B.V. Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J. Cereb. Blood Flow Metab 2007, 27:909-918.
    • (2007) J. Cereb. Blood Flow Metab , vol.27 , pp. 909-918
    • Bell, R.D.1    Sagare, A.P.2    Friedman, A.E.3    Bedi, G.S.4    Holtzman, D.M.5    Deane, R.6    Zlokovic, B.V.7
  • 9
    • 14644416500 scopus 로고    scopus 로고
    • Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions
    • Bennett D.A., Schneider J.A., Bienias J.L., Evans D.A., Wilson R.S. Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions. Neurology 2005, 64:834-841.
    • (2005) Neurology , vol.64 , pp. 834-841
    • Bennett, D.A.1    Schneider, J.A.2    Bienias, J.L.3    Evans, D.A.4    Wilson, R.S.5
  • 11
    • 66249141948 scopus 로고    scopus 로고
    • Alzheimer's disease genetics current status and future perspectives
    • Bertram L. Alzheimer's disease genetics current status and future perspectives. Int. Rev. Neurobiol 2009, 84:167-184.
    • (2009) Int. Rev. Neurobiol , vol.84 , pp. 167-184
    • Bertram, L.1
  • 12
    • 0029119753 scopus 로고
    • Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease
    • Bertrand P., Poirier J., Oda T., Finch C.E., Pasinetti G.M. Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease. Brain Res. Mol. Brain Res 1995, 33:174-178.
    • (1995) Brain Res. Mol. Brain Res , vol.33 , pp. 174-178
    • Bertrand, P.1    Poirier, J.2    Oda, T.3    Finch, C.E.4    Pasinetti, G.M.5
  • 13
    • 14644442872 scopus 로고    scopus 로고
    • Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice
    • Billings L.M., Oddo S., Green K.N., McGaugh J.L., LaFerla F.M. Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 2005, 45:675-688.
    • (2005) Neuron , vol.45 , pp. 675-688
    • Billings, L.M.1    Oddo, S.2    Green, K.N.3    McGaugh, J.L.4    LaFerla, F.M.5
  • 16
    • 0025863618 scopus 로고
    • Neuropathological staging of Alzheimer-related changes
    • Braak H., Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol. (Berl) 1991, 82:239-259.
    • (1991) Acta Neuropathol. (Berl) , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 19
    • 0028298886 scopus 로고
    • Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons
    • Bu G., Maksymovitch E.A., Nerbonne J.M., Schwartz A.L. Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons. J. Biol. Chem 1994, 269:18521-18528.
    • (1994) J. Biol. Chem , vol.269 , pp. 18521-18528
    • Bu, G.1    Maksymovitch, E.A.2    Nerbonne, J.M.3    Schwartz, A.L.4
  • 21
    • 36849014338 scopus 로고    scopus 로고
    • Schizophrenia and Sex Associated Differences in the Expression of Neuronal and Oligodendrocyte Specific Genes in Individual Thalamic Nuclei
    • Byne W., Dracheva S., Chin B., Schmeidler J.M., Davis K.L., Haroutunian V. Schizophrenia and Sex Associated Differences in the Expression of Neuronal and Oligodendrocyte Specific Genes in Individual Thalamic Nuclei. Schizo. Res 2008, 98:118-128.
    • (2008) Schizo. Res , vol.98 , pp. 118-128
    • Byne, W.1    Dracheva, S.2    Chin, B.3    Schmeidler, J.M.4    Davis, K.L.5    Haroutunian, V.6
  • 22
    • 0141891169 scopus 로고    scopus 로고
    • Lack of association between the levels of the low-density lipoprotein receptor-related protein (LRP) and cognitive decline or dementia
    • Causevic M., Ramoz N., Haroutunian V., Davis K.L., Buxbaum J.D. Lack of association between the levels of the low-density lipoprotein receptor-related protein (LRP) and cognitive decline or dementia. J. Neuropathol. Exp. Neurol 2003, 62:999-1005.
    • (2003) J. Neuropathol. Exp. Neurol , vol.62 , pp. 999-1005
    • Causevic, M.1    Ramoz, N.2    Haroutunian, V.3    Davis, K.L.4    Buxbaum, J.D.5
  • 23
    • 24944495484 scopus 로고    scopus 로고
    • Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI: a longitudinal MRI study
    • Chételat G., Landeau B., Eustache F., Mézenge F., Viader F., de la Sevette V., Desgranges B., Baron J.C. Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI: a longitudinal MRI study. Neuroimage 2005, 27:934-946.
    • (2005) Neuroimage , vol.27 , pp. 934-946
    • Chételat, G.1    Landeau, B.2    Eustache, F.3    Mézenge, F.4    Viader, F.5    de la Sevette, V.6    Desgranges, B.7    Baron, J.C.8
  • 24
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem 1987, 162:156-159.
    • (1987) Anal. Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 33
    • 0029886811 scopus 로고    scopus 로고
    • The Clinical Dementia Rating scale: community-based validation of "profound" and "terminal" stages
    • Dooneief G., Marder K., Tang M.X., Ster Y., Dooneief G. The Clinical Dementia Rating scale: community-based validation of "profound" and "terminal" stages. Neurology 1996, 46:1746-1749.
    • (1996) Neurology , vol.46 , pp. 1746-1749
    • Dooneief, G.1    Marder, K.2    Tang, M.X.3    Ster, Y.4    Dooneief, G.5
  • 34
    • 0034843740 scopus 로고    scopus 로고
    • N-methyl-D-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia
    • Dracheva S., Marras S.A., Elhakem S.L., Kramer F.R., Davis K.L., Haroutunian V. N-methyl-D-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia. Am. J. Psychiatry 2001, 9:1400-1410.
    • (2001) Am. J. Psychiatry , vol.9 , pp. 1400-1410
    • Dracheva, S.1    Marras, S.A.2    Elhakem, S.L.3    Kramer, F.R.4    Davis, K.L.5    Haroutunian, V.6
  • 35
    • 15244340676 scopus 로고    scopus 로고
    • Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model
    • Fryer J.D., Simmons K., Parsadanian M., Bales K.R., Paul S.M., Sullivan P.M., Holtzman D.M. Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. J. Neurosci 2005, 25:2803-2810.
    • (2005) J. Neurosci , vol.25 , pp. 2803-2810
    • Fryer, J.D.1    Simmons, K.2    Parsadanian, M.3    Bales, K.R.4    Paul, S.M.5    Sullivan, P.M.6    Holtzman, D.M.7
  • 36
    • 0028884524 scopus 로고
    • Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of very old patients
    • Giannakopoulos P., Hof P.R., Giannakopoulos A.S., Herrmann F.R., Michel J.P., Bouras C. Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of very old patients. Arch. Neurol 1995, 52:1150-1159.
    • (1995) Arch. Neurol , vol.52 , pp. 1150-1159
    • Giannakopoulos, P.1    Hof, P.R.2    Giannakopoulos, A.S.3    Herrmann, F.R.4    Michel, J.P.5    Bouras, C.6
  • 39
    • 0035115847 scopus 로고    scopus 로고
    • Two distal downstream enhancers direct expression of the human apolipoprotein E gene to astrocytes in the brain
    • Grehan S., Tse E., Taylor J.M. Two distal downstream enhancers direct expression of the human apolipoprotein E gene to astrocytes in the brain. J. Neurosci 2001, 21:812-822.
    • (2001) J. Neurosci , vol.21 , pp. 812-822
    • Grehan, S.1    Tse, E.2    Taylor, J.M.3
  • 40
    • 33751245561 scopus 로고    scopus 로고
    • Tau protein abnormalities associated with the progression of alzheimer disease type dementia
    • Haroutunian V., Davies P., Vianna C., Buxbaum J.D., Purohit D.P. Tau protein abnormalities associated with the progression of alzheimer disease type dementia. Neurobiol. Aging 2007, 28:1-7.
    • (2007) Neurobiol. Aging , vol.28 , pp. 1-7
    • Haroutunian, V.1    Davies, P.2    Vianna, C.3    Buxbaum, J.D.4    Purohit, D.P.5
  • 41
    • 61649089088 scopus 로고    scopus 로고
    • Transcriptional vulnerability of brain regions in Alzheimer's disease and dementia
    • Haroutunian V., Katsel P., Schmeidler J. Transcriptional vulnerability of brain regions in Alzheimer's disease and dementia. Neurobiol. Aging 2009, 30:561-573.
    • (2009) Neurobiol. Aging , vol.30 , pp. 561-573
    • Haroutunian, V.1    Katsel, P.2    Schmeidler, J.3
  • 42
    • 0031781988 scopus 로고    scopus 로고
    • Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease
    • Haroutunian V., Perl D.P., Purohit D.P., Marin D., Khan K., Lantz M., Davis K.L., Mohs R.C. Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease. Arch. Neurol 1998, 55:1185-1191.
    • (1998) Arch. Neurol , vol.55 , pp. 1185-1191
    • Haroutunian, V.1    Perl, D.P.2    Purohit, D.P.3    Marin, D.4    Khan, K.5    Lantz, M.6    Davis, K.L.7    Mohs, R.C.8
  • 44
    • 0030001328 scopus 로고    scopus 로고
    • Brain expression of apolipoproteins E, J, and A-I in Alzheimer's disease
    • Harr S.D., Uint L., Hollister R., Hyman B.T., Mendez A.J. Brain expression of apolipoproteins E, J, and A-I in Alzheimer's disease. J. Neurochem 1996, 66:2429-2435.
    • (1996) J. Neurochem , vol.66 , pp. 2429-2435
    • Harr, S.D.1    Uint, L.2    Hollister, R.3    Hyman, B.T.4    Mendez, A.J.5
  • 46
    • 0001665337 scopus 로고
    • Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor
    • Herz J., Hamann U., Rogne S., Myklebost O., Gausepohl H., Stanley K.K. Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J 1988, 7:4119-4127.
    • (1988) EMBO J , vol.7 , pp. 4119-4127
    • Herz, J.1    Hamann, U.2    Rogne, S.3    Myklebost, O.4    Gausepohl, H.5    Stanley, K.K.6
  • 47
    • 0034836428 scopus 로고    scopus 로고
    • LRP: a multifunctional scavenger and signaling receptor
    • Herz J., Strickland D.K. LRP: a multifunctional scavenger and signaling receptor. J. Clin. Invest 2001, 108:779-784.
    • (2001) J. Clin. Invest , vol.108 , pp. 779-784
    • Herz, J.1    Strickland, D.K.2
  • 48
    • 0032739315 scopus 로고    scopus 로고
    • A quantitative and immunohistochemical study on apolipoprotein E in brain tissue in Alzheimer's disease
    • Hesse C., Bogdanovic N., Davidsson P., Blennow K. A quantitative and immunohistochemical study on apolipoprotein E in brain tissue in Alzheimer's disease. Dement. Geriatr. Cogn. Disord 1999, 10:452-459.
    • (1999) Dement. Geriatr. Cogn. Disord , vol.10 , pp. 452-459
    • Hesse, C.1    Bogdanovic, N.2    Davidsson, P.3    Blennow, K.4
  • 54
    • 0022491546 scopus 로고
    • Extensive postmortem stability of RNA from rat and human brain
    • Johnson S.A., Morgan D.G., Finch C.E. Extensive postmortem stability of RNA from rat and human brain. J. Neurosci. Res 1986, 16:267-280.
    • (1986) J. Neurosci. Res , vol.16 , pp. 267-280
    • Johnson, S.A.1    Morgan, D.G.2    Finch, C.E.3
  • 55
    • 0031963852 scopus 로고    scopus 로고
    • Isoform-specific effect of apolipoprotein E on cell survival and beta-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures
    • Jordán J., Galindo M.F., Miller R.J., Reardon C.A., Getz G.S., LaDu M.J. Isoform-specific effect of apolipoprotein E on cell survival and beta-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures. J. Neurosci 1998, 18:195-204.
    • (1998) J. Neurosci , vol.18 , pp. 195-204
    • Jordán, J.1    Galindo, M.F.2    Miller, R.J.3    Reardon, C.A.4    Getz, G.S.5    LaDu, M.J.6
  • 57
    • 0030752288 scopus 로고    scopus 로고
    • Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease
    • Kang D.E., Saitoh T., Chen X., Xia Y., Masliah E., Hansen L.A., Thomas R.G., Thal L.J., Katzman R. Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease. Neurology 1997, 49:56-61.
    • (1997) Neurology , vol.49 , pp. 56-61
    • Kang, D.E.1    Saitoh, T.2    Chen, X.3    Xia, Y.4    Masliah, E.5    Hansen, L.A.6    Thomas, R.G.7    Thal, L.J.8    Katzman, R.9
  • 58
    • 70449565191 scopus 로고    scopus 로고
    • Gain in brain immunity in the oldest-old differentiates cognitively normal from demented individuals
    • Katsel P., Tan W., Haroutunian V. Gain in brain immunity in the oldest-old differentiates cognitively normal from demented individuals. PLoS One 2009, 4:e7642.
    • (2009) PLoS One , vol.4
    • Katsel, P.1    Tan, W.2    Haroutunian, V.3
  • 59
    • 0035503797 scopus 로고    scopus 로고
    • Demonstration by fluorescence resonance energy transfer of two sites of interaction between the low-density lipoprotein receptor-related protein and the amyloid precursor protein: role of the intracellular adapter protein Fe65
    • Kinoshita A., Whelan C.M., Smith C.J., Mikhailenko I., Rebeck G.W., Strickland D.K., Hyman B.T. Demonstration by fluorescence resonance energy transfer of two sites of interaction between the low-density lipoprotein receptor-related protein and the amyloid precursor protein: role of the intracellular adapter protein Fe65. J. Neurosci 2001, 21:8354-8361.
    • (2001) J. Neurosci , vol.21 , pp. 8354-8361
    • Kinoshita, A.1    Whelan, C.M.2    Smith, C.J.3    Mikhailenko, I.4    Rebeck, G.W.5    Strickland, D.K.6    Hyman, B.T.7
  • 60
    • 0030592750 scopus 로고    scopus 로고
    • Cell surface. APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP)
    • Knauer M.F., Orlando R.A., Glabe C.G. Cell surface. APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP). Brain Res 1996, 740:6-14.
    • (1996) Brain Res , vol.740 , pp. 6-14
    • Knauer, M.F.1    Orlando, R.A.2    Glabe, C.G.3
  • 61
    • 0028276801 scopus 로고
    • Evidence that production and release of amyloid beta-protein involves the endocytic pathway
    • Koo E.H., Squazzo S.L. Evidence that production and release of amyloid beta-protein involves the endocytic pathway. J. Biol. Chem 1994, 269:17386-17389.
    • (1994) J. Biol. Chem , vol.269 , pp. 17386-17389
    • Koo, E.H.1    Squazzo, S.L.2
  • 63
    • 0029128232 scopus 로고
    • LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation
    • Kounnas M.Z., Moir R.D., Rebeck G.W., Bush A.I., Argraves W.S., Tanzi R.E., Hyman B.T., Strickland D.K. LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell 1995, 82:331-340.
    • (1995) Cell , vol.82 , pp. 331-340
    • Kounnas, M.Z.1    Moir, R.D.2    Rebeck, G.W.3    Bush, A.I.4    Argraves, W.S.5    Tanzi, R.E.6    Hyman, B.T.7    Strickland, D.K.8
  • 64
    • 0028173897 scopus 로고
    • Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP)
    • Krieger M., Herz J. Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu. Rev. Biochem 1994, 63:601-637.
    • (1994) Annu. Rev. Biochem , vol.63 , pp. 601-637
    • Krieger, M.1    Herz, J.2
  • 67
    • 34250819839 scopus 로고    scopus 로고
    • Intracellular amyloid-beta in Alzheimer's disease
    • LaFerla F.M., Green K.N., Oddo S. Intracellular amyloid-beta in Alzheimer's disease. Nat. Rev. Neurosci 2007, 8:499-509.
    • (2007) Nat. Rev. Neurosci , vol.8 , pp. 499-509
    • LaFerla, F.M.1    Green, K.N.2    Oddo, S.3
  • 69
    • 0029736930 scopus 로고    scopus 로고
    • Apolipoprotein E in cerebrospinal fluid from patients with Alzheimer's disease and other forms of dementia is reduced but without any correlation to the apoE4 isoform
    • Landén M., Hesse C., Fredman P., Regland B., Wallin A., Blennow K. Apolipoprotein E in cerebrospinal fluid from patients with Alzheimer's disease and other forms of dementia is reduced but without any correlation to the apoE4 isoform. Dementia 1996, 7:273-278.
    • (1996) Dementia , vol.7 , pp. 273-278
    • Landén, M.1    Hesse, C.2    Fredman, P.3    Regland, B.4    Wallin, A.5    Blennow, K.6
  • 71
    • 0031042451 scopus 로고    scopus 로고
    • Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population
    • Lendon C.L., Talbot C.J., Craddock N.J., Han S.W., Wragg M., Morris J.C., Goate A.M. Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population. Neurosci. Lett 1997, 222:187-190.
    • (1997) Neurosci. Lett , vol.222 , pp. 187-190
    • Lendon, C.L.1    Talbot, C.J.2    Craddock, N.J.3    Han, S.W.4    Wragg, M.5    Morris, J.C.6    Goate, A.M.7
  • 72
    • 0034796509 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor family: endocytosis and signal transduction
    • Li Y., Cam J., Bu G. Low-density lipoprotein receptor family: endocytosis and signal transduction. Mol. Neurobiol 2001, 23:53-67.
    • (2001) Mol. Neurobiol , vol.23 , pp. 53-67
    • Li, Y.1    Cam, J.2    Bu, G.3
  • 77
    • 0025908356 scopus 로고
    • The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
    • Mirra S.S., Heyman A., McKeel D., Sumi S.M., Crain B.J., Brownlee L.M., Vogel F.S., Hughes J.P., van Belle G., Berg L. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991, 41:479-486.
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3    Sumi, S.M.4    Crain, B.J.5    Brownlee, L.M.6    Vogel, F.S.7    Hughes, J.P.8    van Belle, G.9    Berg, L.10
  • 78
    • 77957756456 scopus 로고
    • Guide to the CERAD Protocol for the Neuropathological Assessment of Alzheimer's Disease
    • Mirra S.S., Vogel F.S., Heyman A. Guide to the CERAD Protocol for the Neuropathological Assessment of Alzheimer's Disease. CERAD. Durham, NC 1987.
    • (1987) CERAD. Durham, NC
    • Mirra, S.S.1    Vogel, F.S.2    Heyman, A.3
  • 80
    • 0033621540 scopus 로고    scopus 로고
    • Abeta42-positive non-pyramidal neurons around amyloid plaques in Alzheimer's disease
    • Mochizuki A., Tamaoka A., Shimohata A., Komatsuzaki Y., Shoji S. Abeta42-positive non-pyramidal neurons around amyloid plaques in Alzheimer's disease. Lancet 2000, 355:42-43.
    • (2000) Lancet , vol.355 , pp. 42-43
    • Mochizuki, A.1    Tamaoka, A.2    Shimohata, A.3    Komatsuzaki, Y.4    Shoji, S.5
  • 81
    • 0026731852 scopus 로고
    • Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues
    • Moestrup S.K., Gliemann J., Pallesen G. Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. Cell Tissue Res 1992, 269:375-382.
    • (1992) Cell Tissue Res , vol.269 , pp. 375-382
    • Moestrup, S.K.1    Gliemann, J.2    Pallesen, G.3
  • 83
    • 0027425211 scopus 로고
    • The clinical dementia rating (CDR): current version and scoring rules
    • Morris J.C. The clinical dementia rating (CDR): current version and scoring rules. Neurology 1993, 43:2412-2414.
    • (1993) Neurology , vol.43 , pp. 2412-2414
    • Morris, J.C.1
  • 87
    • 0034193309 scopus 로고    scopus 로고
    • Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin
    • Oleinikov A.V., Zhao J., Makker S.P. Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin. Biochem. J 2000, 347:613-621.
    • (2000) Biochem. J , vol.347 , pp. 613-621
    • Oleinikov, A.V.1    Zhao, J.2    Makker, S.P.3
  • 88
    • 0033516554 scopus 로고    scopus 로고
    • Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42
    • Perez R.G., Soriano S., Hayes J.D., Ostaszewski B., Xia W., Selkoe D.J., Chen X., Stokin G.B., Koo E.H. Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42. J. Biol. Chem 1999, 274:18851-18856.
    • (1999) J. Biol. Chem , vol.274 , pp. 18851-18856
    • Perez, R.G.1    Soriano, S.2    Hayes, J.D.3    Ostaszewski, B.4    Xia, W.5    Selkoe, D.J.6    Chen, X.7    Stokin, G.B.8    Koo, E.H.9
  • 89
    • 0036846405 scopus 로고    scopus 로고
    • The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing
    • Pietrzik C.U., Busse T., Merriam D.E., Weggen S., Koo E.H. The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing. EMBO J 2002, 21:5691-5700.
    • (2002) EMBO J , vol.21 , pp. 5691-5700
    • Pietrzik, C.U.1    Busse, T.2    Merriam, D.E.3    Weggen, S.4    Koo, E.H.5
  • 90
    • 2442498577 scopus 로고    scopus 로고
    • FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein
    • Pietrzik C.U., Yoon I.S., Jaeger S., Busse T., Weggen S., Koo E.H. FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein. J. Neurosci 2004, 24:4259-4265.
    • (2004) J. Neurosci , vol.24 , pp. 4259-4265
    • Pietrzik, C.U.1    Yoon, I.S.2    Jaeger, S.3    Busse, T.4    Weggen, S.5    Koo, E.H.6
  • 91
    • 0029893904 scopus 로고    scopus 로고
    • The frequency of apolipoprotein E4 allele is not increased in patients with probable vascular dementia
    • Pirttila T., Lehtimaki T., Rinne J., Mattila K., Frey H., Nikkari T. The frequency of apolipoprotein E4 allele is not increased in patients with probable vascular dementia. Acta Neurol. Scand 1996, 93:352-354.
    • (1996) Acta Neurol. Scand , vol.93 , pp. 352-354
    • Pirttila, T.1    Lehtimaki, T.2    Rinne, J.3    Mattila, K.4    Frey, H.5    Nikkari, T.6
  • 93
    • 0023080585 scopus 로고
    • Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins
    • Pitas R.E., Boyles J.K., Lee S.H., Foss D., Mahley R.W. Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins. Biochim. Biophys. Acta 1987, 917:148-161.
    • (1987) Biochim. Biophys. Acta , vol.917 , pp. 148-161
    • Pitas, R.E.1    Boyles, J.K.2    Lee, S.H.3    Foss, D.4    Mahley, R.W.5
  • 95
    • 0032498945 scopus 로고    scopus 로고
    • Alzheimer disease and related neurodegenerative diseases in elderly patients with schizophrenia: a postmortem neuropathologic study of 100 cases
    • Purohit D.P., Perl D.P., Haroutunian V., Powchik P., Davidson M., Davis K.L. Alzheimer disease and related neurodegenerative diseases in elderly patients with schizophrenia: a postmortem neuropathologic study of 100 cases. Arch. Gen. Psychiatry 1998, 55:205-211.
    • (1998) Arch. Gen. Psychiatry , vol.55 , pp. 205-211
    • Purohit, D.P.1    Perl, D.P.2    Haroutunian, V.3    Powchik, P.4    Davidson, M.5    Davis, K.L.6
  • 96
    • 0035020834 scopus 로고    scopus 로고
    • Elevation of LDL receptor-related protein levels via ligand interactions in Alzheimer disease and in vitro
    • Qiu Z., Strickland D.K., Hyman B.T., Rebeck G.W. Elevation of LDL receptor-related protein levels via ligand interactions in Alzheimer disease and in vitro. J. Neuropathol. Exp. Neurol 2001, 60:430-440.
    • (2001) J. Neuropathol. Exp. Neurol , vol.60 , pp. 430-440
    • Qiu, Z.1    Strickland, D.K.2    Hyman, B.T.3    Rebeck, G.W.4
  • 97
    • 0028894661 scopus 로고
    • Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein
    • Rebeck G.W., Harr S.D., Strickland D.K., Hyman B.T. Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein. Ann. Neurol 1995, 37:211-217.
    • (1995) Ann. Neurol , vol.37 , pp. 211-217
    • Rebeck, G.W.1    Harr, S.D.2    Strickland, D.K.3    Hyman, B.T.4
  • 99
    • 0036851863 scopus 로고    scopus 로고
    • The liver X receptor gene team: potential new players in atherosclerosis
    • Repa J.J., Mangelsdorf D.J. The liver X receptor gene team: potential new players in atherosclerosis. Nat. Med 2002, 8:1243-1248.
    • (2002) Nat. Med , vol.8 , pp. 1243-1248
    • Repa, J.J.1    Mangelsdorf, D.J.2
  • 100
    • 0030005627 scopus 로고    scopus 로고
    • Apolipoprotein E alleles as risk factors in Alzheimer's disease
    • Roses A.D. Apolipoprotein E alleles as risk factors in Alzheimer's disease. Annu. Review Med 1996, 47:387-400.
    • (1996) Annu. Review Med , vol.47 , pp. 387-400
    • Roses, A.D.1
  • 102
    • 0037454477 scopus 로고    scopus 로고
    • Early intraneuronal Abeta deposition in the hippocampus of APP transgenic mice
    • Shie F.S., LeBoeuf R.C., Jin L.W., LeBoeur R.C. Early intraneuronal Abeta deposition in the hippocampus of APP transgenic mice. Neuroreport 2003, 14:123-129.
    • (2003) Neuroreport , vol.14 , pp. 123-129
    • Shie, F.S.1    LeBoeuf, R.C.2    Jin, L.W.3    LeBoeur, R.C.4
  • 103
    • 44549087658 scopus 로고    scopus 로고
    • Structural and quantitative comparison of cerebrospinal fluid glycoproteins in Alzheimer's disease patients and healthy individuals
    • Sihlbom C., Davidsson P., Sjögren M., Wahlund L.O., Nilsson C.L. Structural and quantitative comparison of cerebrospinal fluid glycoproteins in Alzheimer's disease patients and healthy individuals. Neurochem. Res. 2008, 33:1332-1340.
    • (2008) Neurochem. Res. , vol.33 , pp. 1332-1340
    • Sihlbom, C.1    Davidsson, P.2    Sjögren, M.3    Wahlund, L.O.4    Nilsson, C.L.5
  • 106
    • 4444276735 scopus 로고    scopus 로고
    • Clearance of Alzheimer's Abeta peptide: the many roads to perdition
    • Tanzi R.E., Moir R.D., Wagner S.L. Clearance of Alzheimer's Abeta peptide: the many roads to perdition. Neuron 2004, 5:605-608.
    • (2004) Neuron , vol.5 , pp. 605-608
    • Tanzi, R.E.1    Moir, R.D.2    Wagner, S.L.3
  • 108
    • 0032509346 scopus 로고    scopus 로고
    • Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein
    • Trommsdorff M., Borg J.P., Margolis B., Herz J. Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein. J. Biol. Chem 1998, 273:33556-33560.
    • (1998) J. Biol. Chem , vol.273 , pp. 33556-33560
    • Trommsdorff, M.1    Borg, J.P.2    Margolis, B.3    Herz, J.4
  • 109
    • 0034629292 scopus 로고    scopus 로고
    • Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease
    • Ulery P.G., Beers J., Mikhailenko I., Tanzi R.E., Rebeck G.W., Hyman B.T., Strickland D.K. Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease. J. Biol. Chem 2000, 275:7410-7415.
    • (2000) J. Biol. Chem , vol.275 , pp. 7410-7415
    • Ulery, P.G.1    Beers, J.2    Mikhailenko, I.3    Tanzi, R.E.4    Rebeck, G.W.5    Hyman, B.T.6    Strickland, D.K.7
  • 110
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • RESEARCH0034
    • Vandesompele J., De Preter K., Pattyn F., Poppe B., Van Roy N., De Paepe A., Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002, 3. RESEARCH0034.
    • (2002) Genome Biol , vol.3
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3    Poppe, B.4    Van Roy, N.5    De Paepe, A.6    Speleman, F.7
  • 111
    • 0033623415 scopus 로고    scopus 로고
    • Abeta-generating enzymes: recent advances in beta- and gamma-secretase research
    • Vassar R., Citron M. Abeta-generating enzymes: recent advances in beta- and gamma-secretase research. Neuron 2000, 27:419-422.
    • (2000) Neuron , vol.27 , pp. 419-422
    • Vassar, R.1    Citron, M.2
  • 115
    • 0031911126 scopus 로고    scopus 로고
    • Increased apolipoprotein E mRNA in the hippocampus in Alzheimer disease and in rats after entorhinal cortex lesioning
    • Zarow C., Victoroff J. Increased apolipoprotein E mRNA in the hippocampus in Alzheimer disease and in rats after entorhinal cortex lesioning. Exp. Neurol 1998, 149:79-86.
    • (1998) Exp. Neurol , vol.149 , pp. 79-86
    • Zarow, C.1    Victoroff, J.2
  • 116
    • 33846021307 scopus 로고    scopus 로고
    • Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice
    • Zerbinatti C.V., Wahrle S.E., Kim H., Cam J.A., Bales K., Paul S.M., Holtzman D.M., Bu G. Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice. J. Biol. Chem 2006, 281:36180-36186.
    • (2006) J. Biol. Chem , vol.281 , pp. 36180-36186
    • Zerbinatti, C.V.1    Wahrle, S.E.2    Kim, H.3    Cam, J.A.4    Bales, K.5    Paul, S.M.6    Holtzman, D.M.7    Bu, G.8


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