Modulation of Aβ deposition in APP transgenic mice by an apolipoprotein E null background

Annals of the New York Academy of Sciences

Volumn 920, Issue , 2000, Pages 171-178

  Irizarry, M C ^a   Rebeck, G W ^b   Cheung, B ^c   Bales, K ^a   Paul, S M ^b   Holzman, D ^c   Hyman, B T ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN;

ALLELE; ALZHEIMER DISEASE; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; IN VITRO STUDY; KNOCKOUT MOUSE; LEUKOCYTE ACTIVATION; MORPHOLOGY; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; TRANSGENIC MOUSE; VASCULAR AMYLOIDOSIS;

ANIMALIA; MUS MUSCULUS;

EID: 0034528397     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb06919.x     Document Type: Conference Paper

References (30)

1. Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Alzheimer's disease
2. Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions
3. Frequency of the apolipoprotein E ε2 allele is diminished in sporadic Alzheimer disease
4. Clinical and pathological correlates of apolipoprotein E ε4 in Alzheimer's disease
5. Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology
6. Regional variation in the distribution of apolipoprotein E and A-beta in Alzheimer's disease
7. Isoform-specific binding of apolipoprotein E to beta-amyloid
8. Detection of apolipoprotein E/dimeric soluble amyloid beta complexes in Alzheimer's disease brain supernatants
9. Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments
10. Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro
11. Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: Implications for the pathogenesis and treatment of Alzheimer disease
12. Seeding of A-beta fibril formation is inhibited by all three isotypes of apolipoprotein E
13. Concentration-dependent inhibitory effects of apolipoprotein E on Alzheimer's beta-amyloid fibril formation in vitro
14. Isoform-specific effect of apolipoprotein E on cell survival and β-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures
15. α2-Macroglobulin enhances the clearance of endogenous soluble β-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons
16. Genetic association of an alpha2-macroglobulin (Va11000lle) polymorphism and Alzheimer's disease
17. Alpha-2 macroglobulin is genetically associated with Alzheimer disease
18. Confirmation of an association between a polymorphism in exon 3 of the low-density lipoprotein receptor-related protein gene and Alzheimer's disease
19. Correlative memory deficits, Aβ elevation and amyloid plaques in transgenic mice
20. APP-Sw transgenic mice develop age related amyloid deposits and neuropil abnormalities, but no neuronal loss in CA1
21. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
22. Glutamate receptor dysregulation in the hippocampus of transgenic mice carrying mutated human amyloid precursor protein
23. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
24. Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F β-amyloid precursor protein and Alzheimer's disease
25. Aβ deposition is associated with neuropil changes, but not with overt neuronal loss in the PDAPP transgenic mice
26. The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease
27. Perforant pathway changes and the memory impairment of Alzheimer's disease
28. Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model
29. Lack of apolipoprotein E dramatically reduces amyloid β-protein deposition
30. Apolipoprotein E affects the amount, form, and anatomical distribution of Aβ deposition in homozygous APPV717F transgenic mice