A quantitative and immunohistochemical study on apolipoprotein E in brain tissue in Alzheimer's disease

Dementia and Geriatric Cognitive Disorders

Volumn 10, Issue 6, 1999, Pages 452-459

  Hesse, Camilla ^a   Bogdanovic, Nenad ^b   Davidssona, Pia ^a   Blennow, Kaj ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Alzheimer's disease; Apolipoprotein E; Neurofibrillary tangles; Regeneration; Senile plaques

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; APOLIPOPROTEIN E4; LIPID;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN INJURY; BRAIN TISSUE; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; FEMALE; FRONTAL CORTEX; GENE FREQUENCY; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NERVE REGENERATION; NEUROFIBRILLARY TANGLE; NEUROPIL; PATHOGENESIS; PRIORITY JOURNAL; RECYCLING; SENILE PLAQUE; STAINING; SYNAPSE; TEMPORAL CORTEX; WESTERN BLOTTING;

EID: 0032739315     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000017189     Document Type: Article

References (41)

1. Coleman PD, Flood DG: Neuron numbers and dendrite extent in normal aging and Alzheimer's disease. Neurobiol Aging 1987;8:521-545.
2. Davies CA, Mann DMA, Sumpter PQ, Yates PO: A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease. J Neuroi Sci 1987;78:151-164.
3. Hamos JE, DeGennaro LJ, Drachman DA: Synaptic loss in Alzheimer's disease and other dementias. Neurology 1989;39:355-361.
4. Blennow K, Bogdanovic B, Alafuzoff I, Ekman R, Davidsson P: Synaptic pathology in Alzheimer's disease: Relation to severity of dementia but not to senile plaques, neurofibrillary tangles or the ApoE4 allele. J Neural Transm 1996;103:603-618.
5. Tomlinson BE, Corsellis JAN: Ageing in the dementias; in Hume Adams J, Corsellis JAN, Durchen LW (eds): Greenfield's Neuropathology. London, Arnold, 1984, pp 951-1025.
6. Boyles JK, Pitas RE, Wilson E, Mahley RW, Taylor JM: Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J Clin Invest 1985;76:1501-1513.
7. Mahley RW: Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology. Science 1988;240:622-630.
8. Poirier J: Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease. Trends Neuroi Sci 1994;17:525-530.
9. Zannis Vl, Breslow JL, Utermann G, Mahley RW, Weisgraber KH, Havel RJ, Goldstein JL, Brown MS, Schonfeld G, Hazzard WR, Blum C: Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes. J Lipid Res 1982;23:911-914.
10. Namba Y, Tomonaga M, Kawasaki H, Otomo E, Ikeda K: Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res 1991;541:163-166.
11. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA: Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993;261:921-923.
12. Poirier J, Davignon J, Bouthillier D, Kogan S, Bertrand P, Gauthier S: Apolipoprotein E polymorphism and Alzheimer's disease. Lancet 1993;342:697-699.
13. Saunders AM, Strittmatter WJ, Schmechel D, St George-Hyslop PH, Pericak-Vance MA, Joo SH, Rosi BL, Gusella JF, Crapper-MacLachlan DR, Alberts MJ, Hulette C, Crain B, Goldgaber D, Roses AD: Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993;43: 1467-1472.
14. Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD: Apolipoprotein E: High-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer's disease. Proc Natl Acad Sci USA 1993; 90:1977-1981.
15. Strittmatter WJ, Weisgraber KH, Huang DY, Dong LM, Salvesen GS, Pericak-Vance M, Schmechel D, Saunders AM, Goldgaber D, Roses AD: Binding of human apolipoprotein E to synthetic amyloid β peptide: Isoform-specific effects and implications for late-onset Alzheimer's disease. Proc Natl Acad Sci USA 1993;90:8098-8102.
16. Strittmatter WJ, Weisgraber KH, Goedert M, Saunders AM, Huang D, Corder EH, Dong LM, Jakes R, Alberts MJ, Gilbert JR, Han SH, Hulette C, Einstein G, Schmechel D, Pericak-Vance MA, Roses AD: Hypothesis: Microtubule instability and paired helical filaments formation in the Alzheimer's disease brain are related to apolipoprotein E genotype. Exp Neurol 1994;125:163-171.
17. Bertrand P, Poirier J, Oda T, Finch C, Pasinetti G: Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin 9) in Alzheimer disease. Mol Brain Res 1995;33:174-178.
18. Pirttilä T, Soininen H, Heinonen O, Lehtimäki T, Bogdanovic N, Paljärvi L, Kosunen O, Winblad B, Riekkinen SR, Wisniewski HM, Mehta PD: Apolipoprotein E (apoE) levels in brains from Alzheimer disease patients and controls. Brain Res 1996;722:71-77.
19. Harr S, Uint L, Hollister R, Hyman B, Mendez A: Brain expression of apolipoproteins E, J and A-I in Alzheimer's disease. J Neurochem 1996; 66:2429-2435.
20. Blennow K, Hesse C, Fredman P: Cerebrospinal fluid apolipoprotein E is reduced in Alzheimer's disease. Neuroreport 1994;5:2534-2536.
21. Landen M, Hesse C, Fredman P, Regland B, Wallin A, Blennow K: Apolipoprotein E in cerebrospinal fluid from patients with Alzheimer's disease and other forms of dementia is reduced but without any correlation to the ApoE4 isoform. Dementia 1996;7:273-278.
22. Hahne S, Nordstedt C, Åhlin A, Nybäck H: Levels of cerebrospinal fluid apolipoprotein E in patients with Alzheimer's disease and healthy controls. Neurosci Let 1997;224:99-102.
23. Lefranc D, Vermersch P, Dallongeville J, Daems-Monpeurt C, Petit H, Delacourte A: Relevance of quantification of apolipoprotein E in the cerebrospinal fluid in Alzheimer's disease. Neurosci Lett 1996;212:91-94.
24. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of department of health and human services task force on Alzheimer's disease. Neurology 1984;34:939-944.
25. Mirra SS, Heyman A, McKeel D: The consortium to establish a registry of Alzheimer's disease CERAD. II. Standardization of the neuropathological assessment of Alzheimer's disease. Neurology 1991;41:479-486.
26. Bogdanovic N, Morris JC: Diagnostic criteria for Alzheimer's disease in multi-centre brain banking; in Cruz-Sanchez FF (ed): Neuropathological Diagnostic Criteria for Brain Banking. Biomedical and Health Research Series. Amsterdam, IOS Press, 1995, pp 20-29.
27. Alafuzoff I, Iqbal K, Fridén H, Adolfsson R, Winblad B: Histopathological criteria for progressive dementia disorders: Clinical-pathological correlation and classification by multivariate data analysis. Acta Neuropathol (Berl) 1987;74:209-225.
28. Adolfsson R, Gottfries CG, Nyström L, Winblad B: Prevalence of dementia in institutionalized Swedish old people: The work load imposed by caring for these patients. Acta Psychiatr Scand 1981;63:225-244.
29. Smith PK, Krohn KI, Hermansson GT, Mallia AU, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenh DC: Measurement of protein using bicinchoninic acid. Annu Biochem 1985;150:76-85.
30. 4. Nature 1972;227:680-685.
31. Leary JJ, Brigati DJ, Ward DC: Rapid and sensitive colorimetric method for visualizing biotin-labeled DNA probes hybridized to DNA or RNA immobilized in nitrocellulose Bio-Blots. Proc Natl Acad Sci USA 1983;80:4045-4049.
32. Wernette-Hammond ME, Laurer S, Corsini A, Walker D, Taylor J, Rall S: Glycosylation of human apolipoprotein E. J Biol Chem 1989; 264:9094-9101.
33. Metzger R, LaDu M, Pan J, Getz G, Frail D, Falduto M: Neurons of the human frontal cortex display apolipoprotein E immunoreactivity: Implications for Alzheimer's disease. J Neuropathol Exp Neurol 1996;55:372-380.
34. Gearing M, SchneiderJA, Robins RS, Hollister RD, Mori H, Games D, Hyman BT, Mirra SS: Regional variation in the distribution of apolipoprotein E and Aβ in Alzheimer's disease. J Neuropathol Exp Neurol 1995;54:833-841.
35. Mufson EJ, Benzing WC, Cole GM, Wang H, Emerich DF, Sladek JR Jr, Morrison JH, Kordower JH: Apolipoprotein E immunoreactivity in aged rhesus monkey cortex: Colocalization with amyloid plaques. Neurobiol Aging 1994; 15:621-627.
36. LaDu M, Falduto M, Manelli A, Reardon C, Getz G, Frail D: Isoform-specific binding of apolipoprotein E to β-amyloid. J Biol Chem 1994;269:23403-23406.
37. Rebeck GW, Reiter JS, Strickland DK, Hyman BT: Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions. Neuron 1993;11:575-580.
38. Richey PL, Siedlak SL, Smith MA, Perry G: Apolipoprotein E interaction with the neurofibrillary tangles and senile plaques in Alzheimer disease: Implications for disease pathogenesis. Biochem Biophys Res Commun 1995;208: 657-663.
39. Poirier J, Hess M, May PC, Pasinetti G, Finch CE: Astroglial gene expression in the hippocampus following partial deafferentiation in the rat and in Alzheimer's disease; in Nagatsu T (ed): Basic, Clinical and Therapeutic Aspects of Alzheimer's and Parkinson's Diseases. New York, Plenum Press, 1990, pp 191-194.
40. May PC, Lampert-Etchells M, Johnson SA, Poirier J, Masters JN, Finch CE: Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat. Neuron 1990;5:831-839.
41. May PC, Finch CE: Sulfated glycoprotein-2: New relationships of this multifunctional protein to neurodegeneration. Trends Neurol Sci 1992;15:391-395.