Elevation of LDL receptor-related protein levels via ligand interactions in alzheimer disease and in vitro

Journal of Neuropathology and Experimental Neurology

Volumn 60, Issue 5, 2001, Pages 430-440

  Qiu, Zhihua ^b   Strickland, Dudley K ^b   Hyman, Bradley T ^b   Rebeck, G William ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NONE

Author keywords

Amyloid precursor protein; Apolipoprotein E; Astrocyte; Immunoblot; Lipoprotein; 2 Macroglobulin

Indexed keywords

ALPHA 2 MACROGLOBULIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; LIGAND; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN;

AGED; ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; ASTROCYTOSIS; CONTROLLED STUDY; FRONTAL CORTEX; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; RECEPTOR BINDING; WESTERN BLOTTING;

EID: 0035020834     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/60.5.430     Document Type: Article

References (61)

1. Strittmatter W, Roses A. Apolipoprotein E and Alzheimer's disease. Ann Rev Neurosci 1996;19:53-77
2. Blacker D, Wilcox MA, Laird NM, et al. Alpha-2 macroglobulin is genetically associated with Alzheimer disease. Nature Genet 1998;19:357-60
3. Wu WS, Holmans P, Wavrant-DeVrieze F, et al. Genetic studies on chromosome 12 in late onset Alzheimer's disease. JAMA 1998;280: 619-22
4. Liao A, Nitsch RM, Greenberg SM, et al. Genetic association of an alpha-2 macroglobulin (Val 1000 Ile) polymorphism and Alzheimer's disease. Hum Molec Genet 1998;7:1953-56
5. Kang DE, Saitoh T, Chen X, et al. Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease. Neurol 1997;49:56-61
6. Hollenbach E, Ackermann S, Hyman BT, Rebeck GW. Confirmation of an association between a polymorphism in exon 3 of the low density lipoprotein receptor-related protein gene and Alzheimer's disease. Neurol 1998;50:1905-7
7. Lambert J-C, Wavrant-DeVrieze F, Amouyel P, Chartier-Harlin M-C. Association at LRP locus with sporadic late-onset Alzheimer's disease. Lancet 1998;351:1787-88
8. Rebeck GW, Reiter JS, Strickland DK, Hyman BT. Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions. Neuron 1993;11:575-80
9. 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein. Ann Neurol 1995;37:211-17
10. Holtzman DM, Pitas RE, Kilbridge J, et al. Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line. Proc Natl Acad Sci USA 1995;92:9480-84
11. Bellosta S, Nathan BP, Orth M, Dong L-M, Mahley RW, Pitas RE. Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth. J Biol Chem 1995;270:27063-71
12. Fagan AM, Bu G, Sun Y, Daugherty A, Holtzman DM. Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein. J Biol Chem 1996;271:30121-25
13. Narita M, Bu G, Holtzman DM, Schwartz AL. The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor, modulates hippocampal neurite development. J Neurochem 1997;68:587-95
14. Mentz S, De Lacalle S, Baerga-Oritiz A, Knauer MF, Knauer DJ, Komives EA. Mechanism of thrombin clearance by human astrocyloma cells. J Neurochem 1999;72:980-87
15. Misra UK, Chu CT, Gawdi G, Pizzo SV. The relationship between low density lipoprotein-related protein/a2-macroglobulin (a2M) receptors and the newly described a2M signaling receptor. J Biol Chem 1994;269:18303-6
16. Tolar M, Keller JN, Chan S, Mattson MP, Marques MA, Crutcher KA. Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity. J Neurosci 1999;19:7100-7110
17. Urmoneit B, Prikulis I. Wihl G, et al. Cerebrovascular smooth muscle cells internalize Alzheimer amyloid beta protein via a lipoprotein pathway: Implications for cerebral amyloid angiopathy. Lab Invest 1997;77:157-66
18. Jordan J, Galindo MF, Miller RJ, Reardon CA, Getz GS, LaDu MJ. Isoform-specific effect of apolipoprotein E on cell survival and β-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures. J Neurosci 1998;18:195-204
19. Narita M, Holtzman DM, Schwartz AL, Bu G. a2-Macroglobulin complexes with and mediates the endocytosis of β-amyloid peptide via cell surface low-density lipoprotein receptor-related protein. J Neurochem 1997;69:1904-11
20. Qiu Z, Strickland DK, Hyman BT, Rebeck GW. α2-macroglobulin enhances the clearance of endogenous soluble β-umyloid peptide via low-density lipoprotein receptor-related protein in conical neurons. J Neurochem 1999;73:1393-98
21. Kounnas MZ, Moir RD, Rebeck GW, et al. LDL receptor-related protein, a multifunctional apoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation. Cell 1995;82:331-40
22. Ulery PG, Beers J, Mikhailenko I, et al. Modulation of beta-amyloid precursor protein processing by the low-density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease. J Biol chem 2000;275:7410-15
23. Braak H, Braak E. Neuropathological staging of Alzheimer related changes. Acta Neuropathol 1991;82:239-59
24. Rebeck GW, Alonzo NC, Berezovska O, et al. Structure and functions of human cerebrospinal fluid lipoproteins from individuals of different APOE genotypes. Exp Neurol 1998;149:175-82
25. Kounnas MZ, Morris RE, Thompson MR, FitzGerald DJ, Strickland DK, Saelinger CB. The α2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A. J Biol Chem 1992;267:12420-23
26. McCarthy KD, De Vellis J. preparation of separate astroglial and oligodendroglial cells cultures from rat cerebral tissue. J cell biology 1980;85:890-902
27. Giulian D, Young DG, Woodward J, Brown DC, Lachman LB. Interleukin-1 is an astroglial growth factor in the developing brain. J Neurosci 1988;8:709-14
28. Williams SE, Ashcom JD, Argraves WS, Strickland DK. A novel mechanism for controlling the activity of α2-macroglobulin receptor/low density lipoproiein receptor-related protein. J Biol Chem 1992;267:9035-40
29. Tooyama I, Kawamata T, Akiyama H, Moestrup SK, Gliemann J, McGeer PL. Immunohistochemical study of α2 macroglobulin receptor in Alzheimer and control postmortem human brain. Mol Chem Neuropathol 1993;18:153-60
30. Rebeck GW, Hyman BT. Neuroanatomical connections and specific regional vulnerability in Alzheimer's disease. Neurobiol Aging 1993;14:45-47
31. Quinn KA, Pye VJ, Dai YP, Chesterman CN, Owensby DA. Characterization of the soluble form of the low density related protein (LRP). Experimental Cell Research 1999;251:433-41
32. Hussaini IM, Brown MD, Karns LR, et al. Epidermal growth factor differentially regulates low-density lipoprotein receptor-related protein gene expression in neoplastic and fetal human astrocytes. Glia 1999;25:71-84
33. Michikawa M, Fan QW, Isobe I, Yanagisawa K. Apolipoprotein exhibite isoform-specific promotion of lipid efflux from astrocytes and neurons in culture. J Neurochem 2000:74:1008-16
34. Bu G, Rennke S. Receptor-associated protein is a folding chaperone for low-density lipoprotein receptor-related protein. J Biol Chem 1996;271:22218-24
35. Chen KS, EM, Grajeda H, et al. Neurodegenerative Alzheimer-like pathology in PDAPP 717V→F trangenic mice. Prog Brain Res 1998;117:327-34
36. Tooyania I, Kawamata T, Akiyama H, et al. Subcellular localization of the low density lipoprotein receptor-related protein (a2-macroglobulin receptor) in human brain. Brain Res 1995;691:235-38
37. Pirtilla T, Lehtimaki T, Rinne J, Mattila K, Frey H, Nikkari T. The frequency of apolipoprotein E4 allele is not increased in patients with probable vascular dementia. Acta Neurol Scand 1996;93:352-54
38. Harr SD, Uint L, Hollister R, Hyman BT, Mendez AJ. Brain expression of apolipoprotein E. J, and A-I in Alzheimer's disease. 1996 1996;66:2429-35
39. Hesse C, Bogdanovic N, Davidsson P, Blennow K. A quantitative and immunohistochemical study on apolipoprotein E in brain tissue in Alzheimer's disease. Dement Geriatr Cogn Disord 1999;10:452-59
40. Ishii K, Tamaoka A, Mizusawa H, et al. Abetal-40 but not Abetal-42 levels in cortex correlate with apolipoprotein E epsilon4 allele dosage in sporadic Alzheimer's disease. Brain Res 1997;748:250-52
41. Wolf H, Grunwald M, Ecke GM, et al. The prognosis of mild cognitive imoairement in the elderly. J Neural Transm Suppl 1998;54: 31-50
42. Zarow, Victoroff J. Increased apolipoprotein E mRNA in the hippocampus in Alzheimer's disease and in rats after entorhinal cortex lesioning. Exp Neurol 1998;149:79-86
43. Moir RD, Lynch T, Bush AI, et al. Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain. J Biol Chem 1998;273:5013-19
44. Suh YH, Chong YH, Kim SH, et al. Molecular physiology, biochemistry, and pharmacology of Alzheimer's amyloid precursor protein (APP). Ann NY Acad Sci 1996;15:169-83
45. Delamarche C, Berger F, Gallard L, Pouplard-Barthelaix A. Aging and Alzheimer's disease: Protease inhibitors in cerebrospinal fluid. Neurobiol Aging 1991;12:71-74
46. Wagner SL, Geddes JW, Cotman CW, et al. Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer's disease. Proc Natl Acad Sci USA 1989;86:8284-88
47. Choi BH, Kim RC, Vaughan PJ, et al. Decrease in protease nexin in Alzheimer's disease brain. Neurobiol Aging 1995;16:557-62
48. Kawamata T, Tooyama I, Yamada T, Walker DG, McGeer PL. Lactotransferrin immunocytochemistry in Alzheimer and normal human brain. Am J Path 1993;142:1574-85
49. Schenk D, Barbour R, Dunn W, et al. Immunization with amyloid-beta attenutes Alzheimer-disease-like pathology in the PDAPP mouse. Nature 1999;400:173-77
50. Yang DS, Small DH, Seydel U, et al. Apolipoprotein E promotes the binding and uptake of b-amyloid into Chinese hamster ovary cells in an isoform-specific manner. Neuroscience 1999;90:1217-26
51. Beffert U, Amount N, Dea D, Lussier-Cacan S, Davignon J, Poirier J. Beta-amyloid peptides increase the binding and internalization of apolipoprotein E to hippocampal neurons. J Neurochem 1998;70: 1458-66
52. Beffert U, Conn JS, Petit-Turcotte C, et al. Apolipoprotein E and beta-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein E genotype dependent. Brain Res 1999;843:87-94
53. Kang DE, Pietrzik CU, Baum L, et al. Modulation of amyloid b-protein clearance and Alzheimer's disease susceptibility by LDL receptor-related protein pathway. J Clin Invest 2000; 106:1159-66
54. Hu J, Ladu MJ, Van Eldik LJ. Apolipoprotein E attenuates beta-amyloid-induced astrocyte activation. J Neurochem 1998;71:1626-34
55. Laskowitz DT, Matthew WD, Bennett ER, et al. Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production. Neuroreport 1998;9:615-18
56. Bu G, Sun Y, Schwartz AL, Holtzman DM. Nerve growth factor induces rapid increases in functional cell surface low density lipoprotein receptor-related protein J Biol Chem 1998;273:13359-65
57. Wang XS, Gruenstein E. Rapid elevation of neuronal cytoplasmic calcium by apolipoprotein E peptide. J Cell Physiol 1997;173:73-83
58. 2+-channel. Brain Pathol 1998;8:641-53
59. Goretzki L, Muller BM. Low-density-lipoprotein-receptor-related protein (LRP) interacts with a GTP-binding protein. Biochem J 1998;336:381-86
60. Trommsdorff M, Borg JP, Margolis B, Herz J. Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein. J Biol Chem 1998;273:33556-60
61. Gotthardt M, Trommsdorff M, Nevitt MF, et al. Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. J Biol Chem 2000;275: 25616-24