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Volumn 3, Issue 1, 2012, Pages 3-8

Beyond free radical scavenging: Beneficial effects of edaravone (Radicut) in various diseases (Review)

Author keywords

Cerebral infarction; Edaravone; Free radical scavenger; Non neurologic disease; Radicut

Indexed keywords

ALANINE AMINOTRANSFERASE; AMYLASE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CELL ADHESION MOLECULE; CREATININE; CXCL3 CHEMOKINE; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; GLUTATHIONE PEROXIDASE; HEAT SHOCK PROTEIN; HEMOGLOBIN; HYDROPEROXIDE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; KERATINOCYTE DERIVED CHEMOKINE; LACTATE DEHYDROGENASE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 5; MYELOPEROXIDASE; NORPHENAZONE; PROTEIN BAX; PROTEIN BCL XL; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG;

EID: 84855364396     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2011.352     Document Type: Review
Times cited : (68)

References (70)
  • 1
    • 57449103131 scopus 로고    scopus 로고
    • The lipophilic multifunctional antioxidant edaravone (Radicut) improves behavior following embolic strokes in rabbits: A combination therapy study with tissue plasminogen activator
    • Lapchak PA and Zivin JA: The lipophilic multifunctional antioxidant edaravone (Radicut) improves behavior following embolic strokes in rabbits: a combination therapy study with tissue plasminogen activator. Exp Neurol 215: 95-100, 2009.
    • (2009) Exp Neurol , vol.215 , pp. 95-100
    • Lapchak, P.A.1    Zivin, J.A.2
  • 2
    • 34547574317 scopus 로고    scopus 로고
    • Neuroprotective effects of free radical scavengers in stroke
    • Wang CX and Shuaib A: Neuroprotective effects of free radical scavengers in stroke. Drugs Aging 24: 537-546, 2007.
    • (2007) Drugs Aging , vol.24 , pp. 537-546
    • Wang, C.X.1    Shuaib, A.2
  • 3
    • 33745955359 scopus 로고    scopus 로고
    • Therapeutic strategies for the treatment of stroke
    • Green AR and Shuaib A: Therapeutic strategies for the treatment of stroke. Drug Discov Today 11: 681-693, 2006.
    • (2006) Drug Discov Today , vol.11 , pp. 681-693
    • Green, A.R.1    Shuaib, A.2
  • 6
    • 34247844511 scopus 로고    scopus 로고
    • Guidelines for the early management of adults with ischemic stroke
    • A guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists
    • Adams HP Jr, del Zoppo G, Alberts MJ, Bhatt DL, Brass L, Furlan A, Grubb RL, Higashida RT, Jauch EC, Kidwell C, Lyden PD, Morgenstern LB, Qureshi AI, Rosenwasser RH, Scott PA and Wijdicks EF: Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke 38: 1655-1711, 2007.
    • (2007) Stroke , vol.38 , pp. 1655-1711
    • Adams Jr., H.P.1    del Zoppo, G.2    Alberts, M.J.3    Bhatt, D.L.4    Brass, L.5    Furlan, A.6    Grubb, R.L.7    Higashida, R.T.8    Jauch, E.C.9    Kidwell, C.10    Lyden, P.D.11    Morgenstern, L.B.12    Qureshi, A.I.13    Rosenwasser, R.H.14    Scott, P.A.15    Wijdicks, E.F.16
  • 7
    • 0028292964 scopus 로고
    • Protective effects of MCI-186 on cerebral ischemia: Possible involvement of free radical scavenging and antioxidant actions
    • Watanabe T, Yuki S, Egawa M and Nishi H: Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J Pharmacol Exp Ther 268: 1597-1604, 1994.
    • (1994) J Pharmacol Exp Ther , vol.268 , pp. 1597-1604
    • Watanabe, T.1    Yuki, S.2    Egawa, M.3    Nishi, H.4
  • 8
    • 0037335983 scopus 로고    scopus 로고
    • Hospital-based study of the care and cost of acute ischemic stroke in Japan
    • Yoneda Y, Uehara T, Yamasaki H, Kita Y, Tabuchi M and Mori E: Hospital-based study of the care and cost of acute ischemic stroke in Japan. Stroke 34: 718-724, 2003.
    • (2003) Stroke , vol.34 , pp. 718-724
    • Yoneda, Y.1    Uehara, T.2    Yamasaki, H.3    Kita, Y.4    Tabuchi, M.5    Mori, E.6
  • 9
    • 0030801031 scopus 로고    scopus 로고
    • Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia
    • Yamamoto T, Yuki S, Watanabe T, Mitsuka M, Saito KI and Kogure K: Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia. Brain Res 762: 240-242, 1997.
    • (1997) Brain Res , vol.762 , pp. 240-242
    • Yamamoto, T.1    Yuki, S.2    Watanabe, T.3    Mitsuka, M.4    Saito, K.I.5    Kogure, K.6
  • 10
    • 0141954290 scopus 로고    scopus 로고
    • Development of the nitrone-based spin trap agent NXY-059 to treat acute ischemic stroke
    • Lapchak PA and Araujo DM: Development of the nitrone-based spin trap agent NXY-059 to treat acute ischemic stroke. CNS Drug Rev 9: 253-262, 2003.
    • (2003) CNS Drug Rev , vol.9 , pp. 253-262
    • Lapchak, P.A.1    Araujo, D.M.2
  • 11
    • 0141642104 scopus 로고    scopus 로고
    • Glutathione peroxidase overexpression inhibits cytochrome C release and proapoptotic mediators to protect neurons from experimental stroke
    • Hoehn B, Yenari MA, Sapolsky RM and Steinberg GK: Glutathione peroxidase overexpression inhibits cytochrome C release and proapoptotic mediators to protect neurons from experimental stroke. Stroke 34: 2489-2494, 2003.
    • (2003) Stroke , vol.34 , pp. 2489-2494
    • Hoehn, B.1    Yenari, M.A.2    Sapolsky, R.M.3    Steinberg, G.K.4
  • 12
    • 0033998384 scopus 로고    scopus 로고
    • Melatonin increases activities of glutathione peroxidase and superoxide dismutase in fetal rat brain
    • Okatani Y, Wakatsuki A and Kaneda C: Melatonin increases activities of glutathione peroxidase and superoxide dismutase in fetal rat brain. J Pineal Res 28: 89-96, 2000.
    • (2000) J Pineal Res , vol.28 , pp. 89-96
    • Okatani, Y.1    Wakatsuki, A.2    Kaneda, C.3
  • 13
    • 0142169969 scopus 로고    scopus 로고
    • Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression
    • Rajesh KG, Sasaguri S, Suzuki R and Maeda H: Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression. Am J Physiol Heart Circ Physiol 285: H2171-H2178, 2003.
    • (2003) Am J Physiol Heart Circ Physiol , vol.285
    • Rajesh, K.G.1    Sasaguri, S.2    Suzuki, R.3    Maeda, H.4
  • 17
    • 0043198117 scopus 로고    scopus 로고
    • A free radical scavenger, edaravone, attenuates steatosis and cell death via reducing inflammatory cytokine production in rat acute liver injury
    • Nakamoto N, Tada S, Kameyama K, Kitamura K, Kurita S, Saito Y, Saito H and Ishii H: A free radical scavenger, edaravone, attenuates steatosis and cell death via reducing inflammatory cytokine production in rat acute liver injury. Free Radic Res 37: 849-859, 2003.
    • (2003) Free Radic Res , vol.37 , pp. 849-859
    • Nakamoto, N.1    Tada, S.2    Kameyama, K.3    Kitamura, K.4    Kurita, S.5    Saito, Y.6    Saito, H.7    Ishii, H.8
  • 19
    • 52149083263 scopus 로고    scopus 로고
    • Edaravone prevents Fas-induced fulminant hepatic failure in mice by regulating mitochondrial Bcl-xL and Bax
    • Miyasou T, Kwon AH, Tsuji K, Qiu Z, Okumura T and Kamiyama Y: Edaravone prevents Fas-induced fulminant hepatic failure in mice by regulating mitochondrial Bcl-xL and Bax. Shock 30: 212-216, 2008.
    • (2008) Shock , vol.30 , pp. 212-216
    • Miyasou, T.1    Kwon, A.H.2    Tsuji, K.3    Qiu, Z.4    Okumura, T.5    Kamiyama, Y.6
  • 20
    • 78650955653 scopus 로고    scopus 로고
    • Edaravone, a free radical scavenger, promotes engraftment of intraportally transplanted islet cells
    • Nagatani S, Sudo T, Murakami Y, Uemura K, Hiyama E and Sueda T: Edaravone, a free radical scavenger, promotes engraftment of intraportally transplanted islet cells. Pancreas 40: 126-130, 2011.
    • (2011) Pancreas , vol.40 , pp. 126-130
    • Nagatani, S.1    Sudo, T.2    Murakami, Y.3    Uemura, K.4    Hiyama, E.5    Sueda, T.6
  • 25
    • 0037183707 scopus 로고    scopus 로고
    • Myocardial protection of MCI-186 in rabbit ischemia-reperfusion
    • Wu TW, Zeng LH, Wu J and Fung KP: Myocardial protection of MCI-186 in rabbit ischemia-reperfusion. Life Sci 71: 2249-2255, 2002.
    • (2002) Life Sci , vol.71 , pp. 2249-2255
    • Wu, T.W.1    Zeng, L.H.2    Wu, J.3    Fung, K.P.4
  • 26
    • 1242342939 scopus 로고    scopus 로고
    • The hydroxyl radical scavenger MCI-186 protects the liver from experimental cold ischaemia-reperfusion injury
    • Ninomiya M, Shimada M, Harada N, Soejima Y, Suehiro T and Maehara Y: The hydroxyl radical scavenger MCI-186 protects the liver from experimental cold ischaemia-reperfusion injury. Br J Surg 91: 184-190, 2004.
    • (2004) Br J Surg , vol.91 , pp. 184-190
    • Ninomiya, M.1    Shimada, M.2    Harada, N.3    Soejima, Y.4    Suehiro, T.5    Maehara, Y.6
  • 27
  • 28
    • 77649178969 scopus 로고    scopus 로고
    • Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury
    • Yang T, Mao YF, Liu SQ, Hou J, Cai ZY, Hu JY, Ni X, Deng XM and Zhu XY: Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury. Eur J Pharmacol 630: 152-157, 2010.
    • (2010) Eur J Pharmacol , vol.630 , pp. 152-157
    • Yang, T.1    Mao, Y.F.2    Liu, S.Q.3    Hou, J.4    Cai, Z.Y.5    Hu, J.Y.6    Ni, X.7    Deng, X.M.8    Zhu, X.Y.9
  • 29
  • 30
    • 2342647446 scopus 로고    scopus 로고
    • Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney
    • Doi K, Suzuki Y, Nakao A, Fujita T and Noiri E: Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney. Kidney Int 65: 1714-1723, 2004.
    • (2004) Kidney Int , vol.65 , pp. 1714-1723
    • Doi, K.1    Suzuki, Y.2    Nakao, A.3    Fujita, T.4    Noiri, E.5
  • 31
    • 77649263288 scopus 로고    scopus 로고
    • Protective effect of edaravone, a free-radical scavenger, on ischaemia-reperfusion injury in the rat testis
    • Tamamura M, Saito M, Kinoshita Y, Shimizu S, Satoh I, Shomori K, Dimitriadis F and Satoh K: Protective effect of edaravone, a free-radical scavenger, on ischaemia-reperfusion injury in the rat testis. BJU Int 105: 870-876, 2010.
    • (2010) BJU Int , vol.105 , pp. 870-876
    • Tamamura, M.1    Saito, M.2    Kinoshita, Y.3    Shimizu, S.4    Satoh, I.5    Shomori, K.6    Dimitriadis, F.7    Satoh, K.8
  • 36
    • 21444439413 scopus 로고    scopus 로고
    • Edaravone prevented deteriorated cardiac function after myocardial ischemia-reperfusion via inhibiting lipid peroxidation in rat
    • Yagi H, Horinaka S and Matsuoka H: Edaravone prevented deteriorated cardiac function after myocardial ischemia-reperfusion via inhibiting lipid peroxidation in rat. J Cardiovasc Pharmacol 46: 46-51, 2005.
    • (2005) J Cardiovasc Pharmacol , vol.46 , pp. 46-51
    • Yagi, H.1    Horinaka, S.2    Matsuoka, H.3
  • 37
    • 66149158208 scopus 로고    scopus 로고
    • Effect of edaravone, a novel free radical scavenger, supplemented to cardioplegia on myocardial function after cardioplegic arrest: In vitro study of isolated rat heart
    • Yamazaki K, Miwa S, Toyokuni S, Nemoto S, Oriyanhan W, Takaba K, Saji Y, Marui A, Nishina T, Ikeda T and Komeda M: Effect of edaravone, a novel free radical scavenger, supplemented to cardioplegia on myocardial function after cardioplegic arrest: in vitro study of isolated rat heart. Heart Vessels 24: 228-235, 2009.
    • (2009) Heart Vessels , vol.24 , pp. 228-235
    • Yamazaki, K.1    Miwa, S.2    Toyokuni, S.3    Nemoto, S.4    Oriyanhan, W.5    Takaba, K.6    Saji, Y.7    Marui, A.8    Nishina, T.9    Ikeda, T.10    Komeda, M.11
  • 39
  • 42
    • 55649125284 scopus 로고    scopus 로고
    • Pretreatment with edaravone reduces lung mitochondrial damage in an infant rabbit ischemia-reperfusion model
    • Qiu W, Gu H, Zheng L, Zhou J, Chen D and Chen Y: Pretreatment with edaravone reduces lung mitochondrial damage in an infant rabbit ischemia-reperfusion model. J Pediatr Surg 43: 2053-2060, 2008.
    • (2008) J Pediatr Surg , vol.43 , pp. 2053-2060
    • Qiu, W.1    Gu, H.2    Zheng, L.3    Zhou, J.4    Chen, D.5    Chen, Y.6
  • 43
    • 32144457044 scopus 로고    scopus 로고
    • MCI-186 (edaravone), a free radical scavenger, attenuates ischemia-reperfusion injury and activation of phospholipase A(2) in an isolated rat lung model after 18 h of cold preservation
    • Reyes YA, Shimoyama T, Akamatsu H and Sunamori M: MCI-186 (edaravone), a free radical scavenger, attenuates ischemia-reperfusion injury and activation of phospholipase A(2) in an isolated rat lung model after 18 h of cold preservation. Eur J Cardiothorac Surg 29: 304-311, 2006.
    • (2006) Eur J Cardiothorac Surg , vol.29 , pp. 304-311
    • Reyes, Y.A.1    Shimoyama, T.2    Akamatsu, H.3    Sunamori, M.4
  • 46
    • 34848827170 scopus 로고    scopus 로고
    • Microcirculatory changes in experimental mesenteric longitudinal ulcers of the small intestine in rats
    • Shimizu K, Koga H, Iida M and Haruma K: Microcirculatory changes in experimental mesenteric longitudinal ulcers of the small intestine in rats. Dig Dis Sci 52: 3019-3028, 2007.
    • (2007) Dig Dis Sci , vol.52 , pp. 3019-3028
    • Shimizu, K.1    Koga, H.2    Iida, M.3    Haruma, K.4
  • 48
    • 36348979198 scopus 로고    scopus 로고
    • Amelioration of hepatic ischemia/reperfusion injury in the remnant liver after partial hepatectomy in rats
    • Hiranuma S, Ito K, Noda Y, Ozasa H, Koike Y and Horikawa S: Amelioration of hepatic ischemia/reperfusion injury in the remnant liver after partial hepatectomy in rats. J Gastroenterol Hepatol 22: 2167-2172, 2007.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 2167-2172
    • Hiranuma, S.1    Ito, K.2    Noda, Y.3    Ozasa, H.4    Koike, Y.5    Horikawa, S.6
  • 49
    • 33744788665 scopus 로고    scopus 로고
    • Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage
    • Kono H, Woods CG, Maki A, Connor HD, Mason RP, Rusyn I and Fujii H: Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage. Free Radic Res 40: 579-588, 2006.
    • (2006) Free Radic Res , vol.40 , pp. 579-588
    • Kono, H.1    Woods, C.G.2    Maki, A.3    Connor, H.D.4    Mason, R.P.5    Rusyn, I.6    Fujii, H.7
  • 50
    • 51249102618 scopus 로고    scopus 로고
    • A free radical scavenger, edaravone, prevents ischemia-reperfusion injury in liver grafts from non-heart-beating donors
    • Nakamura A, Akamatsu Y, Miyagi S, Fukumori T, Sekiguchi S and Satomi S: A free radical scavenger, edaravone, prevents ischemia-reperfusion injury in liver grafts from non-heart-beating donors. Transplant Proc 40: 2171-2174, 2008.
    • (2008) Transplant Proc , vol.40 , pp. 2171-2174
    • Nakamura, A.1    Akamatsu, Y.2    Miyagi, S.3    Fukumori, T.4    Sekiguchi, S.5    Satomi, S.6
  • 51
    • 12244303263 scopus 로고    scopus 로고
    • Edaravone protects against ischemia/reperfusion-induced oxidative damage to mitochondria in rat liver
    • Okatani Y, Wakatsuki A, Enzan H and Miyahara Y: Edaravone protects against ischemia/reperfusion-induced oxidative damage to mitochondria in rat liver. Eur J Pharmacol 465: 163-170, 2003.
    • (2003) Eur J Pharmacol , vol.465 , pp. 163-170
    • Okatani, Y.1    Wakatsuki, A.2    Enzan, H.3    Miyahara, Y.4
  • 53
    • 11144318582 scopus 로고    scopus 로고
    • Free radical scavenger (edaravone) prevents endotoxin-induced liver injury after partial hepatectomy in rats
    • Tsuji K, Kwon AH, Yoshida H, Qiu Z, Kaibori M, Okumura T and Kamiyama Y: Free radical scavenger (edaravone) prevents endotoxin-induced liver injury after partial hepatectomy in rats. J Hepatol 42: 94-101, 2005.
    • (2005) J Hepatol , vol.42 , pp. 94-101
    • Tsuji, K.1    Kwon, A.H.2    Yoshida, H.3    Qiu, Z.4    Kaibori, M.5    Okumura, T.6    Kamiyama, Y.7
  • 54
    • 58149247799 scopus 로고    scopus 로고
    • Edaravone inhibits the induction of iNOS gene expression at transcriptional and posttranscriptional steps in murine macrophages
    • Yoshida H, Kwon AH, Habara K, Yamada M, Kaibori M, Kamiyama Y, Nishizawa M, Ito S and Okumura T: Edaravone inhibits the induction of iNOS gene expression at transcriptional and posttranscriptional steps in murine macrophages. Shock 30: 734-739, 2008.
    • (2008) Shock , vol.30 , pp. 734-739
    • Yoshida, H.1    Kwon, A.H.2    Habara, K.3    Yamada, M.4    Kaibori, M.5    Kamiyama, Y.6    Nishizawa, M.7    Ito, S.8    Okumura, T.9
  • 55
    • 1542494391 scopus 로고    scopus 로고
    • The free radical scavenger edaravone suppresses experimental closed duodenal loop-induced acute pancreatitis in rats
    • Araki, Y, Andoh A, Yokono T, Asano N, Yoshikawa K, Bamba S, Ishizuka I and Fujiyama Y: The free radical scavenger edaravone suppresses experimental closed duodenal loop-induced acute pancreatitis in rats. Int J Mol Med 12: 121-124, 2003.
    • (2003) Int J Mol Med , vol.12 , pp. 121-124
    • Araki, Y.1    Andoh, A.2    Yokono, T.3    Asano, N.4    Yoshikawa, K.5    Bamba, S.6    Ishizuka, I.7    Fujiyama, Y.8
  • 56
    • 23044516263 scopus 로고    scopus 로고
    • A radical scavenger, edaravone, protects canine kidneys from ischemia-reperfusion injury after 72 hours of cold preservation and autotransplantation
    • Tahara M, Nakayama M, Jin MB, Fujita M, Suzuki T, Taniguchi M, Shimamura T, Furukawa H and Todo S: A radical scavenger, edaravone, protects canine kidneys from ischemia-reperfusion injury after 72 hours of cold preservation and autotransplantation. Transplantation 80: 213-221, 2005.
    • (2005) Transplantation , vol.80 , pp. 213-221
    • Tahara, M.1    Nakayama, M.2    Jin, M.B.3    Fujita, M.4    Suzuki, T.5    Taniguchi, M.6    Shimamura, T.7    Furukawa, H.8    Todo, S.9
  • 57
    • 26044443541 scopus 로고    scopus 로고
    • Effect of a novel free radical scavenger, edaravone, on puromycin aminonucleoside induced nephrosis in rats
    • Someya T, Kaneko K, Yamada T and Yamashiro Y: Effect of a novel free radical scavenger, edaravone, on puromycin aminonucleoside induced nephrosis in rats. Pediatr Nephrol 20: 1430-1434, 2005.
    • (2005) Pediatr Nephrol , vol.20 , pp. 1430-1434
    • Someya, T.1    Kaneko, K.2    Yamada, T.3    Yamashiro, Y.4
  • 58
    • 33845421687 scopus 로고    scopus 로고
    • Protective effect of radical scavenger edaravone against puromycin nephrosis
    • Matsumura H, Ashida A, Hirano K, Nakakura H and Tamai H: Protective effect of radical scavenger edaravone against puromycin nephrosis. Clin Nephrol 66: 405-410, 2006.
    • (2006) Clin Nephrol , vol.66 , pp. 405-410
    • Matsumura, H.1    Ashida, A.2    Hirano, K.3    Nakakura, H.4    Tamai, H.5
  • 59
    • 26644460229 scopus 로고    scopus 로고
    • Edaravone protects against ischemia/reperfusion-induced functional and biochemical changes in rat urinary bladder
    • Matsumoto S, Hanai T, Yoshioka N, Shimizu N, Sugiyama T, Uemura H and Levin RM: Edaravone protects against ischemia/reperfusion-induced functional and biochemical changes in rat urinary bladder. Urology 66: 892-896, 2005.
    • (2005) Urology , vol.66 , pp. 892-896
    • Matsumoto, S.1    Hanai, T.2    Yoshioka, N.3    Shimizu, N.4    Sugiyama, T.5    Uemura, H.6    Levin, R.M.7
  • 60
    • 68849127907 scopus 로고    scopus 로고
    • Acute urinary retention and subsequent catheterization cause lipid peroxidation and oxidative DNA damage in the bladder: Preventive effect of edaravone, a free-radical scavenger
    • Shimizu S, Saito M, Kinoshita Y, Kazuyama E, Tamamura M, Satoh I and Satoh K: Acute urinary retention and subsequent catheterization cause lipid peroxidation and oxidative DNA damage in the bladder: preventive effect of edaravone, a free-radical scavenger. BJU Int 104: 713-717, 2009.
    • (2009) BJU Int , vol.104 , pp. 713-717
    • Shimizu, S.1    Saito, M.2    Kinoshita, Y.3    Kazuyama, E.4    Tamamura, M.5    Satoh, I.6    Satoh, K.7
  • 62
    • 33750088980 scopus 로고    scopus 로고
    • The therapeutic efficacy of edaravone in extensively burned rats
    • Koizumi T, Tanaka H, Sakaki S and Shimazaki S: The therapeutic efficacy of edaravone in extensively burned rats. Arch Surg 141: 992-995, 2006.
    • (2006) Arch Surg , vol.141 , pp. 992-995
    • Koizumi, T.1    Tanaka, H.2    Sakaki, S.3    Shimazaki, S.4
  • 63
    • 18344364000 scopus 로고    scopus 로고
    • A free radical scavenger, edaravone (MCI-186), diminishes intestinal neutrophil lipid peroxidation and bacterial translocation in a rat hemorrhagic shock model
    • Mori T, Yamamoto H, Tabata T, Shimizu T, Endo Y, Hanasawa K, Fujimiya M and Tani T: A free radical scavenger, edaravone (MCI-186), diminishes intestinal neutrophil lipid peroxidation and bacterial translocation in a rat hemorrhagic shock model. Crit Care Med 33: 1064-1069, 2005.
    • (2005) Crit Care Med , vol.33 , pp. 1064-1069
    • Mori, T.1    Yamamoto, H.2    Tabata, T.3    Shimizu, T.4    Endo, Y.5    Hanasawa, K.6    Fujimiya, M.7    Tani, T.8
  • 65
    • 33745986027 scopus 로고    scopus 로고
    • Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum
    • Kawasaki T, Ishihara K, Ago Y, Nakamura S, Itoh S, Baba A and Matsuda T: Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum. Eur J Pharmacol 542: 92-99, 2006.
    • (2006) Eur J Pharmacol , vol.542 , pp. 92-99
    • Kawasaki, T.1    Ishihara, K.2    Ago, Y.3    Nakamura, S.4    Itoh, S.5    Baba, A.6    Matsuda, T.7
  • 67
    • 33645062396 scopus 로고    scopus 로고
    • Inhibitory effects of edaravone on the production of tumor necrosis factor-alpha in the isolated heart undergoing ischemia and reperfusion
    • Onimaru S, Nakamura K, Kariyazono H, Ikeda R, Ueno T, Fukumoto Y, Yabuki A, Sakata R and Yamada K: Inhibitory effects of edaravone on the production of tumor necrosis factor-alpha in the isolated heart undergoing ischemia and reperfusion. Heart Vessels 21: 108-115, 2006.
    • (2006) Heart Vessels , vol.21 , pp. 108-115
    • Onimaru, S.1    Nakamura, K.2    Kariyazono, H.3    Ikeda, R.4    Ueno, T.5    Fukumoto, Y.6    Yabuki, A.7    Sakata, R.8    Yamada, K.9
  • 68
    • 10044219504 scopus 로고    scopus 로고
    • Cardioprotective effects of 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), a novel free radical scavenger, on acute autoimmune myocarditis in rats
    • Okabe TA, Kishimoto C, Hattori M, Nimata M, Shioji K and Kita T: Cardioprotective effects of 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), a novel free radical scavenger, on acute autoimmune myocarditis in rats. Exp Clin Cardiol 9: 177-180, 2004.
    • (2004) Exp Clin Cardiol , vol.9 , pp. 177-180
    • Okabe, T.A.1    Kishimoto, C.2    Hattori, M.3    Nimata, M.4    Shioji, K.5    Kita, T.6


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