-
1
-
-
57449103131
-
The lipophilic multifunctional antioxidant edaravone (Radicut) improves behavior following embolic strokes in rabbits: A combination therapy study with tissue plasminogen activator
-
Lapchak PA and Zivin JA: The lipophilic multifunctional antioxidant edaravone (Radicut) improves behavior following embolic strokes in rabbits: a combination therapy study with tissue plasminogen activator. Exp Neurol 215: 95-100, 2009.
-
(2009)
Exp Neurol
, vol.215
, pp. 95-100
-
-
Lapchak, P.A.1
Zivin, J.A.2
-
2
-
-
34547574317
-
Neuroprotective effects of free radical scavengers in stroke
-
Wang CX and Shuaib A: Neuroprotective effects of free radical scavengers in stroke. Drugs Aging 24: 537-546, 2007.
-
(2007)
Drugs Aging
, vol.24
, pp. 537-546
-
-
Wang, C.X.1
Shuaib, A.2
-
3
-
-
33745955359
-
Therapeutic strategies for the treatment of stroke
-
Green AR and Shuaib A: Therapeutic strategies for the treatment of stroke. Drug Discov Today 11: 681-693, 2006.
-
(2006)
Drug Discov Today
, vol.11
, pp. 681-693
-
-
Green, A.R.1
Shuaib, A.2
-
4
-
-
0037039233
-
The effect of tirilazad mesylate on infarct volume of patients with acute ischemic stroke
-
Van der Worp HB, Kappelle LJ, Algra A, Bar PR, Orgogozo JM, Ringelstein EB, Bath PM and van Gijn J: The effect of tirilazad mesylate on infarct volume of patients with acute ischemic stroke. Neurology 58: 133-135, 2002.
-
(2002)
Neurology
, vol.58
, pp. 133-135
-
-
van der Worp, H.B.1
Kappelle, L.J.2
Algra, A.3
Bar, P.R.4
Orgogozo, J.M.5
Ringelstein, E.B.6
Bath, P.M.7
van Gijn, J.8
-
5
-
-
34547795720
-
NXY-059 for the treatment of acute ischemic stroke
-
Shuaib A, Lees KR, Lyden P, Grotta J, Davalos A, Davis SM, Diener HC, Ashwood T, Wasiewski WW and Emeribe U: NXY-059 for the treatment of acute ischemic stroke. N Engl J Med 357: 562-571, 2007.
-
(2007)
N Engl J Med
, vol.357
, pp. 562-571
-
-
Shuaib, A.1
Lees, K.R.2
Lyden, P.3
Grotta, J.4
Davalos, A.5
Davis, S.M.6
Diener, H.C.7
Ashwood, T.8
Wasiewski, W.W.9
Emeribe, U.10
-
6
-
-
34247844511
-
Guidelines for the early management of adults with ischemic stroke
-
A guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists
-
Adams HP Jr, del Zoppo G, Alberts MJ, Bhatt DL, Brass L, Furlan A, Grubb RL, Higashida RT, Jauch EC, Kidwell C, Lyden PD, Morgenstern LB, Qureshi AI, Rosenwasser RH, Scott PA and Wijdicks EF: Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke 38: 1655-1711, 2007.
-
(2007)
Stroke
, vol.38
, pp. 1655-1711
-
-
Adams Jr., H.P.1
del Zoppo, G.2
Alberts, M.J.3
Bhatt, D.L.4
Brass, L.5
Furlan, A.6
Grubb, R.L.7
Higashida, R.T.8
Jauch, E.C.9
Kidwell, C.10
Lyden, P.D.11
Morgenstern, L.B.12
Qureshi, A.I.13
Rosenwasser, R.H.14
Scott, P.A.15
Wijdicks, E.F.16
-
7
-
-
0028292964
-
Protective effects of MCI-186 on cerebral ischemia: Possible involvement of free radical scavenging and antioxidant actions
-
Watanabe T, Yuki S, Egawa M and Nishi H: Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J Pharmacol Exp Ther 268: 1597-1604, 1994.
-
(1994)
J Pharmacol Exp Ther
, vol.268
, pp. 1597-1604
-
-
Watanabe, T.1
Yuki, S.2
Egawa, M.3
Nishi, H.4
-
8
-
-
0037335983
-
Hospital-based study of the care and cost of acute ischemic stroke in Japan
-
Yoneda Y, Uehara T, Yamasaki H, Kita Y, Tabuchi M and Mori E: Hospital-based study of the care and cost of acute ischemic stroke in Japan. Stroke 34: 718-724, 2003.
-
(2003)
Stroke
, vol.34
, pp. 718-724
-
-
Yoneda, Y.1
Uehara, T.2
Yamasaki, H.3
Kita, Y.4
Tabuchi, M.5
Mori, E.6
-
9
-
-
0030801031
-
Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia
-
Yamamoto T, Yuki S, Watanabe T, Mitsuka M, Saito KI and Kogure K: Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia. Brain Res 762: 240-242, 1997.
-
(1997)
Brain Res
, vol.762
, pp. 240-242
-
-
Yamamoto, T.1
Yuki, S.2
Watanabe, T.3
Mitsuka, M.4
Saito, K.I.5
Kogure, K.6
-
10
-
-
0141954290
-
Development of the nitrone-based spin trap agent NXY-059 to treat acute ischemic stroke
-
Lapchak PA and Araujo DM: Development of the nitrone-based spin trap agent NXY-059 to treat acute ischemic stroke. CNS Drug Rev 9: 253-262, 2003.
-
(2003)
CNS Drug Rev
, vol.9
, pp. 253-262
-
-
Lapchak, P.A.1
Araujo, D.M.2
-
11
-
-
0141642104
-
Glutathione peroxidase overexpression inhibits cytochrome C release and proapoptotic mediators to protect neurons from experimental stroke
-
Hoehn B, Yenari MA, Sapolsky RM and Steinberg GK: Glutathione peroxidase overexpression inhibits cytochrome C release and proapoptotic mediators to protect neurons from experimental stroke. Stroke 34: 2489-2494, 2003.
-
(2003)
Stroke
, vol.34
, pp. 2489-2494
-
-
Hoehn, B.1
Yenari, M.A.2
Sapolsky, R.M.3
Steinberg, G.K.4
-
12
-
-
0033998384
-
Melatonin increases activities of glutathione peroxidase and superoxide dismutase in fetal rat brain
-
Okatani Y, Wakatsuki A and Kaneda C: Melatonin increases activities of glutathione peroxidase and superoxide dismutase in fetal rat brain. J Pineal Res 28: 89-96, 2000.
-
(2000)
J Pineal Res
, vol.28
, pp. 89-96
-
-
Okatani, Y.1
Wakatsuki, A.2
Kaneda, C.3
-
13
-
-
0142169969
-
Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression
-
Rajesh KG, Sasaguri S, Suzuki R and Maeda H: Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression. Am J Physiol Heart Circ Physiol 285: H2171-H2178, 2003.
-
(2003)
Am J Physiol Heart Circ Physiol
, vol.285
-
-
Rajesh, K.G.1
Sasaguri, S.2
Suzuki, R.3
Maeda, H.4
-
14
-
-
77956383408
-
The antioxidant edaravone attenuates ER-stress-mediated cardiac apoptosis and dysfunction in rats with autoimmune myocarditis
-
Shimazaki H, Watanabe K, Veeraveedu PT, Harima M, Thandavarayan RA, Arozal W, Tachikawa H, Kodama M and Aizawa Y: The antioxidant edaravone attenuates ER-stress-mediated cardiac apoptosis and dysfunction in rats with autoimmune myocarditis. Free Radic Res 44: 1082-1090, 2010.
-
(2010)
Free Radic Res
, vol.44
, pp. 1082-1090
-
-
Shimazaki, H.1
Watanabe, K.2
Veeraveedu, P.T.3
Harima, M.4
Thandavarayan, R.A.5
Arozal, W.6
Tachikawa, H.7
Kodama, M.8
Aizawa, Y.9
-
15
-
-
33846045129
-
The specific free radical scavenger edaravone suppresses bleomycin-induced acute pulmonary injury in rabbits
-
Asai T, Ohno Y, Minatoguchi S, Funaguchi N, Yuhgetsu H, Sawada M, Takemura G, Komada A, Fujiwara T and Fujiwara H: The specific free radical scavenger edaravone suppresses bleomycin-induced acute pulmonary injury in rabbits. Clin Exp Pharmacol Physiol 34: 22-26, 2007.
-
(2007)
Clin Exp Pharmacol Physiol
, vol.34
, pp. 22-26
-
-
Asai, T.1
Ohno, Y.2
Minatoguchi, S.3
Funaguchi, N.4
Yuhgetsu, H.5
Sawada, M.6
Takemura, G.7
Komada, A.8
Fujiwara, T.9
Fujiwara, H.10
-
16
-
-
0036853007
-
Beneficial effect of MCI-186 on hepatic warm ischemia-reperfusion in the rat
-
Ninomiya M, Shimada M, Harada N, Shiotani S, Hiroshige S, Soejima Y, Suehiro T and Sugimachi K: Beneficial effect of MCI-186 on hepatic warm ischemia-reperfusion in the rat. Transplantation 74: 1470-1472, 2002.
-
(2002)
Transplantation
, vol.74
, pp. 1470-1472
-
-
Ninomiya, M.1
Shimada, M.2
Harada, N.3
Shiotani, S.4
Hiroshige, S.5
Soejima, Y.6
Suehiro, T.7
Sugimachi, K.8
-
17
-
-
0043198117
-
A free radical scavenger, edaravone, attenuates steatosis and cell death via reducing inflammatory cytokine production in rat acute liver injury
-
Nakamoto N, Tada S, Kameyama K, Kitamura K, Kurita S, Saito Y, Saito H and Ishii H: A free radical scavenger, edaravone, attenuates steatosis and cell death via reducing inflammatory cytokine production in rat acute liver injury. Free Radic Res 37: 849-859, 2003.
-
(2003)
Free Radic Res
, vol.37
, pp. 849-859
-
-
Nakamoto, N.1
Tada, S.2
Kameyama, K.3
Kitamura, K.4
Kurita, S.5
Saito, Y.6
Saito, H.7
Ishii, H.8
-
18
-
-
0043204458
-
Clinical usefulness of edaravone for acute liver injury
-
Tada S, Nakamoto N, Kameyama K, Tsunematsu S, Kumagai N, Saito H and Ishii H: Clinical usefulness of edaravone for acute liver injury. J Gastroenterol Hepatol 18: 851-857, 2003.
-
(2003)
J Gastroenterol Hepatol
, vol.18
, pp. 851-857
-
-
Tada, S.1
Nakamoto, N.2
Kameyama, K.3
Tsunematsu, S.4
Kumagai, N.5
Saito, H.6
Ishii, H.7
-
19
-
-
52149083263
-
Edaravone prevents Fas-induced fulminant hepatic failure in mice by regulating mitochondrial Bcl-xL and Bax
-
Miyasou T, Kwon AH, Tsuji K, Qiu Z, Okumura T and Kamiyama Y: Edaravone prevents Fas-induced fulminant hepatic failure in mice by regulating mitochondrial Bcl-xL and Bax. Shock 30: 212-216, 2008.
-
(2008)
Shock
, vol.30
, pp. 212-216
-
-
Miyasou, T.1
Kwon, A.H.2
Tsuji, K.3
Qiu, Z.4
Okumura, T.5
Kamiyama, Y.6
-
20
-
-
78650955653
-
Edaravone, a free radical scavenger, promotes engraftment of intraportally transplanted islet cells
-
Nagatani S, Sudo T, Murakami Y, Uemura K, Hiyama E and Sueda T: Edaravone, a free radical scavenger, promotes engraftment of intraportally transplanted islet cells. Pancreas 40: 126-130, 2011.
-
(2011)
Pancreas
, vol.40
, pp. 126-130
-
-
Nagatani, S.1
Sudo, T.2
Murakami, Y.3
Uemura, K.4
Hiyama, E.5
Sueda, T.6
-
21
-
-
0038814199
-
A novel free radical scavenger, edarabone, protects against cisplatin-induced acute renal damage in vitro and in vivo
-
Satoh M, Kashihara N, Fujimoto S, Horike H, Tokura T, Namikoshi T, Sasaki T and Makino H: A novel free radical scavenger, edarabone, protects against cisplatin-induced acute renal damage in vitro and in vivo. J Pharmacol Exp Ther 305: 1183-1190, 2003.
-
(2003)
J Pharmacol Exp Ther
, vol.305
, pp. 1183-1190
-
-
Satoh, M.1
Kashihara, N.2
Fujimoto, S.3
Horike, H.4
Tokura, T.5
Namikoshi, T.6
Sasaki, T.7
Makino, H.8
-
22
-
-
77952426123
-
Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations
-
Sasano N, Enomoto A, Hosoi Y, Katsumura Y, Matsumoto Y, Morita A, Shiraishi K, Miyagawa K, Igaki H and Nakagawa K: Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations. Cancer Lett 293: 52-57, 2010.
-
(2010)
Cancer Lett
, vol.293
, pp. 52-57
-
-
Sasano, N.1
Enomoto, A.2
Hosoi, Y.3
Katsumura, Y.4
Matsumoto, Y.5
Morita, A.6
Shiraishi, K.7
Miyagawa, K.8
Igaki, H.9
Nakagawa, K.10
-
23
-
-
36749011255
-
Free radical scavenger edaravone suppresses X-ray-induced apoptosis through p53 inhibition in MOLT-4 cells
-
Sasano N, Enomoto A, Hosoi Y, Katsumura Y, Matsumoto Y, Shiraishi K, Miyagawa K, Igaki H and Nakagawa K: Free radical scavenger edaravone suppresses X-ray-induced apoptosis through p53 inhibition in MOLT-4 cells. J Radiat Res 48: 495-503, 2007.
-
(2007)
J Radiat Res
, vol.48
, pp. 495-503
-
-
Sasano, N.1
Enomoto, A.2
Hosoi, Y.3
Katsumura, Y.4
Matsumoto, Y.5
Shiraishi, K.6
Miyagawa, K.7
Igaki, H.8
Nakagawa, K.9
-
24
-
-
0029999345
-
Effect of MCI-186 on postischemic reperfusion injury in isolated rat heart
-
Minhaz U, Tanaka M, Tsukamoto H, Watanabe K, Koide S, Shohtsu A and Nakazawa H: Effect of MCI-186 on postischemic reperfusion injury in isolated rat heart. Free Radic Res 24: 361-367, 1996.
-
(1996)
Free Radic Res
, vol.24
, pp. 361-367
-
-
Minhaz, U.1
Tanaka, M.2
Tsukamoto, H.3
Watanabe, K.4
Koide, S.5
Shohtsu, A.6
Nakazawa, H.7
-
25
-
-
0037183707
-
Myocardial protection of MCI-186 in rabbit ischemia-reperfusion
-
Wu TW, Zeng LH, Wu J and Fung KP: Myocardial protection of MCI-186 in rabbit ischemia-reperfusion. Life Sci 71: 2249-2255, 2002.
-
(2002)
Life Sci
, vol.71
, pp. 2249-2255
-
-
Wu, T.W.1
Zeng, L.H.2
Wu, J.3
Fung, K.P.4
-
26
-
-
1242342939
-
The hydroxyl radical scavenger MCI-186 protects the liver from experimental cold ischaemia-reperfusion injury
-
Ninomiya M, Shimada M, Harada N, Soejima Y, Suehiro T and Maehara Y: The hydroxyl radical scavenger MCI-186 protects the liver from experimental cold ischaemia-reperfusion injury. Br J Surg 91: 184-190, 2004.
-
(2004)
Br J Surg
, vol.91
, pp. 184-190
-
-
Ninomiya, M.1
Shimada, M.2
Harada, N.3
Soejima, Y.4
Suehiro, T.5
Maehara, Y.6
-
27
-
-
26044452361
-
MCI-186 (edaravone), a free radical scavenger, attenuates hepatic warm ischemia-reperfusion injury in rats
-
Suzuki F, Hashikura Y, Ise H, Ishida A, Nakayama J, Takahashi M, Miyagawa S and Ikeda U: MCI-186 (edaravone), a free radical scavenger, attenuates hepatic warm ischemia-reperfusion injury in rats. Transpl Int 18: 844-853, 2005.
-
(2005)
Transpl Int
, vol.18
, pp. 844-853
-
-
Suzuki, F.1
Hashikura, Y.2
Ise, H.3
Ishida, A.4
Nakayama, J.5
Takahashi, M.6
Miyagawa, S.7
Ikeda, U.8
-
28
-
-
77649178969
-
Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury
-
Yang T, Mao YF, Liu SQ, Hou J, Cai ZY, Hu JY, Ni X, Deng XM and Zhu XY: Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury. Eur J Pharmacol 630: 152-157, 2010.
-
(2010)
Eur J Pharmacol
, vol.630
, pp. 152-157
-
-
Yang, T.1
Mao, Y.F.2
Liu, S.Q.3
Hou, J.4
Cai, Z.Y.5
Hu, J.Y.6
Ni, X.7
Deng, X.M.8
Zhu, X.Y.9
-
29
-
-
0037072579
-
Protection by a radical scavenger edaravone against cisplatin-induced nephrotoxicity in rats
-
Sueishi K, Mishima K, Makino K, Itoh Y, Tsuruya K, Hirakata H and Oishi R: Protection by a radical scavenger edaravone against cisplatin-induced nephrotoxicity in rats. Eur J Pharmacol 451: 203-208, 2002.
-
(2002)
Eur J Pharmacol
, vol.451
, pp. 203-208
-
-
Sueishi, K.1
Mishima, K.2
Makino, K.3
Itoh, Y.4
Tsuruya, K.5
Hirakata, H.6
Oishi, R.7
-
30
-
-
2342647446
-
Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney
-
Doi K, Suzuki Y, Nakao A, Fujita T and Noiri E: Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney. Kidney Int 65: 1714-1723, 2004.
-
(2004)
Kidney Int
, vol.65
, pp. 1714-1723
-
-
Doi, K.1
Suzuki, Y.2
Nakao, A.3
Fujita, T.4
Noiri, E.5
-
31
-
-
77649263288
-
Protective effect of edaravone, a free-radical scavenger, on ischaemia-reperfusion injury in the rat testis
-
Tamamura M, Saito M, Kinoshita Y, Shimizu S, Satoh I, Shomori K, Dimitriadis F and Satoh K: Protective effect of edaravone, a free-radical scavenger, on ischaemia-reperfusion injury in the rat testis. BJU Int 105: 870-876, 2010.
-
(2010)
BJU Int
, vol.105
, pp. 870-876
-
-
Tamamura, M.1
Saito, M.2
Kinoshita, Y.3
Shimizu, S.4
Satoh, I.5
Shomori, K.6
Dimitriadis, F.7
Satoh, K.8
-
32
-
-
4344587197
-
Effects of edaravone on reperfusion injury in patients with acute myocardial infarction
-
Tsujita K, Shimomura H, Kawano H, Hokamaki J, Fukuda M, Yamashita T, Hida S, Nakamura Y, Nagayoshi Y, Sakamoto T, Yoshimura M, Arai H and Ogawa H: Effects of edaravone on reperfusion injury in patients with acute myocardial infarction. Am J Cardiol 94: 481-484, 2004.
-
(2004)
Am J Cardiol
, vol.94
, pp. 481-484
-
-
Tsujita, K.1
Shimomura, H.2
Kawano, H.3
Hokamaki, J.4
Fukuda, M.5
Yamashita, T.6
Hida, S.7
Nakamura, Y.8
Nagayoshi, Y.9
Sakamoto, T.10
Yoshimura, M.11
Arai, H.12
Ogawa, H.13
-
33
-
-
33745536062
-
Long-term efficacy of edaravone in patients with acute myocardial infarction
-
Tsujita K, Shimomura H, Kaikita K, Kawano H, Hokamaki J, Nagayoshi Y, Yamashita T, Fukuda M, Nakamura Y, Sakamoto T, Yoshimura M and Ogawa H: Long-term efficacy of edaravone in patients with acute myocardial infarction. Circ J 70: 832-837, 2006.
-
(2006)
Circ J
, vol.70
, pp. 832-837
-
-
Tsujita, K.1
Shimomura, H.2
Kaikita, K.3
Kawano, H.4
Hokamaki, J.5
Nagayoshi, Y.6
Yamashita, T.7
Fukuda, M.8
Nakamura, Y.9
Sakamoto, T.10
Yoshimura, M.11
Ogawa, H.12
-
34
-
-
34548488248
-
Edaravone preserves coronary microvascular endothelial function after ischemia/reperfusion on the beating canine heart in vivo
-
Sukmawan R, Yada T, Toyota E, Neishi Y, Kume T, Shinozaki Y, Mori H, Ogasawara Y, Kajiya F and Yoshida K: Edaravone preserves coronary microvascular endothelial function after ischemia/reperfusion on the beating canine heart in vivo. J Pharmacol Sci 104: 341-348, 2007.
-
(2007)
J Pharmacol Sci
, vol.104
, pp. 341-348
-
-
Sukmawan, R.1
Yada, T.2
Toyota, E.3
Neishi, Y.4
Kume, T.5
Shinozaki, Y.6
Mori, H.7
Ogasawara, Y.8
Kajiya, F.9
Yoshida, K.10
-
35
-
-
33750042873
-
Edaravone reduces myocardial infarct size and improves cardiac function and remodelling in rabbits
-
Onogi H, Minatoguchi S, Chen XH, Bao N, Kobayashi H, Misao Y, Yasuda S, Yamaki T, Maruyama R, Uno Y, Arai M, Takemura G and Fujiwara H: Edaravone reduces myocardial infarct size and improves cardiac function and remodelling in rabbits. Clin Exp Pharmacol Physiol 33: 1035-1041, 2006.
-
(2006)
Clin Exp Pharmacol Physiol
, vol.33
, pp. 1035-1041
-
-
Onogi, H.1
Minatoguchi, S.2
Chen, X.H.3
Bao, N.4
Kobayashi, H.5
Misao, Y.6
Yasuda, S.7
Yamaki, T.8
Maruyama, R.9
Uno, Y.10
Arai, M.11
Takemura, G.12
Fujiwara, H.13
-
36
-
-
21444439413
-
Edaravone prevented deteriorated cardiac function after myocardial ischemia-reperfusion via inhibiting lipid peroxidation in rat
-
Yagi H, Horinaka S and Matsuoka H: Edaravone prevented deteriorated cardiac function after myocardial ischemia-reperfusion via inhibiting lipid peroxidation in rat. J Cardiovasc Pharmacol 46: 46-51, 2005.
-
(2005)
J Cardiovasc Pharmacol
, vol.46
, pp. 46-51
-
-
Yagi, H.1
Horinaka, S.2
Matsuoka, H.3
-
37
-
-
66149158208
-
Effect of edaravone, a novel free radical scavenger, supplemented to cardioplegia on myocardial function after cardioplegic arrest: In vitro study of isolated rat heart
-
Yamazaki K, Miwa S, Toyokuni S, Nemoto S, Oriyanhan W, Takaba K, Saji Y, Marui A, Nishina T, Ikeda T and Komeda M: Effect of edaravone, a novel free radical scavenger, supplemented to cardioplegia on myocardial function after cardioplegic arrest: in vitro study of isolated rat heart. Heart Vessels 24: 228-235, 2009.
-
(2009)
Heart Vessels
, vol.24
, pp. 228-235
-
-
Yamazaki, K.1
Miwa, S.2
Toyokuni, S.3
Nemoto, S.4
Oriyanhan, W.5
Takaba, K.6
Saji, Y.7
Marui, A.8
Nishina, T.9
Ikeda, T.10
Komeda, M.11
-
38
-
-
28144451821
-
MCI-186 (edaravone), a novel free radical scavenger, protects against acute autoimmune myocarditis in rats
-
Nimata M, Okabe TA, Hattori M, Yuan Z, Shioji K and Kishimoto C: MCI-186 (edaravone), a novel free radical scavenger, protects against acute autoimmune myocarditis in rats. Am J Physiol Heart Circ Physiol 289: H2514-H2518, 2005.
-
(2005)
Am J Physiol Heart Circ Physiol
, vol.289
-
-
Nimata, M.1
Okabe, T.A.2
Hattori, M.3
Yuan, Z.4
Shioji, K.5
Kishimoto, C.6
-
39
-
-
34249099114
-
Efficacy of MCI-186, a free-radical scavenger and antioxidant, for resuscitation of nonbeating donor hearts
-
Kotani Y, Ishino K, Osaki S, Honjo O, Suezawa T, Kanki K, Yutani C and Sano S: Efficacy of MCI-186, a free-radical scavenger and antioxidant, for resuscitation of nonbeating donor hearts. J Thorac Cardiovasc Surg 133: 1626-1632, 2007.
-
(2007)
J Thorac Cardiovasc Surg
, vol.133
, pp. 1626-1632
-
-
Kotani, Y.1
Ishino, K.2
Osaki, S.3
Honjo, O.4
Suezawa, T.5
Kanki, K.6
Yutani, C.7
Sano, S.8
-
40
-
-
3042697180
-
Protective effect of edaravone against hypoxia-reoxygenation injury in rabbit cardiomyocytes
-
Yamawaki M, Sasaki N, Shimoyama M, Miake J, Ogino K, Igawa O, Tajima F, Shigemasa C and Hisatome I: Protective effect of edaravone against hypoxia-reoxygenation injury in rabbit cardiomyocytes. Br J Pharmacol 142: 618-626, 2004.
-
(2004)
Br J Pharmacol
, vol.142
, pp. 618-626
-
-
Yamawaki, M.1
Sasaki, N.2
Shimoyama, M.3
Miake, J.4
Ogino, K.5
Igawa, O.6
Tajima, F.7
Shigemasa, C.8
Hisatome, I.9
-
41
-
-
33746495023
-
Effect of the free radical scavenger MCI-186 on pulmonary ischemia-reperfusion injury in dogs
-
Akao T, Takeyoshi I, Totsuka O, Arakawa K, Muraoka M, Kobayashi K, Konno K, Matsumoto K and Morishita Y: Effect of the free radical scavenger MCI-186 on pulmonary ischemia-reperfusion injury in dogs. J Heart Lung Transplant 25: 965-971, 2006.
-
(2006)
J Heart Lung Transplant
, vol.25
, pp. 965-971
-
-
Akao, T.1
Takeyoshi, I.2
Totsuka, O.3
Arakawa, K.4
Muraoka, M.5
Kobayashi, K.6
Konno, K.7
Matsumoto, K.8
Morishita, Y.9
-
42
-
-
55649125284
-
Pretreatment with edaravone reduces lung mitochondrial damage in an infant rabbit ischemia-reperfusion model
-
Qiu W, Gu H, Zheng L, Zhou J, Chen D and Chen Y: Pretreatment with edaravone reduces lung mitochondrial damage in an infant rabbit ischemia-reperfusion model. J Pediatr Surg 43: 2053-2060, 2008.
-
(2008)
J Pediatr Surg
, vol.43
, pp. 2053-2060
-
-
Qiu, W.1
Gu, H.2
Zheng, L.3
Zhou, J.4
Chen, D.5
Chen, Y.6
-
43
-
-
32144457044
-
MCI-186 (edaravone), a free radical scavenger, attenuates ischemia-reperfusion injury and activation of phospholipase A(2) in an isolated rat lung model after 18 h of cold preservation
-
Reyes YA, Shimoyama T, Akamatsu H and Sunamori M: MCI-186 (edaravone), a free radical scavenger, attenuates ischemia-reperfusion injury and activation of phospholipase A(2) in an isolated rat lung model after 18 h of cold preservation. Eur J Cardiothorac Surg 29: 304-311, 2006.
-
(2006)
Eur J Cardiothorac Surg
, vol.29
, pp. 304-311
-
-
Reyes, Y.A.1
Shimoyama, T.2
Akamatsu, H.3
Sunamori, M.4
-
44
-
-
58849096654
-
Effects of edaravone, a free-radical scavenger, on bleomycin-induced lung injury in mice
-
Tajima S, Bando M, Ishii Y, Hosono T, Yamasawa H, Ohno S, Takada T, Suzuki E, Gejyo F and Sugiyama Y: Effects of edaravone, a free-radical scavenger, on bleomycin-induced lung injury in mice. Eur Respir J 32: 1337-1343, 2008.
-
(2008)
Eur Respir J
, vol.32
, pp. 1337-1343
-
-
Tajima, S.1
Bando, M.2
Ishii, Y.3
Hosono, T.4
Yamasawa, H.5
Ohno, S.6
Takada, T.7
Suzuki, E.8
Gejyo, F.9
Sugiyama, Y.10
-
45
-
-
1542543458
-
Edaravone, a newly developed radical scavenger, protects against ischemia-reperfusion injury of the small intestine in rats
-
Tomatsuri N, Yoshida N, Takagi T, Katada K, Isozaki Y, Imamoto E, Uchiyama K, Kokura S, Ichikawa H, Naito Y, Okanoue T and Yoshikawa T: Edaravone, a newly developed radical scavenger, protects against ischemia-reperfusion injury of the small intestine in rats. Int J Mol Med 13: 105-109, 2004.
-
(2004)
Int J Mol Med
, vol.13
, pp. 105-109
-
-
Tomatsuri, N.1
Yoshida, N.2
Takagi, T.3
Katada, K.4
Isozaki, Y.5
Imamoto, E.6
Uchiyama, K.7
Kokura, S.8
Ichikawa, H.9
Naito, Y.10
Okanoue, T.11
Yoshikawa, T.12
-
46
-
-
34848827170
-
Microcirculatory changes in experimental mesenteric longitudinal ulcers of the small intestine in rats
-
Shimizu K, Koga H, Iida M and Haruma K: Microcirculatory changes in experimental mesenteric longitudinal ulcers of the small intestine in rats. Dig Dis Sci 52: 3019-3028, 2007.
-
(2007)
Dig Dis Sci
, vol.52
, pp. 3019-3028
-
-
Shimizu, K.1
Koga, H.2
Iida, M.3
Haruma, K.4
-
47
-
-
0141519508
-
Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin
-
Kono H, Asakawa M, Fujii H, Maki A, Amemiya H, Yamamoto M, Matsuda M and Matsumoto Y: Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin. J Pharmacol Exp Ther 307: 74-82, 2003.
-
(2003)
J Pharmacol Exp Ther
, vol.307
, pp. 74-82
-
-
Kono, H.1
Asakawa, M.2
Fujii, H.3
Maki, A.4
Amemiya, H.5
Yamamoto, M.6
Matsuda, M.7
Matsumoto, Y.8
-
48
-
-
36348979198
-
Amelioration of hepatic ischemia/reperfusion injury in the remnant liver after partial hepatectomy in rats
-
Hiranuma S, Ito K, Noda Y, Ozasa H, Koike Y and Horikawa S: Amelioration of hepatic ischemia/reperfusion injury in the remnant liver after partial hepatectomy in rats. J Gastroenterol Hepatol 22: 2167-2172, 2007.
-
(2007)
J Gastroenterol Hepatol
, vol.22
, pp. 2167-2172
-
-
Hiranuma, S.1
Ito, K.2
Noda, Y.3
Ozasa, H.4
Koike, Y.5
Horikawa, S.6
-
49
-
-
33744788665
-
Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage
-
Kono H, Woods CG, Maki A, Connor HD, Mason RP, Rusyn I and Fujii H: Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage. Free Radic Res 40: 579-588, 2006.
-
(2006)
Free Radic Res
, vol.40
, pp. 579-588
-
-
Kono, H.1
Woods, C.G.2
Maki, A.3
Connor, H.D.4
Mason, R.P.5
Rusyn, I.6
Fujii, H.7
-
50
-
-
51249102618
-
A free radical scavenger, edaravone, prevents ischemia-reperfusion injury in liver grafts from non-heart-beating donors
-
Nakamura A, Akamatsu Y, Miyagi S, Fukumori T, Sekiguchi S and Satomi S: A free radical scavenger, edaravone, prevents ischemia-reperfusion injury in liver grafts from non-heart-beating donors. Transplant Proc 40: 2171-2174, 2008.
-
(2008)
Transplant Proc
, vol.40
, pp. 2171-2174
-
-
Nakamura, A.1
Akamatsu, Y.2
Miyagi, S.3
Fukumori, T.4
Sekiguchi, S.5
Satomi, S.6
-
51
-
-
12244303263
-
Edaravone protects against ischemia/reperfusion-induced oxidative damage to mitochondria in rat liver
-
Okatani Y, Wakatsuki A, Enzan H and Miyahara Y: Edaravone protects against ischemia/reperfusion-induced oxidative damage to mitochondria in rat liver. Eur J Pharmacol 465: 163-170, 2003.
-
(2003)
Eur J Pharmacol
, vol.465
, pp. 163-170
-
-
Okatani, Y.1
Wakatsuki, A.2
Enzan, H.3
Miyahara, Y.4
-
52
-
-
33845307219
-
Edaravone reduces ischemia-reperfusion injury mediators in rat liver
-
Taniguchi M, Uchinami M, Doi K, Yoshida M, Sasaki H, Tamagawa K, Horiuchi T and Tanaka K: Edaravone reduces ischemia-reperfusion injury mediators in rat liver. J Surg Res 137: 69-74, 2007.
-
(2007)
J Surg Res
, vol.137
, pp. 69-74
-
-
Taniguchi, M.1
Uchinami, M.2
Doi, K.3
Yoshida, M.4
Sasaki, H.5
Tamagawa, K.6
Horiuchi, T.7
Tanaka, K.8
-
53
-
-
11144318582
-
Free radical scavenger (edaravone) prevents endotoxin-induced liver injury after partial hepatectomy in rats
-
Tsuji K, Kwon AH, Yoshida H, Qiu Z, Kaibori M, Okumura T and Kamiyama Y: Free radical scavenger (edaravone) prevents endotoxin-induced liver injury after partial hepatectomy in rats. J Hepatol 42: 94-101, 2005.
-
(2005)
J Hepatol
, vol.42
, pp. 94-101
-
-
Tsuji, K.1
Kwon, A.H.2
Yoshida, H.3
Qiu, Z.4
Kaibori, M.5
Okumura, T.6
Kamiyama, Y.7
-
54
-
-
58149247799
-
Edaravone inhibits the induction of iNOS gene expression at transcriptional and posttranscriptional steps in murine macrophages
-
Yoshida H, Kwon AH, Habara K, Yamada M, Kaibori M, Kamiyama Y, Nishizawa M, Ito S and Okumura T: Edaravone inhibits the induction of iNOS gene expression at transcriptional and posttranscriptional steps in murine macrophages. Shock 30: 734-739, 2008.
-
(2008)
Shock
, vol.30
, pp. 734-739
-
-
Yoshida, H.1
Kwon, A.H.2
Habara, K.3
Yamada, M.4
Kaibori, M.5
Kamiyama, Y.6
Nishizawa, M.7
Ito, S.8
Okumura, T.9
-
55
-
-
1542494391
-
The free radical scavenger edaravone suppresses experimental closed duodenal loop-induced acute pancreatitis in rats
-
Araki, Y, Andoh A, Yokono T, Asano N, Yoshikawa K, Bamba S, Ishizuka I and Fujiyama Y: The free radical scavenger edaravone suppresses experimental closed duodenal loop-induced acute pancreatitis in rats. Int J Mol Med 12: 121-124, 2003.
-
(2003)
Int J Mol Med
, vol.12
, pp. 121-124
-
-
Araki, Y.1
Andoh, A.2
Yokono, T.3
Asano, N.4
Yoshikawa, K.5
Bamba, S.6
Ishizuka, I.7
Fujiyama, Y.8
-
56
-
-
23044516263
-
A radical scavenger, edaravone, protects canine kidneys from ischemia-reperfusion injury after 72 hours of cold preservation and autotransplantation
-
Tahara M, Nakayama M, Jin MB, Fujita M, Suzuki T, Taniguchi M, Shimamura T, Furukawa H and Todo S: A radical scavenger, edaravone, protects canine kidneys from ischemia-reperfusion injury after 72 hours of cold preservation and autotransplantation. Transplantation 80: 213-221, 2005.
-
(2005)
Transplantation
, vol.80
, pp. 213-221
-
-
Tahara, M.1
Nakayama, M.2
Jin, M.B.3
Fujita, M.4
Suzuki, T.5
Taniguchi, M.6
Shimamura, T.7
Furukawa, H.8
Todo, S.9
-
57
-
-
26044443541
-
Effect of a novel free radical scavenger, edaravone, on puromycin aminonucleoside induced nephrosis in rats
-
Someya T, Kaneko K, Yamada T and Yamashiro Y: Effect of a novel free radical scavenger, edaravone, on puromycin aminonucleoside induced nephrosis in rats. Pediatr Nephrol 20: 1430-1434, 2005.
-
(2005)
Pediatr Nephrol
, vol.20
, pp. 1430-1434
-
-
Someya, T.1
Kaneko, K.2
Yamada, T.3
Yamashiro, Y.4
-
58
-
-
33845421687
-
Protective effect of radical scavenger edaravone against puromycin nephrosis
-
Matsumura H, Ashida A, Hirano K, Nakakura H and Tamai H: Protective effect of radical scavenger edaravone against puromycin nephrosis. Clin Nephrol 66: 405-410, 2006.
-
(2006)
Clin Nephrol
, vol.66
, pp. 405-410
-
-
Matsumura, H.1
Ashida, A.2
Hirano, K.3
Nakakura, H.4
Tamai, H.5
-
59
-
-
26644460229
-
Edaravone protects against ischemia/reperfusion-induced functional and biochemical changes in rat urinary bladder
-
Matsumoto S, Hanai T, Yoshioka N, Shimizu N, Sugiyama T, Uemura H and Levin RM: Edaravone protects against ischemia/reperfusion-induced functional and biochemical changes in rat urinary bladder. Urology 66: 892-896, 2005.
-
(2005)
Urology
, vol.66
, pp. 892-896
-
-
Matsumoto, S.1
Hanai, T.2
Yoshioka, N.3
Shimizu, N.4
Sugiyama, T.5
Uemura, H.6
Levin, R.M.7
-
60
-
-
68849127907
-
Acute urinary retention and subsequent catheterization cause lipid peroxidation and oxidative DNA damage in the bladder: Preventive effect of edaravone, a free-radical scavenger
-
Shimizu S, Saito M, Kinoshita Y, Kazuyama E, Tamamura M, Satoh I and Satoh K: Acute urinary retention and subsequent catheterization cause lipid peroxidation and oxidative DNA damage in the bladder: preventive effect of edaravone, a free-radical scavenger. BJU Int 104: 713-717, 2009.
-
(2009)
BJU Int
, vol.104
, pp. 713-717
-
-
Shimizu, S.1
Saito, M.2
Kinoshita, Y.3
Kazuyama, E.4
Tamamura, M.5
Satoh, I.6
Satoh, K.7
-
61
-
-
73849085537
-
Edaravone, a novel free radical scavenger, reduces high-mobility group box 1 and prolongs survival in a neonatal sepsis model
-
Kato S, Hussein MH, Kakita H, Goto T, Daoud GA, Kato T, Sugiura T, Nobata M, Nakajima Y, Endo T, Mizuno K, Ito T, Kato I, Suzuki S and Togari H: Edaravone, a novel free radical scavenger, reduces high-mobility group box 1 and prolongs survival in a neonatal sepsis model. Shock 32: 586-592, 2009.
-
(2009)
Shock
, vol.32
, pp. 586-592
-
-
Kato, S.1
Hussein, M.H.2
Kakita, H.3
Goto, T.4
Daoud, G.A.5
Kato, T.6
Sugiura, T.7
Nobata, M.8
Nakajima, Y.9
Endo, T.10
Mizuno, K.11
Ito, T.12
Kato, I.13
Suzuki, S.14
Togari, H.15
-
62
-
-
33750088980
-
The therapeutic efficacy of edaravone in extensively burned rats
-
Koizumi T, Tanaka H, Sakaki S and Shimazaki S: The therapeutic efficacy of edaravone in extensively burned rats. Arch Surg 141: 992-995, 2006.
-
(2006)
Arch Surg
, vol.141
, pp. 992-995
-
-
Koizumi, T.1
Tanaka, H.2
Sakaki, S.3
Shimazaki, S.4
-
63
-
-
18344364000
-
A free radical scavenger, edaravone (MCI-186), diminishes intestinal neutrophil lipid peroxidation and bacterial translocation in a rat hemorrhagic shock model
-
Mori T, Yamamoto H, Tabata T, Shimizu T, Endo Y, Hanasawa K, Fujimiya M and Tani T: A free radical scavenger, edaravone (MCI-186), diminishes intestinal neutrophil lipid peroxidation and bacterial translocation in a rat hemorrhagic shock model. Crit Care Med 33: 1064-1069, 2005.
-
(2005)
Crit Care Med
, vol.33
, pp. 1064-1069
-
-
Mori, T.1
Yamamoto, H.2
Tabata, T.3
Shimizu, T.4
Endo, Y.5
Hanasawa, K.6
Fujimiya, M.7
Tani, T.8
-
64
-
-
43049110610
-
Edaravone improves the survival of rats subjected to hemorrhagic shock without resuscitation
-
Uji Y, Yamamoto H, Mori T, Akabori H, Tsuchihashi H, Shimizu T, Endo Y and Tani T: Edaravone improves the survival of rats subjected to hemorrhagic shock without resuscitation. Surg Today 38: 476-477, 2008.
-
(2008)
Surg Today
, vol.38
, pp. 476-477
-
-
Uji, Y.1
Yamamoto, H.2
Mori, T.3
Akabori, H.4
Tsuchihashi, H.5
Shimizu, T.6
Endo, Y.7
Tani, T.8
-
65
-
-
33745986027
-
Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum
-
Kawasaki T, Ishihara K, Ago Y, Nakamura S, Itoh S, Baba A and Matsuda T: Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum. Eur J Pharmacol 542: 92-99, 2006.
-
(2006)
Eur J Pharmacol
, vol.542
, pp. 92-99
-
-
Kawasaki, T.1
Ishihara, K.2
Ago, Y.3
Nakamura, S.4
Itoh, S.5
Baba, A.6
Matsuda, T.7
-
66
-
-
70450224259
-
The effect of edaravone on plasma monocyte chemoattractant protein-1 levels in patients with acute myocardial infarction
-
Nakamura Y, Yamada Y, Shimomura H, Nagayoshi Y, Tsujita K, Yamashita T, Fukuda M, Ohba K, Nako H, Ogura Y, Chitose T, Yamaguchi M, Nagata T, Soejima H, Kaikita K, Sugiyama S and Ogawa H: The effect of edaravone on plasma monocyte chemoattractant protein-1 levels in patients with acute myocardial infarction. J Cardiol 54: 416-424, 2009.
-
(2009)
J Cardiol
, vol.54
, pp. 416-424
-
-
Nakamura, Y.1
Yamada, Y.2
Shimomura, H.3
Nagayoshi, Y.4
Tsujita, K.5
Yamashita, T.6
Fukuda, M.7
Ohba, K.8
Nako, H.9
Ogura, Y.10
Chitose, T.11
Yamaguchi, M.12
Nagata, T.13
Soejima, H.14
Kaikita, K.15
Sugiyama, S.16
Ogawa, H.17
-
67
-
-
33645062396
-
Inhibitory effects of edaravone on the production of tumor necrosis factor-alpha in the isolated heart undergoing ischemia and reperfusion
-
Onimaru S, Nakamura K, Kariyazono H, Ikeda R, Ueno T, Fukumoto Y, Yabuki A, Sakata R and Yamada K: Inhibitory effects of edaravone on the production of tumor necrosis factor-alpha in the isolated heart undergoing ischemia and reperfusion. Heart Vessels 21: 108-115, 2006.
-
(2006)
Heart Vessels
, vol.21
, pp. 108-115
-
-
Onimaru, S.1
Nakamura, K.2
Kariyazono, H.3
Ikeda, R.4
Ueno, T.5
Fukumoto, Y.6
Yabuki, A.7
Sakata, R.8
Yamada, K.9
-
68
-
-
10044219504
-
Cardioprotective effects of 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), a novel free radical scavenger, on acute autoimmune myocarditis in rats
-
Okabe TA, Kishimoto C, Hattori M, Nimata M, Shioji K and Kita T: Cardioprotective effects of 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), a novel free radical scavenger, on acute autoimmune myocarditis in rats. Exp Clin Cardiol 9: 177-180, 2004.
-
(2004)
Exp Clin Cardiol
, vol.9
, pp. 177-180
-
-
Okabe, T.A.1
Kishimoto, C.2
Hattori, M.3
Nimata, M.4
Shioji, K.5
Kita, T.6
-
69
-
-
47149093702
-
Preventive effects of edaravone, a free radical scavenger, on lipopolysaccharide-induced lung injury in mice
-
Tajima S, Soda M, Bando M, Enomoto M, Yamasawa H, Ohno S, Takada T, Suzuki E, Gejyo F and Sugiyama Y: Preventive effects of edaravone, a free radical scavenger, on lipopolysaccharide-induced lung injury in mice. Respirology 13: 646-653, 2008.
-
(2008)
Respirology
, vol.13
, pp. 646-653
-
-
Tajima, S.1
Soda, M.2
Bando, M.3
Enomoto, M.4
Yamasawa, H.5
Ohno, S.6
Takada, T.7
Suzuki, E.8
Gejyo, F.9
Sugiyama, Y.10
-
70
-
-
33646102687
-
A free radical scavenger but not FGF-2-mediated angiogenic therapy rescues myonephropathic metabolic syndrome in severe hindlimb ischemia
-
Kaneko K, Yonemitsu Y, Fujii T, Onimaru M, Jin CH, Inoue M, Hasegawa M, Onohara T, Maehara Y and Sueishi K: A free radical scavenger but not FGF-2-mediated angiogenic therapy rescues myonephropathic metabolic syndrome in severe hindlimb ischemia. Am J Physiol Heart Circ Physiol 290: H1484-H1492, 2006.
-
(2006)
Am J Physiol Heart Circ Physiol
, vol.290
-
-
Kaneko, K.1
Yonemitsu, Y.2
Fujii, T.3
Onimaru, M.4
Jin, C.H.5
Inoue, M.6
Hasegawa, M.7
Onohara, T.8
Maehara, Y.9
Sueishi, K.10
|