Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage

Free Radical Research

Volumn 40, Issue 6, 2006, Pages 579-588

  Kono, Hiroshi ^a   Woods, Courtney G ^b   Maki, Akira ^a,b   Connor, Henry D ^c   Mason, Ronald P ^c   Rusyn, Ivan ^b   Fujii, Hideki ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

^b IL   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Electron spin resonance; Ischemia reperfusion; Liver injury; Reactive oxygen species

Indexed keywords

4 HYDROXYNONENAL; ALANINE AMINOTRANSFERASE; CYTOKINE; FREE RADICAL; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; LIPID; NORPHENAZONE; OXIDIZING AGENT; REACTIVE OXYGEN METABOLITE; SCAVENGER; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ELECTRON SPIN RESONANCE; ENZYME ACTIVITY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INHIBITION KINETICS; LIPID PEROXIDATION; LIVER ISCHEMIA; MALE; MEDICAL ASSESSMENT; NEUTROPHIL CHEMOTAXIS; NONHUMAN; RAT; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPIN TRAPPING; TISSUE INJURY;

ACUTE DISEASE; ANIMALS; ANTIPYRINE; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICALS; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SPIN TRAPPING; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 33744788665     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.1080/10715760600606374     Document Type: Article

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