The specific free radical scavenger edaravone suppresses bleomycin-induced acute pulmonary injury in rabbits

Clinical and Experimental Pharmacology and Physiology

Volumn 34, Issue 1-2, 2007, Pages 22-26

  Asai, Toshihiro ^a   Ohno, Yasushi ^a   Minatoguchi, Shinya ^a   Funaguchi, Norihiko ^a   Yuhgetsu, Hideyuki ^a   Sawada, Masahiro ^a   Takemura, Genzou ^a   Komada, A ^b   Fujiwara, Takako ^c   Fujiwara, Hisayoshi ^a  

^a GIFU UNIVERSITY   (Japan)

^b AOMORI UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^c KYOTO WOMEN'S UNIVERSITY   (Japan)

Author keywords

Anti oxidant; Bleomycin induced lung fibrosis; Matrix metalloproteinases; MCI 186; Transforming growth factor ; TUNEL

Indexed keywords

BLEOMYCIN; NORPHENAZONE; REACTIVE OXYGEN METABOLITE; SCAVENGER; SODIUM CHLORIDE; TRANSFORMING GROWTH FACTOR BETA;

ANALYSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; EOSINOPHIL; INFLAMMATORY CELL; LUNG INJURY; LUNG PARENCHYMA; LYMPHOCYTE; MALE; NEUTROPHIL; NICK END LABELING; NONHUMAN; PNEUMONIA; RABBIT;

ANIMALS; ANTIPYRINE; APOPTOSIS; BLEOMYCIN; FREE RADICAL SCAVENGERS; IN SITU NICK-END LABELING; MALE; MATRIX METALLOPROTEINASE 1; PULMONARY FIBROSIS; RABBITS; TRANSFORMING GROWTH FACTOR BETA;

EID: 33846045129     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2007.04528.x     Document Type: Article

References (29)

1. Phan SH, Kunke SLI. Lung cytokine production in bleomycin-induced lung fibrosis. Exp. Lung Res. 1992; 18: 29-43.
2. Punithavathi D, Venkatesan N, Babu M. Curcumin inhibition of bleomycin-induced pulmonary fibrosis in rats. Br. J. Pharmacol. 2000; 131: 169-72.
3. Trush MA, Mimnaugh EG, Ginsburg E, Gram TE. Studies on the interaction of bleomycin with rat lung microsomes: Involvement of adventitious iron and reactive oxygen in bleomycin-mediated DNA chain breakage. J. Pharmacol. Exp. Ther. 1982; 221: 159-65.
4. Kuwano K, Hagimoto N, Tanaka T et al. Expression of apoptosis-regulatory genes in epithelial cells in pulmonary fibrosis in mice. J. Pathol. 2000; 190: 221-9.
5. Uhal BD, Joshi I, True AL et al. Fibroblasts isolated after fibrotic lung injury induce apoptosis of alveolar epithelial cells in vitro. Am. J. Physiol. Lung. Cell Mol. Physiol. 1995; 269: 819-28.
6. Khalil N, O'Connor RN, Flanders KC, Unruh H. TGF-beta 1, but not TGF-beta 2 or TGF-beta 3, is differentially present in epithelial cells of advanced pulmonary fibrosis: An immunohistochemical study. Am. J. Respir. Cell Mol. Biol. 1996; 14: 131-8.
7. Xu YD, Hua J, Mui A, O'Connor R, Grotendorst G, Khalil N. Release of biologically active TGF-beta 1 by alveolar epithelial cells results in pulmonary fibrosis. Am. J. Physiol. Lung Cell Mol. Physiol. 2003; 285: 527-53.
8. Giri SN, Hyde DM, Hollinger MA. Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice. Thorax 1993; 48: 959-96.
9. Yaguchi T, Fukuda Y, Ishizaki M, Yamanaka N. Immunohistochemical and gelatin zymography studies for matrix metalloproteinases in bleomycin-induced pulmonary fibrosis. Pathol. Int. 1998; 48: 954-63.
10. Abe K, Yuki S, Kogure K. Strong attenuation of ischemic and post-ischemic brain edema in rats by a novel free radical scavenger. Stroke 1988; 1: 480-5.
11. Cuzzocrea S, Riley DP, Caputi AP, Salvemini D. Antioxidative therapy: A new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacol. Rev. 2001; 53: 135-59.
12. Dirnagl U, Iadecola C, Moskowitz MA. Pathology of ischaemic stroke: An integrated view. Trends Neurosci. 1999; 22: 391-7.
13. Gilgun-Sherki Y, Rosenbaum Z, Melamed E, Offen D. Anioxidant therapy in acute central nervous system injury: Current state. Pharmacol. Rev. 2002; 54: 271-84.
14. Watanabe T, Yuki S, Egawa M, Nishi H. Protective effect of MCI-186 on cerebral ischemia: Possible involvement of free radical scavenging and antioxidant action. J. Pharmacol. Exp. Ther. 1994; 268: 1597-604.
15. Houkin K, Nakayama M, Kamada K, Noujou T, Abe H, Kashiwaba T. Neuroprotective effect of the free radical scavenger MCI-186 in patients with cerebral infarction: Clinical evaluation using magnetic resonance imaging and spectroscopy. J. Stroke Cerebrovasc. 1998; 7: 315-22.
16. Takahashi G, Sakurai M, Abe K, Itoyama Y, Tabayashi K. MCI-186 prevents spinal cord damage and affects enzyme levels of nitric oxide synthase and Cu/Zn superoxide dismutase after transient ischemia in rabbits. J. Thorac. Cardiovasc. Surg. 2003; 126: 1461-6.
17. Kunugi S, Fukuda Y, Ishizaki M, Yamanaka N. Role of MMP-2 in alveolar epithelial cell repair after bleomycin administration in rabbits. Lab. Invest. 2001; 81: 1309-18.
18. Borzone G, Moreno R, Urrea R, Meneses M, Oyarzun M, Lisboa C. Bleomycin-induced chronic lung damage does not resemble human idiopathic pulmonary fibrosis. Am. J. Respir. Cell Mol. Biol. 1998; 163: 1648-53.
19. Zhang K, Flanders KC, Phan SH. Cellular localization of transforming growth factor-beta expression in bleomycin-induced pulmonary fibrosis. Am. J. Pathol. 1995; 147: 352-61.
20. Kim GW, Sugawara T, Chan PH. Involvement of oxidative stress and caspase-3 in cortical infarction after photothrombotic ischemia in mice. J. Cereb. Blood Flow Metab. 2000; 20: 1690-701.
21. Fukuda Y, Ishizaki M, Okada Y, Seiki M, Yamanaka N. Matrix metalloproteinases and tissue inhibitor of metalloproteinase-2 in fetal rabbit lung. Am. J. Physiol. Lung Cell Mol. Physiol. 2000; 279: L555-61.
22. Mutsaers SE, Foster ML, Chambers RC, Laurent GJ, McAnulty RJ. Increased endothelin-1 and its localization during the development of bleomycin-induced pulmonary fibrosis in rats. Am. J. Respir. Cell Mol. Biol. 1998; 18: 611-19.
23. Wu TW, Zeng LH, Wu J, Fung KP. MCI-186: Further histochemical and biological evidence of neuroprotection. Life Sci. 2000; 67: 2387-92.
24. Shichinohe H, Kuroda S, Yasuda H et al. Neuroprotective effects of the free radical scavenger edaravone (MCI-186) in mice permanent focal brain ischemia. Brain Res. 2004; 1029: 200-6.
25. Adamson IY, Young L, Bowden DH. Relationship of alveolar epithelial injury and repair to the induction of pulmonary fibrosis. Am. J. Pathol 1988; 130: 377-83.
26. Kuwano K, Hagimoto N, Kawasaki M et al. Essential roles of the Fas-Fas-ligand pathway in pulmonary fibrosis. J. Clin. Invest. 1999; 104: 13-19.
27. Kuwano K, Kunitake R, Kawasaki M et al. P21Waf1/Cip1/Sdi1 and p53 expression in association with DNA strand breaks in idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 1996; 154: 477-83.
28. Namura S, Nagata I, Takami S, Masayasu H, Kikuchi H. Ebselen reduces cytochrome c release from mitochondria and subsequent DNA fragmentation after transient focal cerebral ischemia in mice. Stroke 2001; 32: 1906-11.
29. Rajesh KG, Sasaguri S, Suzuki R, Maeda H. Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression. Am. J. Physiol. Heart Circ. Physiol. 2003; 5: H2171-8.