A free radical scavenger, edaravone (MCI-186), diminishes intestinal neutrophil lipid peroxidation and bacterial translocation in a rat hemorrhagic shock model

Critical Care Medicine

Volumn 33, Issue 5, 2005, Pages 1064-1069

  Mori, Tsuyoshi ^a   Yamamoto, Hiroshi ^a   Tabata, Takahisa ^a   Shimizu, Tomoharu ^a   Endo, Yoshihiro ^a   Hanasawa, Kazuyoshi ^a   Fujimiya, Mineko ^a   Tani, Tohru ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

4 hydroxy 2 nonenal; Bacterial translocation; Edaravone; Hemorrhagic shock; Neutrophils; Silkworm larvae plasma test

Indexed keywords

4 HYDROXYNONENAL; BETA GLUCAN; ENDOTOXIN; MYELOPEROXIDASE; NORPHENAZONE; PEPTIDOGLYCAN;

ANIMAL MODEL; ARTICLE; BACTERIAL TRANSLOCATION; CELL LABELING; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFECT; DRUG MECHANISM; HEMORRHAGIC SHOCK; ILEUM; IMMUNOHISTOCHEMISTRY; INCIDENCE; LAMINA PROPRIA; LARVA; LIPID PEROXIDATION; MALE; MEAN ARTERIAL PRESSURE; MESENTERY LYMPH NODE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RAT; SILKWORM; TISSUE CULTURE;

ANIMALS; ANTIPYRINE; BACTERIAL TRANSLOCATION; FREE RADICAL SCAVENGERS; ILEUM; LIPID PEROXIDATION; LYMPH NODES; MALE; NEUTROPHILS; RATS; RATS, SPRAGUE-DAWLEY; SHOCK, HEMORRHAGIC;

EID: 18344364000     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000162952.14590.EC     Document Type: Article

References (52)

1. Tanaka M: Pharmacological and clinical profile of the free radical scavenger edaravone as a neuroprotective agent. Nippon Yakurigaku Zasshi 2002; 119:301-308
2. Tabrizchi R: Edaravone Mitsubishi-Tokyo. Curr Opin Investig Drugs 2000; 1:347-354
3. Watanabe T, Morita I, Nishi H, et al: Preventive effect of MCI-186 on 15-HPETE induced vascular endothelial cell injury in vitro. Prostaglandins Leukot Essent Fatty Acids 1988; 33:81-87
4. Ochi H, Morita I, Murota S, et al: Mechanism for endothelial cell injury induced by 15-hydroperoxyeicosatetraenoic acid, an archidonate lipoxygenase product. Biochem Biophys Acta 1992; 1136:247-252
5. Nishi H, Watanabe T, Sakurai H, et al: Effect of MCI-186 on brain edema in rats. Stroke 1989; 20:1236-1240
6. Minhaz U, Tanaka M, Tsukamoto H, et al: Effect of MCI-186 on postischemic reperfusion injury in isolated rat heart. Free Radic Res 1996; 24:361-367
7. Okatani Y, Wakatsuki A, Enzan H, et al: Edaravone protects against ischemia/reperfusion-induced oxidative damage to mitochondria in rat liver. Eur J Pharmacol 2003; 465:163-170
8. Kono H, Asakawa M, Fujii H, et al: Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin. J Pharmacol Exp Ther 2003; 307:74-82
9. Tomatsuri N, Yoshida N, Takagi T, et al: Edaravone, a newly developed radical scavenger, protects against ischemia-reperfusion injury of the small intestine in rats. Int J Mol Med 2004; 13:105-109
10. Ozturk C, Avlan D, Cinel I, et al: Selenium pretreatment prevents bacterial translocation in rat intestinal ischemia/reperfusion model. Pharmacol Res 2002; 46:171-175
11. Eleftheriadis E, Kotzampassi K, Papanotas K, et al: Gut ischemia, oxidative stress, and bacterial translocation in elevated abdominal pressure in rats. World J Surg 1996; 20:11-16
12. Yang H, Sheng Z, Guo Z, et al: Oxygen free radical injury and its relation to bacterial and endotoxin translocation after delayed fluid resuscitation: Clinical and experimental study. Chin Med J (Engl) 1997; 110:118-124
13. Zhong Z, Enomoto N, Connor H, et al: Glycine improved survival after hemorrhagic shock in the rat. Shock 1999; 12:54-62
14. Tamion F, Richard V, Bonmarchand G: Reduced synthesis of inflammatory cytokine by a free radical scavenger after hemorrhagic shock in rats. Crit Care Med 2000; 28:2522-2527
15. Mannion D, Fitzpatrick G, Feeley M, et al: Role of Xanthine oxidase inhibition in survival from hemorrhagic shock. Circ Shock 1994; 42:39-43
16. Rhee P, Waxman K, Clark L, et al: Superoxide dismutase polyethlene glycol improves survival in hemorrhagic shock. Am Surg 1991; 57:747-750
17. Weiss SJ: Tissue destruction by neutrophils. N Engl J Med 1989; 320:365-376
18. Knaus UG, Heyworth PG, Evans T, et al: Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science 1991; 254:1512-1515
19. Li Y, Ferrante A, Poulos A, et al: Neutrophil oxygen radical generation. Synergistic responses to tumor necrosis factor and mono/polyunsaturated fatty acids. J Clin Invest 1996; 97:1605-1609
20. Shimizu T, Tani T, Hanasawa K, et al: The role of bacterial translocation on neutrophil activation during hemorrhagic shock in rats. Shock 2001; 16:59-63
21. Shimizu T, Tani T, Endo Y, et al: Elevation of plasma peptidoglycan and peripheral blood neutrophil activation during hemorrhagic shock: Plasma peptidoglycan reflects bacterial translocation and may affect neutrophil activation. Crit Care Med 2002; 30:77-82
22. Watanabe T, Egawa M: Effects of an antistroke agent MCI-186 on cerebral arachidonate cascade. J Pharmacol Exp Ther 1994; 271:1624-1629
23. Watanabe T, Yuki S, Egawa M, et al: Protective effects of MCI-186 on cerebral ischemia: Possible involvement of free radical scavenging and antioxidant actions. J Pharmacol Exp Ther 1994; 268:1597-1604
24. Ando K, Nishi H, Watanabe T, et al: General pharmacological studies of 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), a novel radical scavenging agent. J Pharmacol Ther 1997; 25:213-243
25. Tani T, Fujino M, Hanasawa K, et al: Bacterial translocation and TNF-α gene expression in experimental hemorrhagic shock. Crit Care Med 2000; 28:3705-3709
26. Tsuchiya M, Asahi N, Suzuoki F, et al: Detection of peptidoglycan and beta-glucan with silkworm larvae plasma test. FEMS Immunol Med Microbiol 1996; 15:129-134
27. Kobayashi T, Tani T, Yokota T, et al: Detection of peptidoglycan in human plasma using the silkworm larvae plasma test. FEMS Immunol Med Microbiol 2000; 28:49-53
28. Yamamoto H, Kishi T, Lee CE, et al: Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites. J Neurosci 2003; 23:2939-2946
29. Yamamoto H, Fujimiya M, Shirai Y, et al: Immunohistochemical localization of serotonin transporter in normal and colchicine treated rat brain. Neurosci Res 1998; 32:305-312
30. Imaeda H, Yamamoto H, Takaki A, et al: In vivo response of neutrophils and epithelial cells to lipopolysaccharide injected into the monkey ileum. Histochem Cell Biol 2002; 118:381-388
31. Davidson MT, Deitch EA, Lu Q, et al: A study of the biologic activity of trauma-hemorrhagic shock mesenteric lymph over time and the relative role of cytokines. Surgery 2004; 136:32-41
32. Kale IT, Kuzu MA, Berkem H, et al: The presence of hemorrhagic shock increases the rate of bacterial translocation in blunt abdominal trauma. J Trauma 1998; 44:171-174
33. Choudhry MA, Fazal N, Namak SY, et al: PGE2 suppresses intestinal T cell function in thermal injury: A cause of enhanced bacterial translocation. Shock 2001; 16:183-188
34. Guo W, Ding J, Huang Q, et al: Alterations in intestinal bacterial flora modulate the systemic cytokine response to hemorrhagic shock. Am J Physiol 1995; 269:G827-G832
35. Peitzman AB, Udekwu AO, Ochoa J, et al: Bacterial translocation in trauma patients. J Trauma 1991; 31:1083-1086
36. Kanwar S, Windsor AC, Welsh F, et al: Lack of correlation between failure of gut barrier function and septic complications after major upper gastrointestinal surgery. Ann Surg 2000; 231:88-95
37. Moore FA, Moore EE, Poggetti R, et al: Gut bacterial translocation via the portal vein: A clinical perspective with major torso trauma. J Trauma 1991; 31:629-636
38. Reed LL, Martin M, Manglano R, et al: Bacterial translocation following abdominal trauma in humans. Circ Shock 1994; 42:1-6
39. Brathwaite CE, Ross SE, Nagele R, et al: Bacterial translocation occurs in humans after traumatic injury: Evidence using immunofluorescence. J Trauma 1993; 34:586-589
40. Deitch EA: Bacterial translocation or lymphatic drainage of toxic products from the gut: What is important in human beings? Surgery 2002; 131:241-244
41. Wang JE, Jorgensen PF, Ellingsen EA, et al: Peptidoglycan primes for LPS-induced release of proinflammatory cytokines in whole human blood. Shock 2001; 16:178-182
42. Wang JE, Dahle MK, McDonald M, et al: Peptidoglycan and lipoteichoic acid in Gram-positive bacterial sepsis: Receptors, signal transduction, biological effects, and synergism. Shock 2003; 20:402-414
43. Wang JE, Dahle MK, Yndestad A, et al: Peptidoglycan of Staphylococcus aureus causes inflammation and organ injury in the rat. Crit Care Med 2004; 32:546-552
44. McCord JM, Roy RS, Schaffer SW: Free radicals and myocardial ischemia. The role of xanthine oxidase. Adv Myocardiol 1985; 5:183-189
45. Toyokuni S: Reactive oxygen species-induced molecular damage and its application in pathology. Pathol Int 1999; 49:91-102
46. Supinski G, Stofan D, Nethery D, et al: Apocynin improves diaphragmatic function after endotoxin administration. J Appl Physiol 1999; 87:776-782
47. Veronneau M, Comte B, Des Rosiers C: Quantitative gas chromatographic-mass spectrometric assay of 4-hydroxynonenal bound to thiol proteins in ischemic/reperfused rat hearts. Free Radic Biol Med 2002; 33:1380-1388
48. Irie H, Kato T, Ikebe K, et al: Antioxidant effect of MCI-186, a new free-radical scavenger, on ischemia-reperfusion injury in a rat hindlimb amputation model. J Surg Res 2004; 120:312-319
49. Wu T, Zeng L, Wu J, et al: MCI-186: Further histochemical and biochemical evidence of neuroprotection. Life Sci 2000; 67:2387-2392
50. Yamamoto T, Yuki S, Watanabe T, et al: Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia. Brain Res 1997; 762:240-242
51. Kawai H, Nakai H, Suga M, et al: Effects of a novel free radical scavenger, MCI-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model. J Pharmacol Exp Ther 1997; 281:921-927
52. Masaki Y, Kumano K, He N, et al: Protective effects of MCI-186 on cold kidney preservation/reperfusion injury in the rat. Transplant Proc 1996; 28:1885-1886