-
1
-
-
0037229213
-
Effect of a novel free radical scavenger edaravone (MCI-186) on acute brain infarction. Randomized placebo-controlled double-blind study at multicenters
-
Edaravone Acute Infarction Study Group
-
Edaravone Acute Infarction Study Group Effect of a novel free radical scavenger edaravone (MCI-186) on acute brain infarction. Randomized placebo-controlled double-blind study at multicenters. Cerebrovasc. Dis. 2003, 15:222-229.
-
(2003)
Cerebrovasc. Dis.
, vol.15
, pp. 222-229
-
-
-
2
-
-
4444317770
-
The reaction rate of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186)) with hydroxyl radical
-
Abe S., Kirima K., Tsuchiya K., Okamoto M., Hasegawa T., Houchi H., Yoshizumi M., Tamaki T. The reaction rate of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186)) with hydroxyl radical. Chem. Pharm. Bull. (Tokyo) 2004, 52:186-191.
-
(2004)
Chem. Pharm. Bull. (Tokyo)
, vol.52
, pp. 186-191
-
-
Abe, S.1
Kirima, K.2
Tsuchiya, K.3
Okamoto, M.4
Hasegawa, T.5
Houchi, H.6
Yoshizumi, M.7
Tamaki, T.8
-
3
-
-
36749011255
-
Free radical scavenger edaravone suppresses X-ray-induced apoptosis through p53 inhibition in MOLT-4 cells
-
Sasano N., Enomoto A., Hosoi Y., Katsumura Y., Matsumoto Y., Shiraishi K., Miyagawa K., Igaki H., Nakagawa K. Free radical scavenger edaravone suppresses X-ray-induced apoptosis through p53 inhibition in MOLT-4 cells. J. Radiat. Res. (Tokyo) 2007, 48:495-503.
-
(2007)
J. Radiat. Res. (Tokyo)
, vol.48
, pp. 495-503
-
-
Sasano, N.1
Enomoto, A.2
Hosoi, Y.3
Katsumura, Y.4
Matsumoto, Y.5
Shiraishi, K.6
Miyagawa, K.7
Igaki, H.8
Nakagawa, K.9
-
4
-
-
10744232780
-
Decreased c-Myc expression and its involvement in X-ray-induced apoptotic cell death of human T-cell leukemia cell line MOLT-4
-
Enomoto A., Suzuki N., Kang Y., Hirano K., Matsumoto Y., Zhu J., Morita A., Hosoi Y., Sakai K., Koyama H. Decreased c-Myc expression and its involvement in X-ray-induced apoptotic cell death of human T-cell leukemia cell line MOLT-4. Int. J. Radiat. Biol. 2003, 79:589-600.
-
(2003)
Int. J. Radiat. Biol.
, vol.79
, pp. 589-600
-
-
Enomoto, A.1
Suzuki, N.2
Kang, Y.3
Hirano, K.4
Matsumoto, Y.5
Zhu, J.6
Morita, A.7
Hosoi, Y.8
Sakai, K.9
Koyama, H.10
-
5
-
-
0035195557
-
The evolution of diverse biological responses to DNA damage: insights from yeast and p53
-
Wahl G.M., Carr A.M. The evolution of diverse biological responses to DNA damage: insights from yeast and p53. Nature Cell Biol. 2001, 3:E277-E286.
-
(2001)
Nature Cell Biol.
, vol.3
-
-
Wahl, G.M.1
Carr, A.M.2
-
6
-
-
10744228800
-
Puma is an essential mediator of p53-dependent and- independent apoptotic pathways
-
Jeffers J.R., Parganas E., Lee Y., Yang C., Wang J., Brennan J., MacLean K.H., Han J., Ihle J.N., McKinnon P.J., Cleveland J.L., Zambetti G.P. Puma is an essential mediator of p53-dependent and- independent apoptotic pathways. Cancer Cell 2003, 4:321-328.
-
(2003)
Cancer Cell
, vol.4
, pp. 321-328
-
-
Jeffers, J.R.1
Parganas, E.2
Lee, Y.3
Yang, C.4
Wang, J.5
Brennan, J.6
MacLean, K.H.7
Han, J.8
Ihle, J.N.9
McKinnon, P.J.10
Cleveland, J.L.11
Zambetti, G.P.12
-
7
-
-
0035265686
-
PUMA a novel proapoptotic gene is induced by p53
-
Nakano K., Vousden K.H. PUMA a novel proapoptotic gene is induced by p53. Mol. Cell 2001, 7:683-694.
-
(2001)
Mol. Cell
, vol.7
, pp. 683-694
-
-
Nakano, K.1
Vousden, K.H.2
-
8
-
-
0242410719
-
P53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
-
Villunger A., Michalak E.M., Coultas L., Müllauer F., Böck G., Ausserlechner M.J., Adams J.M., Strasser A. p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 2003, 302:1036-1038.
-
(2003)
Science
, vol.302
, pp. 1036-1038
-
-
Villunger, A.1
Michalak, E.M.2
Coultas, L.3
Müllauer, F.4
Böck, G.5
Ausserlechner, M.J.6
Adams, J.M.7
Strasser, A.8
-
9
-
-
0037452759
-
PUMA mediates the apoptotic response to p53 in colorectal cancer cells
-
Yu J., Wang Z., Kinzler K.W., Vogelstein B., Zhang L. PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc. Natl. Acad. Sci. USA 2003, 100:1931-1936.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 1931-1936
-
-
Yu, J.1
Wang, Z.2
Kinzler, K.W.3
Vogelstein, B.4
Zhang, L.5
-
10
-
-
0034803529
-
Evaluation of the relative contribution of p53-mediated pathway in X-ray-induced apoptosis in human leukemic MOLT-4 cells by transfection with a mutant p53 gene at different expression levels
-
Nakano H., Kohara M., Shinohara K. Evaluation of the relative contribution of p53-mediated pathway in X-ray-induced apoptosis in human leukemic MOLT-4 cells by transfection with a mutant p53 gene at different expression levels. Cell Tissue Res. 2001, 306:101-106.
-
(2001)
Cell Tissue Res.
, vol.306
, pp. 101-106
-
-
Nakano, H.1
Kohara, M.2
Shinohara, K.3
-
11
-
-
0030814125
-
Radiosensitization of human tumor cells by the phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay
-
Rosenzweig K.E., Youmell M.B., Palayoor S.T., Price B.D. Radiosensitization of human tumor cells by the phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay. Clin. Cancer Res. 1997, 3:1149-1156.
-
(1997)
Clin. Cancer Res.
, vol.3
, pp. 1149-1156
-
-
Rosenzweig, K.E.1
Youmell, M.B.2
Palayoor, S.T.3
Price, B.D.4
-
12
-
-
0032189483
-
Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin
-
Sarkaria J.N., Tibbetts R.S., Busby E.C., Kennedy A.P., Hill D.E., Abraham R.T. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res. 1998, 58:4375-4382.
-
(1998)
Cancer Res.
, vol.58
, pp. 4375-4382
-
-
Sarkaria, J.N.1
Tibbetts, R.S.2
Busby, E.C.3
Kennedy, A.P.4
Hill, D.E.5
Abraham, R.T.6
-
13
-
-
0141652967
-
Wortmannin-enhanced X-ray-induced apoptosis of human T-cell leukemia MOLT-4 cells possibly through the JNK/SAPK pathway
-
Tomita M., Suzuki N., Matsumoto Y., Enomoto A., Yin H.L., Hosoi Y., Hirano K., Sakai K. Wortmannin-enhanced X-ray-induced apoptosis of human T-cell leukemia MOLT-4 cells possibly through the JNK/SAPK pathway. Radiat. Res. 2003, 160:467-477.
-
(2003)
Radiat. Res.
, vol.160
, pp. 467-477
-
-
Tomita, M.1
Suzuki, N.2
Matsumoto, Y.3
Enomoto, A.4
Yin, H.L.5
Hosoi, Y.6
Hirano, K.7
Sakai, K.8
-
14
-
-
0000746722
-
Phase I clinical study of MCI-186 (Edaravone; 3-methyl-1-phenyl-2-pyrazolin-5-one) in healthy volunteers: safety and pharmacokinetics of single and multiple administration
-
Shibata H., Arai S., Izawa M., Murasaki M., Takamatsu Y., Izawa O., Takahashi C., Tanaka M. Phase I clinical study of MCI-186 (Edaravone; 3-methyl-1-phenyl-2-pyrazolin-5-one) in healthy volunteers: safety and pharmacokinetics of single and multiple administration. Jpn. J. Clin. Pharmacol. Ther. 1998, 29:863-876.
-
(1998)
Jpn. J. Clin. Pharmacol. Ther.
, vol.29
, pp. 863-876
-
-
Shibata, H.1
Arai, S.2
Izawa, M.3
Murasaki, M.4
Takamatsu, Y.5
Izawa, O.6
Takahashi, C.7
Tanaka, M.8
-
15
-
-
33845480548
-
Caspase function in programmed cell death
-
Kumar S. Caspase function in programmed cell death. Cell Death Differ. 2007, 14:32-43.
-
(2007)
Cell Death Differ.
, vol.14
, pp. 32-43
-
-
Kumar, S.1
-
16
-
-
0034643340
-
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
-
Nishikawa T., Edelstein D., Du X., Yamagishi S., Matsumura T., Kaneda Y., Yorek M.A., Beebe D., Oates P.J., Hammes H.P., Giardino I., Brownlee M. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 2000, 404:787-790.
-
(2000)
Nature
, vol.404
, pp. 787-790
-
-
Nishikawa, T.1
Edelstein, D.2
Du, X.3
Yamagishi, S.4
Matsumura, T.5
Kaneda, Y.6
Yorek, M.A.7
Beebe, D.8
Oates, P.J.9
Hammes, H.P.10
Giardino, I.11
Brownlee, M.12
-
17
-
-
33645163703
-
Sodium orthovanadate suppresses DNA damage-induced caspase activation and apoptosis by inactivating p53
-
Morita A., Zhu J., Suzuki N., Enomoto A., Matsumoto Y., Tomita M., Suzuki T., Ohtomo K., Hosoi Y. Sodium orthovanadate suppresses DNA damage-induced caspase activation and apoptosis by inactivating p53. Cell Death Differ. 2006, 13:499-511.
-
(2006)
Cell Death Differ.
, vol.13
, pp. 499-511
-
-
Morita, A.1
Zhu, J.2
Suzuki, N.3
Enomoto, A.4
Matsumoto, Y.5
Tomita, M.6
Suzuki, T.7
Ohtomo, K.8
Hosoi, Y.9
-
18
-
-
0034818446
-
Post-translational modifications and activation of p53 by genotoxic stresses
-
Appella E., Anderson C.W. Post-translational modifications and activation of p53 by genotoxic stresses. Eur. J. Biochem. 2001, 268:2764-2772.
-
(2001)
Eur. J. Biochem.
, vol.268
, pp. 2764-2772
-
-
Appella, E.1
Anderson, C.W.2
-
19
-
-
0036365079
-
Bax and BH3-domain-only proteins in p53-mediated apoptosis
-
Wu X., Deng Y. Bax and BH3-domain-only proteins in p53-mediated apoptosis. Front. Biosci. 2002, 7:d151-d156.
-
(2002)
Front. Biosci.
, vol.7
-
-
Wu, X.1
Deng, Y.2
-
20
-
-
0035939844
-
Activation of p53 transcriptional activity requires ATM's kinase domain and multiple N-terminal serine residues of p53
-
Turenne G.A., Paul P., Laflair L., Price B.D. Activation of p53 transcriptional activity requires ATM's kinase domain and multiple N-terminal serine residues of p53. Oncogene 2001, 20:5100-5110.
-
(2001)
Oncogene
, vol.20
, pp. 5100-5110
-
-
Turenne, G.A.1
Paul, P.2
Laflair, L.3
Price, B.D.4
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