Effect of edaravone, a novel free radical scavenger, supplemented to cardioplegia on myocardial function after cardioplegic arrest: In vitro study of isolated rat heart

Heart and Vessels

Volumn 24, Issue 3, 2009, Pages 228-235

  Yamazaki, Kazuhiro ^a   Miwa, Senri ^a   Toyokuni, Shinya ^b   Nemoto, Shintaro ^c   Oriyanhan, Wnimunk ^a   Takaba, Kiyoaki ^a   Saji, Yoshiaki ^a   Marui, Akira ^a   Nishina, Takeshi ^a   Ikeda, Tadashi ^a   Komeda, Masashi ^d  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c OSAKA MEDICAL COLLEGE   (Japan)

^d Nagoya Heart Center   (Japan)

Author keywords

Cardioplegia; Free radical scavenger; Ischemia reperfusion; Myocardial protection

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ASPARTATE AMINOTRANSFERASE; CREATINE KINASE; FREE RADICAL; HEART ENZYME; LACTATE DEHYDROGENASE; LACTIC ACID; NORPHENAZONE; REACTIVE OXYGEN METABOLITE; ST THOMAS HOSPITAL SOLUTION; WATER;

ANIMAL TISSUE; ARTICLE; CARDIOPLEGIA; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG STRUCTURE; HEART FUNCTION; HEART LEFT VENTRICLE DP-DT; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; IN VITRO STUDY; ISOLATED HEART; MALE; NONHUMAN; OPEN HEART SURGERY; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TEMPERATURE; WATER CONTENT;

ANIMALS; ANTIPYRINE; FREE RADICAL SCAVENGERS; HEART; HEART ARREST, INDUCED; OXIDATIVE STRESS; RATS; REPERFUSION INJURY;

EID: 66149158208     PISSN: 09108327     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00380-008-1106-1     Document Type: Article

References (39)

1. Tortolani AJ, Powell SR, Misik V, Weglicki WB, Pogo GJ, Kramer JH (1993) Detection of alkoxyl and carbon-centered free radicals in coronary sinus blood from patients undergoing elective cardioplegia. Free Radic Biol Med 14:421-426
2. Suzuki S, Kaneko M, Chapman DC, Dhalla NS (1991) Alterations in cardiac contractile proteins due to oxygen free radicals. Biochim Biophys Acta 1074:95-100
3. Dhalla NS, Elmoselhi AB, Hata T, Makino N (2000) Status of myocardial antioxidants in ischemia-reperfusion injury. Cardiovasc Res 47:446-456
4. Yamashita N, Hoshida S, Otsu K, Asahi M, Kuzuya T, Hori M (1999) Exercise provides direct biphasic cardioprotection via manganese superoxide dismutase activation. J Exp Med 189: 1699-1706
5. Tanaka M, Stoler RC, Fitzharris GP, Jennings RB, Reimer KA (1990) Evidence against the "early protection-delayed death" hypothesis of superoxide dismutase therapy in experimental myocardial infarction. Polyethylene glycol-superoxide dismutase plus catalase does not limit myocardial infarct size in dogs. Circ Res 67:636-644
6. Fukushima S, Coppen SR, Varela-Carver A, Brindley G, Yamahara K, Sarathchandra P, Yacoub MH, Suzuki K (2006) Enhanced efficacy of superoxide dismutase-induced cardioprotection by retrograde intracoronary administration. Cardiovasc Res 69:459-465
7. Mickle DA, Weisel RD, Burton GW, Ingold KU (1991) Effect of orally administered alpha-tocopheryl acetate on human myocardial alpha-tocopherol levels. Cardiovasc Drugs Ther 5(Suppl 2):309-312
8. Dingchao H, Zhiduan Q, Liye H, Xiaodong F (1994) The protective effects of high-dose ascorbic acid on myocardium against reperfusion injury during and after cardiopulmonary bypass. Thorac Cardiovasc Surg 42:276-278
9. Mizuno A, Umemura K, Nakashima M (1998) Inhibitory effect of MCI-186, a free radical scavenger, on cerebral ischemia following rat middle cerebral artery occlusion. Gen Pharm 30:575-578
10. Watanabe T, Yuki S, Saito K, Sato S, Sugimoto J, Ohori Y (1997) Pharmacological studies of MCI-186, a new drug for acute stroke. Jpn Pharmacol Ther 25:181-188
11. Watanabe T, Yuki S, Egawa M, Nishi H (1994) Protective effects of MCI-186 on cerebral ischemia: Possible involvement of free radical scavenging and antioxidant actions. J Pharmacol Exp Ther 268:1597-1604
12. Yagi H, Horinaka S, Matsuoka H (2005) Edaravone prevented deteriorated cardiac function after myocardial ischemia-reperfusion via inhibiting lipid peroxidation in rat. J Cardiovasc Pharmacol 46:46-51
13. Yanagisawa A, Miyagawa M, Ishikawa K, Murota S (1994) Cardioprotective effect of MCI-186 during acute ischemia-reperfusion injury in rats. Int J Angiology 3:12-15
14. Minhaz U, Tanaka M, Tsukamoto H, Watanabe K, Koide S, Shohtsu A, Nakazawa H (1996) Effect of MCI-186 on postischemic reperfusion injury in isolated rat heart. Free Radic Res 24:36136-36137
15. Wu TW, Zeng LH, Wu J, Fung KP (2002) Myocardial protection of MCI-186 in rabbit ischemia-reperfusion. Life Sciences 71: 2249-255
16. Yamawaki M, Sasaki N, Shimoyama M, Miake J, Ogino K, Igawa O, Tajima F, Shigemasa C, Hisatome I (2004) Protective effect of edaravone against hypoxia-reoxigenation injury in rabbit cardiomyocutes. Br J Pharmacol 142:618-626
17. Kotani Y, Ishino K, Osaki S, Honjo O, Suezawa T, Kanki K, Yutani C, Sano S (2007) Efficacy of MCI-186, a free-radical scavenger and antioxidant, for resuscitation of nonbeating donor hearts. J Thorac Cardiovasc Surg 133:1626-1632
18. Kasai H, Nishimura S (1984) Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents. Nucleic Acids Res 12:2137-2145
19. Toyokuni S (1999) Reactive oxygen species-induced molecular damage and its application in pathology. Pathol Int 49:91-102
20. Toyokuni S, Tanaka T, Hattori Y, Nishiyama Y, Yoshida A, Uchida K, Hiai H, Ochi H, Osawa T (1997) Quantitative immunohistochemical determination of 8-hydroxy-2′-deoxyguanosine by a monoclonal antibody N45.1: Its application to ferric nitrilotriacetate-induced renal carcinogenesis model. Lab Invest 76:365-374
21. Miwa S, Toyokuni S, Nishina T, Nomoto T, Hiroyasu M, Nishimura K, Komeda M (2002) Spatiotemporal alteration of 8-hydroxy-2′-deoxyguanosine levels in cardiomyocytes after myocardial infarction in rats. Free Radic Res 36:853-858
22. Yamazaki K, Miwa S, Ueda K, Tanaka S, Toyokuni S, Unimonh O, Nishimura K, Komeda M (2004) Prevention of myocardial reperfusion injury by poly(ADP-ribose) synthetase inhibitor, 3-aminobenzamide, in cardioplegic solution: In vitro study of isolated rat heart model. Eur J Cardiothorac Surg 26:270-275
23. Oriyanhan W, Yamazaki K, Miwa S, Takaba K, Ikeda T, Komeda M (2005) Taurine prevents myocardial ischemia/reperfusion-induced oxidative stress and apoptosis in prolonged hypothermic rat heart preservation. Heart Vessels 20:278-285
24. Zwier JL, Flaherty JT, Weisfeldt ML (1987) Direct measurement of free radical generation following reperfusion of ischemic myocardium. Proc Natl Acad Sci USA 84:1407-1407
25. Becker LB (2004) New concepts in reactive oxygen species and cardiovascular reperfusion physiology. Cardiovasc Res 61:461-470
26. Blasig IE, Ebert B, Hennig C, Pali T, Tosaki A (1990) Inverse relationship between ESR spin trapping of oxyradicals and degree of functional recovery during myocardial reperfusion in isolated working rat heart. Cardiovasc Res 24:263-270
27. Vanden Hoek T, Becker LB, Shao ZH, Li CQ, Schumacker PT (2000) Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion. Circ Res 86:541-548
28. Sorescu D, Griendling KK (2002) Reactive oxygen species, mitochondria, and NAD(P)H oxidases in the development and progression of heart failure. Congest Heart Fail 8:132-140
29. Laine GA, Allen SJ (1991) Left ventricular myocardial edema. Lymph flow, interstitial fibrosis, and cardiac function. Circ Res 68:1713-1721
30. Hsu D, Weng ZC, Nicolosi AC, Detwiler PW, Sciacca R, Spotnitz HM (1993) Quantitative effects of myocardial edema on the left ventricular pressure-volume relation. J Thorac Cardiovasc Surg 106:651-657
31. Penna C, Rastaldo R, Mancardi D, Raimondo S, Cappello S, Gattullo D, Losano G, Pagliaro P (2006) Post-conditioning induced cardioprotection requires signaling through a redox-sensitive mechanism, mitochondrial ATP-sensitive K+ channel and protein kinase C activation. Basic Res Cardiol 101:180-189
32. Wang W, Schulze CJ, Suarez-Pinzon WL, Dyck JR, Sawicki G, Schulz R (2002) Intracellular action of matrix metalloproteinase-2 accounts for acute myocardial ischemia and reperfusion injury. Circulation 106:1543-1549
33. Onimaru S, Nakamura K, Kariyazono H, Ikeda R, Ueno T, Fukumoto Y, Yabuki R, Yamada K (2006) Inhibitory effects of edaravone on the production of tumor necrosis factor-alpha in the isolated heart undergoing ischemia and reperfusion. Heart Vessels 21:108-115
34. Sukmawan R, Yada T, Toyota E, Neishi Y, Kume T, Shinozaki Y, Mori H, Ogasawara Y, Kajiya F, Yoshida K (2007) Edaravone preserves coronary microvascular endothelial function after ischemia/reperfusion on the beating canine heart in vivo. J Pharmacol Sci 104:341-348
35. Vanden Hoek TL, Li C, Shao Z, Schumacker PT, Becker LB (1997) Significant levels of oxidants are generated by isolated cardiomyocytes during ischemia prior to reperfusion. J Mol Cell Cardiol 29:2571-2583
36. Watanabe K, Watanabe K, Hayase T (1997) Radical scavenging mechanism of MCI-186. Jpn Pharmacol Ther 25:189-197
37. Yokota S, Kumagai Y, Uchiumi M (1997) A pharmakinetic of MCI-186, a novel drug for cerebrovascular disease in elderly and young healthy subjects. Jpn J Clin Phamacol Ther 28:693-702
38. Abdel-Rahman U, Margraf S, Aybek T, Logters T, Bitu-Moreno J, Francishetti I, Kranert T, Grunwald F, Windolf J, Moritz A, Schulz M (2007) inhibition of neutrophil activity improves cardiac function after cardiopulmonary bypass. J Inflamm 4:21
39. Jacob S, Kallilordis A, Sellke F, Dunning J (2008) Is blood cardioplegia superior to crystalloid cardioplegia? Interact Cardiovasc Thorac Surg 7:491-498