Edaravone, a novel free radical scavenger, reduces high-mobility group bOX 1 and prolongs survival in a neonatal sepsis model

Shock

Volumn 32, Issue 6, 2009, Pages 586-592

  Kato, Shin ^a   Hussein, Mohamed Hamed ^a,b,c   Kakita, Hiroki ^a   Goto, Tatenobu ^a   Daoud, Ghada A ^a,c   Kato, Takenori ^a   Sugiura, Takahiro ^a   Nobata, Masanori ^a   Nakajima, Yoko ^a   Endo, Takeshi ^a   Mizuno, Keisuke ^a   Ito, Tetsuya ^a   Kato, Ineko ^a   Suzuki, Satoshi ^a   Togari, Hajime ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b CAIRO UNIVERSITY   (Egypt)

^c VACSERA   (Egypt)

Author keywords

Cecal ligation and perforation; Cytokines; Newborn; NO; Oxidative stress; Septic shock; TNF

Indexed keywords

CYTOKINE; FREE RADICAL; HIGH MOBILITY GROUP B1 PROTEIN; HYDROPEROXIDE; NORPHENAZONE; SCAVENGER; TEMPOL; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTERIAL GAS; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; EXPERIMENTAL MODEL; HEART OUTPUT; HEART RATE; INFLAMMATION; INTESTINE PERFORATION; MEAN ARTERIAL PRESSURE; NEWBORN; NEWBORN SEPSIS; NONHUMAN; OXIDATIVE STRESS; SEPTIC SHOCK; SURVIVAL TIME; SWINE; TREATMENT OUTCOME;

ANIMALS; ANIMALS, NEWBORN; ANTIOXIDANTS; ANTIPYRINE; BLOOD PRESSURE; BODY WEIGHT; CYCLIC N-OXIDES; FREE RADICAL SCAVENGERS; FREE RADICALS; HEART RATE; HMGB1 PROTEIN; INFLAMMATION; SEPSIS; SPIN LABELS; SWINE; TIME FACTORS;

EID: 73849085537     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e3181a2b886     Document Type: Article

References (37)

1. Bizzarro MJ, Raskind C, Baltimore RS, Gallagher PG: Seventy-five years of neonatal sepsis at Yale: 1928-2003. Pediatrics 116(3):595-602, 2005.
2. Kermorvant-Duchemin E, Laborie S, Rabilloud M, Lapillonne A, Claris O: Outcome and prognostic factors in neonates with septic shock. Pediatr Crit Care Med 9(2):186-191, 2008.
3. Sriskandan S, Altmann DM: The immunology of sepsis. J Pathol 214(2): 211-223, 2008.
4. Riedemann NC, Guo RF, Ward PA: Novel strategies for the treatment of sepsis. Nat Med 9(5):517-524, 2003.
5. Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J, Frazier A, Yang H, Ivanova S, Borovikova L, et al.: HMG-1 as a late mediator of endotoxin lethality in mice. Science 285(5425):248-251, 1999.
6. Wang H, Liao H, Ochani M, Justiniani M, Lin X, Yang L, Al-Abed Y, Metz C, Miller EJ, Tracey KJ, et al.: Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat Med 10(11):1216-1221, 2004.
7. Victor VM, Rocha M, Esplugues JV, De la Fuente M: Role of free radicals in sepsis: antioxidant therapy. Curr Pharm Des 11(24):3141-3158, 2005.
8. Fernandes D, Assreuy J: Nitric oxide and vascular reactivity in sepsis. Shock 30:10-13, 2008.
9. Takakura K, Taniguchi T, Muramatsu I, Takeuchi K, Fukuda S: Modification of alpha1-adrenoceptors by peroxynitrite as a possible mechanism of systemic hypotension in sepsis. Crit Care Med 30(43):894-899, 2002.
10. Takakura K, Xiaohong W, Takeuchi K, Yasuda Y, Fukuda S: Deactivation of norepinephrine by peroxynitrite as a new pathogenesis in the hypotension of septic shock. Anesthesiology 98(4):928-934, 2003.
11. Macarthur H, Couri DM, Wilken GH, Westfall TC, Lechner AJ, Matuschak GM, Chen Z, Salvemini D: Modulation of serum cytokine levels by a novel superoxide dismutase mimetic, M40401, in an Escherichia coli model of septic shock: correlation with preserved circulating catecholamines. Crit Care Med 31(1):237-245, 2003.
12. Edaravone Acute Infarction Study Group: Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc Dis 15(3): 222-229, 2003.
13. Watanabe T, Yuki S, Egawa M, Nishi H: Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J Pharmacol Exp Ther 268(3):1597-1604, 1994.
14. Nakamoto N, Tada S, Kameyama K, Kitamura K, Kurita S, Saito Y, Saito H, Ishii H: A free radical scavenger, edaravone, attenuates steatosis and cell death via reducing inflammatory cytokine production in rat acute liver injury. Free Radic Res 37(8):849-859, 2003.
15. Noor JI, Ikeda T, Mishima K, Aoo N, Ohta S, Egashira N, Iwasaki K, Fujiwara M, Ikenoue T: Short-term administration of a new free radical scavenger, edaravone, is more effective than its long-term administration for the treatment of neonatal hypoxic-ischemic encephalopathy. Stroke 36(11):2468-2474, 2005.
16. Kono H, Asakawa M, Fujii H, Maki A, Amemiya H, Yamamoto M, Matsuda M, Matsumoto Y: Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin. J Pharmacol Exp Ther 307(1):74-82, 2003.
17. Thiemermann C: Membrane-permeable radical scavengers (tempol) for shock, ischemia-reperfusion injury, and inflammation. Crit Care Med 31(Suppl 1): S76-S84, 2003.
18. Kato T, Hussein MH, Sugiura T, Suzuki S, Fukuda S, Tanaka T, Kato I, Togari H: Development and characterization of a novel porcine model of neonatal sepsis. Shock 21(4):329-335, 2004.
19. Kakita H, Hussein MH, Daoud GA, Kato T, Murai H, Sugiura T, Mizuno K, Yamada Y, Ito T, Fukuda S, et al.: Total hydroperoxide and biological antioxidant potentials in a neonatal sepsis model. Pediatr Res 60(6):675-679, 2006.
20. Pombo JF, Troy BL, Russell RO Jr: Left ventricular volumes and ejection fraction by echocardiography. Circulation 43(4):480-490, 1971.
21. Andersson U, Wang H, Palmblad K, Aveberger AC, Bloom O, Erlandsson-Harris H, Janson A, Kokkola R, Zhang M, Yang H, et al.: High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med 192(4):565-570, 2000.
22. Yamamoto T, Yuki S, Watanabe T, Mitsuka M, Saito KI, Kogure K: Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia. Brain Res 762(1-2):240-242, 1997.
23. Yoshida H, Kwon AH, Kaibori M, Tsuji K, Habara K, Yamada M, Kamiyama Y, Nishizawa M, Ito S, Okumura T: Edaravone prevents iNOS expression by inhibiting its promoter transactivation and mRNA stability in cytokine-stimulated hepatocytes. Nitric Oxide 18(2):105-112, 2008.
24. Yoshida H, Kwon AH, Habara K, Yamada M, Kaibori M, Kamiyama Y, Nishizawa M, Ito S, Okumura T: Edaravone inhibits the induction of iNOS gene expression at transcriptional and posttranscriptional steps in murine macrophages. Shock 30(6):734-739, 2008.
25. Onimaru S, Nakamura K, Kariyazono H, Ikeda R, Ueno T, Fukumoto Y, Yabuki A, Sakata R, Yamada K: Inhibitory effects of edaravone on the production of tumor necrosis factorYalpha in the isolated heart undergoing ischemia and reperfusion. Heart Vessels 21(2):108-115, 2006.
26. Thiemermann C, Vane J: Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo. Eur J Pharmacol 182(3):591-595, 1990.
27. Kilbourn RG, Gross SS, Jubran A, Adams J, Griffith OW, Levi R, Lodato RF: NG-methyl-L-arginine inhibits tumor necrosis factorYinduced hypotension: implications for the involvement of nitric oxide. Proc Natl Acad Sci U S A 87(9):3629-3632, 1990.
28. Matejovic M, Krouzecky A, Rokyta R Jr, Radej J, Kralova H, Treska V, Radermacher P, Novak I: Effects of combining inducible nitric oxide synthase inhibitor and radical scavenger during porcine bacteremia. Shock 27(1):61-68, 2007.
29. Klemm P, Thiemermann C, Winklmaier G, Martorana PA, Henning R: Effects of nitric oxide synthase inhibition combined with nitric oxide inhalation in a porcine model of endotoxin shock. Br J Pharmacol 114(2):363-368, 1995.
30. Cowley HC, Bacon PJ, Goode HF, Webster NR, Jones JG, Menon DK: Plasma antioxidant potential in severe sepsis: a comparison of survivors and nonsurvivors. Crit Care Med 24(7):1179-1183, 1996.
31. Matejovic M, Krouzecky A, Martinkova V, Rokyta R Jr, Radej J, Kralova H, Treska V, Radermacher P, Novak I: Effects of tempol, a free radical scavenger, on long-term hyperdynamic porcine bacteremia. Crit Care Med 33(5): 1057-1063, 2005.
32. Rudiger A, Singer M: Mechanisms of sepsis-induced cardiac dysfunction. Crit Care Med 35(6):1599-1608, 2007.
33. Fernandes CJ Jr, Akamine N, Knobel E: Myocardial depression in sepsis. Shock 30(Suppl 1):14-17, 2008.
34. Carcillo JA, Fields AI: Clinical practice parameters for hemodynamic support of pediatric and neonatal patients in septic shock. Crit Care Med 30(6): 1365-1378, 2002.
35. Yu M, Wang H, Ding A, Golenbock DT, Latz E, Czura CJ, Fenton MJ, Tracey KJ, Yang H: HMGB1 signals through toll-like receptor (TLR) 4 and TLR2. Shock 26(2):174-179, 2006.
36. Hussein MH, Kato T, Sugiura T, Daoud GA, Suzuki S, Fukuda S, Sobajima H, Kato I, Togari H: Effect of hemoperfusion using polymyxin BYimmobilized fiber on IL-6, HMGB1, and IFN gamma in a neonatal sepsis model. Pediatr Res 58(2):309-314, 2005.
37. O'Brien WF, Golden SM, Davis SE, Bibro MC: Endotoxemia in the neonatal lamb. Am J Obstet Gynecol 151(5):671-674, 1985