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Volumn 48, Issue 6, 2007, Pages 495-503

Free radical scavenger edaravone suppresses X-ray-induced apoptosis through p53 inhibition in MOLT-4 cells

Author keywords

Edaravone; Free radical scavenger; MOLT 4 cells; Radioprotective effect; X ray induced apoptosis

Indexed keywords

CELL DEATH; FREE RADICALS;

EID: 36749011255     PISSN: 04493060     EISSN: 13499157     Source Type: Journal    
DOI: 10.1269/jrr.07061     Document Type: Article
Times cited : (23)

References (58)
  • 3
    • 0028181452 scopus 로고
    • Radiation response of mouse lymphoid and myeloid cell lines: III. Different signals can lead to apoptosis and may influence sensitivity to killing by DNA double-strand breakage
    • Radford, I. R. and Murphy, T. K. (1994) Radiation response of mouse lymphoid and myeloid cell lines: III. Different signals can lead to apoptosis and may influence sensitivity to killing by DNA double-strand breakage. Int. J. Radiat. Biol. 65: 229-239.
    • (1994) Int. J. Radiat. Biol , vol.65 , pp. 229-239
    • Radford, I.R.1    Murphy, T.K.2
  • 4
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide range implications in tissue kinetics
    • Kerr, J. F. R., Wyllie, A. H. and Currie, A. R. (1972) Apoptosis: a basic biological phenomenon with wide range implications in tissue kinetics. Br. J. Cancer 26: 239-257.
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.R.1    Wyllie, A.H.2    Currie, A.R.3
  • 5
    • 0023847959 scopus 로고
    • Radiation-induced interphase death of rat thymocyte is internally programmed (apoptosis)
    • Yamada, T. and Ohyama, H. (1988) Radiation-induced interphase death of rat thymocyte is internally programmed (apoptosis). Int. J. Radiat. Biol. 53: 65-75.
    • (1988) Int. J. Radiat. Biol , vol.53 , pp. 65-75
    • Yamada, T.1    Ohyama, H.2
  • 7
    • 0028292964 scopus 로고
    • Protective effects of MCI-186 on cerebral ischemia: Possible involvement of free radical scavenging and antioxidant actions
    • Watanabe, T., Yuki, S., Egawa, M. and Nishi, H. (1994) Protective effects of MCI-186 on cerebral ischemia: Possible involvement of free radical scavenging and antioxidant actions. J. Pharmacol. Exp. Ther. 268: 1597-1603.
    • (1994) J. Pharmacol. Exp. Ther , vol.268 , pp. 1597-1603
    • Watanabe, T.1    Yuki, S.2    Egawa, M.3    Nishi, H.4
  • 8
    • 0030801031 scopus 로고    scopus 로고
    • Delayed neuronal death prevented by inhibition of hydroxyl radical formation in a transient cerebral ischemia
    • Yamamoto, T., Yuki, S., Watanabe, T., Mitsuka, M., Saito, K. and Kogure, K. (1997) Delayed neuronal death prevented by inhibition of hydroxyl radical formation in a transient cerebral ischemia. Brain Res. 762: 240-242.
    • (1997) Brain Res , vol.762 , pp. 240-242
    • Yamamoto, T.1    Yuki, S.2    Watanabe, T.3    Mitsuka, M.4    Saito, K.5    Kogure, K.6
  • 9
    • 0032054483 scopus 로고    scopus 로고
    • Inhibitory effect of MCI-186, a free radical scavenger, on cerebral ischemia following rat middle cerebral artery occlusion
    • Mizuno, A., Uemura, K. and Nakashima, M. (1998) Inhibitory effect of MCI-186, a free radical scavenger, on cerebral ischemia following rat middle cerebral artery occlusion. Gen. Parmacol. 30: 575-578.
    • (1998) Gen. Parmacol , vol.30 , pp. 575-578
    • Mizuno, A.1    Uemura, K.2    Nakashima, M.3
  • 10
    • 0023947826 scopus 로고
    • Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger
    • Abe, K., Yuki, S. and Kogure, K. (1988) Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger. Stroke 19: 280-285.
    • (1988) Stroke , vol.19 , pp. 280-285
    • Abe, K.1    Yuki, S.2    Kogure, K.3
  • 12
    • 0027967666 scopus 로고
    • Effects of an antistroke agent MCI-186 on cerebral arachidonate cascade
    • Watanabe, T. and Egawa, M. (1994) Effects of an antistroke agent MCI-186 on cerebral arachidonate cascade. J. Pharmacol. Exp. Ther. 271: 1624-1629.
    • (1994) J. Pharmacol. Exp. Ther , vol.271 , pp. 1624-1629
    • Watanabe, T.1    Egawa, M.2
  • 13
    • 0030979729 scopus 로고    scopus 로고
    • Effects of a novel free radical scavenger, MCI-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model
    • Kawai, H., Nakai, H., Suga, M., Yuki, S., Watanabe, T. and Saito, K. -I. (1997) Effects of a novel free radical scavenger, MCI-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model. J. Pharmacol. Exp. Ther. 281: 921-927.
    • (1997) J. Pharmacol. Exp. Ther , vol.281 , pp. 921-927
    • Kawai, H.1    Nakai, H.2    Suga, M.3    Yuki, S.4    Watanabe, T.5    Saito, K.-I.6
  • 14
    • 4544327928 scopus 로고    scopus 로고
    • Free radical-induced oxidation products of 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186)
    • Watanabe, K., Watanabe, K., Kuwahara, T. and Yamamoto, Y. (1997) Free radical-induced oxidation products of 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186). J. Jpn. Oil Chem. Soc. 46: 797-801.
    • (1997) J. Jpn. Oil Chem. Soc , vol.46 , pp. 797-801
    • Watanabe, K.1    Watanabe, K.2    Kuwahara, T.3    Yamamoto, Y.4
  • 16
    • 7944234144 scopus 로고    scopus 로고
    • Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia
    • Shichinohe, Y., Kuroda, S., Yasuda, H., Ishikawa, T., Iwai, M., Horiuchi, M. and Iwasaki, Y. (2004) Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia. Brain Res. 1029: 200-206.
    • (2004) Brain Res , vol.1029 , pp. 200-206
    • Shichinohe, Y.1    Kuroda, S.2    Yasuda, H.3    Ishikawa, T.4    Iwai, M.5    Horiuchi, M.6    Iwasaki, Y.7
  • 17
    • 1442352732 scopus 로고    scopus 로고
    • The neuroprotective effect of a free radical scavenger and mild hypothermia following transient focal ischemia in rats
    • Nito, C., Kamiya, T., Amemiya, S., Kato, K. and Katayama, Y. (2003) The neuroprotective effect of a free radical scavenger and mild hypothermia following transient focal ischemia in rats. Acta. Neurochir. Suppl. 86: 199-203.
    • (2003) Acta. Neurochir. Suppl , vol.86 , pp. 199-203
    • Nito, C.1    Kamiya, T.2    Amemiya, S.3    Kato, K.4    Katayama, Y.5
  • 18
    • 0037162628 scopus 로고    scopus 로고
    • Effect of the free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), on hypoxia-ischemiainduced brain injury in neonatal rats
    • Ikeda, T., Xia, XY., Kaneko, M., Sameshima, H. and Ikenoue, T. (2002) Effect of the free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), on hypoxia-ischemiainduced brain injury in neonatal rats. Neurosci. Lett. 329: 33-36.
    • (2002) Neurosci. Lett , vol.329 , pp. 33-36
    • Ikeda, T.1    Xia, X.Y.2    Kaneko, M.3    Sameshima, H.4    Ikenoue, T.5
  • 19
    • 27544467163 scopus 로고    scopus 로고
    • A free radical scavenger, edaravone, inhibits lipid peroxidation and the production of nitric oxide in hypoxic-ischemic brain damage of neonatal rats
    • Noor, JI., Ikeda, T., Ueda, Y. and Ikenoue, T. (2005) A free radical scavenger, edaravone, inhibits lipid peroxidation and the production of nitric oxide in hypoxic-ischemic brain damage of neonatal rats. Am. J. Obstet. Gynecol. 193: 1703-1708.
    • (2005) Am. J. Obstet. Gynecol , vol.193 , pp. 1703-1708
    • Noor, J.I.1    Ikeda, T.2    Ueda, Y.3    Ikenoue, T.4
  • 20
    • 0032972451 scopus 로고    scopus 로고
    • Involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rat
    • Nakashima, N., Niwa, M., Iwai, T. and Uematsu, T. (1999) Involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rat. Free Radic. Biol. Med. 26: 722-729.
    • (1999) Free Radic. Biol. Med , vol.26 , pp. 722-729
    • Nakashima, N.1    Niwa, M.2    Iwai, T.3    Uematsu, T.4
  • 21
    • 0023688132 scopus 로고
    • Preventive effect of MCI-186 on 15-HPETE induced vascular endothelial cell injury in vitro
    • Watanabe, T., Morita, I., Nishi, H. and Murota, S. (1988) Preventive effect of MCI-186 on 15-HPETE induced vascular endothelial cell injury in vitro. Prostaglandins Leukot. Essent. Fatty Acids 33: 81-87.
    • (1988) Prostaglandins Leukot. Essent. Fatty Acids , vol.33 , pp. 81-87
    • Watanabe, T.1    Morita, I.2    Nishi, H.3    Murota, S.4
  • 22
    • 1542288734 scopus 로고    scopus 로고
    • Alterations of antiproliferative effects of serum obtained from patients with acute cerebral infarction treated with a radical scavenger, edaravone, with or without amlodipine using an in vitro cultured basilar artery smooth muscle cells
    • Yamaguchi, T., Ida, T., Kobayashi, T., Hiraga, M., Oishi, K., Uchida, M. K. and Echizen, H. (2004) Alterations of antiproliferative effects of serum obtained from patients with acute cerebral infarction treated with a radical scavenger, edaravone, with or without amlodipine using an in vitro cultured basilar artery smooth muscle cells. Yakugaku Zasshi 124: 25-29.
    • (2004) Yakugaku Zasshi , vol.124 , pp. 25-29
    • Yamaguchi, T.1    Ida, T.2    Kobayashi, T.3    Hiraga, M.4    Oishi, K.5    Uchida, M.K.6    Echizen, H.7
  • 23
    • 0037229213 scopus 로고    scopus 로고
    • Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized placebo-controlled, double-blind study at multicenters
    • Edaravone Acute Infarction Study Group
    • Edaravone Acute Infarction Study Group. (2003) Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized placebo-controlled, double-blind study at multicenters. Cerebrovasc Dis. 15: 222-229.
    • (2003) Cerebrovasc Dis , vol.15 , pp. 222-229
  • 25
    • 2542436923 scopus 로고    scopus 로고
    • Research and development of the free radical scavenger edaravone as a neuroprotectant
    • Watanabe, T., Tanaka, M., Watanabe, K., Takamatsu, Y. and Tobe, A. (2004) Research and development of the free radical scavenger edaravone as a neuroprotectant. Yakugaku Zasshi. 124: 99-111.
    • (2004) Yakugaku Zasshi , vol.124 , pp. 99-111
    • Watanabe, T.1    Tanaka, M.2    Watanabe, K.3    Takamatsu, Y.4    Tobe, A.5
  • 28
    • 4544327928 scopus 로고    scopus 로고
    • Free radical-induced oxidation products of 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186)
    • Watanabe, K., Watanabe, K., Kuwahara, T. and Yamamoto, Y. (1997) Free radical-induced oxidation products of 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186). J. Jpn. Oil. Chem. Soc. 46: 797-801.
    • (1997) J. Jpn. Oil. Chem. Soc , vol.46 , pp. 797-801
    • Watanabe, K.1    Watanabe, K.2    Kuwahara, T.3    Yamamoto, Y.4
  • 30
    • 4544336251 scopus 로고    scopus 로고
    • In vivo radioprotection of mice by 3-methyl-1-phenyl-2-pyrazolin-5-one (Edaravone; Radicut), a clinical drug
    • Anzai, K., Furuse, M., Yoshida, A., Matsuyama, A., Moritake, T., Tsuboi, K. and Ikota, N. (2003) In vivo radioprotection of mice by 3-methyl-1-phenyl-2-pyrazolin-5-one (Edaravone; Radicut), a clinical drug. J. Radiat. Res. 45: 319-323.
    • (2003) J. Radiat. Res , vol.45 , pp. 319-323
    • Anzai, K.1    Furuse, M.2    Yoshida, A.3    Matsuyama, A.4    Moritake, T.5    Tsuboi, K.6    Ikota, N.7
  • 32
    • 0034803529 scopus 로고    scopus 로고
    • Evaluation of the relative contribution of p53-mediated pathway in X-ray-induced apoptosis in human leukemic MOLT-4 cells by transfection with a mutant p53 gene at different expression levels
    • Nakano, H., Kohara, M. and Shinohara, K. (2001) Evaluation of the relative contribution of p53-mediated pathway in X-ray-induced apoptosis in human leukemic MOLT-4 cells by transfection with a mutant p53 gene at different expression levels. Cell Tissue Res. 306: 101-106.
    • (2001) Cell Tissue Res , vol.306 , pp. 101-106
    • Nakano, H.1    Kohara, M.2    Shinohara, K.3
  • 33
    • 0034736121 scopus 로고    scopus 로고
    • p41 as a possible marker for cell death is generated by caspase cleavage of p42/SET β in irradiated MOLT-4 cells
    • Morita, A., Suzuki, N., Matsumoto, Y., Hirano, K., Enomoto, A., Zhu, J. and Sakai, K. (2000) p41 as a possible marker for cell death is generated by caspase cleavage of p42/SET β in irradiated MOLT-4 cells. Biochem. Biophys. Res. Commun. 278: 627-632.
    • (2000) Biochem. Biophys. Res. Commun , vol.278 , pp. 627-632
    • Morita, A.1    Suzuki, N.2    Matsumoto, Y.3    Hirano, K.4    Enomoto, A.5    Zhu, J.6    Sakai, K.7
  • 34
    • 0034738785 scopus 로고    scopus 로고
    • Involvement of SAPK/JNK pathway in X-ray-induced rapid cell death of human Tcell leukemia cell line MOLT-4
    • Enomoto, A., Suzuki, N., Hirano, K., Matsumoto, Y., Morita, A., Sakai, K. and Koyama, H. (2000) Involvement of SAPK/JNK pathway in X-ray-induced rapid cell death of human Tcell leukemia cell line MOLT-4. Cancer Lett. 155: 137-144.
    • (2000) Cancer Lett , vol.155 , pp. 137-144
    • Enomoto, A.1    Suzuki, N.2    Hirano, K.3    Matsumoto, Y.4    Morita, A.5    Sakai, K.6    Koyama, H.7
  • 35
  • 36
    • 2942546544 scopus 로고    scopus 로고
    • Delayed expression of apoptosis in X-irradiated human leukemic MOLT-4 cells transfected with mutant p53
    • Nakano, H., Yonekawa, H. and Shinohara, K. (2003) Delayed expression of apoptosis in X-irradiated human leukemic MOLT-4 cells transfected with mutant p53. J. Radiat. Res. (Tokyo) 44: 179-183.
    • (2003) J. Radiat. Res. (Tokyo) , vol.44 , pp. 179-183
    • Nakano, H.1    Yonekawa, H.2    Shinohara, K.3
  • 37
    • 0027437289 scopus 로고
    • Interphase death and reproductive death in X-irradiated MOLT-4 cells
    • Shinohara, K. and Nakano, H. (1993) Interphase death and reproductive death in X-irradiated MOLT-4 cells. Radiat. Res. 135: 197-205.
    • (1993) Radiat. Res , vol.135 , pp. 197-205
    • Shinohara, K.1    Nakano, H.2
  • 39
    • 0034630317 scopus 로고    scopus 로고
    • Apoptotic DNA fragmentation
    • Nagata, S. (2000) Apoptotic DNA fragmentation. Exp. Cell Res. 256: 12-18.
    • (2000) Exp. Cell Res , vol.256 , pp. 12-18
    • Nagata, S.1
  • 40
    • 0027305202 scopus 로고
    • Radiation induced apoptosis and necrosis in Molt-4 cells: A study of dose effect relationships and their modification
    • Akagi, Y., Ito, K. and Sawada, S. (1993) Radiation induced apoptosis and necrosis in Molt-4 cells: a study of dose effect relationships and their modification. Int. J. Radiat. Biol. 64: 47-56.
    • (1993) Int. J. Radiat. Biol , vol.64 , pp. 47-56
    • Akagi, Y.1    Ito, K.2    Sawada, S.3
  • 41
    • 21344443983 scopus 로고    scopus 로고
    • Effects of antioxidants on X-ray- or hyperthermia- induced apoptosis in human lymphoma U937 cells
    • Cui, Z. G., Kondo, T., Feril, Jr. L. B., Waki, K., Inanami, O. and Kuwabara, M. (2004) Effects of antioxidants on X-ray- or hyperthermia- induced apoptosis in human lymphoma U937 cells. Apoptosis 9: 757-763.
    • (2004) Apoptosis , vol.9 , pp. 757-763
    • Cui, Z.G.1    Kondo, T.2    Feril Jr., L.B.3    Waki, K.4    Inanami, O.5    Kuwabara, M.6
  • 42
    • 0034785349 scopus 로고    scopus 로고
    • The benefits and hazards of antioxidants: Controlling apoptosis and other protective mechanisms in cancer patients and the human population
    • Salganik, R. I. (2001) The benefits and hazards of antioxidants: Controlling apoptosis and other protective mechanisms in cancer patients and the human population. J. Am. Coll. Nutr. 20: 464S-472S.
    • (2001) J. Am. Coll. Nutr , vol.20
    • Salganik, R.I.1
  • 43
    • 0035195557 scopus 로고    scopus 로고
    • The evolution of diverse biological responses to DNA damage: Insights from yeast and p53
    • Wahl, G. M. and Carr, A. M. (2001) The evolution of diverse biological responses to DNA damage: insights from yeast and p53. Nature Cell Biol. 3: E277-E286.
    • (2001) Nature Cell Biol , vol.3
    • Wahl, G.M.1    Carr, A.M.2
  • 44
    • 1542347565 scopus 로고    scopus 로고
    • p53 binding to target sites is dynamically regulated before and after ionizing radiation-mediated DNA damage
    • Crosby, M. E., Oancea, M. and Almasan, A. (2004) p53 binding to target sites is dynamically regulated before and after ionizing radiation-mediated DNA damage. J. Environ. Pathol. Toxicol. Oncol. 23: 67-79.
    • (2004) J. Environ. Pathol. Toxicol. Oncol , vol.23 , pp. 67-79
    • Crosby, M.E.1    Oancea, M.2    Almasan, A.3
  • 47
    • 0032785021 scopus 로고    scopus 로고
    • Caspase structure, proteolytic substrates, and function during apoptotic cell death
    • Nicholson, D. W. (1999) Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ. 6: 1028-1042.
    • (1999) Cell Death Differ , vol.6 , pp. 1028-1042
    • Nicholson, D.W.1
  • 48
    • 0033179760 scopus 로고    scopus 로고
    • BCL-2 family members and the mitochondria in apoptosis
    • Gross, A., McDonnell, J. M. and Korsmeyer, S. J. (1999) BCL-2 family members and the mitochondria in apoptosis. Genes. Dev. 13: 1899-1911.
    • (1999) Genes. Dev , vol.13 , pp. 1899-1911
    • Gross, A.1    McDonnell, J.M.2    Korsmeyer, S.J.3
  • 50
    • 0142169969 scopus 로고    scopus 로고
    • Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression
    • Rajesh, K. G., Sasaguri, S., Suzuki, R. and Maeda, H. (2003) Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression. Am. J. Physiol. Heart Circ. Physiol. 285: H2171-H2178.
    • (2003) Am. J. Physiol. Heart Circ. Physiol , vol.285
    • Rajesh, K.G.1    Sasaguri, S.2    Suzuki, R.3    Maeda, H.4
  • 51
    • 33750599225 scopus 로고    scopus 로고
    • Edaravone protects PC12 cells from ischemic like injury via attenuating the damage to mitochondria
    • Song, Y., Li, M., Li, J. C. and Wei, E. Q. (2006) Edaravone protects PC12 cells from ischemic like injury via attenuating the damage to mitochondria. J. Zhejiang Univ. Sci. B 7: 749-756.
    • (2006) J. Zhejiang Univ. Sci. B , vol.7 , pp. 749-756
    • Song, Y.1    Li, M.2    Li, J.C.3    Wei, E.Q.4
  • 52
    • 12244299440 scopus 로고    scopus 로고
    • The impact of different antioxidant agents alone or in combination on reactive oxygen species, antioxidant enzymes and cytokines in a series of advanced cancer patients at different sites: Correlation with disease progression
    • Mantovani, G., Maccio, A., Madeddu, C., Mura, L., Gramignano, G., Russo, M. R., Murgia, V., Camboni, P., Ferreli, L., Mocci, M. and Massa, E. (2003) The impact of different antioxidant agents alone or in combination on reactive oxygen species, antioxidant enzymes and cytokines in a series of advanced cancer patients at different sites: correlation with disease progression. Free Radic. Res. 37: 213-223.
    • (2003) Free Radic. Res , vol.37 , pp. 213-223
    • Mantovani, G.1    Maccio, A.2    Madeddu, C.3    Mura, L.4    Gramignano, G.5    Russo, M.R.6    Murgia, V.7    Camboni, P.8    Ferreli, L.9    Mocci, M.10    Massa, E.11
  • 53
    • 0028786454 scopus 로고
    • Trolox inhibits apoptosis in irradiated MOLT-4 lymphocytes
    • McClain, D. E., Kalinich, J. F. and Ramakrishnan, N. (1995) Trolox inhibits apoptosis in irradiated MOLT-4 lymphocytes. FASEB J. 9: 1345-1354.
    • (1995) FASEB J , vol.9 , pp. 1345-1354
    • McClain, D.E.1    Kalinich, J.F.2    Ramakrishnan, N.3
  • 54
    • 0033021253 scopus 로고    scopus 로고
    • Attenuation of caspase-3-dependent apoptosis by Trolox post-treatment of X-irradiated MOLT-4 cells
    • Inanami, O., Takahashi, K. and Kuwabara, M. (1999) Attenuation of caspase-3-dependent apoptosis by Trolox post-treatment of X-irradiated MOLT-4 cells. Int. J. Radiat. Biol. 75: 155-163.
    • (1999) Int. J. Radiat. Biol , vol.75 , pp. 155-163
    • Inanami, O.1    Takahashi, K.2    Kuwabara, M.3
  • 55
    • 26444613280 scopus 로고    scopus 로고
    • Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain
    • Zhang, N., Komine-Kobayashi, M., Tanaka, R., Liu, M., Mizuno, Y. and Urabe, T. (2005) Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain. Stroke. 36: 2220-2225.
    • (2005) Stroke , vol.36 , pp. 2220-2225
    • Zhang, N.1    Komine-Kobayashi, M.2    Tanaka, R.3    Liu, M.4    Mizuno, Y.5    Urabe, T.6
  • 56
    • 21444439413 scopus 로고    scopus 로고
    • Edaravone prevented deteriorated cardiac function after myocardial ischemia-reperfusion via inhibiting lipid peroxidation in rat
    • Yagi, Y., Horinaka, S. and Matsuoka, H. (2005) Edaravone prevented deteriorated cardiac function after myocardial ischemia-reperfusion via inhibiting lipid peroxidation in rat. J. Cardiovasc. Pharmacol. 46: 46-51.
    • (2005) J. Cardiovasc. Pharmacol , vol.46 , pp. 46-51
    • Yagi, Y.1    Horinaka, S.2    Matsuoka, H.3
  • 58
    • 0026552891 scopus 로고
    • The radioprotector WR-2721 reduces neutron-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in mouse splenocytes when administered prior to or following irradiation
    • Grdina, D. J., Kataoka, Y., Basic, I. and Perrin, J. (1992) The radioprotector WR-2721 reduces neutron-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in mouse splenocytes when administered prior to or following irradiation. Carcinogenesis 13: 811-814.
    • (1992) Carcinogenesis , vol.13 , pp. 811-814
    • Grdina, D.J.1    Kataoka, Y.2    Basic, I.3    Perrin, J.4


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