Edaravone, a free radical scavenger, promotes engraftment of intraportally transplanted islet cells

Pancreas

Volumn 40, Issue 1, 2011, Pages 126-130

  Nagatani, Satoru ^a   Sudo, Takeshi ^a   Murakami, Yoshiaki ^a   Uemura, Kenichiro ^a   Hiyama, Eiso ^b   Sueda, Taijiro ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

edaravone; engraftment; free radical scavenger; pancreatic islet transplantation

Indexed keywords

GLUCOSE; INSULIN; NORPHENAZONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL STRUCTURE; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; INSULIN RELEASE; MALE; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; TREATMENT OUTCOME;

ANIMALS; ANTIPYRINE; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; FREE RADICAL SCAVENGERS; GLUCOSE TOLERANCE TEST; GRAFT SURVIVAL; IN SITU NICK-END LABELING; INSULIN; ISLETS OF LANGERHANS TRANSPLANTATION; LIVER; MALE; RATS; RATS, INBRED F344;

EID: 78650955653     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPA.0b013e3181f7e436     Document Type: Article

References (27)

1. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med. 2000;343:230-238.
2. Lenzen S, Drinkgern J, Tiedge M. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med. 1996;20:463-466.
3. Davalli AM, Ogawa Y, Ricordi C, et al. A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice. Transplantation. 1995;59:817-820.
4. Biarnes M, Montolio M, Nacher V, et al. Beta-cell death and mass in syngeneically transplanted islets exposed to short-and long-term hyperglycemia. Diabetes. 2002;51:66-72.
5. Sudo T, Hiyama E, Murakami Y, et al. Hepatic regeneration promotes engraftment of intraportally transplanted islet cells. Surgery. 2005;137:612-619.
6. Miao G, Mace J, Kirby M, et al. In vitro and in vivo improvement of islet survival following treatment with nerve growth factor. Transplantation. 2006;81:519-524.
7. Abe K, Yuki S, Kogure K. Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger. Stroke. 1988;19:480-485.
8. Edaravone Acute Infarction Study Group. Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infraction. Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc Dis. 2003;15:222-229.
9. Nishi H, Watanabe T, Sakurai H, et al. Effect of MCI-186 on brain edema in rats. Stroke. 1989;20:1236-1240.
10. Ninomiya M, Shimada M, Harada N, et al. Beneficial effect of MCI-186 on hepatic warm ischemia-reperfusion in the rat. Transplantation. 2002;74:1470-1472.
11. Tahara M, Nakayama M, Jin MB, et al. A radical scavenger, edaravone, protects canine kidneys from ischemia-reperfusion injury after 72 hours of cold preservation and autotransplantation. Transplantation. 2005;80:213-221.
12. Sutton R, Peters M, McShane P, et al. Isolation of rat pancreatic islets by ductal injection of collagenase. Transplantation. 1986;42:689-691.
13. Okeda T, Ono J, Takaki R, et al. Simple method for the collection of pancreatic islets by the use of Ficoll-Conray gradient. Endocrinol Jpn. 1979;26:495-499.
14. Watanabe T, Yuki S, Egawa M, et al. Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J Pharmacol Exp Ther. 1994;268:1597-1604.
15. Kawai H, Nakai H, Suga M, et al. Effects of a novel free radical scavenger, MCl-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model. J Pharmacol Exp Ther. 1997;281:921-927.
16. Suzuki F, Hashikura Y, Ise H, et al. MCI-186 (edaravone), a free radical scavenger, attenuates hepatic warm ischemia-reperfusion injury in rats. Transpl Int. 2005;18:844-853.
17. Masaki Y, Kumano K, He N, et al. Protective effects of MCI-186 on cold kidney preservation/reperfusion injury in the rat. Transplant Proc. 1996;28:1885-1886.
18. Doi K, Suzuki Y, Nakao A, et al. Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney. Kidney Int. 2004;65:1714-1723.
19. Akao T, Takeyoshi I, Totsuka O, et al. Effect of the free radical scavenger MCI-186 on pulmonary ischemia-reperfusion injury in dogs. J Heart Lung Transplant. 2006;25:965-971.
20. Rao P, Maeda H, Yutong X, et al. Protective effect of a radical scavenger, MCI-186 on islet cell damages induced by oxidative stress. Transplant Proc. 2005;37:3457-3458.
21. Thomas F,Wu J, Contreras JL, et al. A tripartite anoikis-like mechanism causes early isolated islet apoptosis. Surgery. 2001;130:333-338.
22. Berney T, Molano RD, Cattan P, et al. Endotoxin-mediated delayed islet graft function is associated with increased intra-islet cytokine production and islet cell apoptosis. Transplantation. 2001;71:125-132.
23. Turrens JF, Freeman BA, Levitt JG, et al. The effect of hyperoxia on superoxide production by lung submitochondrial particles. Arch Biochem Biophys. 1982;217:401-410.
24. Davalli AM, Scaglia L, Zangen DH, et al. Vulnerability of islets in the immediate posttransplantation period. Dynamic changes in structure and function. Diabetes. 1996;45:1161-1167.
25. Zhang W, Sato K, Hayashi T, et al. Extension of ischemic therapeutic time window by a free radical scavenger, Edaravone, reperfused with tPA in rat brain. Neurol Res. 2004;26:342-348.
26. Hagar H, Ueda N, Shah SV. Role of reactive oxygen metabolites in DNA damage and cell death in chemical hypoxic injury to LLC-PK1 cells. Am J Physiol. 1996;271:F209YF215.
27. Tada S, NakamotoN, Kameyama K, et al. Clinical usefulness of edaravone for acute liver injury. J Gastroenterol Hepatol. 2003;18:851-857.