Edaravone prevents Fas-induced fulminant hepatic failure in mice by regulating mitochondrial Bcl-xL and Bax

Shock

Volumn 30, Issue 2, 2008, Pages 212-216

  Miyasou, Takeshi ^a   Kwon, A Hon ^a   Tsuji, Katsushige ^a   Qiu, Zeyu ^a   Okumura, Tadayoshi ^a   Kamiyama, Yasuo ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

Anti Fas monoclonal antibody; Apoptosis; Bcl xL Bax ratio; Cytochrome c; Mitochondrial permeability transition

Indexed keywords

ASPARTATE AMINOTRANSFERASE; CASPASE 3; CYTOCHROME C; FAS ANTIGEN; NORPHENAZONE; PROTEIN BAX; PROTEIN BCL XL; SODIUM CHLORIDE; BAX PROTEIN, MOUSE; BCL2L1 PROTEIN, MOUSE; DRUG DERIVATIVE; FAS PROTEIN, MOUSE; MITOCHONDRIAL PROTEIN; PHENAZONE; PHENYLMETHYLPYRAZOLONE; PROTEIN BCL X; SCAVENGER;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BAGG ALBINO MOUSE; BLOOD SAMPLING; CONTROL GROUP; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; LIVER CELL; LIVER FAILURE; MITOCHONDRION; MOUSE; NICK END LABELING; NONHUMAN; PROTEIN SECRETION; SURVIVAL RATE; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; LIVER MITOCHONDRION; METABOLISM; MORTALITY; PHYSIOLOGY; SURVIVAL;

ANIMALS; ANTIGENS, CD95; ANTIPYRINE; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; FEMALE; FREE RADICAL SCAVENGERS; LIVER FAILURE, ACUTE; MICE; MICE, INBRED BALB C; MITOCHONDRIA, LIVER; MITOCHONDRIAL PROTEINS; SURVIVAL ANALYSIS;

EID: 52149083263     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e31816171f4     Document Type: Article

References (34)

1. Hoofnagle JH, Carithers RL Jr, Shapiro C, Ascher N: Fulminant hepatic failure: summary of a workshop. Hepatology 21:240-252, 1995.
2. Lee WM: Acute liver failure. N Engl J Med 329:1862-1872, 1993.
3. Galle PR, Hofmann WJ, Walczak H, Schaller H, Otto G, Stremmel W, Krammer PH, Runkel L: Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage. J Exp Med 182:1223-1230, 1995.
4. Mita E, Hayashi N, Iio S, Takehara T, Hijioka T, Kasahara A, Fusamoto H, Kamada T: Role of Fas ligand in apoptosis induced by hepatitis C virus infection. Biochem Biophys Res Commun 204:468-474,1994.
5. Ogasawara J, Watanabe-Fukunaga R, Adachi M, Matsuzawa A, Kasugai T, Kitamura Y, Itoh N, Suda T, Nagata S: Lethal effect of the anti-Fas antibody in mice. Nature 364:806-809, 1993.
6. Fridovich I: The biology of oxygen radicals. Science 201:875-880, 1978.
7. Wang X, Lu Y, Cederbaum AI: Induction of cytochrome P450 2E1 increases hepatotoxicity caused by Fas agonistic Jo2 antibody in mice. Hepatology 42:400-410, 2005.
8. Edaravone Acute Infection Study Group: Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc Dis 15:222-229, 2003.
9. Porter NA, Caldwell SE, Mills KA: Mechanisms of free radical oxidation of unsaturated lipids. Lipids 30:277-290, 1995.
10. Tsuji K, Kwon AH, Yoshida H, Qiu Z, Kaibori M, Okumura T, Kamiyama Y: Free radical scavenger (edaravone) prevents endotoxin-induced liver injury after partial hepatectomy in rats. J Hepatol 42:94-101, 2005.
11. Malassagne B, Ferret PJ, Hammoud R, Tulliez M, Bedda S, Trebeden H, Jaffray P, Calmus Y, Weil B, Batteux F: The superoxide dismutase mimetic MnTBAP prevents Fas-induced acute liver failure in the mouse. Gastroenterology 121:1451-1459, 2001.
12. Kono H, Asakawa M, Fujii H, Maki A, Amemiya H, Yamamoto M, Matsuda M, Matsumoto Y: Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin. J Pharmacol Exp Ther 307:74-82, 2003.
13. Nakamoto N, Tada S, Kameyama K, Kitamura K, Kurita S, Saito Y, Saito H, Ishii H: A free radical scavenger, edaravone, attenuates steatosis and cell death via reducing inflammatory cytokine production in rat acute liver injury. Free Radic Res 37:849-859, 2003.
14. Carson DA, Ribeiro JM: Apoptosis and disease. Lancet 341:1251-1254, 1993.
15. Kischkel FC, Hellbardt S, Behrmann I, Germer M, Pawlita M, Krammer PH, Peter ME: Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J 14:5579-5588, 1995.
16. Suda T, Takahashi T, Golstein P, Nagata S: Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 75:1169-1178, 1993.
17. Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S, Sameshima M, Hase A, Seto Y, Nagata S: The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66:233-243, 1991.
18. Yonehara S, Ishii A, Yonehara M: A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor. J Exp Med 169:1747-1756, 1989.
19. Nagata S: Apoptosis by death factor. Cell 88:355-365, 1997.
20. Kunstle G, Leist M, Uhlig S, Revesz L, Feifel R, MacKenzie A, Wendel A: ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-alpha. Immunol Lett 55:5-10, 1997.
21. Kuida K, Zheng TS, Na S, Kuan C, Yang D, Karasuyama H, Rakic P, Flavell RA: Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384:368-372, 1996.
22. Scaffidi C, Fulda S, Srinivasan A, Friesen C, Li F, Tomaselli KJ, Debatin KM, Krammer PH, Peter ME: Two CD95 (APO-1/Fas) signaling pathways. EMBO J 17:1675-1687, 1998.
23. Zheng TS, Flavell RA: Divinations and surprises: genetic analysis of caspase function in mice. Exp Cell Res 256:67-73, 2000.
24. Li H, Zhu H, Xu CJ, Yuan J: Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94:491-501, 1998.
25. Scaffidi C, Kirchhoff S, Krammer PH, Peter ME: Apoptosis signaling in lymphocytes. Curr Opin Immunol 11:277-285, 1999.
26. Yin XM, Wang K, Gross A, Zhao Y, Zinkel S, Klocke B, Roth KA, Korsmeyer SJ: Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 400:886-891, 1999.
27. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD: The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275:1132-1136, 1997.
28. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP, Xiaodong W: Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275:1129-1132, 1997.
29. Xiang J, Chao DT, Korsmeyer SJ: BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases. Proc Natl Acad Sci U S A 93:14559-14563, 1966.
30. Reed JC: Double identity for proteins of the Bcl-2 family. Nature 387:773-776, 1997.
31. Minana JB, Gomez-Cambronero L, Lloret A, Pallardo FV, Del Olmo J, Escudero A, Rodrigo JM, Pellin A, Vina JR, Vina J, et al.: Mitochondrial oxidative stress and CD95 ligand: a dual mechanism for hepatocyte apoptosis in chronic alcoholism. Hepatology 35:1205-1214, 2002.
32. Kurose I, Higuchi H, Kato S, Miura S, Watanabe N, Kamegaya Y, Tomita K, Takaishi M, Horie Y, Fukuda M, et al.: Oxidative stress on mitochondria and cell membrane of cultured rat hepatocytes and perfused liver exposed to ethanol. Gastroenterology 112:1331-1343, 1997.
33. Hoek JB, Cahill A, Pastorino JG: Alcohol and mitochondria: a dysfunctional relationship. Gastroenterology 122:2049-2063, 2002.
34. Rajesh KG, Sasaguri S, Suzuki R, Maeda H: Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression. Am J Physiol Heart Circ Physiol 285:H2171-H2178, 2003.