A novel free radical scavenger, edarabone, protects against cisplatin-induced acute renal damage in vitro and in vivo

Journal of Pharmacology and Experimental Therapeutics

Volumn 305, Issue 3, 2003, Pages 1183-1190

  Satoh, Minoru ^a,b   Kashihara, Naoki ^a   Fujimoto, Sohachi ^a   Horike, Hideyuki ^a   Tokura, Takehiko ^a   Namikoshi, Tamehachi ^a   Sasaki, Tamaki ^a   Makino, Hirofumi ^b  

^a KAWASAKI MEDICAL SCHOOL   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; CYTOCHROME C OXIDASE; HYDROXYL RADICAL; NORPHENAZONE; PROTEIN; REACTIVE OXYGEN METABOLITE; SCAVENGER;

ACUTE KIDNEY FAILURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; HISTOCHEMISTRY; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; MALE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MOUSE; NICK END LABELING; NONHUMAN; OXIDATION; PATHOGENESIS; PRIORITY JOURNAL; PROTECTION; RAT; RAT STRAIN; WESTERN BLOTTING;

ACUTE DISEASE; ANIMALS; ANTIPYRINE; APOPTOSIS; CELL SIZE; CELL SURVIVAL; CISPLATIN; FREE RADICAL SCAVENGERS; KIDNEY DISEASES; KIDNEY FUNCTION TESTS; LIPID METABOLISM; MALE; MITOCHONDRIA; NUCLEIC ACIDS; OXIDATION-REDUCTION; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

EID: 0038814199     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.047522     Document Type: Article

References (41)

1. Abe K, Yuki S, and Kogure K (1988) Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger. Stroke 19:480-485.
2. Baeuerle PA and Henkel T (1994) Function and activation of NF-κB in the immune system. Annu Rev Immunol 12:141-179.
3. Barnes P and Karin M (1997) Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. New Engl J Med 336:1066-1071.
4. Baud L and Ardaillou R (1986) Reactive oxygen species: production and role in the kidney. Am J Physiol 251:F765-F776.
5. Brady HR, Zeidel ML, Kone BC, Giebisch G, and Gullans SR (1993) Differential actions of cisplatin on renal proximal tubule and inner medullary collecting duct cells. J Pharmacol Exp Ther 265:1421-1428.
6. Cooley ME, Davis L, and Abrahm J (1994) Cisplatin: a clinical review. Part II. Nursing assessment and management of side effects of cisplatin. Cancer Nurs 17:283-293.
7. Crul M, Schellens JH, Beijnen JH, and Maliepaard M (1997) Cisplatin resistance and DNA repair. Cancer Treat Rev 23:341-366.
8. Davis CA, Nick HS, and Agarwal A (2001) Manganese superoxide dismutase attenuates cisplatin-induced renal injury: importance of superoxide. J Am Soc Nephrol 12:2683-2690.
9. Deng J, Kohda Y, Chiao H, Wang Y, Hu X, Hewitt SM, Miyaji T, McLeroy P, Nibhanupudy B, Li S, and Star RA (2001) Interleukin-10 inhibits ischemic and cisplatin-induced acute renal injury. Kidney Int 60:2118-2128.
10. Di LF, Blank PS, Colonna R, Gambassi G, Silverman HS, Stern MD, and Hansford RG (1995) Mitochondrial membrane potential in single living adult rat cardiac myocytes exposed to anoxia or metabolic inhibition. J Physiol (Lond) 486:1-13.
11. Goldstein RS and Mayor GH (1983) The nephrotoxicity of cisplatin. Life Sci 32:685-690.
12. Gordon JA and Gattone Vh 2nd (1986) Mitochondrial alterations in cisplatin-induced acute renal failure. Am J Physiol 250:F991-F998.
13. Hara M, Yoshida M, Nishijima H, Yokosuka M, Iigo M, Ohtani KR, Shimada A, Hasegawa T, Akama Y, and Hirata K (2001) Melatonin, a pineal secretory product with antioxidant properties, protects against cisplatin-induced nephrotoxicity in rats. J Pineal Res 30:129-138.
14. Huang Q, Dunn R2, Jayadev S, DiSorbo O, Pack FD, Farr SB, Stoll RE, and Blanchard KT (2001) Assessment of cisplatin-induced nephrotoxicity by microarray technology. Toxicol Sci 63:196-207.
15. Kawai H, Nakai H, Suga M, Yuki S, Watanabe T, and Saito K (1997) Effects of a novel free radical scavenger, MCI-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model. J Pharmacol Exp Ther 281:921-927.
16. Keller RJ, Halmes NC, Hinson JA, and Pumford NR (1993) Immunochemical detection of oxidized proteins. Chem Res Toxicol 6:430-433.
17. Kruidering M, van de Water B, Zhan Y, Baelde JJ, Heer E, Mulder GJ, Stevens JL, and Nagelkerke JF (1997) Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain. J Pharmacol Exp Ther 280:638-649.
18. Lau AH (1999) Apoptosis induced by cisplatin nephrotoxic injury. Kidney Int 56: 1295-1298.
19. Lebwohl D and Canetta R (1998) Clinical development of platinum complexes in cancer therapy: an historical perspective and an update. Eur J Cancer 34:1522-1534.
20. Lieberthal W, Triaca V, and Levine J (1996) Mechanisms of death induced by cisplatin in proximal tubular epithelial cells: apoptosis vs. necrosis. Am J Physiol 270:F700-F708.
21. Lu AL, Li X, Gu Y, Wright PM, and Chang DY (2001) Repair of oxidative DNA damage: mechanisms and functions. Cell Biochem Biophys 35:141-170.
22. Mancini M, Sedghinasab M, Knowlton K, Tam A, Hockenbery D, and Anderson BO (1998) Flow cytometric measurement of mitochondrial mass and function: a novel method for assessing chemoresistance. Ann Surg Oncol 5:287-295.
23. Masuda H, Tanaka T, and Takahama U (1994) Cisplatin generates superoxide anion by interaction with DNA in a cell-free system. Biochem Biophys Res Commun 203:1175-1180.
24. Matsushima H, Yonemura K, Ohishi K, and Hishida A (1998) The role of oxygen free radicals in cisplatin-induced acute renal failure in rats. J Lab Clin Med 131:518-526.
25. Montine TJ and Borch RF (1988) Quiescent LLC-PK1 cells as a model for cisdiamminedichloroplatinum (II) nephrotoxicity and modulation by thiol rescue agents. Cancer Res 48:6017-6024.
26. Murota S, Morita I, and Suda N (1990) The control of vascular endothelial cell injury. Ann N Y Acad Sci 598:182-187.
27. Park MS, De LM, and Devarajan P (2002) Cisplatin induces apoptosis in LLC-PK1 cells via activation of mitochondrial pathways. J Am Soc Nephrol 13:858-865.
28. Ramesh G and Reeves WB (2002) TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity. J Clin Investig 110:835-842.
29. Rao M, Kumar MM, and Rao MA (1999) In vitro and in vivo effects of phenolic antioxidants against cisplatin-induced nephrotoxicity. J Biochem (Tokyo) 125: 383-390.
30. Saad SY, Najjar TA, Noreddin AM, and Al RA (2001) Effects of gemcitabine on cisplatin-induced nephrotoxicity in rats: schedule-dependent study. Pharmacol Res 43:193-198.
31. Safirstein R, Winston J, Goldstein M, Moel D, Dikman S, and Guttenplan J (1986) Cisplatin nephrotoxicity. Am J Kidney Dis 8:356-367.
32. Schmidley JW (1990) Free radicals in central nervous system ischemia. Stroke 21:1086-1090.
33. Schreck R, Rieber P, and Baeuerle PA (1991) Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1. EMBO (Eur Mol Biol Organ) J 10:2247-2258.
34. Seligman AM, Karnovsky MJ, Wasserkrug HL, and Hanker JS (1968) Nondroplet ultrastructural demonstration of cytochrome oxidase activity with a polymerizing osmiophilic reagent, diaminobenzidine (DAB). J Cell Biol 38:1-14.
35. Stadtman ER (1992) Protein oxidation and aging. Science (Wash DC) 257:1220-1224.
36. Takaya K, Koya D, Isono M, Sugimoto T, Sugaya T, Kashiwagi A, and Haneda M (2003) Involvement of ERK pathway in albumin-induced MCP-1 expression in mouse proximal tubular cells. Am J Physiol Renal Physiol 294: F1037-F1045.
37. Toyokuni S, Tanaka T, Hattori Y, Nishiyama Y, Yoshida A, Uchida K, Hiai H, Ochi H, and Osawa T (1997) Quantitative immunohistochemical determination of 8-hydroxy-2′-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model. Lab Investig 76:365-374.
38. Watanabe T and Egawa M (1994b) Effects of an antistroke agent MCl-186 on cerebral arachidonate cascade. J Pharmacol Exp Ther 271:1624-1629.
39. Watanabe T, Yuki S, Egawa M, and Nishi H (1994a) Protective effects of edarabone on cerebral ischemia possible involvement of free radical scavenging and antioxidant actions. J Pharmacol Exp Ther 268:1597-1604.
40. Wu TW, Zeng LH, Wu J, and Fung KP (2000) Edarabone: further histochemical and biochemical evidence of neuroprotection. Life Sci 67:2387-2392.
41. Zhang JG and Lindup WE (1994) Cisplatin nephrotoxicity: decreases in mitochondrial protein sulfhydryl concentration and calcium uptake by mitochondria from rat renal cortical slices. Biochem Pharmacol 47:1127-1135.