Synthesis and antitumor activity of some new 1,3,4-oxadiazole, pyrazole and pyrazolo [3,4-d]pyrimidine derivatives attached to 4-benzothiazol-2-yl phenyl moiety

Der Pharma Chemica

Volumn 3, Issue 6, 2011, Pages 282-292

  El Hamouly, Wageeh S ^a   Amin, Kamelia M ^b   El Assaly, Samy A ^a   El Meguid, Eman A Abd ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

1,3,4 oxadiazole; 4 benzothiazol 2 yl phenyl; Antibreast cancer activity; O aminothiophenol; Pyrazole; Pyrazolo 3,4 d pyrimidine

Indexed keywords

(4 BENZOTHIAZOL 2 YL PHENYL)(4,6 DITHIOXO 4,5,6,7 TETRAHYDROPYRAZOLO[3,4 D]PYRIMIDIN 1 YL) METHANONE; (5 AMINO 4 IMINO 4,5 DIHYDROPYRAZOL[3,4 D]PYRIMIDIN 1 YL)(4 BENZOTHIAZOL 2 YL PHENYL)METHANONE; 1 (4 BENZOTHIAZOL 2 YL BENZOYL) 5 (4 CHLOROPHENYL) 4 IMINO 1,4,5,7 TETRAHYDROPYRAZOLO[3,4 D]PYRIMIDIN 6 ONE; 2 (4 CYANOPHENYL)BENZO[D]THIAZOLE; 2 [4 (5 PHENYL 1,3,4 OXADIAZOL 2 YL)PHENYL]BENZO[D]THIAZOLE; 2 [4 [5 (4 NITROPHENYL) 1,3,4 OXADIAZOL 2 YL]PHENYL]BENZO[D]THIAZOLE; 2 [4 [5 (METHYLTHIO) 1,3,4 OXADIAZOL 2 YL]PHENYL]BENZO[D]THIAZOLE; 4 (BENZO[D]THIAZOL 2 YL)BENZOHYDRAZIDE; 4 (BENZO[D]THIAZOL 2 YL)BENZOIC ACID; 4 [5 [4 (BENZO[D]THIAZOL 2 YL)PHENYL] 1,3,4 OXADIAZOL 2 YL] BENZANAMIDE; 4 AMINO 5 ETHYNYL 6 HYDROXYPYRAZOL[3,4 B]PYRIDIN 1 YL (4 BENZOTHIAZOL 2 YL PHENYL) METHANONE; 5 [4 (BENZO[D]THIAZOL 2 YL)PHENYL] 1,3,4 OXADIAZOL 2 YL O METHYLCARBONOTHIOATE; 5 [4 (BENZO[D]THIAZOL 2 YL)PHENYL] 1,3,4 OXADIAZOLE 2(3H) THIONE; 5 [4 (BENZO[D]THIAZOL 2 YL)PHENYL] 3 (MORPHOLINOMETHYL) 1,3,4 OXADIAZOL 2(3H) THIONE; 5 [4 (BENZO[D]THIAZOL 2 YL)PHENYL] 3 [(DIMETHYLAMINO)METHYL] 1,3,4 OXADIAZOL 2(3H) THIONE; 5 AMINO 1 (4 BENZOTHIAZOL 2 YL BENZOYL) 1H PYRAZOLE 4 CARBONITRILE; 5 AMINO 1 (4 BENZOTHIAZOL 2 YL BENZOYL) 1H PYRAZOLE 4 CARBOXYLIC ACID ETHYL ESTER; 5 AMINO 2 (4 BENZOTHIAZOL 2 YL BENZOYL) 1,2 DIHYDROPYRAZOL 3 ONE; ANTINEOPLASTIC AGENT; DOXORUBICIN; ETHYL 2 [5 [4 (BENZO[D]THIAZOL 2 YL)PHENYL] 1,3,4 OXADIAZOL 2 YL THIO]ACETATE; ETHYL 2 [5 [4 (BENZO[D]THIAZOL 2 YL)PHENYL] 1,3,4 OXADIAZOL 2 YL THIO]PROPANOATE; ETHYL 4 (BENZO[D]THIAZOL 2 YL)BENZOATE; METHYL 2 [5 [4 (BENZO[D]THIAZOL 2 YL)PHENYL] 1,3,4 OXADIAZOL 2 YL THIO]ACETATE; N [2 (4 BENZOTHIAZOL 2 YL BENZOYL) 4 CYANO 2H PYRAZOL 3 YL] FORMIMIDIC ACID ETHYL ESTER; N [2 (4 BENZOTHIAZOL 2 YLBENZOYL) 4 CYANO 2H PYRAZOL 3 YL] 2 CYANOACETAMIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CELL STRAIN MCF 7; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY;

EID: 84855304610     PISSN: None     EISSN: 0975413X     Source Type: Journal    
DOI: None     Document Type: Article

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