Synthesis, anticonvulsant activity and 3D-QSAR study of some prop-2-eneamido and 1-acetyl-pyrazolin derivatives of aminobenzothiazole

European Journal of Medicinal Chemistry

Volumn 45, Issue 1, 2010, Pages 149-159

  Amnerkar, Nikhil D ^a   Bhusari, Kishore P ^a  

^a RTM NAGPUR UNIVERSITY   (India)

Author keywords

3D QSAR; Aminobenzothiazole; Anticonvulsant activity; Prop 2 eneamide; Pyrazoline

Indexed keywords

2 [(1 ACETYL 5 PHENYL) 2 PYRAZOLIN 3 YL]AMINOBENZOTHIAZOLE; 2 [[1 ACETYL 5 (4 CHLOROPHENYL)] 2 PYRAZOLIN 3 YL]AMINOBENZOTHIAZOLE; 3 (3 HYDROXY 4 METHOXYPHENYL)PROP 2 ENEAMIDOBENZOTHIAZOLE; 3 (4 CHLOROPHENYL)PROP 2 ENEAMIDOBENZOTHIAZOLE; 3 (4 HYDROXYPHENYL)PROP 2 ENEAMIDOBENZOTHIAZOLE; 3 (4 METHOXYPHENYL)PROP 2 ENEAMIDOBENZOTHIAZOLE; 3 (FURAN 2 YL)PROP 2 ENEAMIDOBENZOTHIAZOLE; 3 PHENYL PROP 2 ENEAMIDOBENZOTHIAZOLE; 6 CHLORO(3 PHENYL PROP 2 ENEAMIDO)BENZOTHIAZOLE; 6 CHLORO[3 (3 HYDROXY 4 METHOXYPHENYL)PROP 2 ENEAMIDO]BENZOTHIAZOLE; 6 CHLORO[3 (4 CHLOROPHENYL)PROP 2 ENEAMIDO]BENZOTHIAZOLE; 6 CHLORO[3 (4 HYDROXYPHENYL)PROP 2 ENEAMIDO]BENZOTHIAZOLE; 6 CHLORO[3 (4 METHOXYPHENYL)PROP 2 ENEAMIDO]BENZOTHIAZOLE; 6 CHLORO[3 (FURAN 2 YL)PROP 2 ENEAMIDO]BENZOTHIAZOLE; 6 METHYL 2 [(1 ACETYL 5 (4 CHLOROPHENYL)) 2 PYRAZOLIN 3 YL]AMINOBENZOTHIAZOLE; 6 METHYL(3 PHENYL PROP 2 ENEAMIDO)BENZOTHIAZOLE; 6 METHYL[3 (3 HYDROXY 4 METHOXYPHENYL)PROP 2 ENEAMIDO]BENZOTHIAZOLE; 6 METHYL[3 (4 CHLOROPHENYL)PROP 2 ENEAMIDO]BENZOTHIAZOLE; 6 METHYL[3 (4 HYDROXYPHENYL)PROP 2 ENEAMIDO]BENZOTHIAZOLE; 6 METHYL[3 (4 METHOXYPHENYL)PROP 2 ENEAMIDO]BENZOTHIAZOLE; 6 METHYL[3 (FURAN 2 YL)PROP 2 ENEAMIDO]BENZOTHIAZOLE; 6 NITRO(3 PHENYL PROP 2 ENEAMIDO)BENZOTHIAZOLE; 6 NITRO[3 (3 HYDROXY 4 METHOXYPHENYL)PROP 2 ENEAMIDO]BENZOTHIAZOLE; 6 NITRO[3 (4 CHLOROPHENYL)PROP 2 ENEAMIDO]BENZOTHIAZOLE; 6 NITRO[3 (4 HYDROXYPHENYL)PROP 2 ENEAMIDO]BENZOTHIAZOLE; 6 NITRO[3 (4 METHOXYPHENYL)PROP 2 ENEAMIDO]BENZOTHIAZOLE; 6 NITRO[3 (FURAN 2 YL)PROP 2 ENEAMIDO]BENZOTHIAZOLE; ANTICONVULSIVE AGENT; BENZOTHIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; FEMALE; LIVER TOXICITY; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; RAT; SEIZURE; STRUCTURE ACTIVITY RELATION;

ALANINE TRANSAMINASE; ALKENES; ANIMALS; ANTICONVULSANTS; ASPARTATE AMINOTRANSFERASES; BEHAVIOR, ANIMAL; BENZOTHIAZOLES; FEMALE; LIVER; MALE; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PYRAZOLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; SOFTWARE;

EID: 72149100457     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.09.037     Document Type: Article

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