Synthesis and biological evaluation of novel Mannich bases of 2-arylimidazo[2,1-b]benzothiazoles as potential anti-cancer agents

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 4258-4266

  Kumbhare, Ravindra M ^a   Vijay Kumar, K ^a   Janaki Ramaiah, M ^a   Dadmal, Tulshiram ^a   Pushpavalli, S N C V L ^a   Mukhopadhyay, Debasmita ^a   Divya, B ^a   Anjana Devi, T ^a   Kosurkar, Umesh ^a   Pal Bhadra, Manika ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

2 Aminobenzothiazole; 2 arylimidazo 2,1 b benzothiazoles; Cell cycle effects; Cytotoxicity; Tubulin depolymerization

Indexed keywords

2 (3,4 DIMETHOXYPHENYL) 5 FLUOROBENZOTHIAZOLE; 2 ARYLIMIDAZO[2,1 B]BENZOTHIAZOLE DERIVATIVE; 3 (MORPHOLINOMETHYL) 2 PHENYL 7 ETHOXY IMIDAZO[2,1 B]BENZOTHIAZOLE; 3 (MORPHOLINOMETHYL) 2 PHENYL 7 METHYLIMIDAZO[2,1 B]BENZOTHIAZOLE; 3 (PYRROLIDINOMETHYL) 2 (4 CHLOROPHENYL)IMIDAZO [2,1 B]BENZOTHIAZOLE; 3 (PYRROLIDINOMETHYL) 2 PHENYL 7 ETHOXY IMIDAZO[2,1 B]BENZOTHIAZOLE; 3 (PYRROLIDINOMETHYL) 2 PHENYL 7 FLUORO IMIDAZO[2,1 B]BENZOTHIAZOLE; 3 (PYRROLIDINOMETHYL) 2 PHENYL 7 METHYL IMIDAZO[2,1 B]BENZOTHIAZOLE; 3 (PYRROLIDINOMETHYL) 2 PHENYL IMIDAZO[2,1 B]BENZOTHIAZOLE; 3 [4 (2 PYRIDINYL)PIPERAZINOMETHYL] 2 PHENYL 7 ETHOXYIMIDAZO[2,1 B]BENZOTHIAZOLE; ANTINEOPLASTIC AGENT; BENZOTHIAZOLE DERIVATIVE; CASPASE 3; CHECKPOINT KINASE 2; CYCLIN B; MITOGEN ACTIVATED PROTEIN KINASE 1; N,N DIETHYL 2 (3 IMIDAZO[2,1 B] [1,3]BENZOTHIAZOLE 2 YLPHENOXY)ETHNAMINE DIHYDROCHLORIDE; NOCODAZOLE; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR JUNB; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MANNICH REACTION; UPREGULATION;

ANTINEOPLASTIC AGENTS; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; G2 PHASE; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MANNICH BASES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED; THIAZOLES;

EID: 80052933857     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.06.031     Document Type: Article

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