Synthesis and antibacterial activity of a novel series of DNA gyrase inhibitors: 5-[(E)-2-arylvinyl]pyrazoles

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 19, 2005, Pages 4299-4303

  Tanitame, Akihiko ^a   Oyamada, Yoshihiro ^a   Ofuji, Keiko ^a   Terauchi, Hideo ^a   Kawasaki, Motoji ^a   Wachi, Masaaki ^b   Yamagishi, Jun Ichi ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

5 (E) 2 Arylvinyl pyrazoles; DNA gyrase inhibitor; Multidrug resistant strains

Indexed keywords

AMPICILLIN; CLARITHROMYCIN; GYRASE INHIBITOR; PYRAZOLE DERIVATIVE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SPARFLOXACIN; VANCOMYCIN;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; GRAM POSITIVE BACTERIUM; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; DNA GYRASE; DRUG RESISTANCE; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; PYRAZOLES; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP;

POSIBACTERIA;

EID: 23944491198     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.06.103     Document Type: Article

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