Design, synthesis, and evaluation of 3,4-disubstituted pyrazole analogues as anti-tumor CDK inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 16, 2007, Pages 4557-4561

  Lin, Ronghui ^a   Chiu, George ^a   Yu, Yang ^a   Connolly, Peter J ^a   Li, Shengjian ^a   Lu, Yanhua ^a   Adams, Mary ^a   Fuentes Pesquera, Angel R ^a   Emanuel, Stuart L ^a   Greenberger, Lee M ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Anti proliferative agents; Anti tumor agents; Cyclin dependent kinase inhibitor; Pyrazole analogues

Indexed keywords

3 (BENZIMIDAZOL 2 YL) 4 [2 (PYRIDIN 3 YL) VINYL] PYRAZOLE; 3 (IMIDAZOL 2 YL) 4 [2 (PYRIDIN 3 YL) VINYL] PYRAZOLE; ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE INHIBITOR; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DESIGN; DRUG INHIBITION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; TUMOR CELL;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASES; DRUG DESIGN; HUMANS; MOLECULAR STRUCTURE; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34447295096     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.05.092     Document Type: Article

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