SCOPUS 정보 검색 플랫폼

Volumn 45, Issue 3, 2002, Pages 744-747

Antitumor benzothiazoles. 16. Synthesis and pharmaceutical properties of antitumor 2-(4-aminophenyl)benzothiazole amino acid prodrugs

(5) Hutchinson, Ian a Jennings, Sharon A a Vishnuvajjala, B Rao b Westwell, Andrew D a Stevens, Malcolm F G a

a UNIVERSITY OF NOTTINGHAM (United Kingdom)

b NATIONAL CANCER INSTITUTE (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 AMINO 3 METHYLPHENYL) 5 FLUOROBENZOTHIAZOLE DERIVATIVE; 2 (4 AMINOPHENYL)BENZOTHIAZOLE DERIVATIVE; ALANINE DERIVATIVE; AMINO ACID DERIVATIVE; ANTINEOPLASTIC AGENT; BENZOTHIAZOLE DERIVATIVE; LYSINE DERIVATIVE; NSC 710305; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL LINE; CLINICAL TRIAL; DOG; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DEGRADATION; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; LIPOPHILICITY; MOUSE; NONHUMAN; PHASE 1 CLINICAL TRIAL; THERMOSTABILITY;

ALANINE; ANTINEOPLASTIC AGENTS; DRUG STABILITY; HYDROGEN-ION CONCENTRATION; LYSINE; PRODRUGS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 0037203997 PISSN: 00222623 EISSN: None Source Type: Journal
DOI: 10.1021/jm011025r Document Type: Article

Times cited : (482)

References (18)

1
- 0035938423
- Antitumour benzothiazoles. Part 15. The synthesis and physicochemical properties of 2-(4-aminophenyl)benzothiazole sulphamate salt derivatives
- (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 1093-1095
- Shi, D.-F.¹ Bradshaw, T.D.² Chua, M.S.³ Westwell, A.D.⁴ Stevens, M.F.G.⁵

2
- 0029780539
- Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo
- (1996) J. Med. Chem. , vol.39 , pp. 3375-3384
- Shi, D.-F.¹ Bradshaw, T.D.² Wrigley, S.³ McCall, C.J.⁴ Lelieveld, P.⁵ Fichtner, I.⁶ Stevens, M.F.G.⁷

3
- 0031933503
- 2-(4-Aminophenyl)benzothiazoles: Novel agents with selective profiles of in vitro anti-tumour activity
- (1998) Br. J. Cancer , vol.77 , pp. 745-752
- Bradshaw, T.D.¹ Wrigley, S.² Schultz, R.J.³ Paull, K.D.⁴ Stevens, M.F.G.⁵

4
- 7344246555
- Influence of 2-(4-aminophenyl)benzothiazoles on growth of human ovarian carcinoma cells in vitro and in vivo
- (1999) Br. J. Cancer , vol.77 , pp. 421-429
- Bradshaw, T.D.¹ Shi, D.-F.² Schultz, R.J.³ Paull, K.D.⁴ Kelland, L.⁵ Wilson, A.⁶ Garner, C.⁷ Fiebig, H.H.⁸ Wrigley, S.⁹ Stevens, M.F.G.¹⁰

5
- 0031035181
- An information-intensive approach to the molecular pharmacology of cancer
- (1997) Science , vol.275 , pp. 343-349
- Weinstein, J.N.¹ Myers, T.G.² O'Connor, P.M.³ Friend, S.H.⁴ Fornace, A.J.⁵ Kohn, K.W.⁶ Fojo, T.⁷ Bates, S.E.⁸ Rubinstein, L.V.⁹ Anderson, N.L.¹⁰ Buolamwini, J.K.¹¹ Van Osdol, W.W.¹² Monks, A.P.¹³ Scudiero, D.A.¹⁴ Sausville, E.A.¹⁵ Zaharevitz, D.W.¹⁶ Bunow, B.¹⁷ Viswanadhan, V.N.¹⁸ Johnson, G.S.¹⁹ Wittes, R.E.²⁰ Paull, K.D.²¹ more..

6
- 0032971926
- Antitumor benzothiazoles. 7. Synthesis of 2-(4-acylaminophenyl)benzothiazoles and investigations into the role of acetylation in the antitumor activities of the parent amines
- (1999) J. Med. Chem. , vol.42 , pp. 381-392
- Chua, M.-S.¹ Shi, D.-F.² Bradshaw, T.D.³ Hutchinson, I.⁴ Shaw, P.N.⁵ Barrett, D.A.⁶ Stanley, L.A.⁷ Stevens, M.F.G.⁸

7
- 0033533836
- Antitumor benzothiazoles. 8. Synthesis, metabolic formation, and biological properties of the C- and N-oxidation products of antitumor 2-(4-aminophenyl)-benzothiazoles
- (1999) J. Med. Chem. , vol.42 , pp. 4172-4184
- Kashiyama, E.¹ Hutchinson, I.² Chua, M.-S.³ Stinson, S.F.⁴ Phillips, L.R.⁵ Kaur, G.⁶ Sausville, E.A.⁷ Bradshaw, T.D.⁸ Westwell, A.D.⁹ Stevens, M.F.G.¹⁰

8
- 0034665390
- Role of CYP1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells
- (2000) Cancer Res. , vol.60 , pp. 5196-5203
- Chua, M.-S.¹ Kashiyama, E.² Bradshaw, T.D.³ Stinson, S.F.⁴ Brantley, E.⁵ Sausville, E.A.⁶ Stevens, M.F.G.⁷

9
- 0035042610
- The discovery of the potent and selective antitumour agent 2-(4-amino-3-methylphenyl)-benzothiazole (DF 203) and related compounds
- (2001) Curr. Med. Chem. , vol.8 , pp. 203-210
- Bradshaw, T.D.¹ Stevens, M.F.G.² Westwell, A.D.³

10
- 0034650277
- The regiospecific synthesis of 5- and 7-monosubstituted and 5,6-disubstituted 2-arylbenzothiazoles
- (2000) Tetrahedron Lett. , vol.41 , pp. 425-428
- Hutchinson, I.¹ Stevens, M.F.G.² Westwell, A.D.³

11
- 0035953321
- Antitumor benzothiazoles. 14. Synthesis and in vitro biological properties of fluorinated 2-(4-aminophenyl)benzothiazoles
- (2001) J. Med. Chem. , vol.44 , pp. 1446-1455
- Hutchinson, I.¹ Chua, M.-S.² Browne, H.L.³ Trapani, V.⁴ Bradshaw, T.D.⁵ Westwell, A.D.⁶ Stevens, M.F.G.⁷

12
- 0002582585
- Antitumour benzothiazoles. Part 4.1 An NMR study of the sites of protonation of 2-(4-aminophenyl)benzothiazoles
- (1996) J. Chem. Soc., Perkin Trans. 2 , pp. 1271-1274
- Wheelhouse, R.T.¹ Shi, D.-F.² Wilman, D.E.V.³ Stevens, M.F.G.⁴

13
- 0029054737
- Amino acid derivatives of Dapsone as water soluble prodrugs
- (1995) Int. J. Pharm. , vol.121 , pp. 157-167
- Pochopin, N.L.¹ Charman, W.N.² Stella, V.J.³

14
- 0008351049
- Substituted 2-arylbenzazole compounds and their use as antitumour agents. International Patent Number WO 01/ 14354 A1 (Publication Date: March 1, 2001). Accepted for Phase 1 clinical evaluation by the Cancer Research Campaign, U.K.; also given the name "Phortress"
- Stevens, M.F.G.¹ Poole, T.D.² Westwell, A.D.³ Hutchinson, I.⁴ Chua, M.-S.⁵

15
- 0008351050
- Preclinical evaluation of amino acid prodrugs of novel antitumor 2-(4-amino-3-methylphenyl)benzothiazoles
- in press
- Mol. Cancer Ther.
- Bradshaw, T.D.¹ Browne, H.L.² Trapani, V.³ Chua, M.-S.⁴ Fichtner, I.⁵ Bibby, M.J.⁶ Cooper, P.A.⁷ Alley, M.C.⁸ Donohue, S.J.⁹ Sausville, E.A.¹⁰ Stevens, M.F.G.¹¹

16
- 0008351051
- The scale-up synthesis was performed by Starks Associates Inc., Buffalo, NY, under an NCI contract: P. I., Dr. Jack Parsons

17
- 0008403411
- Data generated by Midwest Research Institute, Kansas City, MO, under an NCI contract: P. I., Dr. Gregory Turner

18
- 0008344732
- Data generated by University of Kansas, Lawrence, KS, under an NCI Contract: P. I., Dr. Valentino J. Stella

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.