Discovery of novel benzothiazolesulfonamides as potent inhibitors of HIV-1 protease

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 22, 2003, Pages 4769-4777

  Nagarajan, Srinivasan R ^a   De Crescenzo, Gary A ^a   Getman, Daniel P ^a   Lu, Hwang Fun ^a   Sikorski, James A ^a,b   Walker, Jeffrey L ^a   McDonald, Joseph J ^a   Houseman, Kathryn A ^a   Kocan, Geralyn P ^a   Kishore, Nandini ^a   Mehta, Pramod P ^a   Funkes Shippy, Christie L ^a   Blystone, Lisa ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b AtheroGenics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(N 3 PYRIDYLMETHYLOXYFORMAMIDO)HYDROXY 1 [(2 AMINOBENZOTHIAZOLE 6 SULFONYL)(2 METHYLPROPYL)AMINO] 4 PHENYLBUTANE; (N 3 PYRIDYLMETHYLOXYFORMAMIDO)HYDROXY 1 [(BENZOTHIAZOLE 6 SULFONYL)(2 METHYLPROPYL)AMINO] 4 PHENYLBUTANE; (N 3 TETRAHYDROFURANYLOXYFORMAMIDO)HYDROXY 1 [(2 AMINOBENZOTHIAZOLE 6 SULFONYL)(2 METHYLPROPYL)AMINO] 4 PHENYLBUTANE; (N 3 TETRAHYDROFURANYLOXYFORMAMIDO)HYDROXY 1 [(BENZOTHIAZOLE 6 SULFONYL)(2 METHYLPROPYL)AMINO] 4 PHENYLBUTANE; (N 5 THIAZOLYLMETHYLOXYFORMAMIDO)HYDROXY 1 [(2 AMINOBENZOTHIAZOLE 6 SULFONYL)(2 METHYLPROPYL)AMINO] 4 PHENYLBUTANE; (N 5 THIAZOLYLMETHYLOXYFORMAMIDO)HYDROXY 1 [(BENZOTHIAZOLE 6 SULFONYL)(2 METHYLPROPYL)AMINO] 4 PHENYLBUTANE; (N BENZYLOXYFORMAMIDO)HYDROXY 1 [(2 AMINOBENZOTHIAZOLE 5 SULFONYL)(2 METHYLPROPYL)AMINO] 4 PHENYLBUTANE; (N BENZYLOXYFORMAMIDO)HYDROXY 1 [(2 AMINOBENZOTHIAZOLE 6 SULFONYL)(2 METHYLPROPYL)AMINO] 4 PHENYLBUTANE; (N BENZYLOXYFORMAMIDO)HYDROXY 1 [(2 AMINOBENZOTHIAZOLE 7 SULFONYL)(2 METHYLPROPYL)AMINO] 4 PHENYLBUTANE; (N BENZYLOXYFORMAMIDO)HYDROXY 1 [(2 METHYLPROPYL)(4 NITROPHENYLSULFONYL)AMINO] 4 PHENYLBUTANE; (N BENZYLOXYFORMAMIDO)HYDROXY 1 [(BENZOTHIAZOLE 6 SULFONYL)(2 METHYLPROPYL)AMINO] 4 PHENYLBUTANE; (N BUTYLOXYFORMAMIDO)HYDROXY 1 [(4 AMINOPHENYLSULFONYL)(2 METHYLPROPYL)AMINO] 4 PHENYLBUTANE; (N TERT BUTYLOXYFORMAMIDO)HYDROXY 1 [(2 AMINOBENZOTHIAZOLE 6 SULFONYL)(2 METHYLPROPYL)AMINO] 4 PHENYLBUTANE; AMINOHYDROXY 1 [(2 AMINOBENZOTHIAZOLE 6 SULFONYL)(2 METHYLPROPYL)AMINO] 4 PHENYLBUTANE; BENZOTHIAZOLE 6 SULFONIC ACID; BENZOTHIAZOLE DERIVATIVE; HYDROXY 1 [(BENZOTHIAZOLE 6 SULFONYL)(2 METHYLPROPYL)AMINO] 4 PHENYLBUTANE; N (2 METHYLPHENYLCARBOXAMIDO)HYDROXY 1 [(2 AMINOBENZOTHIAZOLE 6 SULFONYL)(2 METHYLPROPYL)AMINO] 4 PHENYLBUTANE; N (3 AMINO 2 METHYLPHENYLCARBOXAMIDO)HYDROXY 1 [(2 AMINOBENZOTHIAZOLE 6 SULFONYL)(2 METHYLPROPYL)AMINO] 4 PHENYLBUTANE; N (3 AMINO 2 METHYLPHENYLCARBOXAMIDO)HYDROXY 1 [(BENZOTHIAZOLE 6 SULFONYL)(2 METHYLPROPYL)AMINO] 4 PHENYLBUTANE; N (3 HYDROXY 2 METHYLPHENYLAMIDO)HYDROXY 1 [(BENZOTHIAZOLE 6 SULFONYL)(2 METHYLPROPYL)AMINO] 4 PHENYLBUTANE; N (3 HYDROXY 2 METHYLPHENYLCARBOXAMIDO)HYDROXY 1 [(2 AMINOBENZOTHIAZOLE 6 SULFONYL)(2 METHYLPROPYL)AMINO] 4 PHENYLBUTANE; N 2 (2,6 DIMETHYLPHENOXYMETHYLCARBOXAMIDO)HYDROXY 1 [(2 AMINOBENZOTHIAZOLE 6 SULFONYL)(2 METHYLPROPYL)AMINO] 4 PHENYLBUTANE; N 2 (2,6 DIMETHYLPHENOXYMETHYLFORMAMIDO)HYDROXY 1 [(2 BENZOTHIAZOLE 6 SULFONYL)(2 METHYLPROPYL)AMINO] 4 PHENYLBUTANE; PROTEINASE; PROTEINASE INHIBITOR; SULFONAMIDE; UNCLASSIFIED DRUG; [N 2 (2 METHYL 3 METHYLSULFONYL)PROPIONYL]HYDROXY 1 [(2 BENZOTHIAZOLE 6 SULFONYL)(2 METHYLPROPYL)AMINO] 4 PHENYLBUTANE;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; HALF LIFE TIME; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; RAT;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 10744228836     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.07.001     Document Type: Article

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