Design and synthesis of some substituted 1H-pyrazolyl-thiazolo[4,5-d]pyrimidines as anti-inflammatory-antimicrobial agents

European Journal of Medicinal Chemistry

Volumn 38, Issue 1, 2003, Pages 27-36

  Bekhit, Adnan A ^a   Fahmy, Hesham T Y ^a   Rostom, Sherif A F ^a   Baraka, Azza M ^b  

^a Alexandria University Faculty of Pharmacy   (Egypt)

^b ALEXANDRIA UNIVERSITY   (Egypt)

Author keywords

1H Pyrazoles; Acute toxicity; Anti inflammatory activity; Antimicrobial activity; Human COX 1 and COX 2 enzymatic activity; Thiazolo 4,5 d pyrimidines; Ulcerogenic effect

Indexed keywords

AMPICILLIN; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; PYRIMIDINE DERIVATIVE;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BIOASSAY; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG DESIGN; DRUG SAFETY; DRUG SYNTHESIS; ESCHERICHIA COLI; FUNGUS; GASTROINTESTINAL DISEASE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; GRANULOMA; HEMATOLOGIC DISEASE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NEPHROTOXICITY; NONHUMAN; PAW EDEMA; RAT; STAPHYLOCOCCUS AUREUS; ULCER; ULCEROGENESIS;

EID: 0037366533     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(02)00009-0     Document Type: Article

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