Design, structure-activity relationship, and pharmacokinetic profile of pyrazole-based indoline factor Xa inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 23, 2007, Pages 6481-6488

  Varnes, Jeffrey G ^a   Wacker, Dean A ^a   Jacobson, Irina C ^a   Quan, Mimi L ^a   Ellis, Christopher D ^a   Rossi, Karen A ^a   He, Ming Y ^a   Luettgen, Joseph M ^a   Knabb, Robert M ^a   Bai, Steven ^a   He, Kan ^a   Lam, Patrick Y S ^a   Wexler, Ruth R ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Coagulation; Factor Xa

Indexed keywords

ANILINE; BLOOD CLOTTING FACTOR 10A INHIBITOR; DRUG METABOLITE; INDOLINE DERIVATIVE; RAZAXABAN; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTICOAGULATION; ARTICLE; CONTROLLED STUDY; DOG; DRUG BINDING; DRUG DESIGN; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG METABOLISM; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROLYSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTITHROMBIN III; CACO-2 CELLS; DRUG DESIGN; FACTOR XA; HUMANS; INDOLES; PROTEIN BINDING; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

CANIS FAMILIARIS;

EID: 35649028680     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.09.091     Document Type: Article

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