Convergent synthesis and antibacterial activity of pyrazole and pyrazoline derivatives of diazepam

European Journal of Pharmaceutical Sciences

Volumn 20, Issue 2, 2003, Pages 173-179

  Berghot, Moged A ^a   Moawad, Evelin B ^a  

^a Mansoura University   (Egypt)

Author keywords

Diazepam; Pyrazoles; Pyrazolines

Indexed keywords

BACTERIA; DERIVATIVES; ORGANIC COMPOUNDS; SYNTHESIS (CHEMICAL);

ANTIBACTERIAL ACTIVITY;

DRUG PRODUCTS;

4 AMINO 3 [(7' CHLORO 1',3' DIHYDRO 1' METHYL 5' PHENYL 2'H 1',4' BENZODIAZEPIN 2' ON 3' YL)CARBONYL] 7 PHENYLPYRAZOLO[5,1 C] 1,2,4 TRIAZINE; 5 AMINO 3 (7' CHLORO 1',3' DIHYDRO 1' METHYL 5' PHENYL 2'H 1',4' BENZODIAZEPIN 2' ON 3' YL) 1H PYRAZOLE; DIAZEPAM; PYRAZOLE DERIVATIVE; PYRAZOLINE DERIVATIVE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SPECTROSCOPY;

EID: 0141782720     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(03)00162-3     Document Type: Article

References (13)

1. 13C-NMR properties of pyrazoles. Magn. Reson. 31:(2):1993;107-168.
2. Berghot M.A. Heterocyclic groups annulated to 1,4-benzodiazepine systems. Arch. Die Pharm. 325:1992;285-289.
3. Berghot M.A. Facile synthesis and biological evaluation of some heterocylic systems containing diazepam. Arch. Pharm. Res. 24:(4):2001;263-269.
4. Elagamey A.A., El-Taweel F.M.A. Nitrile in heterocyclic synthesis: synthesis of pyrazolo(1,5-a) pyrimidine, pyrazolo(1,5-c)(1,2,4) triazine and pyrazolo(4,3-e) (1,2,4) triazine. J. Prakt. Chem. 333:(2):1991;333-338.
5. Elghandour A.H.H., Ibrahim M.K.A., Elshikh S.M.M., Ali F.M.M. Studies with polyfunctionally substituted heteroaromatic: synthesis of several new thiazoles,pyrazolo(5,1-c) triazines and polyfunctionally substituted pyridines and pyrimidines. Tetrahedron. 48:(42):1992;9295-9304.
6. Gruickshank, R., Duguid, J.R., Marmion, B.P., Swain, R.H.A., 1975. Medicinal Microbiology, Vol. 11. Churchill Livingstone, New York, p. 190.
7. Hara T., Kayama Y., Mori T., Itoch K., Fujimori H., Sunami T., Hashimoto Y., Ishimoto S. Synthesis and biological action of 6-phenyl-pyrrolo[1,2-a][1,4]-benzodiazepines. J. Med. Chem. 21:1978;263-266.
8. Hoffmann F., 1980. The Vademe-Cumn-Roch products on the Egyptian Market, McGraw-Hill, Basel, Switzerland, p. 129.
9. Stefanovich V., Cerprini M. Biological properties of fused heterocyclic diazepam. J. Pharm. Sci. 60:1971;78-81.
10. Sternbach L.H. The benzodiazepine story. Prog. Drug. Res. 22:1978;229-232.
11. Sternbach L.H. The benzodiazepine story. J. Med. Chem. 22:1979;1-7.
12. Subbanwad G.R., Vibhute Y.B. Studies on synthesis and antimicrobial activity of some new pyrazolines and N-phenyl pyrazolines. J. Indian Chem. Soc. 69:(11):1992;781-783.
13. Teruhisa N., Hideo O. Relationship between the antimicrobial and surface activities of 3-alkylpyrazoles. J. Phar. Soc. Japan. 76:1956;390-392.