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Volumn 3, Issue 1, 2011, Pages 71-82

The impact of hypoxia on oncolytic virotherapy

Author keywords

Combination strategy; HIF; Hypoxia; Macrophage; Oncolysis; Oncolytic virus; Viral replication; Viral spread

Indexed keywords

HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; VIRUS PROTEIN; VON HIPPEL LINDAU PROTEIN;

EID: 84855255095     PISSN: None     EISSN: 11791624     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (12)

References (114)
  • 1
    • 33947245441 scopus 로고    scopus 로고
    • History of oncolytic viruses: Genesis to genetic engineering
    • Kelly E, Russell SJ. History of oncolytic viruses: genesis to genetic engineering. Mol Ther. 2007;15(4):651-659.
    • (2007) Mol Ther , vol.15 , Issue.4 , pp. 651-659
    • Kelly, E.1    Russell, S.J.2
  • 2
    • 45449114994 scopus 로고    scopus 로고
    • Reprogrammed viruses as cancer therapeutics: Targeted, armed and shielded
    • Cattaneo R, Miest T, Shashkova E V, Barry MA. Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded. Nat Rev Microbiol. 2008;6(7):529-540.
    • (2008) Nat Rev Microbiol , vol.6 , Issue.7 , pp. 529-540
    • Cattaneo, R.1    Miest, T.2    Shashkova, E.V.3    Barry, M.A.4
  • 3
    • 41949096891 scopus 로고    scopus 로고
    • Oncolytic virotherapy: Molecular targets in tumor-selective replication and carrier cell-mediated delivery of oncolytic viruses
    • Guo ZS, Thorne SH, Bartlett DL. Oncolytic virotherapy: molecular targets in tumor-selective replication and carrier cell-mediated delivery of oncolytic viruses. Biochim Biophys Acta. 2008;1785(2):217-231.
    • (2008) Biochim Biophys Acta , vol.1785 , Issue.2 , pp. 217-231
    • Guo, Z.S.1    Thorne, S.H.2    Bartlett, D.L.3
  • 4
    • 57749201655 scopus 로고    scopus 로고
    • Targeted and armed oncolytic poxviruses: A novel multi-mechanistic therapeutic class for cancer
    • Kirn DH, Thorne SH. Targeted and armed oncolytic poxviruses: a novel multi-mechanistic therapeutic class for cancer. Nat Rev Cancer. 2009; 9(1):64-71.
    • (2009) Nat Rev Cancer , vol.9 , Issue.1 , pp. 64-71
    • Kirn, D.H.1    Thorne, S.H.2
  • 5
    • 73449144100 scopus 로고    scopus 로고
    • Buy one get one free: Armed viruses for the treatment of cancer cells and their microenvironment
    • Kaur B, Cripe T P, Chiocca EA. "Buy one get one free": armed viruses for the treatment of cancer cells and their microenvironment. Curr Gene Ther. 2009;9(5):341-355.
    • (2009) Curr Gene Ther , vol.9 , Issue.5 , pp. 341-355
    • Kaur, B.1    Cripe, T.P.2    Chiocca, E.A.3
  • 6
    • 78650034947 scopus 로고    scopus 로고
    • The combination of immu-nosuppression and carrier cells significantly enhances the efficacy of oncolytic poxvirus in the pre-immunized host
    • Guo ZS, Parimi V, O'Malley ME, et al. The combination of immu-nosuppression and carrier cells significantly enhances the efficacy of oncolytic poxvirus in the pre-immunized host. Gene Ther. 2010;17(12): 1465-1475.
    • (2010) Gene Ther , vol.17 , Issue.12 , pp. 1465-1475
    • Guo, Z.S.1    Parimi, V.2    O'Malley, M.E.3
  • 7
    • 77953539465 scopus 로고    scopus 로고
    • Clinical trials with oncolytic reovirus: Moving beyond phase I into combinations with standard therapeutics
    • Harrington KJ, Vile RG, Melcher A, Chester J, Pandha HS. Clinical trials with oncolytic reovirus: moving beyond phase I into combinations with standard therapeutics. Cytokine Growth Factor Rev. 2010; 21(2-3): 91-98.
    • (2010) Cytokine Growth Factor Rev , vol.21 , Issue.2-3 , pp. 91-98
    • Harrington, K.J.1    Vile, R.G.2    Melcher, A.3    Chester, J.4    Pandha, H.S.5
  • 8
    • 77956267058 scopus 로고    scopus 로고
    • Targeting localized immune suppression within the tumor through repeat cycles of immune cell- oncolytic virus combination therapy
    • Thorne SH, Liang W, Sampath P, et al. Targeting localized immune suppression within the tumor through repeat cycles of immune cell- oncolytic virus combination therapy. Mol Ther. 2010;18(9):1698-1705.
    • (2010) Mol Ther , vol.18 , Issue.9 , pp. 1698-1705
    • Thorne, S.H.1    Liang, W.2    Sampath, P.3
  • 9
    • 80052507771 scopus 로고    scopus 로고
    • Activating systemic T cell immunity against self tumor antigens to support oncolytic virotherapy with vesicular stomatitis virus
    • April 11. [Epub ahead of print.]
    • Wongthida P, Diaz RM, Pulido C, et al. Activating systemic T cell immunity against self tumor antigens to support oncolytic virotherapy with vesicular stomatitis virus. Hum Gene Ther. 2011; April 11. [Epub ahead of print.]
    • (2011) Hum Gene Ther
    • Wongthida, P.1    Diaz, R.M.2    Pulido, C.3
  • 10
    • 77955400126 scopus 로고    scopus 로고
    • Potentiating oncolytic viruses by targeted drug intervention
    • Mahoney DJ, Stojdl D F. Potentiating oncolytic viruses by targeted drug intervention. Curr Opin Mol Ther. 2010;12(4):394-402.
    • (2010) Curr Opin Mol Ther , vol.12 , Issue.4 , pp. 394-402
    • Mahoney, D.J.1    Stojdl, D.F.2
  • 11
    • 77952311664 scopus 로고    scopus 로고
    • Oncolytic viruses move forward in clinical trials
    • Rowan K. Oncolytic viruses move forward in clinical trials. J Natl Cancer Inst. 2010;102(9):590-595.
    • (2010) J Natl Cancer Inst , vol.102 , Issue.9 , pp. 590-595
    • Rowan, K.1
  • 12
    • 77955104827 scopus 로고    scopus 로고
    • Phase I/II study of oncolytic HSV GM-CSF in combination with radiotherapy and cisplatin in untreated stage III/IV squamous cell cancer of the head and neck
    • Harrington KJ, Hingorani M, Tanay MA, et al. Phase I/II study of oncolytic HSV GM-CSF in combination with radiotherapy and cisplatin in untreated stage III/IV squamous cell cancer of the head and neck. Clin Cancer Res. 2010;16(15):4005-4015.
    • (2010) Clin Cancer Res , vol.16 , Issue.15 , pp. 4005-4015
    • Harrington, K.J.1    Hingorani, M.2    Tanay, M.A.3
  • 13
    • 77957253429 scopus 로고    scopus 로고
    • OPTIM trial: A phase III trial of an oncolytic herpes virus encoding GM-CSF for unresectable stage III or IV melanoma
    • Kaufman HL, Bines SD. OPTIM trial: a phase III trial of an oncolytic herpes virus encoding GM-CSF for unresectable stage III or IV melanoma. Future Oncol. 2010;6(6):941-949.
    • (2010) Future Oncol , vol.6 , Issue.6 , pp. 941-949
    • Kaufman, H.L.1    Bines, S.D.2
  • 14
    • 79957902460 scopus 로고    scopus 로고
    • Sequential therapy with JX-594, a targeted oncolytic poxvirus, followed by sorafenib in hepatocellular carcinoma: Preclinical and clinical demonstration of combination efficacy
    • Heo J, Breitbach CJ, Moon A, et al. Sequential therapy with JX-594, a targeted oncolytic poxvirus, followed by sorafenib in hepatocellular carcinoma: preclinical and clinical demonstration of combination efficacy. Mol Ther. 2011;19(6):1170-1179.
    • (2011) Mol Ther , vol.19 , Issue.6 , pp. 1170-1179
    • Heo, J.1    Breitbach, C.J.2    Moon, A.3
  • 15
    • 80052406557 scopus 로고    scopus 로고
    • Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans
    • Breitbach CJ, Burke J, Jonker D, et al. Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans. Nature. 2011;477(7362):99-102.
    • (2011) Nature , vol.477 , Issue.7362 , pp. 99-102
    • Breitbach, C.J.1    Burke, J.2    Jonker, D.3
  • 16
    • 33847389767 scopus 로고    scopus 로고
    • Clinical trials with oncolytic adenovirus in China
    • Yu W, Fang H. Clinical trials with oncolytic adenovirus in China. Curr Cancer Drug Targets. 2007;7(2):141-148.
    • (2007) Curr Cancer Drug Targets , vol.7 , Issue.2 , pp. 141-148
    • Yu, W.1    Fang, H.2
  • 17
    • 38649123395 scopus 로고    scopus 로고
    • Innate immunity, tumor microenvironment and oncolytic virus therapy: Friends or foes?
    • Stanford MM, Breitbach CJ, Bell JC, McFadden G. Innate immunity, tumor microenvironment and oncolytic virus therapy: friends or foes? Curr Opin Mol Ther. 2008;10(1):32-37.
    • (2008) Curr Opin Mol Ther , vol.10 , Issue.1 , pp. 32-37
    • Stanford, M.M.1    Breitbach, C.J.2    Bell, J.C.3    McFadden, G.4
  • 18
    • 77953616808 scopus 로고    scopus 로고
    • Impact of tumor microenvironment on oncolytic viral therapy
    • Wojton J, Kaur B. Impact of tumor microenvironment on oncolytic viral therapy. Cytokine Growth Factor Rev. 2010;21(2-3):127-134.
    • (2010) Cytokine Growth Factor Rev , vol.21 , Issue.2-3 , pp. 127-134
    • Wojton, J.1    Kaur, B.2
  • 19
    • 77953543001 scopus 로고    scopus 로고
    • Double trouble for tumours: Exploiting the tumour microenvironment to enhance anticancer effect of oncolytic viruses
    • De Silva N, Atkins H, Kirn DH, Bell JC, Breitbach CJ. Double trouble for tumours: exploiting the tumour microenvironment to enhance anticancer effect of oncolytic viruses. Cytokine Growth Factor Rev. 2010;21(2-3):135-141.
    • (2010) Cytokine Growth Factor Rev , vol.21 , Issue.2-3 , pp. 135-141
    • de Silva, N.1    Atkins, H.2    Kirn, D.H.3    Bell, J.C.4    Breitbach, C.J.5
  • 20
    • 23344454815 scopus 로고    scopus 로고
    • The potential impact of hypoxia on the success of oncolytic virotherapy
    • Hay JG. The potential impact of hypoxia on the success of oncolytic virotherapy. Curr Opin Mol Ther. 2005;7(4):353-358.
    • (2005) Curr Opin Mol Ther , vol.7 , Issue.4 , pp. 353-358
    • Hay, J.G.1
  • 21
    • 70450200778 scopus 로고    scopus 로고
    • The case of oncolytic viruses versus the immune system: Waiting on the judgment of Solomon
    • Prestwich RJ, Errington F, Diaz RM, et al. The case of oncolytic viruses versus the immune system: waiting on the judgment of Solomon. Hum Gene Ther. 2009;20(10):1119-1132.
    • (2009) Hum Gene Ther , vol.20 , Issue.10 , pp. 1119-1132
    • Prestwich, R.J.1    Errington, F.2    Diaz, R.M.3
  • 22
    • 77953460809 scopus 로고    scopus 로고
    • New perspectives in cancer virotherapy: Bringing the immune system into play
    • Boisgerault N, Tangy F, Gregoire M. New perspectives in cancer virotherapy: bringing the immune system into play. Immunotherapy. 2010;2(2):185-199.
    • (2010) Immunotherapy , vol.2 , Issue.2 , pp. 185-199
    • Boisgerault, N.1    Tangy, F.2    Gregoire, M.3
  • 25
    • 0042208208 scopus 로고    scopus 로고
    • Development of recombinant vesicular stomatitis viruses that exploit defects in host defense to augment specific oncolytic activity
    • Obuchi M, Fernandez M, Barber GN. Development of recombinant vesicular stomatitis viruses that exploit defects in host defense to augment specific oncolytic activity. J Virol. 2003;77(16): 8843-8856.
    • (2003) J Virol , vol.77 , Issue.16 , pp. 8843-8856
    • Obuchi, M.1    Fernandez, M.2    Barber, G.N.3
  • 26
    • 10744223476 scopus 로고    scopus 로고
    • VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents
    • Stojdl DF, Lichty BD, tenOever BR, et al. VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents. Cancer Cell. 2003;4(4):263-275.
    • (2003) Cancer Cell , vol.4 , Issue.4 , pp. 263-275
    • Stojdl, D.F.1    Lichty, B.D.2    Tenoever, B.R.3
  • 27
    • 11144324185 scopus 로고    scopus 로고
    • Disruption of Erk-dependent type I interferon induction breaks the myxoma virus species barrier
    • Wang F, Ma Y, Barrett J W, et al. Disruption of Erk-dependent type I interferon induction breaks the myxoma virus species barrier. Nat Immunol. 2004;5(12):1266-1274.
    • (2004) Nat Immunol , vol.5 , Issue.12 , pp. 1266-1274
    • Wang, F.1    Ma, Y.2    Barrett, J.W.3
  • 28
    • 79958119977 scopus 로고    scopus 로고
    • Oncolytic specificity of Newcastle disease virus is mediated by selectivity for apoptosis-resistant cells
    • Mansour M, Palese P, Zamarin D. Oncolytic specificity of Newcastle disease virus is mediated by selectivity for apoptosis-resistant cells. J Virol. 2011;85(12):6015-6023.
    • (2011) J Virol , vol.85 , Issue.12 , pp. 6015-6023
    • Mansour, M.1    Palese, P.2    Zamarin, D.3
  • 29
    • 84855259830 scopus 로고    scopus 로고
    • Oncolytic viruses: The power of directed evolution
    • article no. 586389. doi:10.1155/2012/ 586389
    • Bauzon M, Hermiston T W. Oncolytic viruses: the power of directed evolution. Adv Virol. 2012; article no. 586389. doi:10.1155/2012/ 586389.
    • (2012) Adv Virol
    • Bauzon, M.1    Hermiston, T.W.2
  • 30
    • 49149090311 scopus 로고    scopus 로고
    • Directed evolution generates a novel oncolytic virus for the treatment of colon cancer
    • Kuhn I, Harden P, Bauzon M, et al. Directed evolution generates a novel oncolytic virus for the treatment of colon cancer. PLoS One. 2008;3(6):e2409.
    • (2008) PLoS One , vol.3 , Issue.6
    • Kuhn, I.1    Harden, P.2    Bauzon, M.3
  • 31
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-674.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 32
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
    • Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res. 1989;49(23):6449-6465.
    • (1989) Cancer Res , vol.49 , Issue.23 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 33
    • 53549102755 scopus 로고    scopus 로고
    • The tumor microenvironment and its role in promoting tumor growth
    • Whiteside TL. The tumor microenvironment and its role in promoting tumor growth. Oncogene. 2008;27(45):5904-5912.
    • (2008) Oncogene , vol.27 , Issue.45 , pp. 5904-5912
    • Whiteside, T.L.1
  • 34
    • 38449114010 scopus 로고    scopus 로고
    • Effect of tumor microenvi-ronment modulation on the effcacy of oncolytic virus therapy
    • Kurozumi K, Hardcastle J, Thakur R, et al. Effect of tumor microenvi-ronment modulation on the effcacy of oncolytic virus therapy. J Natl Cancer Inst. 2007;99(23):1768-1781.
    • (2007) J Natl Cancer Inst , vol.99 , Issue.23 , pp. 1768-1781
    • Kurozumi, K.1    Hardcastle, J.2    Thakur, R.3
  • 35
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
    • Hockel M, Vaupel P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst. 2001;93(4): 266-276.
    • (2001) J Natl Cancer Inst , vol.93 , Issue.4 , pp. 266-276
    • Hockel, M.1    Vaupel, P.2
  • 36
    • 33846204728 scopus 로고    scopus 로고
    • Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: Implications for anticancer therapies
    • Martinive P, Defresne F, Bouzin C, et al. Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: implications for anticancer therapies. Cancer Res. 2006;66(24):11736-11744.
    • (2006) Cancer Res , vol.66 , Issue.24 , pp. 11736-11744
    • Martinive, P.1    Defresne, F.2    Bouzin, C.3
  • 38
    • 79959215471 scopus 로고    scopus 로고
    • Differential hypoxic regulation of hypoxia-inducible factors 1alpha and 2alpha
    • Lin Q, Cong X, Yun Z. Differential hypoxic regulation of hypoxia-inducible factors 1alpha and 2alpha. Mol Cancer Res. 2011; 9(6):757-765.
    • (2011) Mol Cancer Res , vol.9 , Issue.6 , pp. 757-765
    • Lin, Q.1    Cong, X.2    Yun, Z.3
  • 39
    • 0034107952 scopus 로고    scopus 로고
    • Mammalian oxygen sensing, signalling and gene regulation
    • Wenger RH. Mammalian oxygen sensing, signalling and gene regulation. J Exp Biol. 2000;203(Pt 8):1253-1263.
    • (2000) J Exp Biol , vol.203 , Issue.Pt 8 , pp. 1253-1263
    • Wenger, R.H.1
  • 40
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • Pouyssegur J, Dayan F, Mazure NM. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature. 2006;441(7092): 437-443.
    • (2006) Nature , vol.441 , Issue.7092 , pp. 437-443
    • Pouyssegur, J.1    Dayan, F.2    Mazure, N.M.3
  • 41
    • 54549089738 scopus 로고    scopus 로고
    • Hypoxia signalling through mTOR and the unfolded protein response in cancer
    • Wouters BG, Koritzinsky M. Hypoxia signalling through mTOR and the unfolded protein response in cancer. Nat Rev Cancer. 2008;8(11): 851-864.
    • (2008) Nat Rev Cancer , vol.8 , Issue.11 , pp. 851-864
    • Wouters, B.G.1    Koritzinsky, M.2
  • 42
    • 70449687092 scopus 로고    scopus 로고
    • Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha
    • Soeda A, Park M, Lee D, et al. Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha. Oncogene. 2009;28(45):3949-3959.
    • (2009) Oncogene , vol.28 , Issue.45 , pp. 3949-3959
    • Soeda, A.1    Park, M.2    Lee, D.3
  • 43
    • 79960702572 scopus 로고    scopus 로고
    • Hypoxia induces tumor aggressiveness and the expansion of CD133-positive cells in a hypoxia-inducible factor-1α-dependent manner in pancreatic cancer cells
    • Hashimoto O, Shimizu K, Semba S, et al. Hypoxia induces tumor aggressiveness and the expansion of CD133-positive cells in a hypoxia-inducible factor-1α-dependent manner in pancreatic cancer cells. Pathobiolog y. 2011;78(4):181-192.
    • (2011) Pathobiolog Y , vol.78 , Issue.4 , pp. 181-192
    • Hashimoto, O.1    Shimizu, K.2    Semba, S.3
  • 45
    • 80052722539 scopus 로고    scopus 로고
    • Metabolic alterations in highly tumorigenic glioblastoma cells: Preference for hypoxia and high dependency on glycolysis
    • Zhou Y, Zhou Y, Shingu T, et al. Metabolic alterations in highly tumorigenic glioblastoma cells: preference for hypoxia and high dependency on glycolysis. J Biol Chem. 2011;286(37):32843-32853.
    • (2011) J Biol Chem , vol.286 , Issue.37 , pp. 32843-32853
    • Zhou, Y.1    Zhou, Y.2    Shingu, T.3
  • 46
    • 70349754442 scopus 로고    scopus 로고
    • MTOR signal and hypoxia-inducible factor-1 alpha regulate CD133 expression in cancer cells
    • Matsumoto K, Arao T, Tanaka K, et al. mTOR signal and hypoxia-inducible factor-1 alpha regulate CD133 expression in cancer cells. Cancer Res. 2009;69(18):7160-7164.
    • (2009) Cancer Res , vol.69 , Issue.18 , pp. 7160-7164
    • Matsumoto, K.1    Arao, T.2    Tanaka, K.3
  • 48
    • 10344240885 scopus 로고    scopus 로고
    • Cell cycle kinase inhibitor expression and hypoxia-induced cell cycle arrest in human cancer cell lines
    • Box AH, Demetrick DJ. Cell cycle kinase inhibitor expression and hypoxia-induced cell cycle arrest in human cancer cell lines. Carcinogenesis. 2004;25(12):2325-2335.
    • (2004) Carcinogenesis , vol.25 , Issue.12 , pp. 2325-2335
    • Box, A.H.1    Demetrick, D.J.2
  • 49
    • 78650333871 scopus 로고    scopus 로고
    • Targeting hypoxic cells through the DNA damage response
    • Olcina M, Lecane PS, Hammond EM. Targeting hypoxic cells through the DNA damage response. Clin Cancer Res. 2010;16(23):5624-5629.
    • (2010) Clin Cancer Res , vol.16 , Issue.23 , pp. 5624-5629
    • Olcina, M.1    Lecane, P.S.2    Hammond, E.M.3
  • 50
    • 0010170555 scopus 로고
    • Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells
    • Young SD, Marshall RS, Hill R P. Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells. Proc Natl Acad Sci U S A. 1988;85(24):9533-9537.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , Issue.24 , pp. 9533-9537
    • Young, S.D.1    Marshall, R.S.2    Hill, R.P.3
  • 51
    • 44849100198 scopus 로고    scopus 로고
    • NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha
    • Rius J, Guma M, Schachtrup C, et al. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 2008;453(7196):807-811.
    • (2008) Nature , vol.453 , Issue.7196 , pp. 807-811
    • Rius, J.1    Guma, M.2    Schachtrup, C.3
  • 52
    • 78149330949 scopus 로고    scopus 로고
    • HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
    • Corzo CA, Condamine T, Lu L, et al. HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J Exp Med. 2010;207(11):2439-2453.
    • (2010) J Exp Med , vol.207 , Issue.11 , pp. 2439-2453
    • Corzo, C.A.1    Condamine, T.2    Lu, L.3
  • 53
    • 57149142495 scopus 로고    scopus 로고
    • The impact of O2 availability on human cancer
    • Bertout JA, Patel SA, Simon MC. The impact of O2 availability on human cancer. Nat Rev Cancer. 2008;8(12):967-975.
    • (2008) Nat Rev Cancer , vol.8 , Issue.12 , pp. 967-975
    • Bertout, J.A.1    Patel, S.A.2    Simon, M.C.3
  • 54
    • 77955295091 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor infammation
    • Imtiyaz HZ, Williams E P, Hickey MM, et al. Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor infammation. J Clin Invest. 2010;120(8):2699-2714.
    • (2010) J Clin Invest , vol.120 , Issue.8 , pp. 2699-2714
    • Imtiyaz, H.Z.1    Williams, E.P.2    Hickey, M.M.3
  • 55
    • 78449300594 scopus 로고    scopus 로고
    • CXCL12/CXCR4/CXCR7 chemokine axis and cancer progression
    • Sun X, Cheng G, Hao M, et al. CXCL12/CXCR4/CXCR7 chemokine axis and cancer progression. Cancer Metastasis Rev. 2010;29(4): 709-722.
    • (2010) Cancer Metastasis Rev , vol.29 , Issue.4 , pp. 709-722
    • Sun, X.1    Cheng, G.2    Hao, M.3
  • 56
    • 77957350018 scopus 로고    scopus 로고
    • Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression
    • Doedens AL, Stockmann C, Rubinstein M P, et al. Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression. Cancer Res. 2010;70(19): 7465-7475.
    • (2010) Cancer Res , vol.70 , Issue.19 , pp. 7465-7475
    • Doedens, A.L.1    Stockmann, C.2    Rubinstein, M.P.3
  • 57
    • 24044461733 scopus 로고    scopus 로고
    • Macrophage responses to hypoxia: Implications for tumor progression and anti-cancer therapies
    • Lewis C, Murdoch C. Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies. Am J Pathol. 2005;167(3):627-635.
    • (2005) Am J Pathol , vol.167 , Issue.3 , pp. 627-635
    • Lewis, C.1    Murdoch, C.2
  • 58
    • 34347231274 scopus 로고    scopus 로고
    • Macrophages and the hypoxic tumour microen-vironment
    • Knowles HJ, Harris AL. Macrophages and the hypoxic tumour microen-vironment. Front Biosci. 2007;12:4298-4314.
    • (2007) Front Biosci , vol.12 , pp. 4298-4314
    • Knowles, H.J.1    Harris, A.L.2
  • 59
    • 77950944395 scopus 로고    scopus 로고
    • Macrophages, innate immunity and cancer: Balance, tolerance, and diversity
    • Mantovani A, Sica A. Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr Opin Immunol. 2010;22(2):231-237.
    • (2010) Curr Opin Immunol , vol.22 , Issue.2 , pp. 231-237
    • Mantovani, A.1    Sica, A.2
  • 60
    • 58149147369 scopus 로고    scopus 로고
    • Hypoxia-adenosinergic immunosuppression: Tumor protection by T regulatory cells and cancerous tissue hypoxia
    • Sitkovsky M V, Kjaergaard J, Lukashev D, Ohta A. Hypoxia-adenosinergic immunosuppression: tumor protection by T regulatory cells and cancerous tissue hypoxia. Clin Cancer Res. 2008;14(19): 5947-5952.
    • (2008) Clin Cancer Res , vol.14 , Issue.19 , pp. 5947-5952
    • Sitkovsky, M.V.1    Kjaergaard, J.2    Lukashev, D.3    Ohta, A.4
  • 61
    • 65449154326 scopus 로고    scopus 로고
    • The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis
    • Noman MZ, Buart S, Van Pelt J, et al. The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis. J Immunol. 2009;182(6):3510-3521.
    • (2009) J Immunol , vol.182 , Issue.6 , pp. 3510-3521
    • Noman, M.Z.1    Buart, S.2    van Pelt, J.3
  • 62
    • 80054769985 scopus 로고    scopus 로고
    • Hypoxia-dependent inhibition of tumor cell susceptibility to CTL-mediated lysis involves NANOG induction in target cells
    • Hasmim M, Noman MZ, Lauriol J, et al. Hypoxia-dependent inhibition of tumor cell susceptibility to CTL-mediated lysis involves NANOG induction in target cells. J Immunol. 2011;187(8):4031-4039.
    • (2011) J Immunol , vol.187 , Issue.8 , pp. 4031-4039
    • Hasmim, M.1    Noman, M.Z.2    Lauriol, J.3
  • 63
    • 79960393113 scopus 로고    scopus 로고
    • Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells
    • Facciabene A, Peng X, Hagemann IS, et al. Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature. 2011; 475(7355):226-230.
    • (2011) Nature , vol.475 , Issue.7355 , pp. 226-230
    • Facciabene, A.1    Peng, X.2    Hagemann, I.S.3
  • 64
    • 79957534572 scopus 로고    scopus 로고
    • Targeting hypoxia in cancer therapy
    • Wilson WR, Hay M P. Targeting hypoxia in cancer therapy. Nat Rev Cancer. 2011;11(6):393-410.
    • (2011) Nat Rev Cancer , vol.11 , Issue.6 , pp. 393-410
    • Wilson, W.R.1    Hay, M.P.2
  • 65
    • 44349157832 scopus 로고    scopus 로고
    • Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
    • Dewhirst M W, Cao Y, Moeller B. Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer. 2008; 8(6):425-437.
    • (2008) Nat Rev Cancer , vol.8 , Issue.6 , pp. 425-437
    • Dewhirst, M.W.1    Cao, Y.2    Moeller, B.3
  • 66
    • 68349128259 scopus 로고    scopus 로고
    • Hypoxia and radiation therapy: Past history, ongoing research, and future promise
    • Rockwell S, Dobrucki IT, Kim EY, Marrison ST, Vu VT. Hypoxia and radiation therapy: past history, ongoing research, and future promise. Curr Mol Med. 2009;9(4):442-458.
    • (2009) Curr Mol Med , vol.9 , Issue.4 , pp. 442-458
    • Rockwell, S.1    Dobrucki, I.T.2    Kim, E.Y.3    Marrison, S.T.4    Vu, V.T.5
  • 67
    • 79958191830 scopus 로고    scopus 로고
    • Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways
    • Rohwer N, Cramer T. Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways. Drug Resist Updat. 2011;14(3):191-201.
    • (2011) Drug Resist Updat , vol.14 , Issue.3 , pp. 191-201
    • Rohwer, N.1    Cramer, T.2
  • 68
    • 77957786826 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha determines gastric cancer chemosensitivity via modulation of p53 and NF-kappaB
    • Rohwer N, Dame C, Haugstetter A, et al. Hypoxia-inducible factor 1alpha determines gastric cancer chemosensitivity via modulation of p53 and NF-kappaB. PLoS One. 2010;5(8):e12038.
    • (2010) PLoS One , vol.5 , Issue.8
    • Rohwer, N.1    Dame, C.2    Haugstetter, A.3
  • 69
    • 2942590732 scopus 로고    scopus 로고
    • Exploiting tumour hypoxia in cancer treatment
    • Brown JM, Wilson WR. Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer. 2004;4(6):437-447.
    • (2004) Nat Rev Cancer , vol.4 , Issue.6 , pp. 437-447
    • Brown, J.M.1    Wilson, W.R.2
  • 70
    • 77951838524 scopus 로고    scopus 로고
    • Antiangiogenic cancer therapy combined with oncolytic virotherapy leads to regression of established tumors in mice
    • Kottke T, Hall G, Pulido J, et al. Antiangiogenic cancer therapy combined with oncolytic virotherapy leads to regression of established tumors in mice. J Clin Invest. 2010;120(5):1551-1560.
    • (2010) J Clin Invest , vol.120 , Issue.5 , pp. 1551-1560
    • Kottke, T.1    Hall, G.2    Pulido, J.3
  • 71
    • 79955619094 scopus 로고    scopus 로고
    • Targeting tumor vasculature with an oncolytic virus
    • Breitbach CJ, De Silva NS, Falls TJ, et al. Targeting tumor vasculature with an oncolytic virus. Mol Ther. 2011;19(5):886-894.
    • (2011) Mol Ther , vol.19 , Issue.5 , pp. 886-894
    • Breitbach, C.J.1    de Silva, N.S.2    Falls, T.J.3
  • 72
    • 77949654870 scopus 로고    scopus 로고
    • Enhanced specifc delivery and targeting of oncolytic Sindbis viral vectors by modulating vascular leakiness in tumor
    • Tseng JC, Granot T, DiGiacomo V, Levin B, Meruelo D. Enhanced specifc delivery and targeting of oncolytic Sindbis viral vectors by modulating vascular leakiness in tumor. Cancer Gene Ther. 2010; 17(4):244-255.
    • (2010) Cancer Gene Ther , vol.17 , Issue.4 , pp. 244-255
    • Tseng, J.C.1    Granot, T.2    Digiacomo, V.3    Levin, B.4    Meruelo, D.5
  • 74
    • 34548062828 scopus 로고    scopus 로고
    • Targeted infammation during oncolytic virus therapy severely compromises tumor blood fow
    • Breitbach CJ, Paterson JM, Lemay CG, et al. Targeted infammation during oncolytic virus therapy severely compromises tumor blood fow. Mol Ther. 2007;15(9):1686-1693.
    • (2007) Mol Ther , vol.15 , Issue.9 , pp. 1686-1693
    • Breitbach, C.J.1    Paterson, J.M.2    Lemay, C.G.3
  • 75
    • 38049017526 scopus 로고    scopus 로고
    • Targeting of interferon-beta to produce a specifc, multi-mechanistic oncolytic vaccinia virus
    • Kirn DH, Wang Y, Le Boeuf F, Bell J, Thorne SH. Targeting of interferon-beta to produce a specifc, multi-mechanistic oncolytic vaccinia virus. PLoS Med. 2007;4(12):e353.
    • (2007) PLoS Med , vol.4 , Issue.12
    • Kirn, D.H.1    Wang, Y.2    Le-Boeuf, F.3    Bell, J.4    Thorne, S.H.5
  • 76
    • 0036399291 scopus 로고    scopus 로고
    • New oncolytic adenoviruses with hypoxia- and estrogen receptor-regulated replication
    • Hernandez-Alcoceba R, Pihalja M, Qian D, Clarke MF. New oncolytic adenoviruses with hypoxia- and estrogen receptor-regulated replication. Hum Gene Ther. 2002;13(14):1737-1750.
    • (2002) Hum Gene Ther , vol.13 , Issue.14 , pp. 1737-1750
    • Hernandez-Alcoceba, R.1    Pihalja, M.2    Qian, D.3    Clarke, M.F.4
  • 77
    • 0037509944 scopus 로고    scopus 로고
    • A novel hypoxia-inducible factor (HIF) activated oncolytic adenovirus for cancer therapy
    • Post DE, Van Meir EG. A novel hypoxia-inducible factor (HIF) activated oncolytic adenovirus for cancer therapy. Oncogene. 2003; 22(14):2065-2072.
    • (2003) Oncogene , vol.22 , Issue.14 , pp. 2065-2072
    • Post, D.E.1    van Meir, E.G.2
  • 78
    • 0142157670 scopus 로고    scopus 로고
    • Specifc oncolytic effect of a new hypoxia-inducible factor-dependent replicative adenovirus on von Hippel-Lindau-defective renal cell carcinomas
    • Cuevas Y, Hernandez-Alcoceba R, Aragones J, et al. Specifc oncolytic effect of a new hypoxia-inducible factor-dependent replicative adenovirus on von Hippel-Lindau-defective renal cell carcinomas. Cancer Res. 2003;63(20):6877-6884.
    • (2003) Cancer Res , vol.63 , Issue.20 , pp. 6877-6884
    • Cuevas, Y.1    Hernandez-Alcoceba, R.2    Aragones, J.3
  • 79
    • 7044233630 scopus 로고    scopus 로고
    • Oncolytic effects of adenovirus mutant capable of replicating in hypoxic and normoxic regions of solid tumor
    • Cho WK, Seong YR, Lee YH, et al. Oncolytic effects of adenovirus mutant capable of replicating in hypoxic and normoxic regions of solid tumor. Mol Ther. 2004;10(5):938-949.
    • (2004) Mol Ther , vol.10 , Issue.5 , pp. 938-949
    • Cho, W.K.1    Seong, Y.R.2    Lee, Y.H.3
  • 80
    • 11144229120 scopus 로고    scopus 로고
    • Cancer therapy with a replicating oncolytic adenovirus targeting the hypoxic microenvironment of tumors
    • Post DE, Devi NS, Li Z, et al. Cancer therapy with a replicating oncolytic adenovirus targeting the hypoxic microenvironment of tumors. Clin Cancer Res. 2004;10(24):8603-8612.
    • (2004) Clin Cancer Res , vol.10 , Issue.24 , pp. 8603-8612
    • Post, D.E.1    Devi, N.S.2    Li, Z.3
  • 81
    • 20744442757 scopus 로고    scopus 로고
    • Effect of hypoxia on Ad5 infection, transgene expression and replication
    • Shen BH, Hermiston T W. Effect of hypoxia on Ad5 infection, transgene expression and replication. Gene Ther. 2005;12(11):902-910.
    • (2005) Gene Ther , vol.12 , Issue.11 , pp. 902-910
    • Shen, B.H.1    Hermiston, T.W.2
  • 82
    • 20744460916 scopus 로고    scopus 로고
    • Hypoxia reduces adenoviral replication in cancer cells by downregulation of viral protein expression
    • Pipiya T, Sauthoff H, Huang YQ, et al. Hypoxia reduces adenoviral replication in cancer cells by downregulation of viral protein expression. Gene Ther. 2005;12(11):911-917.
    • (2005) Gene Ther , vol.12 , Issue.11 , pp. 911-917
    • Pipiya, T.1    Sauthoff, H.2    Huang, Y.Q.3
  • 83
    • 33744808553 scopus 로고    scopus 로고
    • The effect of hypoxia on the uptake, replication and lytic potential of group B adenovirus type 3 (Ad3) and type 11p (Ad11p)
    • Shen BH, Bauzon M, Hermiston T W. The effect of hypoxia on the uptake, replication and lytic potential of group B adenovirus type 3 (Ad3) and type 11p (Ad11p). Gene Ther. 2006;13(12):986-990.
    • (2006) Gene Ther , vol.13 , Issue.12 , pp. 986-990
    • Shen, B.H.1    Bauzon, M.2    Hermiston, T.W.3
  • 84
    • 78650017203 scopus 로고    scopus 로고
    • Second-generation HIF-activated oncolytic adenoviruses with improved replication, oncolytic, and antitumor effcacy
    • Cherry T, Longo SL, Tovar-Spinoza Z, Post DE. Second-generation HIF-activated oncolytic adenoviruses with improved replication, oncolytic, and antitumor effcacy. Gene Ther. 2010;17(12):1430-1441.
    • (2010) Gene Ther , vol.17 , Issue.12 , pp. 1430-1441
    • Cherry, T.1    Longo, S.L.2    Tovar-Spinoza, Z.3    Post, D.E.4
  • 85
    • 33751290743 scopus 로고    scopus 로고
    • Increased safety with preserved antitumoral efficacy on hepatocellular carcinoma with dual-regulated oncolytic adenovirus
    • Zhang Q, Chen G, Peng L, et al. Increased safety with preserved antitumoral efficacy on hepatocellular carcinoma with dual-regulated oncolytic adenovirus. Clin Cancer Res. 2006;12(21): 6523-6531.
    • (2006) Clin Cancer Res , vol.12 , Issue.21 , pp. 6523-6531
    • Zhang, Q.1    Chen, G.2    Peng, L.3
  • 86
    • 49849092967 scopus 로고    scopus 로고
    • A novel triple-regulated oncolytic adenovirus carrying p53 gene exerts potent antitumor effcacy on common human solid cancers
    • Wang X, Su C, Cao H, et al. A novel triple-regulated oncolytic adenovirus carrying p53 gene exerts potent antitumor effcacy on common human solid cancers. Mol Cancer Ther. 2008;7(6):1598-1603.
    • (2008) Mol Cancer Ther , vol.7 , Issue.6 , pp. 1598-1603
    • Wang, X.1    Su, C.2    Cao, H.3
  • 87
    • 80054729738 scopus 로고    scopus 로고
    • Adenovirus-mediated hypoxia-targeted gene therapy using HSV thymidine kinase and bacterial nitroreductase prodrug-activating genes in vitro and in vivo
    • Harvey TJ, Hennig IM, Shnyder SD, et al. Adenovirus-mediated hypoxia-targeted gene therapy using HSV thymidine kinase and bacterial nitroreductase prodrug-activating genes in vitro and in vivo. Cancer Gene Ther. 2011;18(11):773-784.
    • (2011) Cancer Gene Ther , vol.18 , Issue.11 , pp. 773-784
    • Harvey, T.J.1    Hennig, I.M.2    Shnyder, S.D.3
  • 88
    • 69249217795 scopus 로고    scopus 로고
    • Ad5/3-9HIF-Delta24-VEGFR-1-Ig, an infectivity enhanced, dual-targeted and antiangiogenic onco-lytic adenovirus for kidney cancer treatment
    • Guse K, Diaconu I, Rajecki M, et al. Ad5/3-9HIF-Delta24-VEGFR-1-Ig, an infectivity enhanced, dual-targeted and antiangiogenic onco-lytic adenovirus for kidney cancer treatment. Gene Ther. 2009;16(8): 1009-1020.
    • (2009) Gene Ther , vol.16 , Issue.8 , pp. 1009-1020
    • Guse, K.1    Diaconu, I.2    Rajecki, M.3
  • 89
    • 63149110100 scopus 로고    scopus 로고
    • Antitumor activity of an oncolytic adenoviral-CD40 ligand (CD154) transgene construct in human breast cancer cells
    • Gomes EM, Rodrigues MS, Phadke A P, et al. Antitumor activity of an oncolytic adenoviral-CD40 ligand (CD154) transgene construct in human breast cancer cells. Clin Cancer Res. 2009;15(4):1317-1325.
    • (2009) Clin Cancer Res , vol.15 , Issue.4 , pp. 1317-1325
    • Gomes, E.M.1    Rodrigues, M.S.2    Phadke, A.P.3
  • 90
    • 34547092699 scopus 로고    scopus 로고
    • Targeted cancer gene therapy using a hypoxia inducible factor dependent oncolytic adenovirus armed with interleukin-4
    • Post DE, Sandberg EM, Kyle MM, et al. Targeted cancer gene therapy using a hypoxia inducible factor dependent oncolytic adenovirus armed with interleukin-4. Cancer Res. 2007;67(14):6872-6881.
    • (2007) Cancer Res , vol.67 , Issue.14 , pp. 6872-6881
    • Post, D.E.1    Sandberg, E.M.2    Kyle, M.M.3
  • 91
    • 78650381982 scopus 로고    scopus 로고
    • A hypoxia- and {alpha}-fetoprotein-dependent oncolytic adenovirus exhibits specifc killing of hepatocellular carcinomas
    • Kwon OJ, Kim PH, Huyn S, et al. A hypoxia- and {alpha}-fetoprotein-dependent oncolytic adenovirus exhibits specifc killing of hepatocellular carcinomas. Clin Cancer Res. 2010;16(24):6071-6082.
    • (2010) Clin Cancer Res , vol.16 , Issue.24 , pp. 6071-6082
    • Kwon, O.J.1    Kim, P.H.2    Huyn, S.3
  • 92
    • 58149214278 scopus 로고    scopus 로고
    • Hypoxia enhances the replication of oncolytic herpes simplex virus
    • Aghi MK, Liu TC, Rabkin S, Martuza RL. Hypoxia enhances the replication of oncolytic herpes simplex virus. Mol Ther. 2009;17(1): 51-56.
    • (2009) Mol Ther , vol.17 , Issue.1 , pp. 51-56
    • Aghi, M.K.1    Liu, T.C.2    Rabkin, S.3    Martuza, R.L.4
  • 93
    • 68049110425 scopus 로고    scopus 로고
    • Hypoxia enhances the replication of oncolytic herpes simplex virus in p53- breast cancer cells
    • Fasullo M, Burch AD, Britton A. Hypoxia enhances the replication of oncolytic herpes simplex virus in p53- breast cancer cells. Cell Cycle. 2009;8(14):2194-2197.
    • (2009) Cell Cycle , vol.8 , Issue.14 , pp. 2194-2197
    • Fasullo, M.1    Burch, A.D.2    Britton, A.3
  • 94
    • 78751631362 scopus 로고    scopus 로고
    • Development of an oncolytic herpes simplex virus using a tumor-specifc HIF-responsive promoter
    • Longo SL, Griffth C, Glass A, Shillitoe EJ, Post DE. Development of an oncolytic herpes simplex virus using a tumor-specifc HIF-responsive promoter. Cancer Gene Ther. 2011;18(2):123-134.
    • (2011) Cancer Gene Ther , vol.18 , Issue.2 , pp. 123-134
    • Longo, S.L.1    Griffth, C.2    Glass, A.3    Shillitoe, E.J.4    Post, D.E.5
  • 95
    • 76749114681 scopus 로고    scopus 로고
    • Lister strain vaccinia virus, a potential therapeutic vector targeting hypoxic tumours
    • Hiley CT, Yuan M, Lemoine NR, Wang Y. Lister strain vaccinia virus, a potential therapeutic vector targeting hypoxic tumours. Gene Ther. 2010;17(2):281-287.
    • (2010) Gene Ther , vol.17 , Issue.2 , pp. 281-287
    • Hiley, C.T.1    Yuan, M.2    Lemoine, N.R.3    Wang, Y.4
  • 96
    • 4143126659 scopus 로고    scopus 로고
    • Replication and cytopathic effect of oncolytic vesicular stomatitis virus in hypoxic tumor cells in vitro and in vivo
    • Connor JH, Naczki C, Koumenis C, Lyles DS. Replication and cytopathic effect of oncolytic vesicular stomatitis virus in hypoxic tumor cells in vitro and in vivo. J Virol. 2004;78(17):8960-8970.
    • (2004) J Virol , vol.78 , Issue.17 , pp. 8960-8970
    • Connor, J.H.1    Naczki, C.2    Koumenis, C.3    Lyles, D.S.4
  • 97
    • 33750304364 scopus 로고    scopus 로고
    • Loss of VHL confers hypoxia-inducible factor (HIF)-dependent resistance to vesicular stomatitis virus: Role of HIF in antiviral response
    • Hwang II, Watson IR, Der SD, Ohh M. Loss of VHL confers hypoxia-inducible factor (HIF)-dependent resistance to vesicular stomatitis virus: role of HIF in antiviral response. J Virol. 2006;80(21):10712-10723.
    • (2006) J Virol , vol.80 , Issue.21 , pp. 10712-10723
    • Hwang, I.I.1    Watson, I.R.2    Der, S.D.3    Ohh, M.4
  • 98
    • 0033587146 scopus 로고    scopus 로고
    • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • Maxwell PH, Wiesener MS, Chang G W, et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 1999;399(6733):271-275.
    • (1999) Nature , vol.399 , Issue.6733 , pp. 271-275
    • Maxwell, P.H.1    Wiesener, M.S.2    Chang, G.W.3
  • 99
    • 78650880193 scopus 로고    scopus 로고
    • Vesicular stomatitis virus-induced immune suppressor cells generate antagonism between intratumoral oncolytic virus and cyclophosphamide
    • Willmon C, Diaz RM, Wongthida P, et al. Vesicular stomatitis virus-induced immune suppressor cells generate antagonism between intratumoral oncolytic virus and cyclophosphamide. Mol Ther. 2011;19(1):140-149.
    • (2011) Mol Ther , vol.19 , Issue.1 , pp. 140-149
    • Willmon, C.1    Diaz, R.M.2    Wongthida, P.3
  • 100
    • 81255164999 scopus 로고    scopus 로고
    • VSV oncolytic treatment interferes with tumor associated dendritic cell function and abrogates tumor antigen presentation
    • Leveille S, Goulet ML, Lichty BD, Hiscott J. VSV oncolytic treatment interferes with tumor associated dendritic cell function and abrogates tumor antigen presentation. J Virol. 2011;85(23): 12160-12169.
    • (2011) J Virol , vol.85 , Issue.23 , pp. 12160-12169
    • Leveille, S.1    Goulet, M.L.2    Lichty, B.D.3    Hiscott, J.4
  • 101
    • 77951098753 scopus 로고    scopus 로고
    • Down-regulation of HIF-1alpha by oncolytic reovirus infection independently of VHL and p53
    • Cho IR, Koh SS, Min HJ, et al. Down-regulation of HIF-1alpha by oncolytic reovirus infection independently of VHL and p53. Cancer Gene Ther. 2010;17(5):365-372.
    • (2010) Cancer Gene Ther , vol.17 , Issue.5 , pp. 365-372
    • Cho, I.R.1    Koh, S.S.2    Min, H.J.3
  • 102
    • 79951821209 scopus 로고    scopus 로고
    • Phase I clinical study of Seneca Valley Virus (SVV-001), a replication-competent picornavirus, in advanced solid tumors with neuroendocrine features
    • Rudin CM, Poirier JT, Senzer NN, et al. Phase I clinical study of Seneca Valley Virus (SVV-001), a replication-competent picornavirus, in advanced solid tumors with neuroendocrine features. Clin Cancer Res. 2011;17(4):888-895.
    • (2011) Clin Cancer Res , vol.17 , Issue.4 , pp. 888-895
    • Rudin, C.M.1    Poirier, J.T.2    Senzer, N.N.3
  • 103
    • 77956929126 scopus 로고    scopus 로고
    • Oncolytic targeting of renal cell carcinoma via encephalomyocarditis virus
    • Roos FC, Roberts AM, Hwang II, et al. Oncolytic targeting of renal cell carcinoma via encephalomyocarditis virus. EMBO Mol Med. 2010;2(7):275-288.
    • (2010) EMBO Mol Med , vol.2 , Issue.7 , pp. 275-288
    • Roos, F.C.1    Roberts, A.M.2    Hwang, I.I.3
  • 104
    • 4944244259 scopus 로고    scopus 로고
    • Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
    • Murdoch C, Giannoudis A, Lewis CE. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood. 2004;104(8):2224-2234.
    • (2004) Blood , vol.104 , Issue.8 , pp. 2224-2234
    • Murdoch, C.1    Giannoudis, A.2    Lewis, C.E.3
  • 105
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • Qian BZ, Pollard J W. Macrophage diversity enhances tumor progression and metastasis. Cell. 2010;141(1):39-51.
    • (2010) Cell , vol.141 , Issue.1 , pp. 39-51
    • Qian, B.Z.1    Pollard, J.W.2
  • 106
    • 79952233838 scopus 로고    scopus 로고
    • Use of macrophages to target therapeutic adenovirus to human prostate tumors
    • Muthana M, Giannoudis A, Scott SD, et al. Use of macrophages to target therapeutic adenovirus to human prostate tumors. Cancer Res. 2011;71(5):1805-1815.
    • (2011) Cancer Res , vol.71 , Issue.5 , pp. 1805-1815
    • Muthana, M.1    Giannoudis, A.2    Scott, S.D.3
  • 107
    • 84855291079 scopus 로고    scopus 로고
    • Hypoxic homing in prostate cancer
    • March 24. doi:10.1038/scibx.2011.1330
    • Baas T. Hypoxic homing in prostate cancer. SciBX. 2011;March 24. doi:10.1038/scibx.2011.1330.
    • (2011) SciBX
    • Baas, T.1
  • 108
    • 49249131785 scopus 로고    scopus 로고
    • Virus combinations and chemotherapy for the treatment of human cancers
    • Kumar S, Gao L, Yeagy B, Reid T. Virus combinations and chemotherapy for the treatment of human cancers. Curr Opin Mol Ther. 2008;10(4):371-379.
    • (2008) Curr Opin Mol Ther , vol.10 , Issue.4 , pp. 371-379
    • Kumar, S.1    Gao, L.2    Yeagy, B.3    Reid, T.4
  • 109
    • 79954607446 scopus 로고    scopus 로고
    • Mathematical modeling predicts synergistic antitumor effects of combining a macrophage-based, hypoxia-targeted gene therapy with chemotherapy
    • Owen MR, Stamper IJ, Muthana M, et al. Mathematical modeling predicts synergistic antitumor effects of combining a macrophage-based, hypoxia-targeted gene therapy with chemotherapy. Cancer Res. 2011;71(8):2826-2837.
    • (2011) Cancer Res , vol.71 , Issue.8 , pp. 2826-2837
    • Owen, M.R.1    Stamper, I.J.2    Muthana, M.3
  • 111
    • 85027956453 scopus 로고    scopus 로고
    • Thunder and lightning: Immunotherapy and oncolytic viruses collide
    • Melcher A, Parato K, Rooney CM, Bell JC. Thunder and lightning: immunotherapy and oncolytic viruses collide. Mol Ther. 2011; 19(6):1008-1016.
    • (2011) Mol Ther , vol.19 , Issue.6 , pp. 1008-1016
    • Melcher, A.1    Parato, K.2    Rooney, C.M.3    Bell, J.C.4
  • 112
    • 84855259828 scopus 로고    scopus 로고
    • Oncolytic viruses, a step into cancer immunotherapy
    • In press
    • Pol JG, Resseguier J, Lighty BD. Oncolytic viruses, a step into cancer immunotherapy. Virus Adapt Treat. 2011;3. In press.
    • (2011) Virus Adapt Treat , vol.3
    • Pol, J.G.1    Resseguier, J.2    Lighty, B.D.3
  • 113
    • 79957894276 scopus 로고    scopus 로고
    • Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
    • Carmeliet P, Jain RK. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov. 2011;10(6):417-427.
    • (2011) Nat Rev Drug Discov , vol.10 , Issue.6 , pp. 417-427
    • Carmeliet, P.1    Jain, R.K.2
  • 114
    • 68049144956 scopus 로고    scopus 로고
    • Tumor vascular changes mediated by inhibition of oncogenic signaling
    • Qayum N, Muschel RJ, Im JH, et al. Tumor vascular changes mediated by inhibition of oncogenic signaling. Cancer Res. 2009;69(15): 6347-6354.
    • (2009) Cancer Res , vol.69 , Issue.15 , pp. 6347-6354
    • Qayum, N.1    Muschel, R.J.2    Im, J.H.3


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