Hypoxia induces tumor aggressiveness and the expansion of CD133-positive cells in a hypoxia-inducible factor-1α-dependent manner in pancreatic cancer cells

Pathobiology

Volumn 78, Issue 4, 2011, Pages 181-192

  Hashimoto, Okito ^a   Shimizu, Kazuya ^c   Semba, Shuho ^a   Chiba, Sachie ^b   Ku, Yonson ^b   Yokozaki, Hiroshi ^a   Hori, Yuichi ^b  

^a Division of Pathology   (Japan)

^b KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c Graduate School of Health Sciences   (Japan)

Author keywords

Cancer stem cell; CD133; CXC chemokine receptor 4; Hypoxia; Hypoxia inducible factor 1 ; Pancreatic cancer

Indexed keywords

BETA ACTIN; CD133 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; HYPOXIA INDUCIBLE FACTOR 1ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CANCER CELL CULTURE; CANCER INVASION; CELL EXPANSION; CELL HYPOXIA; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; METASTASIS; MOUSE; NONHUMAN; PANCREAS CANCER; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROVIRUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR XENOGRAFT; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; ANOXIA; ANTIGENS, CD; BASE SEQUENCE; CELL LINE, TUMOR; DNA PRIMERS; GENE EXPRESSION; GLYCOPROTEINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, SCID; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; NEOPLASTIC STEM CELLS; PANCREATIC NEOPLASMS; PEPTIDES; RECEPTORS, CXCR4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 79960702572     PISSN: 10152008     EISSN: 14230291     Source Type: Journal    
DOI: 10.1159/000325538     Document Type: Article

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