메뉴 건너뛰기




Volumn 2011, Issue , 2011, Pages

Genetic variance in uncoupling protein 2 in relation to obesity, type 2 diabetes, and related metabolic traits: Focus on the functional -866G>A promoter variant (rs659366)

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84455207168     PISSN: 20900708     EISSN: 20900716     Source Type: Journal    
DOI: 10.1155/2011/340241     Document Type: Review
Times cited : (53)

References (110)
  • 1
    • 15144356206 scopus 로고    scopus 로고
    • Cloning and characterization of an uncoupling protein homolog: A potential molecular mediator of human thermogenesis
    • Gimeno R. E., Dembski M., Weng X., Deng N., Shyjan A. W., Gimeno C. J., Iris F., Ellis S. J., Woolf E. A., Tartaglia L. A., Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. Diabetes 1997 46 5 900 906 2-s2.0-15144356206 (Pubitemid 27188271)
    • (1997) Diabetes , vol.46 , Issue.5 , pp. 900-906
    • Gimeno, R.E.1    Dembski, M.2    Weng, X.3    Deng, N.4    Shyjan, A.W.5    Gimeno, C.J.6    Iris, F.7    Ellis, S.J.8    Woolf, E.A.9    Tartaglia, L.A.10
  • 3
    • 0030988140 scopus 로고    scopus 로고
    • Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression
    • DOI 10.1016/S0014-5793(97)00384-0, PII S0014579397003840
    • Boss O., Samec S., Paoloni-Giacobino A., Rossier C., Dulloo A., Seydoux J., Muzzin P., Giacobino J. P., Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Letters 1997 408 1 39 42 2-s2.0-0030988140 10.1016/S0014-5793(97)00384-0 (Pubitemid 27216458)
    • (1997) FEBS Letters , vol.408 , Issue.1 , pp. 39-42
    • Boss, O.1    Samec, S.2    Paoloni-Giacobino, A.3    Rossier, C.4    Dulloo, A.5    Seydoux, J.6    Muzzin, P.7    Giacobino, J.-P.8
  • 4
    • 0032994739 scopus 로고    scopus 로고
    • Uncoupling protein-3 (UCP3): A mitochondrial carrier in search of a function
    • Lowell B. B., Uncoupling protein-3 (UCP3): a mitochondrial carrier in search of a function. International Journal of Obesity 1999 23 supplement 6 S43 S45 2-s2.0-0032994739 (Pubitemid 29322609)
    • (1999) International Journal of Obesity , vol.23 , Issue.SUPPL. 6
    • Lowell, B.B.1
  • 6
    • 0033899544 scopus 로고    scopus 로고
    • Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation
    • Yu X. X., Mao W., Zhong A., Schow P., Brush J., Sherwood S. W., Adams S. H., Pan G., Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation. FASEB Journal 2000 14 11 1611 1618 2-s2.0-0033899544 (Pubitemid 30639072)
    • (2000) FASEB Journal , vol.14 , Issue.11 , pp. 1611-1618
    • Xing Xian Yu1    Mao, W.2    Zhong, A.3    Schow, P.4    Brush, J.5    Sherwood, S.W.6    Adams, S.H.7    Pan, G.8
  • 7
    • 0032998265 scopus 로고    scopus 로고
    • UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells
    • DOI 10.1016/S0014-5793(98)01713-X, PII S001457939801713X
    • Mao W., Yu X. X., Zhong A., Li W., Brush J., Sherwood S. W., Adams S. H., Pan G., UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. FEBS Letters 1999 443 3 326 330 2-s2.0-0032998265 10.1016/S0014-5793(98)01713-X (Pubitemid 29080820)
    • (1999) FEBS Letters , vol.443 , Issue.3 , pp. 326-330
    • Mao, W.1    Yu, X.X.2    Zhong, A.3    Li, W.4    Brush, J.5    Sherwood, S.W.6    Adams, S.H.7    Pan, G.8
  • 10
    • 0031560941 scopus 로고    scopus 로고
    • UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue
    • DOI 10.1006/bbrc.1997.6740
    • Vidal-Puig A., Solanes G., Grujic D., Flier J. S., Lowell B. B., UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochemical and Biophysical Research Communications 1997 235 1 79 82 2-s2.0-0031560941 10.1006/bbrc.1997.6740 (Pubitemid 27302688)
    • (1997) Biochemical and Biophysical Research Communications , vol.235 , Issue.1 , pp. 79-82
    • Vidal-Puig, A.1    Solanes, G.2    Grujic, D.3    Flier, J.S.4    Lowell, B.B.5
  • 11
    • 0033046585 scopus 로고    scopus 로고
    • Post-starvation gene expression of skeletal muscle uncoupling protein 2 and uncoupling protein 3 in response to dietary fat levels and fatty acid composition: A link with insulin resistance
    • DOI 10.2337/diabetes.48.2.436
    • Samec S., Seydoux J., Dulloo A. G., Post-starvation gene expression of skeletal muscle uncoupling protein 2 and uncoupling protein 3 in response to dietary fat levels and fatty acid composition: a link with insulin resistance. Diabetes 1999 48 2 436 441 2-s2.0-0033046585 10.2337/diabetes.48.2.436 (Pubitemid 29061124)
    • (1999) Diabetes , vol.48 , Issue.2 , pp. 436-441
    • Samec, S.1    Seydoux, J.2    Dulloo, A.G.3
  • 12
    • 0032874628 scopus 로고    scopus 로고
    • Skeletal muscle UCP3 and UCP2 gene expression in response to inhibition of free fatty acid flux through mitochondrial β-oxidation
    • DOI 10.1007/s004240051061
    • Samec S., Seydoux J., Dulloo A. G., Skeletal muscle UCP3 and UCP2 gene expression in response to inhibition of free fatty acid flux through mitochondrial β -oxidation. Pflugers Archiv European Journal of Physiology 1999 438 4 452 457 2-s2.0-0032874628 10.1007/s004240051061 (Pubitemid 29419898)
    • (1999) Pflugers Archiv European Journal of Physiology , vol.438 , Issue.4 , pp. 452-457
    • Samec, S.1    Seydoux, J.2    Dulloo, A.G.3
  • 13
    • 0032435791 scopus 로고    scopus 로고
    • Increased uncoupling protein-2 and -3 gene expressions in skeletal muscle of STZ-induced diabetic rats
    • DOI 10.1016/S0014-5793(98)01506-3, PII S0014579398015063
    • Kageyama H., Suga A., Kashiba M., Oka J., Osaka T., Kashiwa T., Hirano T., Nemoto K., Namba Y., Ricquier D., Giacobino J. P., Inoue S., Increased uncoupling protein-2 and -3 gene expressions in skeletal muscle of STZ-induced diabetic rats. FEBS Letters 1998 440 3 450 453 2-s2.0-0032435791 10.1016/S0014-5793(98)01506-3 (Pubitemid 29052332)
    • (1998) FEBS Letters , vol.440 , Issue.3 , pp. 450-453
    • Kageyama, H.1    Suga, A.2    Kashiba, M.3    Oka, J.4    Osaka, T.5    Kashiwa, T.6    Hirano, T.7    Nemoto, K.8    Namba, Y.9    Ricquier, D.10    Giacobino, J.-P.11    Inoue, S.12
  • 14
    • 0037181143 scopus 로고    scopus 로고
    • Glucose induces and leptin decreases expression of uncoupling protein-2 mRNA in human islets
    • DOI 10.1016/S0014-5793(02)02296-2, PII S0014579302022962
    • Brown J. E. P., Thomas S., Digby J. E., Dunmore S. J., Glucose induces and leptin decreases expression of uncoupling protein-2 mRNA in human islets. FEBS Letters 2002 513 2-3 189 192 2-s2.0-0037181143 10.1016/S0014-5793(02)02296- 2 (Pubitemid 34251262)
    • (2002) FEBS Letters , vol.513 , Issue.2-3 , pp. 189-192
    • Brown, J.E.P.1    Thomas, S.2    Digby, J.E.3    Dunmore, S.J.4
  • 15
    • 0030869755 scopus 로고    scopus 로고
    • Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β3-adrenergic agonists, and leptin
    • DOI 10.1074/jbc.272.39.24129
    • Gong D. W., He Y., Karas M., Reitman M., Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β 3-adrenergic agonists, and leptin. Journal of Biological Chemistry 1997 272 39 24129 24132 2-s2.0-0030869755 10.1074/jbc.272.39.24129 (Pubitemid 27418606)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.39 , pp. 24129-24132
    • Gong, D.-W.1    He, Y.2    Karas, M.3    Reitman, M.4
  • 16
    • 0030733473 scopus 로고    scopus 로고
    • Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: Their gene expression in rats fed high-fat diet
    • DOI 10.1016/S0014-5793(97)01381-1, PII S0014579397013811
    • Matsuda J., Hosoda K., Itoh H., Son C., Doi K., Tanaka T., Fukunaga Y., Inoue G., Nishimura H., Yoshimasa Y., Yamori Y., Nakao K., Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: their gene expression in rats fed high-fat diet. FEBS Letters 1997 418 1-2 200 204 2-s2.0-0030733473 10.1016/S0014-5793(97)01381-1 (Pubitemid 27514446)
    • (1997) FEBS Letters , vol.418 , Issue.1-2 , pp. 200-204
    • Matsuda, J.1    Hosoda, K.2    Itoh, H.3    Son, C.4    Doi, K.5    Tanaka, T.6    Fukunaga, Y.7    Inoue, G.8    Nishimura, H.9    Yoshimasa, Y.10    Yamori, Y.11    Nakao, K.12
  • 17
    • 0031972878 scopus 로고    scopus 로고
    • Uncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperature
    • DOI 10.1074/jbc.273.1.5
    • Boss O., Samec S., Kühne F., Bijlenga P., Assimacopoulos-Jeannet F., Seydoux J., Giacobino J. P., Muzzin P., Uncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperature. Journal of Biological Chemistry 1998 273 1 5 8 2-s2.0-0031972878 10.1074/jbc.273.1.5 (Pubitemid 28042165)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.1 , pp. 5-8
    • Boss, O.1    Samec, S.2    Kuhne, F.3    Bijlenga, P.4    Assimacopoulos-Jeannet, F.5    Seydoux, J.6    Giacobino, J.-P.7    Muzzin, P.8
  • 18
    • 25144476923 scopus 로고    scopus 로고
    • Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3
    • 2-s2.0-25144476923 10.1016/j.cmet.2005.06.002
    • Brand M. D., Esteves T. C., Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3. Cell Metabolism 2005 2 2 85 93 2-s2.0-25144476923 10.1016/j.cmet.2005.06.002
    • (2005) Cell Metabolism , vol.2 , Issue.2 , pp. 85-93
    • Brand, M.D.1    Esteves, T.C.2
  • 19
    • 0032742372 scopus 로고    scopus 로고
    • UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged
    • 2-s2.0-0032742372 10.1016/S0014-5793(99)01540-9
    • Cadenas S., Buckingham J. A., Samec S., Seydoux J., Din N., Dulloo A. G., Brand M. D., UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged. FEBS Letters 1999 462 3 257 260 2-s2.0-0032742372 10.1016/S0014-5793(99)01540-9
    • (1999) FEBS Letters , vol.462 , Issue.3 , pp. 257-260
    • Cadenas, S.1    Buckingham, J.A.2    Samec, S.3    Seydoux, J.4    Din, N.5    Dulloo, A.G.6    Brand, M.D.7
  • 20
    • 0037169484 scopus 로고    scopus 로고
    • The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3
    • DOI 10.1074/jbc.M109736200
    • Cadenas S., Echtay K. S., Harper J. A., Jekabsons M. B., Buckingham J. A., Grau E., Abuin A., Chapman H., Clapham J. C., Brand M. D., The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3. Journal of Biological Chemistry 2002 277 4 2773 2778 2-s2.0-0037169484 10.1074/jbc.M109736200 (Pubitemid 34953307)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.4 , pp. 2773-2778
    • Cadenas, S.1    Echtay, K.S.2    Harper, J.A.3    Jekabsons, M.B.4    Buckingham, J.A.5    Grau, E.6    Abuin, A.7    Chapman, H.8    Clapham, J.C.9    Brand, M.D.10
  • 22
    • 0035852755 scopus 로고    scopus 로고
    • + transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone)
    • DOI 10.1073/pnas.98.4.1416
    • Echtay K. S., Winkler E., Frischmuth K., Klingenberg M., Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone). Proceedings of the National Academy of Sciences of the United States of America 2001 98 4 1416 1421 2-s2.0-0035852755 10.1073/pnas.98.4.1416 (Pubitemid 32165513)
    • (2001) Proceedings of the National Academy of Sciences of the United States of America , vol.98 , Issue.4 , pp. 1416-1421
    • Echtay, K.S.1    Winkler, E.2    Frischmuth, K.3    Klingenberg, M.4
  • 26
    • 23244454768 scopus 로고    scopus 로고
    • The reactions catalysed by the mitochondrial uncoupling proteins UCP2 and UCP3
    • DOI 10.1016/j.bbabio.2005.06.002, PII S0005272805001465
    • Esteves T. C., Brand M. D., The reactions catalysed by the mitochondrial uncoupling proteins UCP2 and UCP3. Biochimica et Biophysica Acta 2005 1709 1 35 44 2-s2.0-23244454768 10.1016/j.bbabio.2005.06.002 (Pubitemid 41096089)
    • (2005) Biochimica et Biophysica Acta - Bioenergetics , vol.1709 , Issue.1 , pp. 35-44
    • Esteves, T.C.1    Brand, M.D.2
  • 27
    • 69249211307 scopus 로고    scopus 로고
    • UCP2, a metabolic sensor coupling glucose oxidation to mitochondrial metabolism?
    • 2-s2.0-69249211307 10.1002/iub.188
    • Pecqueur C., Alves-Guerra C., Ricquier D., Bouillaud F., UCP2, a metabolic sensor coupling glucose oxidation to mitochondrial metabolism? IUBMB Life 2009 61 7 762 767 2-s2.0-69249211307 10.1002/iub.188
    • (2009) IUBMB Life , vol.61 , Issue.7 , pp. 762-767
    • Pecqueur, C.1    Alves-Guerra, C.2    Ricquier, D.3    Bouillaud, F.4
  • 28
    • 38049120264 scopus 로고    scopus 로고
    • Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization
    • 2-s2.0-38049120264 10.1096/fj.07-8945com
    • Pecqueur C., Bui T., Gelly C., Hauchard J., Barbot C., Bouillaud F., Ricquier D., Miroux B., Thompson C. B., Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization. FASEB Journal 2008 22 1 9 18 2-s2.0-38049120264 10.1096/fj.07-8945com
    • (2008) FASEB Journal , vol.22 , Issue.1 , pp. 9-18
    • Pecqueur, C.1    Bui, T.2    Gelly, C.3    Hauchard, J.4    Barbot, C.5    Bouillaud, F.6    Ricquier, D.7    Miroux, B.8    Thompson, C.B.9
  • 30
    • 65649099713 scopus 로고    scopus 로고
    • Uncoupling protein-2 regulates lifespan in mice
    • 2-s2.0-65649099713 10.1152/ajpendo.90903.2008
    • Andrews Z. B., Horvath T. L., Uncoupling protein-2 regulates lifespan in mice. American Journal of Physiology 2009 296 4 E621 E627 2-s2.0-65649099713 10.1152/ajpendo.90903.2008
    • (2009) American Journal of Physiology , vol.296 , Issue.4
    • Andrews, Z.B.1    Horvath, T.L.2
  • 31
    • 42349088894 scopus 로고    scopus 로고
    • The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells
    • DOI 10.1158/0008-5472.CAN-08-0053
    • Derdak Z., Mark N. M., Beldi G., Robson S. C., Wands J. R., Baffy G., The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells. Cancer Research 2008 68 8 2813 2819 2-s2.0-42349088894 10.1158/0008-5472.CAN-08- 0053 (Pubitemid 351556280)
    • (2008) Cancer Research , vol.68 , Issue.8 , pp. 2813-2819
    • Derdak, Z.1    Mark, N.M.2    Beldi, G.3    Robson, S.C.4    Wands, J.R.5    Baffy, G.6
  • 33
    • 77957304618 scopus 로고    scopus 로고
    • Reactive oxygen species and uncoupling protein 2 in pancreatic β -cell function
    • supplement 2 10.1111/j.1463-1326.2010.01269.x
    • Pi J., jpi@thehamner.org Collins S., Reactive oxygen species and uncoupling protein 2 in pancreatic β -cell function. Diabetes, Obesity and Metabolism 2010 12 supplement 2 141 148 10.1111/j.1463-1326.2010.01269.x
    • (2010) Diabetes, Obesity and Metabolism , vol.12 , pp. 141-148
    • Pi, J.1    Collins, S.2
  • 34
    • 0034680780 scopus 로고    scopus 로고
    • The uncoupling protein-3 gene is transcribed from tissue-specific promoters in humans but not in rodents
    • 2-s2.0-0034680780 10.1074/jbc.M005713200
    • Esterbauer H., Oberkofler H., Krempler F., Strosberg A. D., Patsch W., The uncoupling protein-3 gene is transcribed from tissue-specific promoters in humans but not in rodents. Journal of Biological Chemistry 2000 275 46 36394 36399 2-s2.0-0034680780 10.1074/jbc.M005713200
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.46 , pp. 36394-36399
    • Esterbauer, H.1    Oberkofler, H.2    Krempler, F.3    Strosberg, A.D.4    Patsch, W.5
  • 35
    • 0030803678 scopus 로고    scopus 로고
    • The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts
    • DOI 10.1074/jbc.272.41.25433
    • Solanes G., Vidal-Puig A., Grujic D., Flier J. S., Lowell B. B., The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts. Journal of Biological Chemistry 1997 272 41 25433 25436 2-s2.0-0030803678 10.1074/jbc.272.41.25433 (Pubitemid 27438845)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.41 , pp. 25433-25436
    • Solanes, G.1    Vidal-Puig, A.2    Grujic, D.3    Flier, J.S.4    Lowell, B.B.5
  • 36
    • 0032991716 scopus 로고    scopus 로고
    • Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets
    • DOI 10.2337/diabetes.48.7.1482
    • Chan C. B., MacDonald P. E., Saleh M. C., Johns D. C., Marbàn E., Wheeler M. B., Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets. Diabetes 1999 48 7 1482 1486 2-s2.0-0032991716 10.2337/diabetes.48.7.1482 (Pubitemid 29297315)
    • (1999) Diabetes , vol.48 , Issue.7 , pp. 1482-1486
    • Chan, C.B.1    MacDonald, P.E.2    Saleh, M.C.3    Johns, D.C.4    Marban, E.5    Wheeler, M.B.6
  • 37
    • 0036444648 scopus 로고    scopus 로고
    • Endogenous regulation of insulin secretion by UCP2
    • Chan C. B., Endogenous regulation of insulin secretion by UCP2. Clinical Laboratory 2002 48 11-12 599 604 2-s2.0-0036444648 (Pubitemid 35415023)
    • (2002) Clinical Laboratory , vol.48 , Issue.11-12 , pp. 599-604
    • Chan, C.B.1
  • 38
    • 0034990987 scopus 로고    scopus 로고
    • Increased uncoupling protein-2 levels in β-cells are associated with impaired glucose-stimulated insulin secretion: Mechanism of action
    • Chan C. B., De Leo D., Joseph J. W., McQuaid T. S., Ha X. F., Xu F., Tsushima R. G., Pennefather P. S., Salapatek A. M. F., Wheeler M. B., Increased uncoupling protein-2 levels in β -cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action. Diabetes 2001 50 6 1302 1310 2-s2.0-0034990987 (Pubitemid 32500162)
    • (2001) Diabetes , vol.50 , Issue.6 , pp. 1302-1310
    • Chan, C.B.1    De Leo, D.2    Joseph, J.W.3    McQuaid, T.S.4    Ha, X.F.5    Xu, F.6    Tsushima, R.G.7    Pennefather, P.S.8    Salapatek, A.M.F.9    Wheeler, M.B.10
  • 39
    • 0346340042 scopus 로고    scopus 로고
    • Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction
    • DOI 10.1172/JCI200319774
    • Krauss S., Zhang C. Y., Scorrano L., Dalgaard L. T., St-Pierre J., Grey S. T., Lowell B. B., Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction. Journal of Clinical Investigation 2003 112 12 1831 1842 2-s2.0-0346340042 10.1172/JCI200319774 (Pubitemid 38063706)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.12 , pp. 1831-1842
    • Krauss, S.1    Zhang, C.-Y.2    Scorrano, L.3    Dalgaard, L.T.4    St-Pierre, J.5    Grey, S.T.6    Lowell, B.B.7
  • 40
    • 0036829870 scopus 로고    scopus 로고
    • Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet
    • Joseph J. W., Koshkin V., Zhang C. Y., Wang J., Lowell B. B., Chan C. B., Wheeler M. B., Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet. Diabetes 2002 51 11 3211 3219 2-s2.0-0036829870 (Pubitemid 35246967)
    • (2002) Diabetes , vol.51 , Issue.11 , pp. 3211-3219
    • Joseph, J.W.1    Koshkin, V.2    Zhang, C.-Y.3    Wang, J.4    Lowell, B.B.5    Chan, C.B.6    Wheeler, M.B.7
  • 41
    • 10944265062 scopus 로고    scopus 로고
    • Free fatty acid-induced β-cell defects are dependent on uncoupling protein 2 expression
    • DOI 10.1074/jbc.M409189200
    • Joseph J. W., Koshkin V., Saleh M. C., Sivitz W. I., Zhang C. Y., Lowell B. B., Chan C. B., Wheeler M. B., Free fatty acid-induced β -cell defects are dependent on uncoupling protein 2 expression. Journal of Biological Chemistry 2004 279 49 51049 51056 2-s2.0-10944265062 10.1074/jbc.M409189200 (Pubitemid 40017846)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.49 , pp. 51049-51056
    • Joseph, J.W.1    Koshkin, V.2    Saleh, M.C.3    Sivitz, W.I.4    Zhang, C.-Y.5    Lowell, B.B.6    Chan, C.B.7    Wheeler, M.B.8
  • 43
    • 67649641804 scopus 로고    scopus 로고
    • Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic β -cell function
    • 2-s2.0-67649641804 10.1210/en.2008-1642
    • Pi J., Bai Y., Daniel K. W., Liu D., Lyght O., Edelstein D., Brownlee M., Corkey B. E., Collins S., Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic β -cell function. Endocrinology 2009 150 7 3040 3048 2-s2.0-67649641804 10.1210/en.2008-1642
    • (2009) Endocrinology , vol.150 , Issue.7 , pp. 3040-3048
    • Pi, J.1    Bai, Y.2    Daniel, K.W.3    Liu, D.4    Lyght, O.5    Edelstein, D.6    Brownlee, M.7    Corkey, B.E.8    Collins, S.9
  • 44
    • 67649670130 scopus 로고    scopus 로고
    • Uncoupling modifier genes from uncoupling protein 2 in pancreatic β -cells
    • 2-s2.0-67649670130 10.1210/en.2009-0440
    • Kulkarni R. N., Uncoupling modifier genes from uncoupling protein 2 in pancreatic β -cells. Endocrinology 2009 150 7 2994 2996 2-s2.0-67649670130 10.1210/en.2009-0440
    • (2009) Endocrinology , vol.150 , Issue.7 , pp. 2994-2996
    • Kulkarni, R.N.1
  • 45
    • 38849084502 scopus 로고    scopus 로고
    • UCP-2 and UCP-3 proteins are differentially regulated in pancreatic beta-cells
    • DOI 10.1371/journal.pone.0001397
    • Li Y., Maedler K., Haataja L., UCP-2 and UCP-3 proteins are differentially regulated in pancreatic beta-cells. PLoS ONE 2008 3 1 2-s2.0-38849084502 10.1371/journal.pone.0001397 e1397 (Pubitemid 351194018)
    • (2008) PLoS ONE , vol.3 , Issue.1
    • Li, Y.1    Maedler, K.2    Haataja, L.3
  • 50
    • 0029087988 scopus 로고
    • Age-related neoplasia in a lifetime study of ad libitum-fed and food- restricted B6C3F1 mice
    • 2-s2.0-0029087988
    • Sheldon W. G., Bucci T. J., Hart R. W., Turturro A., Age-related neoplasia in a lifetime study of ad libitum-fed and food- restricted B6C3F1 mice. Toxicologic Pathology 1995 23 4 458 476 2-s2.0-0029087988
    • (1995) Toxicologic Pathology , vol.23 , Issue.4 , pp. 458-476
    • Sheldon, W.G.1    Bucci, T.J.2    Hart, R.W.3    Turturro, A.4
  • 52
    • 4644307288 scopus 로고    scopus 로고
    • Expression of uncoupling protein-2 in human colon cancer
    • DOI 10.1158/1078-0432.CCR-04-0419
    • Horimoto M., Resnick M. B., Konkin T. A., Routhier J., Wands J. R., Baffy G., Expression of uncoupling protein-2 in human colon cancer. Clinical Cancer Research 2004 10 18, part 1 6203 6207 2-s2.0-4644307288 10.1158/1078-0432.CCR- 04-0419 (Pubitemid 39287527)
    • (2004) Clinical Cancer Research , vol.10 , Issue.18 , pp. 6203-6207
    • Horimoto, M.1    Resnick, M.B.2    Konkin, T.A.3    Routhier, J.4    Wands, J.R.5    Baffy, G.6
  • 53
    • 0031800882 scopus 로고    scopus 로고
    • Development of infrared imaging to measure thermogenesis in cell culture: Thermogenic effects of uncoupling protein-2, troglitazone, and β- adrenoceptor agonists
    • DOI 10.1023/A:1011993019385
    • Paulik M. A., Buckholz R. G., Lancaster M. E., Dallas W. S., Hull-Ryde E. A., Weiel J. E., Lenhard J. M., Development of infrared imaging to measure thermogenesis in cell culture: thermogenic effects of uncoupling protein-2, troglitazone, and β -adrenoceptor agonists. Pharmaceutical Research 1998 15 6 944 949 2-s2.0-0031800882 10.1023/A:1011993019385 (Pubitemid 28307839)
    • (1998) Pharmaceutical Research , vol.15 , Issue.6 , pp. 944-949
    • Paulik, M.A.1    Buckholz, R.G.2    Lancaster, M.E.3    Dallas, W.S.4    Hull-Ryde, E.A.5    Weiel, J.E.6    Lenhard, J.M.7
  • 54
    • 0030854715 scopus 로고    scopus 로고
    • Cellular energy utilization and molecular origin of standard metabolic rate in mammals
    • Rolfe D. F. S., Brown G. C., Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiological Reviews 1997 77 3 731 758 2-s2.0-0030854715 (Pubitemid 27328739)
    • (1997) Physiological Reviews , vol.77 , Issue.3 , pp. 731-758
    • Rolfe, D.F.S.1    Brown, G.C.2
  • 55
    • 33645860825 scopus 로고    scopus 로고
    • Reactive oxygen species have a causal role in multiple forms of insulin resistance
    • 2-s2.0-33645860825 10.1038/nature04634
    • Houstis N., Rosen E. D., Lander E. S., Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006 440 7086 944 948 2-s2.0-33645860825 10.1038/nature04634
    • (2006) Nature , vol.440 , Issue.7086 , pp. 944-948
    • Houstis, N.1    Rosen, E.D.2    Lander, E.S.3
  • 56
    • 34047175336 scopus 로고    scopus 로고
    • Uncoupling protein-2 controls adiponectin gene expression in adipose tissue through the modulation of reactive oxygen species production
    • DOI 10.2337/db06-1300
    • Chevillotte E., Giralt M., Miroux B., Ricquier D., Villarroya F., Uncoupling protein-2 controls adiponectin gene expression in adipose tissue through the modulation of reactive oxygen species production. Diabetes 2007 56 4 1042 1050 2-s2.0-34047175336 10.2337/db06-1300 (Pubitemid 46525055)
    • (2007) Diabetes , vol.56 , Issue.4 , pp. 1042-1050
    • Chevillotte, E.1    Giralt, M.2    Miroux, B.3    Ricquier, D.4    Villarroya, F.5
  • 59
    • 34248385690 scopus 로고    scopus 로고
    • Association of UCP2 and UCP3 gene polymorphisms with serum high-density lipoprotein cholesterol among Korean women
    • DOI 10.1016/j.metabol.2007.01.023, PII S0026049507000662
    • Cha M. H., Kim I. C., Kim K. S., Kang B. K., Choi S. M., Yoon Y., Association of UCP2 and UCP3 gene polymorphisms with serum high-density lipoprotein cholesterol among Korean women. Metabolism 2007 56 6 806 813 2-s2.0-34248385690 10.1016/j.metabol.2007.01.023 (Pubitemid 46734088)
    • (2007) Metabolism: Clinical and Experimental , vol.56 , Issue.6 , pp. 806-813
    • Cha, M.H.1    Kim, I.C.2    Kim, K.S.3    Kang, B.K.4    Choi, S.M.5    Yoon, Y.6
  • 61
    • 9844232617 scopus 로고    scopus 로고
    • Mutational analysis of the coding region of the uncoupling protein 2 gene in obese NIDDM patients: Impact of a common amino acid polymorphism on juvenile and maturity onset forms of obesity and insulin resistance
    • DOI 10.1007/s001250050811
    • Urhammer S. A., Dalgaard L. T., Sørensen T. I. A., Møller A. M., Andersen T., Tybjærg-Hansen A., Hansen T., Clausen J. O., Vestergaard H., Pedersen O., Mutational analysis of the coding region of the uncoupling protein 2 gene in obese NIDDM patients: impact of a common amino acid polymorphism on juvenile and maturity onset forms of obesity and insulin resistance. Diabetologia 1997 40 10 1227 1230 2-s2.0-9844232617 10.1007/s001250050811 (Pubitemid 27421896)
    • (1997) Diabetologia , vol.40 , Issue.10 , pp. 1227-1230
    • Urhammer, S.A.1    Dalgaard, L.T.2    Sorensen, T.I.A.3    Moller, A.M.4    Andersen, T.5    Tybjaerg-Hansen, A.6    Hansen, T.7    Clausen, J.O.8    Vestergaard, H.9    Pedersen, O.10
  • 62
    • 0033406094 scopus 로고    scopus 로고
    • An untranslated insertion variant in the uncoupling protein 2 gene is not related to body mass index and changes in body weight during a 26-year follow-up in Danish Caucasian men
    • DOI 10.1007/s001250051312
    • Dalgaard L. T., Sørensen T. I. A., Andersen T., Hansen T., Pedersen O., An untranslated insertion variant in the uncoupling protein 2 gene is not related to body mass index and changes in body weight during a 26-year follow-up in Danish Caucasian men. Diabetologia 1999 42 12 1413 1416 2-s2.0-0033406094 10.1007/s001250051312 (Pubitemid 30012312)
    • (1999) Diabetologia , vol.42 , Issue.12 , pp. 1413-1416
    • Dalgaard, L.T.1    Sorensen, T.I.A.2    Andersen, T.3    Hansen, T.4    Pedersen, O.5
  • 63
    • 17744363274 scopus 로고    scopus 로고
    • A prevalent polymorphism in the promoter of the UCP3 gene and its relationship to body mass index and long term body weight change in the Danish population
    • DOI 10.1210/jc.86.3.1398
    • Dalgaard L. T., Sørensen T. I. A., Drivsholm T., Borch-Johnsen K., Andersen T., Hansen T., Pedersen O., A prevalent polymorphism in the promoter of the UCP3 gene and its relationship to body mass index and long term body weight change in the Danish population. Journal of Clinical Endocrinology and Metabolism 2001 86 3 1398 1402 2-s2.0-17744363274 10.1210/jc.86.3.1398 (Pubitemid 32323034)
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , Issue.3 , pp. 1398-1402
    • Dalgaard, L.T.1    Sorensen, T.I.A.2    Drivsholm, T.3    Borch-Johnsen, K.4    Andersen, T.5    Hansen, T.6    Pedersen, O.7
  • 65
    • 0034884629 scopus 로고    scopus 로고
    • The uncoupling protein 3-55 C→T variant is not associated with type II diabetes mellitus in Danish subjects [3]
    • DOI 10.1007/s001250100579
    • Dalgaard L. T., Hansen T., Urhammer S. A., Drivsholm T., Borch-Johnsen K., Pedersen O., The uncoupling protein 3-55 C→T variant is not associated with type II diabetes mellitus in Danish subjects. Diabetologia 2001 44 8 1065 1067 2-s2.0-0034884629 10.1007/s001250100579 (Pubitemid 32778143)
    • (2001) Diabetologia , vol.44 , Issue.8 , pp. 1065-1067
    • Dalgaard, L.T.1    Hansen, T.2    Urhammer, S.A.3    Drivsholm, T.4    Borch-Johnsen, K.5    Pedersen, O.6
  • 67
    • 11244344449 scopus 로고    scopus 로고
    • Interactions between physical activity and variants of the genes encoding uncoupling proteins -2 and -3 in relation to body weight changes during a 10-y follow-up
    • DOI 10.1038/sj.ijo.0802841
    • Berentzen T., Dalgaard L. T., Petersen L., Pedersen O., Sørensen T. I. A., Interactions between physical activity and variants of the genes encoding uncoupling proteins -2 and -3 in relation to body weight changes during a 10-y follow-up. International Journal of Obesity 2005 29 1 93 99 2-s2.0-11244344449 10.1038/sj.ijo.0802841 (Pubitemid 40065470)
    • (2005) International Journal of Obesity , vol.29 , Issue.1 , pp. 93-99
    • Berentzen, T.1    Dalgaard, L.T.2    Petersen, L.3    Pedersen, O.4    Sorensen, T.I.A.5
  • 68
    • 0033382027 scopus 로고    scopus 로고
    • Endogenous mutations in human uncoupling protein 3 alter its functional properties
    • DOI 10.1016/S0014-5793(99)01708-1, PII S0014579399017081
    • Brown A. M., Dolan J. W., Willi S. M., Garvey W. T., Argyropoulos G., Endogenous mutations in human uncoupling protein 3 alter its functional properties. FEBS Letters 1999 464 3 189 193 2-s2.0-0033382027 10.1016/S0014-5793(99)01708-1 (Pubitemid 30017940)
    • (1999) FEBS Letters , vol.464 , Issue.3 , pp. 189-193
    • Brown, A.M.1    Dolan, J.W.2    Willi, S.M.3    Garvey, W.T.4    Argyropoulos, G.5
  • 69
    • 0001155789 scopus 로고    scopus 로고
    • A novel missense mutation, R70W, in the human uncoupling protein 3 gene in a family with type 2 diabetes
    • Brown A. M., Willi S. M., Argyropoulos G., Garvey W. T., A novel missense mutation, R70W, in the human uncoupling protein 3 gene in a family with type 2 diabetes. Human Mutation 1999 13 506
    • (1999) Human Mutation , vol.13 , pp. 506
    • Brown, A.M.1    Willi, S.M.2    Argyropoulos, G.3    Garvey, W.T.4
  • 70
    • 0036830548 scopus 로고    scopus 로고
    • A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans
    • Krempler F., Esterbauer H., Weitgasser R., Ebenbichler C., Patsch J. R., Miller K., Xie M., Linnemayr V., Oberkofler H., Patsch W., A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans. Diabetes 2002 51 11 3331 3335 2-s2.0-0036830548 (Pubitemid 35246982)
    • (2002) Diabetes , vol.51 , Issue.11 , pp. 3331-3335
    • Krempler, F.1    Esterbauer, H.2    Weitgasser, R.3    Ebenbichler, C.4    Patsch, J.R.5    Miller, K.6    Xie, M.7    Linnemayr, V.8    Oberkofler, H.9    Patsch, W.10
  • 71
    • 10744222893 scopus 로고    scopus 로고
    • Uncoupling Protein 2 Promoter Polymorphism - 866G/A Affects Its Expression in β-Cells and Modulates Clinical Profiles of Japanese Type 2 Diabetic Patients
    • DOI 10.2337/diabetes.53.2.482
    • Sasahara M., Nishi M., Kawashima H., Ueda K., Sakagashira S., Furuta H., Matsumoto E., Hanabusa T., Sasaki H., Nanjo K., Uncoupling protein 2 promoter polymorphism -866G/A affects its expression in beta-cells and modulates clinical profiles of Japanese type 2 diabetic patients. Diabetes 2004 53 2 482 485 2-s2.0-10744222893 10.2337/diabetes.53.2.482 (Pubitemid 38174566)
    • (2004) Diabetes , vol.53 , Issue.2 , pp. 482-485
    • Sasahara, M.1    Nishi, M.2    Kawashima, H.3    Ueda, K.4    Sakagashira, S.5    Furuta, H.6    Matsumoto, E.7    Hanabusa, T.8    Sasaki, H.9    Nanjo, K.10
  • 75
    • 58849091290 scopus 로고    scopus 로고
    • Effects of UCP2 and UCP3 variants on the manifestation of overweight in Korean children
    • 2-s2.0-58849091290 10.1038/oby.2008.531
    • Jun H. S., Kim I. K., Lee H. J., Lee H. J., Kang J. H., Kim J. R., Shin H. D., Song J., Effects of UCP2 and UCP3 variants on the manifestation of overweight in Korean children. Obesity 2009 17 2 355 362 2-s2.0-58849091290 10.1038/oby.2008.531
    • (2009) Obesity , vol.17 , Issue.2 , pp. 355-362
    • Jun, H.S.1    Kim, I.K.2    Lee, H.J.3    Lee, H.J.4    Kang, J.H.5    Kim, J.R.6    Shin, H.D.7    Song, J.8
  • 76
    • 36148973232 scopus 로고    scopus 로고
    • Association between obesity and insulin resistance with UCP2-UCP3 gene variants in Spanish children and adolescents
    • DOI 10.1016/j.ymgme.2007.07.011, PII S109671920700251X
    • Ochoa M. C., Santos J. L., Azcona C., Moreno-Aliaga M. J., Martínez-González M. A., Martínez J. A., Marti A., Association between obesity and insulin resistance with UCP2-UCP3 gene variants in Spanish children and adolescents. Molecular Genetics and Metabolism 2007 92 4 351 358 2-s2.0-36148973232 10.1016/j.ymgme.2007.07.011 (Pubitemid 350117715)
    • (2007) Molecular Genetics and Metabolism , vol.92 , Issue.4 , pp. 351-358
    • Ochoa, M.C.1    Santos, J.L.2    Azcona, C.3    Moreno-Aliaga, M.J.4    Martinez-Gonzalez, M.A.5    Martinez, J.A.6    Marti, A.7
  • 77
    • 1942424804 scopus 로고    scopus 로고
    • FT Cardiovascular risk in healthy men and markers of oxidative stress in diabetic men are associated with common variation in the gene for uncoupling protein 2
    • DOI 10.1016/j.ehj.2004.01.007
    • Dhamrait S. S., Stephens J. W., Cooper J. A., Acharya J., Mani A. R., Moore K., Miller G. J., Humphries S. E., Hurel S. J., Montgomery H. E., FT Cardiovascular risk in healthy men and markers of oxidative stress in diabetic men are associated with common variation in the gene for uncoupling protein 2. European Heart Journal 2004 25 6 468 475 2-s2.0-1942424804 10.1016/j.ehj.2004. 01.007 (Pubitemid 38524271)
    • (2004) European Heart Journal , vol.25 , Issue.6 , pp. 468-475
    • Dhamrait, S.S.1    Stephens, J.W.2    Cooper, J.A.3    Acharya, J.4    Mani, A.R.5    Moore, K.6    Miller, G.J.7    Humphries, S.E.8    Hurel, S.J.9    Montgomery, H.E.10
  • 78
    • 51849164525 scopus 로고    scopus 로고
    • Genotype-phenotype associations in obesity dependent on definition of the obesity phenotype
    • 2-s2.0-51849164525 10.1159/000137665
    • Kring S. I., Larsen L. H., Holst C., Toubro S., Hansen T., Astrup A., Pedersen O., Sørensen T. I., Genotype-phenotype associations in obesity dependent on definition of the obesity phenotype. Obesity Facts 2008 1 3 138 145 2-s2.0-51849164525 10.1159/000137665
    • (2008) Obesity Facts , vol.1 , Issue.3 , pp. 138-145
    • Kring, S.I.1    Larsen, L.H.2    Holst, C.3    Toubro, S.4    Hansen, T.5    Astrup, A.6    Pedersen, O.7    Sørensen, T.I.8
  • 79
    • 0344082604 scopus 로고    scopus 로고
    • Variants of uncoupling protein-2 gene and obesity: Interaction with peroxisome proliferator-activated receptorγ2
    • DOI 10.1046/j.1365-2265.2003.01926.x
    • Mancini F. P., Sabatino L., Colantuoni V., Pasanisi F., Finelli C., Contaldo F., Masulli M., Riccardi G., Vaccaro O., Variants of uncoupling protein-2 gene and obesity: interaction with peroxisome proliferator-activated receptor γ 2. Clinical Endocrinology 2003 59 6 817 822 2-s2.0-0344082604 10.1046/j.1365-2265.2003.01926.x (Pubitemid 37491590)
    • (2003) Clinical Endocrinology , vol.59 , Issue.6 , pp. 817-822
    • Mancini, F.P.1    Sabatino, L.2    Colantuoni, V.3    Pasanisi, F.4    Finelli, C.5    Contaldo, F.6    Masulli, M.7    Riccardi, G.8    Vaccaro, O.9
  • 82
    • 14044254272 scopus 로고    scopus 로고
    • The common -866G/A polymorphism in the promoter region of the UCP-2 gene is associated with reduced risk of type 2 diabetes in Caucasians from Italy
    • DOI 10.1210/jc.2004-1072
    • Bulotta A., Ludovico O., Coco A., Di Paola R., Quattrone A., Carella M., Pellegrini F., Prudente S., Trischitta V., The common -866G/A polymorphism in the promoter region of the UCP-2 gene is associated with reduced risk of type 2 diabetes in Caucasians from Italy. Journal of Clinical Endocrinology and Metabolism 2005 90 2 1176 1180 2-s2.0-14044254272 10.1210/jc.2004-1072 (Pubitemid 40279251)
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , Issue.2 , pp. 1176-1180
    • Bulotta, A.1    Ludovico, O.2    Coco, A.3    Di Paola, R.4    Quattrone, A.5    Carella, M.6    Pellegrini, F.7    Prudente, S.8    Trischitta, V.9
  • 83
    • 27744550916 scopus 로고    scopus 로고
    • Genetic variation in UCP2 (uncoupling protein-2) is associated with energy metabolism in Pima Indians
    • DOI 10.1007/s00125-005-1934-9
    • Kovacs P., Ma L., Hanson R. L., Franks P., Stumvoll M., Bogardus C., Baier L. J., Genetic variation in UCP2 (uncoupling protein-2) is associated with energy metabolism in Pima Indians. Diabetologia 2005 48 11 2292 2295 2-s2.0-27744550916 10.1007/s00125-005-1934-9 (Pubitemid 41618920)
    • (2005) Diabetologia , vol.48 , Issue.11 , pp. 2292-2295
    • Kovacs, P.1    Ma, L.2    Hanson, R.L.3    Franks, P.4    Stumvoll, M.5    Bogardus, C.6    Baier, L.J.7
  • 84
    • 33845538374 scopus 로고    scopus 로고
    • European differences in the association between the UCP2 -866G > A common gene variant and markers of body mass and fasting plasma insulin [1]
    • DOI 10.1111/j.1463-1326.2006.00573.x
    • Gable D. R., Stephens J. W., Dhamrait S. S., Hawe E., Humphries S. E., European differences in the association between the UCP2 -866G > A common gene variant and markers of body mass and fasting plasma insulin. Diabetes, Obesity and Metabolism 2007 9 1 130 131 2-s2.0-33845538374 10.1111/j.1463-1326. 2006.00573.x (Pubitemid 44921052)
    • (2007) Diabetes, Obesity and Metabolism , vol.9 , Issue.1 , pp. 130-131
    • Gable, D.R.1    Stephens, J.W.2    Dhamrait, S.S.3    Hawe, E.4    Humphries, S.E.5
  • 85
    • 48249100977 scopus 로고    scopus 로고
    • Association of FTO with obesity-related traits in the cebu longitudinal health and nutrition survey (CLHNS) cohort
    • 2-s2.0-48249100977 10.2337/db07-1700
    • Marvelle A. F., Lange L. A., Qin L., Adair L. S., Mohlke K. L., Association of FTO with obesity-related traits in the cebu longitudinal health and nutrition survey (CLHNS) cohort. Diabetes 2008 57 7 1987 1991 2-s2.0-48249100977 10.2337/db07-1700
    • (2008) Diabetes , vol.57 , Issue.7 , pp. 1987-1991
    • Marvelle, A.F.1    Lange, L.A.2    Qin, L.3    Adair, L.S.4    Mohlke, K.L.5
  • 87
    • 42449114459 scopus 로고    scopus 로고
    • Genetic variants in the UCP2-UCP3 gene cluster and risk of diabetes in the women's health initiative observational study
    • 2-s2.0-42449114459 10.2337/db07-1269
    • Hsu Y. H., Niu T., Song Y., Tinker L., Kuller L. H., Liu S., Genetic variants in the UCP2-UCP3 gene cluster and risk of diabetes in the women's health initiative observational study. Diabetes 2008 57 4 1101 1107 2-s2.0-42449114459 10.2337/db07-1269
    • (2008) Diabetes , vol.57 , Issue.4 , pp. 1101-1107
    • Hsu, Y.H.1    Niu, T.2    Song, Y.3    Tinker, L.4    Kuller, L.H.5    Liu, S.6
  • 89
    • 0347990596 scopus 로고    scopus 로고
    • The Common - 866 G/A Polymorphism in the Promoter of Uncoupling Protein 2 Is Associated with Increased Carbohydrate and Decreased Lipid Oxidation in Juvenile Obesity
    • DOI 10.2337/diabetes.53.1.235
    • Le Fur S., Le Stunff C., Dos Santos C., Bougnères P., The common -866 G/A polymorphism in the promoter of uncoupling protein 2 is associated with increased carbohydrate and decreased lipid oxidation in juvenile obesity. Diabetes 2004 53 1 235 239 2-s2.0-0347990596 10.2337/diabetes.53.1.235 (Pubitemid 38044721)
    • (2004) Diabetes , vol.53 , Issue.1 , pp. 235-239
    • Le Fur, S.1    Le Stunff, C.2    Dos Santos, C.3    Bougneres, P.4
  • 90
    • 4043127546 scopus 로고    scopus 로고
    • A polymorphism in the promoter of UCP2 gene modulates lipid levels in patients with type 2 diabetes
    • DOI 10.1016/j.ymgme.2004.06.008, PII S1096719204001611
    • Reis A. F., Dubois-Laforgue D., Bellanné-Chantelot C., Timsit J., Velho G., A polymorphism in the promoter of UCP2 gene modulates lipid levels in patients with type 2 diabetes. Molecular Genetics and Metabolism 2004 82 4 339 344 2-s2.0-4043127546 10.1016/j.ymgme.2004.06.008 (Pubitemid 39078715)
    • (2004) Molecular Genetics and Metabolism , vol.82 , Issue.4 , pp. 339-344
    • Reis, A.F.1    Dubois-Laforgue, D.2    Bellanne-Chantelot, C.3    Timsit, J.4    Velho, G.5
  • 91
    • 77949653045 scopus 로고    scopus 로고
    • A common polymorphism in the promoter of UCP2 is associated with obesity and hyperinsulenemia in northern Indians
    • 2-s2.0-77949653045 10.1007/s11010-009-0311-2
    • Srivastava N., Prakash J., Lakhan R., Agarwal C. G., Pant D. C., Mittal B., A common polymorphism in the promoter of UCP2 is associated with obesity and hyperinsulenemia in northern Indians. Molecular and Cellular Biochemistry 2010 337 1-2 293 298 2-s2.0-77949653045 10.1007/s11010-009-0311-2
    • (2010) Molecular and Cellular Biochemistry , vol.337 , Issue.1-2 , pp. 293-298
    • Srivastava, N.1    Prakash, J.2    Lakhan, R.3    Agarwal, C.G.4    Pant, D.C.5    Mittal, B.6
  • 92
    • 34250354410 scopus 로고    scopus 로고
    • Effects of genetic polymorphisms of UCP2 and UCP3 on very low calorie diet-induced body fat reduction in Korean female subjects
    • DOI 10.1016/j.bbrc.2007.05.110, PII S0006291X07010777
    • Yoon Y., Park B. L., Cha M. H., Kim K. S., Cheong H. S., Choi Y. H., Shin H. D., Effects of genetic polymorphisms of UCP2 and UCP3 on very low calorie diet-induced body fat reduction in Korean female subjects. Biochemical and Biophysical Research Communications 2007 359 3 451 456 2-s2.0-34250354410 10.1016/j.bbrc.2007.05.110 (Pubitemid 46908798)
    • (2007) Biochemical and Biophysical Research Communications , vol.359 , Issue.3 , pp. 451-456
    • Yoon, Y.1    Park, B.L.2    Cha, M.H.3    Kim, K.S.4    Cheong, H.S.5    Choi, Y.H.6    Shin, H.D.7
  • 93
    • 0034883804 scopus 로고    scopus 로고
    • Uncoupling proteins: Functional characteristics and role in the pathogenesis of obesity and Type II diabetes
    • DOI 10.1007/s001250100596
    • Dalgaard L. T., Pedersen O., Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes. Diabetologia 2001 44 8 946 965 2-s2.0-0034883804 10.1007/s001250100596 (Pubitemid 32778126)
    • (2001) Diabetologia , vol.44 , Issue.8 , pp. 946-965
    • Dalgaard, L.T.1    Pedersen, O.2
  • 94
    • 69449089547 scopus 로고    scopus 로고
    • The polymorphisms of UCP2 and UCP3 genes associated with fat metabolism, obesity and diabetes: Etiology and pathophysiology
    • 2-s2.0-69449089547 10.1111/j.1467-789X.2009.00569.x
    • Jia J. J., Zhang X., Ge C. R., Jois M., The polymorphisms of UCP2 and UCP3 genes associated with fat metabolism, obesity and diabetes: etiology and pathophysiology. Obesity Reviews 2009 10 5 519 526 2-s2.0-69449089547 10.1111/j.1467-789X.2009.00569.x
    • (2009) Obesity Reviews , vol.10 , Issue.5 , pp. 519-526
    • Jia, J.J.1    Zhang, X.2    Ge, C.R.3    Jois, M.4
  • 96
    • 0035071837 scopus 로고    scopus 로고
    • The association between the val/ala-55 polymorphism of the uncoupling protein 2 gene and exercise efficiency
    • DOI 10.1038/sj.ijo.0801564
    • Buemann B., Schierning B., Toubro S., Bibby B. M., Sørensen T., Dalgaard L., Pedersen O., Astrup A., The association between the val/ala-55 polymorphism of the uncoupling protein 2 gene and exercise efficiency. International Journal of Obesity 2001 25 4 467 471 10.1038/sj.ijo.0801564 (Pubitemid 32289638)
    • (2001) International Journal of Obesity , vol.25 , Issue.4 , pp. 467-471
    • Buemann, B.1    Schierning, B.2    Toubro, S.3    Bibby, B.M.4    Sorensen, T.5    Dalgaard, L.6    Pedersen, O.7    Astrup, A.8
  • 99
    • 33745312588 scopus 로고    scopus 로고
    • Variation in the UCP2-UCP3 gene cluster predicts the development of type 2 diabetes in healthy middle-aged men
    • DOI 10.2337/db05-1645
    • Gable D. R., Stephens J. W., Cooper J. A., Miller G. J., Humphries S. E., Variation in the UCP2-UCP3 gene cluster predicts the development of type 2 diabetes in healthy middle-aged men. Diabetes 2006 55 5 1504 1511 2-s2.0-33745312588 10.2337/db05-1645 (Pubitemid 44195394)
    • (2006) Diabetes , vol.55 , Issue.5 , pp. 1504-1511
    • Gable, D.R.1    Stephens, J.W.2    Cooper, J.A.3    Miller, G.J.4    Humphries, S.E.5
  • 101
    • 36349009215 scopus 로고    scopus 로고
    • Interaction between the UCP2-866G/A, mtDNA 10398G/A and PGC1α p.Thr394Thr and p.Gly482Ser polymorphisms in type 2 diabetes susceptibility in North Indian population
    • DOI 10.1007/s00439-007-0421-4
    • Rai E., Sharma S., Koul A., Bhat A. K., Bhanwer A. J. S., Bamezai R. N. K., Interaction between the UCP2-866G/A, mtDNA 10398G/A and PGC1 α p.Thr394Thr and p.Gly482Ser polymorphisms in type 2 diabetes susceptibility in North Indian population. Human Genetics 2007 122 5 535 540 2-s2.0-36349009215 10.1007/s00439-007-0421-4 (Pubitemid 350148965)
    • (2007) Human Genetics , vol.122 , Issue.5 , pp. 535-540
    • Rai, E.1    Sharma, S.2    Koul, A.3    Bhat, A.K.4    Bhanwer, A.J.S.5    Bamezai, R.N.K.6
  • 102
    • 42449098483 scopus 로고    scopus 로고
    • The common -866G > A variant in the promoter of UCP2 is associated with decreased risk of coronary artery disease in type 2 diabetic men
    • 2-s2.0-42449098483 10.2337/db07-1292
    • Cheurfa N., Dubois-Laforgue D., Ferrarezi D. A. F., Reis A. F., Brenner G. M., Bouché C., Feuvre C. L., Fumeron F., Timsit J., Marre M., Velho G., The common -866G > A variant in the promoter of UCP2 is associated with decreased risk of coronary artery disease in type 2 diabetic men. Diabetes 2008 57 4 1063 1068 2-s2.0-42449098483 10.2337/db07-1292
    • (2008) Diabetes , vol.57 , Issue.4 , pp. 1063-1068
    • Cheurfa, N.1    Dubois-Laforgue, D.2    Ferrarezi, D.A.F.3    Reis, A.F.4    Brenner, G.M.5    Bouché, C.6    Feuvre, C.L.7    Fumeron, F.8    Timsit, J.9    Marre, M.10    Velho, G.11
  • 104
    • 37349059567 scopus 로고    scopus 로고
    • Interaction between the uncoupling protein 2 -866G>A gene variant and cigarette smoking to increase oxidative stress in subjects with diabetes
    • DOI 10.1016/j.numecd.2007.01.010, PII S0939475307000269
    • Stephens J. W., Dhamrait S. S., Mani A. R., Acharya J., Moore K., Hurel S. J., Humphries S. E., Interaction between the uncoupling protein 2 -866G > A gene variant and cigarette smoking to increase oxidative stress in subjects with diabetes. Nutrition, Metabolism and Cardiovascular Diseases 2008 18 1 7 14 2-s2.0-37349059567 10.1016/j.numecd.2007.01.010 (Pubitemid 350297896)
    • (2008) Nutrition, Metabolism and Cardiovascular Diseases , vol.18 , Issue.1 , pp. 7-14
    • Stephens, J.W.1    Dhamrait, S.S.2    Mani, A.R.3    Acharya, J.4    Moore, K.5    Hurel, S.J.6    Humphries, S.E.7
  • 106
    • 70350433070 scopus 로고    scopus 로고
    • Association of common variants of UCP2 gene with low-grade inflammation in Swedish children and adolescents; The European Youth Heart Study
    • 2-s2.0-70350433070 10.1203/PDR.0b013e3181b1bd35
    • Labayen I., Ortega F. B., Sjöström M., Nilsson T. K., Olsson L. A., Ruiz J. R., Association of common variants of UCP2 gene with low-grade inflammation in Swedish children and adolescents; The European Youth Heart Study. Pediatric Research 2009 66 3 350 354 2-s2.0-70350433070 10.1203/PDR.0b013e3181b1bd35
    • (2009) Pediatric Research , vol.66 , Issue.3 , pp. 350-354
    • Labayen, I.1    Ortega, F.B.2    Sjöström, M.3    Nilsson, T.K.4    Olsson, L.A.5    Ruiz, J.R.6
  • 107
    • 78549247766 scopus 로고    scopus 로고
    • Uncoupling protein 2 G(-866)A polymorphism: A new gene polymorphism associated with C-reactive protein in type 2 diabetic patients C-reactive protein in type 2 diabetic patients
    • 10.1186/1475-2840-9-68
    • Lapice E., emanuela1978@hotmail.it Pinelli M., michele.pinelli@unina.it Pisu E., gianfranco.pagano@unito.it Monticelli A., a.monticelli@ieos.cnr.it Gambino R., gianfranco.pagano@unito.it Pagano G., gianfranco.pagano@unito.it Valsecchi S., michele.pinelli@unina.it Cocozza S., cocozza@unina.it Riccardi G., riccardi@unina.it Vaccaro O., ovaccaro@unina.it Uncoupling protein 2 G(-866)A polymorphism: a new gene polymorphism associated with C-reactive protein in type 2 diabetic patients C-reactive protein in type 2 diabetic patients. Cardiovascular Diabetology 2010 9, article 68 10.1186/1475-2840-9-68
    • (2010) Cardiovascular Diabetology , vol.968
    • Lapice, E.1
  • 108


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.