-
2
-
-
0037283601
-
The relative contribution of insulin resistance and β-cell dysfunction to the pathophysiology of type 2 diabetes
-
Kahn SE 2003 The relative contribution of insulin resistance and β-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 46:3-19
-
(2003)
Diabetologia
, vol.46
, pp. 3-19
-
-
Kahn, S.E.1
-
3
-
-
0035106310
-
Putting the genes for type II diabetes on the map
-
Almind K, Doria A, Kahn CR 2001 Putting the genes for type II diabetes on the map. Nat Med 3:277-279
-
(2001)
Nat Med
, vol.3
, pp. 277-279
-
-
Almind, K.1
Doria, A.2
Kahn, C.R.3
-
4
-
-
0034927069
-
Uncoupling protein 2: Adiposity angel and diabetes devil?
-
O'Railly S 2001 Uncoupling protein 2: adiposity angel and diabetes devil? Nat Med 7:770-772
-
(2001)
Nat Med
, vol.7
, pp. 770-772
-
-
O'Railly, S.1
-
5
-
-
0032991716
-
Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets
-
Chan CB, MacDonald PE, Saleh MC, Johns DC, Marban E, Wheeler MB 1999 Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets. Diabetes 48:1482-1486
-
(1999)
Diabetes
, vol.48
, pp. 1482-1486
-
-
Chan, C.B.1
MacDonald, P.E.2
Saleh, M.C.3
Johns, D.C.4
Marban, E.5
Wheeler, M.B.6
-
6
-
-
0035875087
-
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β cell dysfunction, and type 2 diabetes
-
Zhang CY, Baffy G, Perret G, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng X, Wheeler MB, Shulman GI, Chan CB, Lowell BB 2001 Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β cell dysfunction, and type 2 diabetes. Cell 105:745-755
-
(2001)
Cell
, vol.105
, pp. 745-755
-
-
Zhang, C.Y.1
Baffy, G.2
Perret, G.3
Krauss, S.4
Peroni, O.5
Grujic, D.6
Hagen, T.7
Vidal-Puig, A.J.8
Boss, O.9
Kim, Y.B.10
Zheng, X.11
Wheeler, M.B.12
Shulman, G.I.13
Chan, C.B.14
Lowell, B.B.15
-
7
-
-
0032929816
-
Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves β-cell function
-
1999
-
Wang MY, Shimabukuro M, Lee Y, Trinh KY, Chen JL, Newgard CB, Unger RH 1999 1999 Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves β-cell function. Diabetes 48:1020-1025
-
(1999)
Diabetes
, vol.48
, pp. 1020-1025
-
-
Wang, M.Y.1
Shimabukuro, M.2
Lee, Y.3
Trinh, K.Y.4
Chen, J.L.5
Newgard, C.B.6
Unger, R.H.7
-
8
-
-
0031763146
-
Localization of tub and uncoupling proteins (Ucp) 2 and 3 to a region of rat chromosome 1 linked to glucose intolerance and adiposity in the Goto-Kakizaki (Gk) type 2 diabetic rat
-
Kaisaki PJ, Woon PY, Wallis RH, Monaco AP, Lathrop M, Gauguier D 1998 Localization of tub and uncoupling proteins (Ucp) 2 and 3 to a region of rat chromosome 1 linked to glucose intolerance and adiposity in the Goto-Kakizaki (Gk) type 2 diabetic rat. Mamm Genome 9:910-912
-
(1998)
Mamm Genome
, vol.9
, pp. 910-912
-
-
Kaisaki, P.J.1
Woon, P.Y.2
Wallis, R.H.3
Monaco, A.P.4
Lathrop, M.5
Gauguier, D.6
-
9
-
-
0033764737
-
The Finland-United States Investigation of Non-Insulin-Dependent Diabetes Mellitus Genetics (FUSION) study I. An autosomal genome scan for genes that predispose to type 2 diabetes
-
Ghosh S, Watanabe RM, Valle TT, Hauser ER, Magnuson VL, Langefeld CD, Ally DS, Mohlke KL, Silander K, Kohtamäki K, Chines P, Balow Jr J, Birznieks G, Chang J, Eldridge W, Erdos MR, Karanjawala ZE, Knapp JI, Kudelko K, Martin C, Morales-Mena A, Musick A, Musick T, Pfahl C, Porter R, Rayman JB, Rha D, Segal L, Shapiro S, Sharaf R, Shurtleff B, So A, Tannenbaum J, Te C, Tovar J, Unni A, Welch C, Whiten R, Witt A, Blaschack-Harvan J, Douglas JA, Duren WL, Epstein MP, Fingerlin TE, Kaleta HS, Lange EM, Li C, McEachin RC, Stringham HM, Trager E, White PP, Eriksson J, Toivanen L, Vidgren G, Nylund SJ, Tuomilehto-Wolf E, Ross EH, Demirchyan E, Hagopian WA, Buchanan TA, Tuomilehto J, Bergman RN, Collins FS, Boehnke M 2000 The Finland-United States Investigation of Non-Insulin-Dependent Diabetes Mellitus Genetics (FUSION) study I. An autosomal genome scan for genes that predispose to type 2 diabetes. Am J Hum Genet 67:1174-1185
-
(2000)
Am J Hum Genet
, vol.67
, pp. 1174-1185
-
-
Ghosh, S.1
Watanabe, R.M.2
Valle, T.T.3
Hauser, E.R.4
Magnuson, V.L.5
Langefeld, C.D.6
Ally, D.S.7
Mohlke, K.L.8
Silander, K.9
Kohtamäki, K.10
Chines, P.11
Balow Jr., J.12
Birznieks, G.13
Chang, J.14
Eldridge, W.15
Erdos, M.R.16
Karanjawala, Z.E.17
Knapp, J.I.18
Kudelko, K.19
Martin, C.20
Morales-Mena, A.21
Musick, A.22
Musick, T.23
Pfahl, C.24
Porter, R.25
Rayman, J.B.26
Rha, D.27
Segal, L.28
Shapiro, S.29
Sharaf, R.30
Shurtleff, B.31
So, A.32
Tannenbaum, J.33
Te, C.34
Tovar, J.35
Unni, A.36
Welch, C.37
Whiten, R.38
Witt, A.39
Blaschack-Harvan, J.40
Douglas, J.A.41
Duren, W.L.42
Epstein, M.P.43
Fingerlin, T.E.44
Kaleta, H.S.45
Lange, E.M.46
Li, C.47
McEachin, R.C.48
Stringham, H.M.49
Trager, E.50
White, P.P.51
Eriksson, J.52
Toivanen, L.53
Vidgren, G.54
Nylund, S.J.55
Tuomilehto-Wolf, E.56
Ross, E.H.57
Demirchyan, E.58
Hagopian, W.A.59
Buchanan, T.A.60
Tuomilehto, J.61
Bergman, R.N.62
Collins, F.S.63
Boehnke, M.64
more..
-
10
-
-
0034883804
-
Uncoupling proteins: Functional characteristics and role in the pathogenesis of obesity and type 2 diabetes
-
Dalgaard LT, Pedersen O 2001 Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and type 2 diabetes. Diabetologia 44:946-965
-
(2001)
Diabetologia
, vol.44
, pp. 946-965
-
-
Dalgaard, L.T.1
Pedersen, O.2
-
11
-
-
0034972150
-
A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans
-
Esterbauer H, Schneitler C, Oberkofler H, Ebenbichler C, Paulweber B, Sandhofer F, Ladurner G, Hell E, Strosberg AD, Patsch JR, Krempler F, Patsch W 2001 A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. Nat Genet 28:178-183
-
(2001)
Nat Genet
, vol.28
, pp. 178-183
-
-
Esterbauer, H.1
Schneitler, C.2
Oberkofler, H.3
Ebenbichler, C.4
Paulweber, B.5
Sandhofer, F.6
Ladurner, G.7
Hell, E.8
Strosberg, A.D.9
Patsch, J.R.10
Krempler, F.11
Patsch, W.12
-
12
-
-
0036830548
-
A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans
-
Krempler F, Esterbauer H, Weitgasser R, Ebenbichler C, Patsch JR, Miller K, Xie M, Linnemayr V, Oberkofler H, Patsch W 2002 A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans. Diabetes 51:3331-3335
-
(2002)
Diabetes
, vol.51
, pp. 3331-3335
-
-
Krempler, F.1
Esterbauer, H.2
Weitgasser, R.3
Ebenbichler, C.4
Patsch, J.R.5
Miller, K.6
Xie, M.7
Linnemayr, V.8
Oberkofler, H.9
Patsch, W.10
-
13
-
-
0346787545
-
Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion
-
Wang H, Chu WS, Lu T, Hasstedt SJ, Kern PA, Elbein SC 2004 Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion. Am J Physiol 286:E1-E7
-
(2004)
Am J Physiol
, vol.286
-
-
Wang, H.1
Chu, W.S.2
Lu, T.3
Hasstedt, S.J.4
Kern, P.A.5
Elbein, S.C.6
-
14
-
-
12444292715
-
A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects
-
Sesti G, Cardellini M, Marini MA, Frontoni S, D'Adamo M, Del Guerra S, Lauro D, De Nicolais P, Sbraccia P, Del Prato S, Gambardella S, Federici M, Marchetti P, Lauro R 2003 A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects. Diabetes 52:1280-1283
-
(2003)
Diabetes
, vol.52
, pp. 1280-1283
-
-
Sesti, G.1
Cardellini, M.2
Marini, M.A.3
Frontoni, S.4
D'Adamo, M.5
Del Guerra, S.6
Lauro, D.7
De Nicolais, P.8
Sbraccia, P.9
Del Prato, S.10
Gambardella, S.11
Federici, M.12
Marchetti, P.13
Lauro, R.14
-
16
-
-
0031595923
-
12 Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
-
12 Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 20:284-287
-
(1998)
Nat Genet
, vol.20
, pp. 284-287
-
-
Deeb, S.S.1
Fajas, L.2
Nemoto, M.3
Pihlajamaki, J.4
Mykkanen, L.5
Kuusisto, J.6
Laakso, M.7
Fujimoto, W.8
Auwerx, J.9
-
17
-
-
0034607051
-
Inhibitory effect of a proline-to-alanine substitution at codon 12 of peroxisome proliferator activated receptor-γ2 on thiazolidinedione-induced adipogenesis
-
Masugi J, Tamori Y, Mori H, Koike T, Kasuga M 2000 Inhibitory effect of a proline-to-alanine substitution at codon 12 of peroxisome proliferator activated receptor-γ2 on thiazolidinedione-induced adipogenesis. Biochem Biophys Res Commun 268:178-182
-
(2000)
Biochem Biophys Res Commun
, vol.268
, pp. 178-182
-
-
Masugi, J.1
Tamori, Y.2
Mori, H.3
Koike, T.4
Kasuga, M.5
-
18
-
-
0033624575
-
12 Ala polymorphism is associated with decreased risk of type 2 diabetes
-
12 Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 26:76-80
-
(2000)
Nat Genet
, vol.26
, pp. 76-80
-
-
Altshuler, D.1
Hirschhorn, J.N.2
Klannemark, M.3
Lindgren, C.M.4
Vohl, M.C.5
Nemesh, J.6
Lane, C.R.7
Schaffner, S.F.8
Bolk, S.9
Brewer, C.10
Tuomi, T.11
Gaudet, D.12
Hudson, T.J.13
Daly, M.14
Groop, L.15
Lander, E.S.16
-
19
-
-
0031577482
-
Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker diabetic fatty rats
-
Shimabukuro M, Zhou YT, Lee Y, Unger RH 1997 Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker diabetic fatty rats. Biochem Biophys Res Commun 237:359-361
-
(1997)
Biochem Biophys Res Commun
, vol.237
, pp. 359-361
-
-
Shimabukuro, M.1
Zhou, Y.T.2
Lee, Y.3
Unger, R.H.4
-
20
-
-
0036724133
-
Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-γ inhibition
-
Patane' G, Anello M, Piro S, Vigneri R, Purrello F, Rabuazzo AM 2002 Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-γ inhibition. Diabetes 51:2749-2756
-
(2002)
Diabetes
, vol.51
, pp. 2749-2756
-
-
Patane', G.1
Anello, M.2
Piro, S.3
Vigneri, R.4
Purrello, F.5
Rabuazzo, A.M.6
-
21
-
-
0032488968
-
Troglitazone lowers islet fat and restores β cell function of Zucker diabetic fatty rats
-
Shimabukuro M, Zhou YT, Lee Y, Unger RH 1998 Troglitazone lowers islet fat and restores β cell function of Zucker diabetic fatty rats. J Biol Chem 273:3547-3550
-
(1998)
J Biol Chem
, vol.273
, pp. 3547-3550
-
-
Shimabukuro, M.1
Zhou, Y.T.2
Lee, Y.3
Unger, R.H.4
-
22
-
-
0031847401
-
Peroxisome proliferator-activated receptor-γ agonist, rosiglitazone, protects against nephropathy and pancreatic islet abnormalities in Zucker fatty rats
-
Buckingham RE, Al-Barazanji KA, Toseland CD, Slaughter M, Connor SC, West A, Bond B, Turner NC, Clapham JC 1998 Peroxisome proliferator-activated receptor-γ agonist, rosiglitazone, protects against nephropathy and pancreatic islet abnormalities in Zucker fatty rats. Diabetes 47:1326-1334
-
(1998)
Diabetes
, vol.47
, pp. 1326-1334
-
-
Buckingham, R.E.1
Al-Barazanji, K.A.2
Toseland, C.D.3
Slaughter, M.4
Connor, S.C.5
West, A.6
Bond, B.7
Turner, N.C.8
Clapham, J.C.9
-
23
-
-
1642414416
-
Rosiglitazone prevents the impairment of human islet function induced by fatty acids: Evidence for a role of PPAR72 in the modulation of insulin secretion
-
Lupi R, Del Guerra S, Marselli L, Bugliani M, Boggi U, Mosca F, Marchetti P, Del Prato S 2004 Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPAR72 in the modulation of insulin secretion. Am J Physiol 286:E560-E567
-
(2004)
Am J Physiol
, vol.286
-
-
Lupi, R.1
Del Guerra, S.2
Marselli, L.3
Bugliani, M.4
Boggi, U.5
Mosca, F.6
Marchetti, P.7
Del Prato, S.8
-
24
-
-
0036008643
-
A variation in 3′ UTR of hPTP1B increases specific gene expression and associates with insulin resistance
-
Di Paola R, Frittitta L, Miscio G, Bozzali M, Baratta R, Centra M, Spampinato D, Santagati MG, Ercolino T, Cisternino C, Soccio T, Mastroianno S, Tassi V, Almgren P, Pizzuti A, Vigneri R, Trischitta V 2002 A variation in 3′ UTR of hPTP1B increases specific gene expression and associates with insulin resistance. Am J Hum Genet 70:806-812
-
(2002)
Am J Hum Genet
, vol.70
, pp. 806-812
-
-
Di Paola, R.1
Frittitta, L.2
Miscio, G.3
Bozzali, M.4
Baratta, R.5
Centra, M.6
Spampinato, D.7
Santagati, M.G.8
Ercolino, T.9
Cisternino, C.10
Soccio, T.11
Mastroianno, S.12
Tassi, V.13
Almgren, P.14
Pizzuti, A.15
Vigneri, R.16
Trischitta, V.17
-
25
-
-
0344944629
-
Evidence for genetic epistasis in human insulin resistance: The combined effect of PC-1 (K121Q) and PPARγ2 (P12A) polymorphisms
-
Baratta R, Di Paola R, Spampinato D, Fini G, Marucci A, Coco A, Vigneri R, Frittitta L, Trischitta V 2003 Evidence for genetic epistasis in human insulin resistance: the combined effect of PC-1 (K121Q) and PPARγ2 (P12A) polymorphisms. J Mol Med 81:718-723
-
(2003)
J Mol Med
, vol.81
, pp. 718-723
-
-
Baratta, R.1
Di Paola, R.2
Spampinato, D.3
Fini, G.4
Marucci, A.5
Coco, A.6
Vigneri, R.7
Frittitta, L.8
Trischitta, V.9
-
28
-
-
0033584825
-
Molecular cloning and functional characterization of the promoter region of the human uncoupling protein-2 gene
-
Tu N, Chen H, Winnikes U, Reinert I, Marmann G, Pirke KM, Lentes KU 1999 Molecular cloning and functional characterization of the promoter region of the human uncoupling protein-2 gene. Biochem Biophys Res Commun 265:326-334
-
(1999)
Biochem Biophys Res Commun
, vol.265
, pp. 326-334
-
-
Tu, N.1
Chen, H.2
Winnikes, U.3
Reinert, I.4
Marmann, G.5
Pirke, K.M.6
Lentes, K.U.7
-
29
-
-
1842866369
-
Multifactor-dimensionality reduction shows a two-locus interaction associated with type 2 diabetes mellitus
-
Cho YM, Ritchie MD, Moore JH, Park JY, Lee KU, Shin HD, Lee HK, Park KS 2004 Multifactor-dimensionality reduction shows a two-locus interaction associated with type 2 diabetes mellitus. Diabetologia 47:549-554
-
(2004)
Diabetologia
, vol.47
, pp. 549-554
-
-
Cho, Y.M.1
Ritchie, M.D.2
Moore, J.H.3
Park, J.Y.4
Lee, K.U.5
Shin, H.D.6
Lee, H.K.7
Park, K.S.8
-
30
-
-
0028090414
-
Genetic dissection of complex traits
-
Lander ES, Schork NJ 1994 Genetic dissection of complex traits. Science 265:2037-2048
-
(1994)
Science
, vol.265
, pp. 2037-2048
-
-
Lander, E.S.1
Schork, N.J.2
-
31
-
-
12144285594
-
Assessing the impact of population stratification on genetic association study
-
Freedman ML, Reich D, Penney KL, McDonald GJ, Mignault AA, Pattereon N, Gabriel SB, Topol EJ, Smoller JW, Pato CN, Pato MP, Petryshen TL, Kolonel LN, Lander ES, Sklar P, Henderson B, Hirschhorn JN, Altshuler D 2004 Assessing the impact of population stratification on genetic association study. Nat Genet 36:388-393
-
(2004)
Nat Genet
, vol.36
, pp. 388-393
-
-
Freedman, M.L.1
Reich, D.2
Penney, K.L.3
McDonald, G.J.4
Mignault, A.A.5
Pattereon, N.6
Gabriel, S.B.7
Topol, E.J.8
Smoller, J.W.9
Pato, C.N.10
Pato, M.P.11
Petryshen, T.L.12
Kolonel, L.N.13
Lander, E.S.14
Sklar, P.15
Henderson, B.16
Hirschhorn, J.N.17
Altshuler, D.18
|