Uncoupling proteins: Functional characteristics and role in the pathogenesis of obesity and Type II diabetes

Diabetologia

Volumn 44, Issue 8, 2001, Pages 946-965

  Dalgaard, L T ^a   Pedersen, O ^a  

^a STENO DIABETES CENTER   (Denmark)

Author keywords

Body weight regulation; Brown adipose tissue; Energy expenditure; Gene knockout; Genetics; Metabolic rate; Mutation; Obesity; Polymorphism; Reactive oxygen species; Transgenics; Type II diabetes mellitus; Uncoupling proteins; White adipose tissue

Indexed keywords

REACTIVE OXYGEN METABOLITE; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONTROLLED STUDY; DIABETOGENESIS; ENERGY EXPENDITURE; GENE MUTATION; GENETIC ENGINEERING; GENETIC POLYMORPHISM; HUMAN; METABOLIC RATE; MITOCHONDRIAL MEMBRANE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OXIDATION; PRIORITY JOURNAL; PROTON TRANSPORT; REVIEW; SEQUENCE HOMOLOGY; TRANSGENIC MOUSE; WEIGHT GAIN;

ANIMALS; CARRIER PROTEINS; DIABETES MELLITUS, TYPE 2; ENERGY METABOLISM; GENE EXPRESSION; GENETIC ENGINEERING; HUMANS; ION CHANNELS; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL PROTEINS; MUTATION; OBESITY; PROTEINS;

EID: 0034883804     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250100596     Document Type: Review

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171. A genetic variation in the 5′ flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activity
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175. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β-cell dysfunction, and Type 2 diabetes
176. A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans