-
2
-
-
0033358532
-
Sibling-based tests of linkage and association for quantitative traits
-
Allison DB, Heo M, Kaplan N, and Martin ER. Sibling-based tests of linkage and association for quantitative traits. Am J Hum Genet 64: 1754-1763, 1999.
-
(1999)
Am J Hum Genet
, vol.64
, pp. 1754-1763
-
-
Allison, D.B.1
Heo, M.2
Kaplan, N.3
Martin, E.R.4
-
3
-
-
0031954419
-
Structure and organization of the human uncoupling protein gene and identification of a common biallelic variant in Caucasian and African-American subjects
-
Argyropoulos G, Brown AM, Peterson R, Likes CE, Watson DK, and Garvey WT. Structure and organization of the human uncoupling protein gene and identification of a common biallelic variant in Caucasian and African-American subjects. Diabetes 47: 685-687, 1998.
-
(1998)
Diabetes
, vol.47
, pp. 685-687
-
-
Argyropoulos, G.1
Brown, A.M.2
Peterson, R.3
Likes, C.E.4
Watson, D.K.5
Garvey, W.T.6
-
4
-
-
0036584365
-
Uncoupling proteins and thermoregulation
-
Argyropoulos G and Harper ME. Uncoupling proteins and thermoregulation. J Appl Physiol 92: 2187-2198, 2002.
-
(2002)
J Appl Physiol
, vol.92
, pp. 2187-2198
-
-
Argyropoulos, G.1
Harper, M.E.2
-
5
-
-
0019810028
-
Physiologic evaluation of factors controlling glucose tolerance in man: Measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose
-
Bergman RN, Phillips LS, and Cobelli C. Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest 68: 1456-1467, 1981.
-
(1981)
J Clin Invest
, vol.68
, pp. 1456-1467
-
-
Bergman, R.N.1
Phillips, L.S.2
Cobelli, C.3
-
6
-
-
0030729552
-
Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans
-
Bouchard C, Perusse L, Chagnon YC, Warden C, and Ricquier D. Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans. Hum Mol Genet 6: 1887-1889, 1997.
-
(1997)
Hum Mol Genet
, vol.6
, pp. 1887-1889
-
-
Bouchard, C.1
Perusse, L.2
Chagnon, Y.C.3
Warden, C.4
Ricquier, D.5
-
7
-
-
0021891255
-
Health implications of obesity: An NIH Consensus Development Conference
-
Burton BT, Foster WR, Hirsch J, and Van Itallie TB. Health implications of obesity: an NIH Consensus Development Conference. Int J Obes 9: 155-170, 1985.
-
(1985)
Int J Obes
, vol.9
, pp. 155-170
-
-
Burton, B.T.1
Foster, W.R.2
Hirsch, J.3
Van Itallie, T.B.4
-
8
-
-
0344091561
-
Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans
-
Carlson CS, Eberle MA, Rieder MJ, Smith JD, Kruglyak L, and Nickerson DA. Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans. Nat Genet 33: 518-521, 2003.
-
(2003)
Nat Genet
, vol.33
, pp. 518-521
-
-
Carlson, C.S.1
Eberle, M.A.2
Rieder, M.J.3
Smith, J.D.4
Kruglyak, L.5
Nickerson, D.A.6
-
9
-
-
0034990987
-
Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: Mechanism of action
-
Chan CB, De Leo D, Joseph JW, McQuaid TS, Ha XF, Xu F, Tsushima RG, Pennefather PS, Salapatek AM, and Wheeler MB. Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action. Diabetes 50: 1302-1310, 2001.
-
(2001)
Diabetes
, vol.50
, pp. 1302-1310
-
-
Chan, C.B.1
De Leo, D.2
Joseph, J.W.3
McQuaid, T.S.4
Ha, X.F.5
Xu, F.6
Tsushima, R.G.7
Pennefather, P.S.8
Salapatek, A.M.9
Wheeler, M.B.10
-
10
-
-
0023277545
-
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
-
Chomczynski P and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
-
(1987)
Anal Biochem
, vol.162
, pp. 156-159
-
-
Chomczynski, P.1
Sacchi, N.2
-
11
-
-
0034883804
-
Uncoupling proteins: Functional characteristics and role in the pathogenesis of obesity and Type II diabetes
-
Dalgaard LT and Pedersen O. Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes. Diabetologia 44: 946-965, 2001.
-
(2001)
Diabetologia
, vol.44
, pp. 946-965
-
-
Dalgaard, L.T.1
Pedersen, O.2
-
12
-
-
0036168528
-
Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians
-
Elbein SC, Chu W, Ren Q, Hemphill C, Schay J, Cox NJ, Hanis CL, and Hasstedt SJ. Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians. J Clin Endocrinol Metab 87: 650-654, 2002.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 650-654
-
-
Elbein, S.C.1
Chu, W.2
Ren, Q.3
Hemphill, C.4
Schay, J.5
Cox, N.J.6
Hanis, C.L.7
Hasstedt, S.J.8
-
13
-
-
0036020283
-
Evaluation of apolipoprotein A-II as a positional candidate gene for familial Type II diabetes, altered lipid concentrations, and insulin resistance
-
Elbein SC, Chu W, Ren Q, Wang H, Hemphill C, and Hasstedt SJ. Evaluation of apolipoprotein A-II as a positional candidate gene for familial Type II diabetes, altered lipid concentrations, and insulin resistance. Diabetologia 45: 1026-1033, 2002.
-
(2002)
Diabetologia
, vol.45
, pp. 1026-1033
-
-
Elbein, S.C.1
Chu, W.2
Ren, Q.3
Wang, H.4
Hemphill, C.5
Hasstedt, S.J.6
-
14
-
-
0036061611
-
Quantitative trait linkage analysis of lipid-related traits in familial type 2 diabetes: Evidence for linkage of triglyceride levels to chromosome 19q
-
Elbein SC and Hasstedt SJ. Quantitative trait linkage analysis of lipid-related traits in familial type 2 diabetes: evidence for linkage of triglyceride levels to chromosome 19q. Diabetes 51: 528-535, 2002.
-
(2002)
Diabetes
, vol.51
, pp. 528-535
-
-
Elbein, S.C.1
Hasstedt, S.J.2
-
15
-
-
0033312608
-
Heritability of pancreatic beta-cell function among nondiabetic members of Caucasian familial type 2 diabetic kindreds
-
Elbein SC, Hasstedt SJ, Wegner K, and Kahn SE. Heritability of pancreatic beta-cell function among nondiabetic members of Caucasian familial type 2 diabetic kindreds. J Clin Endocrinol Metab 84: 1398-1403, 1999.
-
(1999)
J Clin Endocrinol Metab
, vol.84
, pp. 1398-1403
-
-
Elbein, S.C.1
Hasstedt, S.J.2
Wegner, K.3
Kahn, S.E.4
-
16
-
-
0032910599
-
A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians
-
Elbein SC, Hoffman MD, Teng K, Leppert MF, and Hasstedt SJ. A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians. Diabetes 48: 1175-1182, 1999.
-
(1999)
Diabetes
, vol.48
, pp. 1175-1182
-
-
Elbein, S.C.1
Hoffman, M.D.2
Teng, K.3
Leppert, M.F.4
Hasstedt, S.J.5
-
17
-
-
0030731492
-
Uncoupling protein 2 region on chromosome 11q13 is not linked to markers of obesity in familial type 2 diabtetes
-
Elbein SC, Leppert M, and Hasstedt S. Uncoupling protein 2 region on chromosome 11q13 is not linked to markers of obesity in familial type 2 diabtetes. Diabetes 46: 2105-2107, 1997.
-
(1997)
Diabetes
, vol.46
, pp. 2105-2107
-
-
Elbein, S.C.1
Leppert, M.2
Hasstedt, S.3
-
18
-
-
0035090002
-
Role of common sequence variants in insulin secretion in familial type 2 diabetic kindreds: The sulfonylurea receptor, glucokinase, and hepatocyte nuclear factor 1alpha genes
-
Elbein SC, Sun J, Scroggin E, Teng K, and Hasstedt SJ. Role of common sequence variants in insulin secretion in familial type 2 diabetic kindreds: the sulfonylurea receptor, glucokinase, and hepatocyte nuclear factor 1alpha genes. Diabetes Care 24: 472-478, 2001.
-
(2001)
Diabetes Care
, vol.24
, pp. 472-478
-
-
Elbein, S.C.1
Sun, J.2
Scroggin, E.3
Teng, K.4
Hasstedt, S.J.5
-
19
-
-
0034972150
-
A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans
-
Esterbauer H, Schneitler C, Oberkofler H, Ebenbichler C, Paulweber B, Sandhofer F, Ladurner G, Hell E, Strosberg AD, Patsch JR, Krempler F, and Patsch W. A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. Nat Genet 28: 178-183, 2001.
-
(2001)
Nat Genet
, vol.28
, pp. 178-183
-
-
Esterbauer, H.1
Schneitler, C.2
Oberkofler, H.3
Ebenbichler, C.4
Paulweber, B.5
Sandhofer, F.6
Ladurner, G.7
Hell, E.8
Strosberg, A.D.9
Patsch, J.R.10
Krempler, F.11
Patsch, W.12
-
20
-
-
0031019249
-
Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia
-
Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, Levi-Meyrueis C, Bouillaud F, Seldin MF, Surwit RS, Ricquier D, and Warden CH. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet 15: 269-272, 1997.
-
(1997)
Nat Genet
, vol.15
, pp. 269-272
-
-
Fleury, C.1
Neverova, M.2
Collins, S.3
Raimbault, S.4
Champigny, O.5
Levi-Meyrueis, C.6
Bouillaud, F.7
Seldin, M.F.8
Surwit, R.S.9
Ricquier, D.10
Warden, C.H.11
-
21
-
-
0032852947
-
The mitochondrial uncoupling protein-2: Current status
-
Fleury C and Sanchis D. The mitochondrial uncoupling protein-2: current status. Int J Biochem Cell Biol 31: 1261-1278, 1999.
-
(1999)
Int J Biochem Cell Biol
, vol.31
, pp. 1261-1278
-
-
Fleury, C.1
Sanchis, D.2
-
22
-
-
0003625911
-
-
Salt Lake City, UT: University of Utah, Dept. of Human Genetics
-
Hasstedt SJ. PAP: Pedigree Analysis Package, V5. Salt Lake City, UT: University of Utah, Dept. of Human Genetics, 2001.
-
(2001)
PPP: Pedigree Analysis Package, V5
-
-
Hasstedt, S.J.1
-
23
-
-
0030846804
-
Recessive inheritance of obesity in familial non-insulin-dependent diabetes mellitus, and lack of linkage to nine candidate genes
-
Hasstedt SJ, Hoffman M, Leppert MF, and Elbein SC. Recessive inheritance of obesity in familial non-insulin-dependent diabetes mellitus, and lack of linkage to nine candidate genes. Am J Hum Genet 61: 668-677, 1997.
-
(1997)
Am J Hum Genet
, vol.61
, pp. 668-677
-
-
Hasstedt, S.J.1
Hoffman, M.2
Leppert, M.F.3
Elbein, S.C.4
-
24
-
-
0033772073
-
Genetic variation in the gene encoding calpain 10 is associated with type 2 diabetes mellitus
-
Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner TH, Mashima H, Schwarz PE, Bosque-Plata L, Horikawa Y, Oda Y, Yoshiuchi I, Colilla S, Polonsky KS, Wei S, Concannon P, Iwasaki N, Schulze J, Baier LJ, Bogardus C, Groop L, Boerwinkle E, Hanis CL, and Bell GI. Genetic variation in the gene encoding calpain 10 is associated with type 2 diabetes mellitus. Nat Genet 26: 163-175, 2000.
-
(2000)
Nat Genet
, vol.26
, pp. 163-175
-
-
Horikawa, Y.1
Oda, N.2
Cox, N.J.3
Li, X.4
Orho-Melander, M.5
Hara, M.6
Hinokio, Y.7
Lindner, T.H.8
Mashima, H.9
Schwarz, P.E.10
Bosque-Plata, L.11
Horikawa, Y.12
Oda, Y.13
Yoshiuchi, I.14
Colilla, S.15
Polonsky, K.S.16
Wei, S.17
Concannon, P.18
Iwasaki, N.19
Schulze, J.20
Baier, L.J.21
Bogardus, C.22
Groop, L.23
Boerwinkle, E.24
Hanis, C.L.25
Bell, G.I.26
more..
-
25
-
-
0027375768
-
Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects: Evidence for a hyperbolic function
-
Kahn SE, Prigeon RL, McCulloch DK, Boyko EJ, Bergman RN, Schwartz MW, Neifing JL, Ward WK, Beard JC, Palmer JP, and Porte D Jr. Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects: evidence for a hyperbolic function. Diabetes 42: 1663-1672, 1993.
-
(1993)
Diabetes
, vol.42
, pp. 1663-1672
-
-
Kahn, S.E.1
Prigeon, R.L.2
McCulloch, D.K.3
Boyko, E.J.4
Bergman, R.N.5
Schwartz, M.W.6
Neifing, J.L.7
Ward, W.K.8
Beard, J.C.9
Palmer, J.P.10
Porte Jr., D.11
-
26
-
-
0035023128
-
Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity-associated insulin resistance
-
Kern PA, Ranganathan S, Li C, Wood L, and Ranganathan G. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity-associated insulin resistance. Am J Physiol Endocrinol Metab 280: E745-E751, 2001.
-
(2001)
Am J Physiol Endocrinol Metab
, vol.280
-
-
Kern, P.A.1
Ranganathan, S.2
Li, C.3
Wood, L.4
Ranganathan, G.5
-
27
-
-
0036830548
-
A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans
-
Krempler F, Esterbauer H, Weitgasser R, Ebenbichler C, Patsch JR, Miller K, Xie M, Linnemayr V, Oberkofler H, and Patsch W. A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans. Diabetes 51: 3331-3335, 2002.
-
(2002)
Diabetes
, vol.51
, pp. 3331-3335
-
-
Krempler, F.1
Esterbauer, H.2
Weitgasser, R.3
Ebenbichler, C.4
Patsch, J.R.5
Miller, K.6
Xie, M.7
Linnemayr, V.8
Oberkofler, H.9
Patsch, W.10
-
28
-
-
0021813187
-
Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
-
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, and Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419, 1985.
-
(1985)
Diabetologia
, vol.28
, pp. 412-419
-
-
Matthews, D.R.1
Hosker, J.P.2
Rudenski, A.S.3
Naylor, B.A.4
Treacher, D.F.5
Turner, R.C.6
-
29
-
-
0039513062
-
Computer-simulation methods in human linkage analysis
-
Ott J. Computer-simulation methods in human linkage analysis. Proc Natl Acad Sci USA 86: 4175-4178, 1989.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 4175-4178
-
-
Ott, J.1
-
31
-
-
0032622532
-
In vitro transcription and translation of lipoprotein lipase
-
Ranganathan G and Kern PA. In vitro transcription and translation of lipoprotein lipase. Methods Mol Biol 109: 337-341, 1999.
-
(1999)
Methods Mol Biol
, vol.109
, pp. 337-341
-
-
Ranganathan, G.1
Kern, P.A.2
-
32
-
-
0029741063
-
The future of genetic studies of complex human diseases
-
Risch N and Merikangas K. The future of genetic studies of complex human diseases. Science 273: 1516-1517, 1996.
-
(1996)
Science
, vol.273
, pp. 1516-1517
-
-
Risch, N.1
Merikangas, K.2
-
33
-
-
0036192111
-
Uncoupling protein-2: Evidence for its function as a metabolic regulator
-
Saleh MC, Wheeler MB, and Chan CB. Uncoupling protein-2: evidence for its function as a metabolic regulator. Diabetologia 45: 174-187, 2002.
-
(2002)
Diabetologia
, vol.45
, pp. 174-187
-
-
Saleh, M.C.1
Wheeler, M.B.2
Chan, C.B.3
-
34
-
-
12444292715
-
A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects
-
Sesti G, Cardellini M, Marini MA, Frontoni S, D'Adamo M, Del Guerra S, Lauro D, De Nicolais P, Sbraccia P, Del Prato S, Gambardella S, Federici M, Marchetti P, and Lauro R. A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects. Diabetes 52: 1280-1283, 2003.
-
(2003)
Diabetes
, vol.52
, pp. 1280-1283
-
-
Sesti, G.1
Cardellini, M.2
Marini, M.A.3
Frontoni, S.4
D'Adamo, M.5
Del Guerra, S.6
Lauro, D.7
De Nicolais, P.8
Sbraccia, P.9
Del Prato, S.10
Gambardella, S.11
Federici, M.12
Marchetti, P.13
Lauro, R.14
-
35
-
-
7344220905
-
Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians
-
Walder K, Norman RA, Hanson RL, Schrauwen P, Neverova M, Jenkinson CP, Easlick J, Warden CH, Pecqueur C, Raimbault S, Ricquier D, Silver MHK, Shuldiner AR, Solanes G, Lowell BB, Chung WK, Leibel RL, Pratley R, and Ravussin E. Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians. Hum Mol Genet 7: 1431-1435, 1998.
-
(1998)
Hum Mol Genet
, vol.7
, pp. 1431-1435
-
-
Walder, K.1
Norman, R.A.2
Hanson, R.L.3
Schrauwen, P.4
Neverova, M.5
Jenkinson, C.P.6
Easlick, J.7
Warden, C.H.8
Pecqueur, C.9
Raimbault, S.10
Ricquier, D.11
Silver, M.H.K.12
Shuldiner, A.R.13
Solanes, G.14
Lowell, B.B.15
Chung, W.K.16
Leibel, R.L.17
Pratley, R.18
Ravussin, E.19
-
36
-
-
0036384237
-
Mutation screening and association of human retinoid X receptor gamma variation with lipid levels in familial type 2 diabetes
-
Wang H, Chu W, Hemphill C, Hasstedt SJ, and Elbein SC. Mutation screening and association of human retinoid X receptor gamma variation with lipid levels in familial type 2 diabetes. Mol Genet Metab 76: 3-12, 2002.
-
(2002)
Mol Genet Metab
, vol.76
, pp. 3-12
-
-
Wang, H.1
Chu, W.2
Hemphill, C.3
Hasstedt, S.J.4
Elbein, S.C.5
-
37
-
-
0032742992
-
The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
-
Weyer C, Bogardus C, Mott DM, and Pratley RE. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 104: 787-794, 1999.
-
(1999)
J Clin Invest
, vol.104
, pp. 787-794
-
-
Weyer, C.1
Bogardus, C.2
Mott, D.M.3
Pratley, R.E.4
-
38
-
-
0035875087
-
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes
-
Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng XX, Wheeler MB, Shulman GI, Chan CB, and Lowell BB. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 105: 745-755, 2001.
-
(2001)
Cell
, vol.105
, pp. 745-755
-
-
Zhang, C.Y.1
Baffy, G.2
Perret, P.3
Krauss, S.4
Peroni, O.5
Grujic, D.6
Hagen, T.7
Vidal-Puig, A.J.8
Boss, O.9
Kim, Y.B.10
Zheng, X.X.11
Wheeler, M.B.12
Shulman, G.I.13
Chan, C.B.14
Lowell, B.B.15
|