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Volumn 31, Issue 1, 2012, Pages 110-133

Peptide and protein drugs: The study of their metabolism and catabolism by mass spectrometry

Author keywords

biopharmaceuticals; catabolism; degradation; LC MS MS; mass spectrometry; metabolism; metabolite; peptide protein drug; quantification; stability; structure elucidation

Indexed keywords

BIOPHARMACEUTICALS; CATABOLISM; LC-MS/MS; QUANTIFICATION; STRUCTURE ELUCIDATION;

EID: 84155165533     PISSN: 02777037     EISSN: 10982787     Source Type: Journal    
DOI: 10.1002/mas.20340     Document Type: Review
Times cited : (66)

References (154)
  • 1
    • 0037435030 scopus 로고    scopus 로고
    • Mass spectrometry-based proteomics
    • DOI 10.1038/nature01511
    • Aebersold R, Mann M,. 2003. Mass spectrometry-based proteomics. Nature 422: 198-207. (Pubitemid 36362757)
    • (2003) Nature , vol.422 , Issue.6928 , pp. 198-207
    • Aebersold, R.1    Mann, M.2
  • 2
    • 0036729743 scopus 로고    scopus 로고
    • Cyclosporin: Revisions in monitoring guidelines and review of current analytical methods
    • DOI 10.1258/000456302320314430
    • Andrews DJ, Cramb R,. 2002. Cyclosporin: Revisions in monitoring guidelines and review of current analytical methods. Ann Clin Biochem 39: (Pt 5): 424-435. (Pubitemid 34983437)
    • (2002) Annals of Clinical Biochemistry , vol.39 , Issue.5 , pp. 424-435
    • Andrews, D.J.1    Cramb, R.2
  • 3
    • 70349311434 scopus 로고    scopus 로고
    • Ghrelin and its therapeutic potential for cachectic patients
    • Ashitani J, Matsumoto N, Nakazato M,. 2009. Ghrelin and its therapeutic potential for cachectic patients. Peptides 30 (10): 1951-1956.
    • (2009) Peptides , vol.30 , Issue.10 , pp. 1951-1956
    • Ashitani, J.1    Matsumoto, N.2    Nakazato, M.3
  • 4
    • 59649118194 scopus 로고    scopus 로고
    • Simultaneous quantification of acylated and desacylated ghrelin in biological fluids
    • Aydin S, Karatas F, Geckil H,. 2008. Simultaneous quantification of acylated and desacylated ghrelin in biological fluids. Biomed Chromatogr 22 (12): 1354-1359.
    • (2008) Biomed Chromatogr , vol.22 , Issue.12 , pp. 1354-1359
    • Aydin, S.1    Karatas, F.2    Geckil, H.3
  • 5
    • 30344442129 scopus 로고    scopus 로고
    • Monitoring the neuropeptide metabolites by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    • DOI 10.1016/j.jpba.2005.06.029, PII S0731708505004322
    • Babu CV, Lho DS, Yoo YS,. 2006. Monitoring the neuropeptide metabolites by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J Pharm Biomed Anal 40 (1): 136-141. (Pubitemid 43061228)
    • (2006) Journal of Pharmaceutical and Biomedical Analysis , vol.40 , Issue.1 , pp. 136-141
    • Babu, C.V.S.1    Lho, D.S.2    Yoo, Y.S.3
  • 6
    • 33745684811 scopus 로고    scopus 로고
    • Electron capture dissociation mass spectrometry in characterization of peptides and proteins
    • Bakhtiar R, Guan Z,. 2006. Electron capture dissociation mass spectrometry in characterization of peptides and proteins. Biotechnol Lett 28 (14): 1047-1059.
    • (2006) Biotechnol Lett , vol.28 , Issue.14 , pp. 1047-1059
    • Bakhtiar, R.1    Guan, Z.2
  • 8
    • 77950267745 scopus 로고    scopus 로고
    • Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor
    • Ban K, Kim KH, Cho CK, Sauvé M, Diamandis EP, Backx PH, Drucker DJ, Husain M,. 2010. Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor. Endocrinology 151 (4): 1520-1531.
    • (2010) Endocrinology , vol.151 , Issue.4 , pp. 1520-1531
    • Ban, K.1    Kim, K.H.2    Cho, C.K.3    Sauvé, M.4    Diamandis, E.P.5    Backx, P.H.6    Drucker, D.J.7    Husain, M.8
  • 9
    • 0023790699 scopus 로고
    • Systemic delivery of therapeutic peptides and proteins
    • Banga AK, Chien YW,. 1988. Systemic delivery of therapeutic peptides and proteins. Int J Pharm 48: 15-50.
    • (1988) Int J Pharm , vol.48 , pp. 15-50
    • Banga, A.K.1    Chien, Y.W.2
  • 10
    • 34548803860 scopus 로고    scopus 로고
    • Presystemic metabolism of orally administered peptide drugs and strategies to overcome it
    • DOI 10.2174/138920007780866834
    • Bernkop-Schnurch A, Schmitz T,. 2007. Presystematic metabolism of orally administered peptide drugs and strategies to overcome it. Curr Drug Metab 8 (5): 509-517. (Pubitemid 47603415)
    • (2007) Current Drug Metabolism , vol.8 , Issue.5 , pp. 509-517
    • Bernkop-Schnurch, A.1    Schmitz, T.2
  • 11
    • 3042789985 scopus 로고    scopus 로고
    • 6 angiotensin IV
    • DOI 10.1016/j.peptides.2004.04.014, PII S0196978104002116
    • Braszko JJ,. 2004. Involvement of D1 dopamine receptors in the cognitive effects of angiotensin IV and des-Phe6 angiotensin IV. Peptides 25: 1195-1203. (Pubitemid 38885734)
    • (2004) Peptides , vol.25 , Issue.7 , pp. 1195-1203
    • Braszko, J.J.1
  • 12
    • 0036560345 scopus 로고    scopus 로고
    • Parathyroid hormone metabolites in renal failure: Bioactivity and clinical implications
    • DOI 10.1046/j.1525-139X.2002.00053.x
    • Brossard JH, Yamamoto LN, D'Amour P,. 2002. Parathyroid hormone metabolites in renal failure: Bioactivity and clinical implications. Semin Dial 15: 196-201. (Pubitemid 41765931)
    • (2002) Seminars in Dialysis , vol.15 , Issue.3 , pp. 196-201
    • Brossard, J.-H.1    Yamamoto, L.N.2    D'Amour, P.3
  • 13
    • 14644415502 scopus 로고    scopus 로고
    • Activation of the newly discovered cyclostome renin-angiotensin system in the river lamprey Lampetra fluviatilis
    • DOI 10.1242/jeb.01362
    • Brown JA, Cobb CS, Frankling SC, Rankin JC,. 2005. Activation of the newly discovered cyclostome rennin-angiotensin system in the river lamprey Lampetra fluviatilis. J Exp Biol 208: 223-232. (Pubitemid 40307226)
    • (2005) Journal of Experimental Biology , vol.208 , Issue.2 , pp. 223-232
    • Brown, J.A.1    Cobb, C.S.2    Frankling, S.C.3    Rankin, J.C.4
  • 14
    • 34948824925 scopus 로고    scopus 로고
    • Measurement of angiotensin metabolites in organ bath and cell culture experiments by Liquid Chromatography - Electrospray Ionization - Mass Spectrometry (LC-ESI-MS)
    • Bujak-Gizycka B, Madej J, Wolkow PP, Olszanecki R, Drabik L, Rutowski J, Korbut R,. 2007. Measurement of angiotensin metabolites in organ bath and cell culture experiments by liquid chromatography-electrospray ionisation-mass spectrometry (LC-ESI-MS). J Physiol Pharmacol 58: 529-540. (Pubitemid 47523095)
    • (2007) Journal of Physiology and Pharmacology , vol.58 , Issue.3 , pp. 529-540
    • Bujak-Gizycka, B.1    Madej, J.2    Wolkow, P.P.3    Olszanecki, R.4    Drabik, L.5    Rutowski, J.6    Korbut, R.7
  • 15
    • 0344420226 scopus 로고    scopus 로고
    • Pharmacokinetic and biodistribution properties of poly(ethylene glycol)-protein conjugates
    • DOI 10.1016/S0169-409X(03)00108-X
    • Caliceti P, Veronese FM,. 2003. Pharmacokinetic and biodistribution properties of poly (ethylene glycol)-protein conjugates. Adv Drug Deliv Rev 55: 1261-1277. (Pubitemid 37464561)
    • (2003) Advanced Drug Delivery Reviews , vol.55 , Issue.10 , pp. 1261-1277
    • Caliceti, P.1    Veronese, F.M.2
  • 16
    • 67149136168 scopus 로고    scopus 로고
    • Actions and therapeutic pathways of ghrelin for gastrointestinal disorders
    • Review.
    • Camilleri M, Papathanasopoulos A, Odunsi ST,. 2009. Actions and therapeutic pathways of ghrelin for gastrointestinal disorders. Nat Rev Gastroenterol Hepatol 6 (6): 343-352. Review.
    • (2009) Nat Rev Gastroenterol Hepatol , vol.6 , Issue.6 , pp. 343-352
    • Camilleri, M.1    Papathanasopoulos, A.2    Odunsi, S.T.3
  • 18
    • 19544384949 scopus 로고    scopus 로고
    • Bioanalytical method development and validation for a large peptide HIV fusion inhibitor (Enfuvirtide, T-20) and its metabolite in human plasma using LC-MS/MS
    • DOI 10.1016/j.jpba.2005.01.024, PII S0731708505000737
    • Chang D, Kolis SJ, Linderholm KH, Julian TF, Nachi R, Dzerk AM, Lin PP, Lee JW, Bansal SK,. 2005. Bioanalytical method development and validation for a large peptide HIV fusion inhibitor (Enfuvirtide, T-20) and its metabolite in human plasma using LC-MS/MS. J Pharm Biomed Anal 38: 487-496. (Pubitemid 40733186)
    • (2005) Journal of Pharmaceutical and Biomedical Analysis , vol.38 , Issue.3 , pp. 487-496
    • Chang, D.1    Kolis, S.J.2    Linderholm, K.H.3    Julian, T.F.4    Nachi, R.5    Dzerk, A.M.6    Lin, P.P.7    Lee, J.W.8    Bansal, S.K.9
  • 19
  • 21
    • 77958615191 scopus 로고    scopus 로고
    • Ghrelin receptor signaling: A promising therapeutic target for metabolic syndrome and cognitive dysfunction
    • Cong WN, Golden E, Pantaleo N, White CM, Maudsley S, Martin B,. 2010. Ghrelin receptor signaling: A promising therapeutic target for metabolic syndrome and cognitive dysfunction. CNS Neurol Disord Drug Targets 9 (5): 557-563.
    • (2010) CNS Neurol Disord Drug Targets , vol.9 , Issue.5 , pp. 557-563
    • Cong, W.N.1    Golden, E.2    Pantaleo, N.3    White, C.M.4    Maudsley, S.5    Martin, B.6
  • 26
    • 67149122307 scopus 로고    scopus 로고
    • Motilin and ghrelin as prokinetic drug targets
    • Review.
    • De Smet B, Mitselos A, Depoortere I,. 2009. Motilin and ghrelin as prokinetic drug targets. Pharmacol Ther 123 (2): 207-223. Review.
    • (2009) Pharmacol Ther , vol.123 , Issue.2 , pp. 207-223
    • De Smet, B.1    Mitselos, A.2    Depoortere, I.3
  • 27
    • 4344675057 scopus 로고    scopus 로고
    • Therapeutic strategies based on glucagon-like peptide 1
    • DOI 10.2337/diabetes.53.9.2181
    • Deacon CF,. 2004. Therapeutic strategies based on glucagon-like peptide 1. Diabetes 53: 2181-2189. (Pubitemid 39145569)
    • (2004) Diabetes , vol.53 , Issue.9 , pp. 2181-2189
    • Deacon, C.F.1
  • 28
    • 9244225118 scopus 로고    scopus 로고
    • Ghrelin degradation by serum and tissue homogenates: Identification of the cleavage sites
    • DOI 10.1210/en.2004-0569
    • DeVriese C, Gregoire F, Lema-Kisoka R, Waelbroeck M, Robberecht P, Delporte C,. 2004. Ghrelin degradation by serum and tissue homogenates: Identification of the cleavage sites. Endocrinology 145: 4997-5005. (Pubitemid 39551118)
    • (2004) Endocrinology , vol.145 , Issue.11 , pp. 4997-5005
    • De Vriese, C.1    Gregoire, F.2    Lema-Kisoka, R.3    Waelbroeck, M.4    Robberecht, P.5    Delporte, C.6
  • 29
    • 33645813378 scopus 로고    scopus 로고
    • Mass spectrometry and protein analysis
    • Domon B, Aebersold R,. 2006. Mass spectrometry and protein analysis. Science 312: 212-217.
    • (2006) Science , vol.312 , pp. 212-217
    • Domon, B.1    Aebersold, R.2
  • 31
    • 0031690490 scopus 로고    scopus 로고
    • Insulin degradation: Progress and potential
    • DOI 10.1210/er.19.5.608
    • Duckworth WC, Bennet RG, Hamel FG,. 1998. Insulin degradation: Progress and potential. Endocr Rev 19: 608-624. (Pubitemid 28467714)
    • (1998) Endocrine Reviews , vol.19 , Issue.5 , pp. 608-624
    • Duckworth, W.C.1    Bennett, R.G.2    Hamel, F.G.3
  • 32
    • 0035238531 scopus 로고    scopus 로고
    • Cyclosporin: An updated review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation (neoral)1 in organ transplantation
    • Dunn CJ, Waqstaff AJ, Perry CM, Plosker GL, Goa KL,. 2001. Cyclosporin: An updated review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation (neoral)1 in organ transplantation. Drugs 61: 1957-2016.
    • (2001) Drugs , vol.61 , pp. 1957-2016
    • Dunn, C.J.1    Waqstaff, A.J.2    Perry, C.M.3    Plosker, G.L.4    Goa, K.L.5
  • 34
    • 42649118128 scopus 로고    scopus 로고
    • Brain angiotensin-converting enzymes: Role of angiotensin-converting enzyme 2 in processing angiotensin II in mice
    • DOI 10.1113/expphysiol.2007.040311
    • Elased KM, Cunha TS, Marcondes FK, Morris M,. 2008. Brain angiotensin-converting enzymes: Role of angiotensin-converting enzyme 2 in processing angiotensin II in mice. Exp Physiol 93 (5): 665-675. (Pubitemid 351595055)
    • (2008) Experimental Physiology , vol.93 , Issue.5 , pp. 665-675
    • Elased, K.M.1    Cunha, T.S.2    Marcondes, F.K.3    Morris, M.4
  • 37
    • 77950933847 scopus 로고    scopus 로고
    • Analysis of cyclosporine A and its metabolites in rat urine and feces by liquid chromatography-tandem mass spectrometry
    • Fang ZG, You BG, Chen YG, Zhang JK, Liu YQ, Zhang XN, Zhang Q,. 2010. Analysis of cyclosporine A and its metabolites in rat urine and feces by liquid chromatography-tandem mass spectrometry. J Chromatogr B 878 (15-16): 1153-1162.
    • (2010) J Chromatogr B , vol.878 , Issue.1516 , pp. 1153-1162
    • Fang, Z.G.1    You, B.G.2    Chen, Y.G.3    Zhang, J.K.4    Liu, Y.Q.5    Zhang, X.N.6    Zhang, Q.7
  • 38
    • 0031791711 scopus 로고    scopus 로고
    • Novel approaches for oral delivery of macromolecules
    • DOI 10.1021/js980076h
    • Fasano A,. 1998. Novel approaches for oral delivery of macromolecules. J Pharm Sci 87: 1351-1356. (Pubitemid 28514140)
    • (1998) Journal of Pharmaceutical Sciences , vol.87 , Issue.11 , pp. 1351-1356
    • Fasano, A.1
  • 39
    • 0024438708 scopus 로고
    • Electrospray ionization for mass spectrometry of large biomolecules
    • Fenn JB, Mann M, Meng CK, Wong SF, Whitehouse CM,. 1989. Electrospray ionization for mass spectrometry of large biomolecules. Science 246: 64-71. (Pubitemid 19252085)
    • (1989) Science , vol.246 , Issue.4926 , pp. 64-71
    • Fenn, J.B.1    Mann, M.2    Meng, C.K.3    Wong, S.F.4    Whitehouse, C.M.5
  • 40
    • 53349095997 scopus 로고    scopus 로고
    • Identification of leucine-enkephalin radical oxidation products by liquid chromatography tandem mass spectrometry
    • Fonseca C, Dominques P, Reis A, Domingues MRM,. 2008. Identification of leucine-enkephalin radical oxidation products by liquid chromatography tandem mass spectrometry. Biomed Chromatogr 22: 947-959.
    • (2008) Biomed Chromatogr , vol.22 , pp. 947-959
    • Fonseca, C.1    Dominques, P.2    Reis, A.3    Domingues, M.R.M.4
  • 41
    • 0030175140 scopus 로고    scopus 로고
    • Cyclosporin nephrotoxicity in relation to its metabolism in psoriasis
    • DOI 10.1006/phrs.1996.0048
    • Furlanut M, Baraldo M, Galla F, Marzocchi V, Pea F,. 1996. Cyclosporin nephrotoxicity in relation to its metabolism in psoriasis. Pharmacol Res 33: 349-352. (Pubitemid 26413595)
    • (1996) Pharmacological Research , vol.33 , Issue.6 , pp. 349-352
    • Furlanut, M.1    Baraldo, M.2    Galla, F.3    Marzocchi, V.4    Pea, F.5
  • 43
    • 0037317467 scopus 로고    scopus 로고
    • The basics of mass spectrometry in the twenty-first century
    • DOI 10.1038/nrd1011
    • Glish GL, Vachet RW,. 2003. The basics of mass spectrometry in the twenty-first century. Nat Rev Drug Discov 2 (2): 140-150. Review. (Pubitemid 37361646)
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.2 , pp. 140-150
    • Glish, G.L.1    Vachet, R.W.2
  • 47
    • 1842685103 scopus 로고    scopus 로고
    • Markers of protein oxidation: Different oxidants give rise to variable yields of bound and released carbonyl products
    • DOI 10.1016/j.freeradbiomed.2004.02.017, PII S0891584904001352
    • Headlam HA, Davies MJ,. 2004. Markers of protein oxidation: Different oxidants give rise to variable yields of bonds and released carbonyl products. Free Radic Biolo Med 36: 1175-1184. (Pubitemid 38479871)
    • (2004) Free Radical Biology and Medicine , vol.36 , Issue.9 , pp. 1175-1184
    • Headlam, H.A.1    Davies, M.J.2
  • 49
    • 2442586742 scopus 로고    scopus 로고
    • Applications of quadrupole-time-of-flight mass spectrometry to facilitate metabolite identification
    • Hop CECA,. 2004. Applications of quadrupole-time-of-flight mass spectrometry to facilitate metabolite identification. Am Pharm Rev 7: 76-79.
    • (2004) Am Pharm Rev , vol.7 , pp. 76-79
    • Hop, C.1
  • 50
    • 0016125497 scopus 로고
    • Atmospheric pressure ionization (API) mass spectrometry. Solvent-mediated ionization of samples introduced in solution and in a liquid chromatograph effluent stream
    • Horning EC, Caroll DI, Dzidic I, Haegele KD, Horning MG, Stillwell RN,. 1974. Atmospheric pressure ionization (API) mass spectrometry. Solvent-mediated ionization of samples introduced in solution and in a liquid chromatograph effluent stream. J Chromatogr Sci 12: 725-729.
    • (1974) J Chromatogr Sci , vol.12 , pp. 725-729
    • Horning, E.C.1    Caroll, D.I.2    Dzidic, I.3    Haegele, K.D.4    Horning, M.G.5    Stillwell, R.N.6
  • 52
    • 28944434196 scopus 로고    scopus 로고
    • On the topic of peptide research and drug discovery
    • DOI 10.1111/j.1399-3011.2005.00307.x
    • Hruby VJ,. 2005. On the topic of peptide research and drug discovery. J Peptide Res 66: 309-310. (Pubitemid 41784376)
    • (2005) Journal of Peptide Research , vol.66 , Issue.6 , pp. 309-310
    • Hruby, V.J.1
  • 55
    • 7044240014 scopus 로고    scopus 로고
    • Analytical procedures for quantification of peptides in pharmaceutical research by liquid chromatography-mass spectrometry
    • DOI 10.1007/s00216-003-2298-y
    • John H, Walden M, Schafer S, Genz S, Forssmann WG,. 2004. Analytical procedures for quantification of peptides in pharmaceutical research by liquid chromatography-mass spectrometry. Anal Bioanal Chem 378 (4): 883-897. (Pubitemid 40890201)
    • (2004) Analytical and Bioanalytical Chemistry , vol.378 , Issue.4 , pp. 883-897
    • John, H.1    Walden, M.2    Schafer, S.3    Genz, S.4    Forssmann, W.-G.5
  • 56
    • 40749110680 scopus 로고    scopus 로고
    • N-terminal acetylation protects glucagon-like peptide GLP-1-(7-34)-amide from DPP-IV-mediated degradation retaining cAMP- and insulin-releasing capacity
    • John H, Maronde E, Forssmann WG, Meyer M, Adermann K,. 2008. N-Terminal acetylation protects glucagon-like peptide GLP-1-(7-34)-amide from DPP-IV-mediated degradation retaining cAMP- and insulin-releasing capacity. Eur J Med Res 13 (2): 73-78. (Pubitemid 351385091)
    • (2008) European Journal of Medical Research , vol.13 , Issue.2 , pp. 73-78
    • John, H.1    Maronde, E.2    Forssmann, W.-G.3    Meyer, M.4    Adermann, K.5
  • 60
    • 14744280737 scopus 로고    scopus 로고
    • Altered extracellular striatal in vivo biotransformation of the opioid neuropeptide dynorphin A(1-17) in the unilateral 6-OHDA rat model of Parkinson's disease
    • DOI 10.1002/jms.754
    • Klintenberg R, Andrén PE,. 2005. Altered extracellular striatal in vivo biotransformation of the opioid neuropeptide dynorphin A(1-17) in the unilateral 6-OHDA rat model of Parkinson's disease. J Mass Spectrom 40 (2): 261-270. (Pubitemid 40327265)
    • (2005) Journal of Mass Spectrometry , vol.40 , Issue.2 , pp. 261-270
    • Klintenberg, R.1    Andren, P.E.2
  • 63
    • 38949163071 scopus 로고    scopus 로고
    • Insulins in equine urine: Qualitative analysis by immunoaffinity purification and liquid chromatography/tandem mass spectrometry for doping control purposes in horse-racing
    • DOI 10.1002/rcm.3360
    • Kuuranne T, Thomas A, Leinonen A, Delahaut P, Bosseloir A, Schänzer W, Thevis M,. 2008. Insulins in equine urine: Qualitative analysis by immunoaffinity purification and liquid chromatography/tandem mass spectrometry for doping control purposes in horse-racing. Rapid Commun Mass Spectrom 22 (3): 355-362. (Pubitemid 351212861)
    • (2008) Rapid Communications in Mass Spectrometry , vol.22 , Issue.3 , pp. 355-362
    • Kuuranne, T.1    Thomas, A.2    Leinonen, A.3    Delahaut, P.4    Bosseloir, A.5    Schanzer, W.6    Thevis, M.7
  • 65
    • 33947724473 scopus 로고    scopus 로고
    • Use of a structural analogue versus a stable isotope labeled internal standard for the quantification of angiotensin IV in rat brain dialysates using nano-liquid chromatography/tandem mass spectrometry
    • DOI 10.1002/rcm.2950
    • Lanckmans K, Sarre S, Smolders I, Michotte Y,. 2007. Use of a structural analogue versus a stable isotope labeled internal standard for the quantification of angiotensin IV in rat brain dialysates using nano-liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 21 (7): 1187-1195. (Pubitemid 46506572)
    • (2007) Rapid Communications in Mass Spectrometry , vol.21 , Issue.7 , pp. 1187-1195
    • Lanckmans, K.1    Sarre, S.2    Smolders, I.3    Michotte, Y.4
  • 66
    • 34848920060 scopus 로고    scopus 로고
    • Nano-LC-MS/MS for the monitoring of angiotensin IV in rat brain microdialysates: Limitations and possibilities
    • DOI 10.1002/jssc.200700159
    • Lanckmans K, Stragier B, Sarre S, Smolders I, Michotte Y,. 2007. Nano-LC-MS/MS for the monitoring of angiotensin IV in rat brain microdialysates: Limitations and possibilities. J Sep Sci 30: 2217-2224. (Pubitemid 47497022)
    • (2007) Journal of Separation Science , vol.30 , Issue.14 , pp. 2217-2224
    • Lanckmans, K.1    Stragier, B.2    Sarre, S.3    Smolders, I.4    Michotte, Y.5
  • 67
    • 0037388842 scopus 로고    scopus 로고
    • Administration of PTH-(7-84) antagonizes the effects of PTH-(1-84) on bone in rats with moderate renal failure
    • DOI 10.1210/en.2002-221026
    • Langub MC, Monier-Faugere M-C, Wang G, Williams JP, Koszewski NJ, Malluche HH,. 2003. Administration of PTH-(7-84) antagonizes the effects of PTH-(1-84) on bone in rats with moderate renal failure. Endocrinology 144: 1135-1138. (Pubitemid 36428451)
    • (2003) Endocrinology , vol.144 , Issue.4 , pp. 1135-1138
    • Langub, M.C.1    Monier-Faugere, M.-C.2    Wang, G.3    Williams, J.P.4    Koszewski, N.J.5    Malluche, H.H.6
  • 68
    • 57249103364 scopus 로고    scopus 로고
    • Intrapulmonary potential of polyethylene glycol-modified glucagon-like peptide-1s as a type 2 anti-diabetic agent
    • Lee KC, Chae SY, Kim TH, Lee S, Lee ES, Youn YS,. 2009. Intrapulmonary potential of polyethylene glycol-modified glucagon-like peptide-1s as a type 2 anti-diabetic agent. Regul Pept 152: 101-107.
    • (2009) Regul Pept , vol.152 , pp. 101-107
    • Lee, K.C.1    Chae, S.Y.2    Kim, T.H.3    Lee, S.4    Lee, E.S.5    Youn, Y.S.6
  • 70
    • 0027998106 scopus 로고
    • Pharmacologic target-mediated drug disposition
    • Levy G,. 1994. Pharmacologic target-mediated drug disposition. Clin Pharmacol Ther 56: 248-252. (Pubitemid 24323915)
    • (1994) Clinical Pharmacology and Therapeutics , vol.56 , Issue.3 , pp. 248-252
    • Levy, G.1
  • 71
    • 54149106857 scopus 로고    scopus 로고
    • Degradation of salmon calcitonin in rat kidney and liver homogenates
    • Liao S, Zhang ZQ, Ruan JX, Qi JK, Liu KL,. 2008. Degradation of salmon calcitonin in rat kidney and liver homogenates. Pharmazie 63 (10): 743-747.
    • (2008) Pharmazie , vol.63 , Issue.10 , pp. 743-747
    • Liao, S.1    Zhang, Z.Q.2    Ruan, J.X.3    Qi, J.K.4    Liu, K.L.5
  • 72
    • 77955901683 scopus 로고    scopus 로고
    • Metabolic stability of human parathyroid hormone peptide hPTH (1-34) in rat tissue homogenates: Kinetics and products of proteolytic degradation
    • Liao S, Qie JK, Xue M, Zhang ZQ, Liu KL, Ruan JX,. 2010. Metabolic stability of human parathyroid hormone peptide hPTH (1-34) in rat tissue homogenates: Kinetics and products of proteolytic degradation. Amino Acids 38 (5): 1595-1605.
    • (2010) Amino Acids , vol.38 , Issue.5 , pp. 1595-1605
    • Liao, S.1    Qie, J.K.2    Xue, M.3    Zhang, Z.Q.4    Liu, K.L.5    Ruan, J.X.6
  • 73
    • 72949106918 scopus 로고    scopus 로고
    • Pharmacokinetics of biotech drugs: Peptides, proteins and monoclonal antibodies
    • Lin JH,. 2009. Pharmacokinetics of biotech drugs: Peptides, proteins and monoclonal antibodies. Curr Drug Metab 10 (7): 661-691.
    • (2009) Curr Drug Metab , vol.10 , Issue.7 , pp. 661-691
    • Lin, J.H.1
  • 75
    • 0036158878 scopus 로고    scopus 로고
    • Peptides as drugs: Is there a market?
    • DOI 10.1002/psc.366
    • Loffet A,. 2002. Peptides as drugs: Is there a market? J Peptide Sci 8: 1-7. (Pubitemid 34121308)
    • (2002) Journal of Peptide Science , vol.8 , Issue.1 , pp. 1-7
    • Loffet, A.1
  • 77
    • 33746644192 scopus 로고    scopus 로고
    • Issues related to targeted delivery of proteins and peptides
    • DOI 10.1208/aapsj080355, 55
    • Lu Y, Yang J, Sega E,. 2006. Issues related to targeted delivery of proteins and peptides. AAPS J 8: E466-E478. (Pubitemid 44149415)
    • (2006) AAPS Journal , vol.8 , Issue.3
    • Lu, Y.1    Yang, J.2    Sega, E.3
  • 78
    • 33749009806 scopus 로고    scopus 로고
    • Detecting and characterizing reactive metabolites by liquid chromatography/tandem mass spectrometry
    • DOI 10.1002/jms.1098
    • Ma S, Subramanian R,. 2006. Detecting and characterizing reactive metabolites by liquid chromatography/tandem mass spectrometry. J Mass Spectrom 41: 1121-1139. (Pubitemid 44454166)
    • (2006) Journal of Mass Spectrometry , vol.41 , Issue.9 , pp. 1121-1139
    • Ma, S.1    Subramanian, R.2
  • 79
    • 33646901012 scopus 로고    scopus 로고
    • Target-mediated drug disposition and dynamics
    • DOI 10.1016/j.bcp.2005.12.041, PII S0006295206000335
    • Mager DE,. 2006. Target-mediated drug disposition and dynamics. Biochem Pharmacol 72: 1-10. (Pubitemid 43795346)
    • (2006) Biochemical Pharmacology , vol.72 , Issue.1 , pp. 1-10
    • Mager, D.E.1
  • 80
    • 0035730322 scopus 로고    scopus 로고
    • General pharmacokinetic model for drugs exhibiting target-mediated drug disposition
    • DOI 10.1023/A:1014414520282
    • Mager DE, Jusko WJ,. 2001. General Pharmacokinetic model for drugs exhibiting target-mediated drug disposition. J Pharm Pharmacol 28: 507-532. (Pubitemid 34289541)
    • (2001) Journal of Pharmacokinetics and Pharmacodynamics , vol.28 , Issue.6 , pp. 507-532
    • Mager, D.E.1    Jusko, W.J.2
  • 81
    • 33847367688 scopus 로고    scopus 로고
    • Enzymatic conversion of dynorphin A in the rat brain is affected by administration of nandrolone decanoate
    • DOI 10.1016/j.peptides.2006.12.011, PII S0196978106006000
    • Magnusson K, Hallberg M, Bergquist J, Nyberg F,. 2007. Enzymatic conversion of dynorphin A in the rat brain is affected by administration of nandrolone decanoate. Peptides 28 (4): 851-858. (Pubitemid 46349328)
    • (2007) Peptides , vol.28 , Issue.4 , pp. 851-858
    • Magnusson, K.1    Hallberg, M.2    Bergquist, J.3    Nyberg, F.4
  • 83
    • 0038057620 scopus 로고    scopus 로고
    • Parathyroid hormone assays - Evolution and revolutions in the care of dialysis patients
    • Malluche HH, Mawad H, Trueba D, Monier-Faugere MC,. 2003. Parathyroid hormone assays-evolution and revolutions in the care of dialysis patients. Clin Nephrol 59: 313-318. (Pubitemid 36592205)
    • (2003) Clinical Nephrology , vol.59 , Issue.5 , pp. 313-318
    • Malluche, H.H.1    Mawad, H.2    Trueba, D.3    Monier-Faugere, M.-C.4
  • 84
    • 0032988493 scopus 로고    scopus 로고
    • Determination of angiotensin metabolites in human plasma by fluorimetric high-performance liquid chromatography using a heart-cut column-switching technique
    • DOI 10.1016/S0378-4347(99)00128-0, PII S0378434799001280
    • Matsui T, Tamaya K, Kawasaki T, Osajima Y,. 1999. Determination of angiotensin metabolites in human plasma by fluorometric high-performance liquid chromatography using a heart-cut column-switching technique. J Chromatogr B 729: 89-95. (Pubitemid 29264112)
    • (1999) Journal of Chromatography B: Biomedical Sciences and Applications , vol.729 , Issue.1-2 , pp. 89-95
    • Matsui, T.1    Tamaya, K.2    Kawasaki, T.3    Osajima, Y.4
  • 85
    • 54849425126 scopus 로고    scopus 로고
    • Discovering and improving novel peptide therapeutics
    • McGregor DP,. 2008. Discovering and improving novel peptide therapeutics. Curr Opin Chem Biol 8: 616-619.
    • (2008) Curr Opin Chem Biol , vol.8 , pp. 616-619
    • McGregor, D.P.1
  • 86
    • 0026541509 scopus 로고
    • Pharmacokinetics of peptides and proteins: Opportunities and challenges
    • McMartin C,. 1992. Pharmacokinetics of peptides and proteins: Opportunities and challenges. Adv Drug Res 22: 39-106.
    • (1992) Adv Drug Res , vol.22 , pp. 39-106
    • McMartin, C.1
  • 87
    • 84889826166 scopus 로고    scopus 로고
    • The role of pharmacokinetics and pharmacodynamics in the development of biotech drugs
    • Meibohm B. editor. Weinheim: Wiley-VCH Verlag GmbH & Co.
    • Meibohm B,. 2006. The role of pharmacokinetics and pharmacodynamics in the development of biotech drugs. In:, Meibohm B, editor. Pharmacokinetics and pharmacodynamics of biotech drugs: Principles and case studies. Weinheim: Wiley-VCH Verlag GmbH & Co. pp. 3-13.
    • (2006) Pharmacokinetics and Pharmacodynamics of Biotech Drugs: Principles and Case Studies , pp. 3-13
    • Meibohm, B.1
  • 88
    • 20744456789 scopus 로고
    • Solid phase peptide synthesis. I. The synthesis of a tetrapeptide
    • Merrifield RB,. 1963. Solid phase peptide synthesis. I. The synthesis of a tetrapeptide. J Am Chem Soc 85: 2149-2154.
    • (1963) J Am Chem Soc , vol.85 , pp. 2149-2154
    • Merrifield, R.B.1
  • 89
    • 0034840942 scopus 로고    scopus 로고
    • Progress in the use of biological assays during the development of biotechnology products
    • DOI 10.1023/A:1013067424248
    • Mire-Sluis AR,. 2001. Progress in the use of biological assays during the development of biotechnology products. Pharm Res 18: 1239-1246. (Pubitemid 32846315)
    • (2001) Pharmaceutical Research , vol.18 , Issue.9 , pp. 1239-1246
    • Mire-Sluis, A.R.1
  • 90
    • 0029096691 scopus 로고
    • Metabolism of dynorphin A 1-13 in human blood and plasma
    • Muller S, Hochhaus G,. 1995. Metabolism of dynorphin A 1-13 in human blood and plasma. Pharm Res 12: 1165-1170.
    • (1995) Pharm Res , vol.12 , pp. 1165-1170
    • Muller, S.1    Hochhaus, G.2
  • 91
    • 0029859560 scopus 로고    scopus 로고
    • Metabolism of dynorphin A1-13 in human CSF
    • DOI 10.1007/BF02532398
    • Müller S, Grundy BL, Hochhaus G,. 1996. Metabolism of dynorphin A 1-13 in human CSF. Neurochem Res 21 (10): 1213-1219. (Pubitemid 26357273)
    • (1996) Neurochemical Research , vol.21 , Issue.10 , pp. 1213-1219
    • Muller, S.1    Grundy, B.L.2    Hochhaus, G.3
  • 92
    • 77954865709 scopus 로고    scopus 로고
    • Combined use of immunoassay and two-dimensional liquid chromatography mass spectrometry for the detection and identification of metabolites from biotherapeutic pharmacokinetic samples
    • Murphy RE, Kinhikar AG, Shields MJ, Del Rosario J, Preston R, Levin N, Ward GH,. 2010. Combined use of immunoassay and two-dimensional liquid chromatography mass spectrometry for the detection and identification of metabolites from biotherapeutic pharmacokinetic samples. J Pharm Biomed Anal 53 (3): 221-227.
    • (2010) J Pharm Biomed Anal , vol.53 , Issue.3 , pp. 221-227
    • Murphy, R.E.1    Kinhikar, A.G.2    Shields, M.J.3    Del Rosario, J.4    Preston, R.5    Levin, N.6    Ward, G.H.7
  • 93
    • 13444260744 scopus 로고    scopus 로고
    • Parathyroid hormone secretion and action: Evidence for discrete receptors for the carboxyl-terminal region and related biological actions of carboxyl-terminal ligands
    • DOI 10.1210/er.2003-0024
    • Murray TM, Rao LG, Divieti P, Bringhurst FR,. 2005. Parathyroid hormone secretion and action: Evidence for discrete receptors for the carboxyl-terminal region and related biological actions of carboxyl-terminal lignads. Endocr Rev 26: 78-113. (Pubitemid 40209388)
    • (2005) Endocrine Reviews , vol.26 , Issue.1 , pp. 78-113
    • Murray, T.M.1    Rao, L.G.2    Divieti, P.3    Bringhurst, F.R.4
  • 94
    • 1642370806 scopus 로고    scopus 로고
    • Monitoring of peptide acylation inside degrading PLGA microspheres by capillary electrophoresis and MALDI-TOF mass spectrometry
    • DOI 10.1016/S0168-3659(03)00366-3, PII S0168365903003663
    • Na DH, Youn YS, Lee SD, Son MW, Kim WB, DeLuca PP, Lee KC,. 2003. Monitoring of peptide acylation inside degrading PLGA microspheres by capillary electrophoresis and MALDI-TOF mass spectrometry. J Control Release 92: 291-299. (Pubitemid 38366152)
    • (2003) Journal of Controlled Release , vol.92 , Issue.3 , pp. 291-299
    • Na, D.H.1    Youn, Y.S.2    Lee, S.D.3    Son, M.-W.4    Kim, W.-B.5    DeLuca, P.P.6    Lee, K.C.7
  • 96
    • 34250888750 scopus 로고    scopus 로고
    • Stability of antimicrobial decapeptide (KSL) and its analogues for delivery in the oral cavity
    • DOI 10.1007/s11095-007-9274-8
    • Na DH, Faraj J, Capan Y, Leung KP, DeLuca PP,. 2007. Stability of antimicrobial decapeptide (KSL) and its analogues for delivery in the oral cavity. Pharm Res 24: 1544-1550. (Pubitemid 46988221)
    • (2007) Pharmaceutical Research , vol.24 , Issue.8 , pp. 1544-1550
    • Na, D.H.1    Faraj, J.2    Capan, Y.3    Leung, K.P.4    DeLuca, P.P.5
  • 97
    • 0033971580 scopus 로고    scopus 로고
    • Simultaneous separation of angiotensin and endothelin peptide families by high-performance liquid chromatography: Application to the specific radioimmunoassay measurement of angiotensin II or endothelin-1 from tissue
    • DOI 10.1016/S0021-9673(99)00906-1, PII S0021967399009061
    • Naik GO, Moe GW,. 2000. Simultaneous separation of angiotensin and endothelin peptide families by high-performance liquid chromatography: Application to the specific radioimmunoassay measurement of angiotensin II or endothelin-1 from tissue. J Chromatogr A 870 (1-2): 349-361. (Pubitemid 30077437)
    • (2000) Journal of Chromatography A , vol.870 , Issue.1-2 , pp. 349-361
    • Naik, G.O.A.1    Moe, G.W.2
  • 99
    • 19444382837 scopus 로고    scopus 로고
    • Incretin mimetics and DPP-IV inhibitors for the treatment of type 2 diabetes
    • DOI 10.1016/S1359-6446(05)03460-4, PII S1359644605034604
    • Nielsen LL,. 2005. Incretin mimetics and DPP-IV inhibitors for the treatment of type 2 diabetes. Drug Discov Today 10: 703-710. (Pubitemid 40724552)
    • (2005) Drug Discovery Today , vol.10 , Issue.10 , pp. 703-710
    • Nielsen, L.L.1
  • 100
    • 77953962353 scopus 로고    scopus 로고
    • Ghrelin: A potential therapeutic target for cancer
    • Nikolopoulos D, Theocharis S, Kouraklis G,. 2010. Ghrelin: A potential therapeutic target for cancer. Regul Pept 163 (1-3): 7-17.
    • (2010) Regul Pept , vol.163 , Issue.13 , pp. 7-17
    • Nikolopoulos, D.1    Theocharis, S.2    Kouraklis, G.3
  • 101
    • 0345269234 scopus 로고    scopus 로고
    • In vivo processing of LVV-hemorphin-7 in rat brain and blood utilizing microdialysis combined with electrospray mass spectrometry
    • DOI 10.1002/rcm.972
    • Nydahl KS, Pierson J, Nyberg F, Caprioli RM, Andrén PE,. 2003. In vivo processing of LVV-hemorphin-7 in rat brain and blood utilizing microdialysis combined with electrospray mass spectrometry. Rapid Commun Mass Spectrom 17 (8): 838-844. (Pubitemid 36433169)
    • (2003) Rapid Communications in Mass Spectrometry , vol.17 , Issue.8 , pp. 838-844
    • Nydahl, K.S.1    Pierson, J.2    Nyberg, F.3    Caprioli, R.M.4    Andren, P.E.5
  • 102
  • 103
    • 0035659395 scopus 로고    scopus 로고
    • Nephrotoxicity of immunosuppressive drugs: New insight and preventive strategies
    • DOI 10.1097/00075198-200112000-00003
    • Olyaei AJ, de Mattos AM, Bennett WM,. 2001. Nephrotoxicity of immunosuppressive drugs: New insight and preventive strategies. Curr Opin Crit Care 7: 384-389. (Pubitemid 34020400)
    • (2001) Current Opinion in Critical Care , vol.7 , Issue.6 , pp. 384-389
    • Olyaei, A.J.1    De Mattos, A.M.2    Bennett, W.M.3
  • 104
    • 0037381236 scopus 로고    scopus 로고
    • Mass spectrometry-based diagnostics: The upcoming revolution in disease detection
    • DOI 10.1373/49.4.533
    • Petricoin EF III, Liotta LA,. 2003. Mass spectrometry-based diagnostics: The upcoming devolution in disease detection. Clin Chem 49: 533-534. (Pubitemid 36379514)
    • (2003) Clinical Chemistry , vol.49 , Issue.4 , pp. 533-534
    • Petricoin, E.F.1    Liotta, L.A.2
  • 106
    • 84155160874 scopus 로고    scopus 로고
    • Pharmaceutical Research Manufacturers of America. Washington, DC: Pharmaceutical Research Manufacturers of America.
    • Pharmaceutical Research Manufacturers of America. 2008. Medicines in development-biotechnology-survey. Washington, DC: Pharmaceutical Research Manufacturers of America.
    • (2008) Medicines in Development-biotechnology-survey
  • 107
    • 34248582576 scopus 로고    scopus 로고
    • Analytical strategies for identifying drug metabolites
    • DOI 10.1002/mas.20128
    • Prakash C, Shaffer CL, Nedderman A,. 2007. Analytical strategies for identifying drug metabolites. Mass Spectrom Rev 26: 340-369. (Pubitemid 46750374)
    • (2007) Mass Spectrometry Reviews , vol.26 , Issue.3 , pp. 340-369
    • Prakash, C.1    Shaffer, C.L.2    Nedderman, A.3
  • 108
    • 19444363444 scopus 로고    scopus 로고
    • Sourcing a chemical succession for cyclosporin from parasites and human pathogens
    • DOI 10.1016/S1359-6446(05)03395-7, PII S1359644605033957
    • Pritchard DI,. 2005. Sourcing a chemical succession for cyclosporin from parasites and human pathogens. Drug Discov Today 10: 688-691. (Pubitemid 40724550)
    • (2005) Drug Discovery Today , vol.10 , Issue.10 , pp. 688-691
    • Pritchard, D.I.1
  • 109
    • 0032549755 scopus 로고    scopus 로고
    • Electrospray ionization mass spectrometric and liquid chromatographic- mass spectrometric studies on the metabolism of synthetic dynorphin a peptides in brain tissue in vitro and in vivo
    • DOI 10.1016/S0021-9673(97)01295-8, PII S0021967397012958
    • Prokai L, Kim HS, Zharikova A, Roboz J, Ma L, Deng L, Simonsick WJ, Jr., 1998. Electrospray ionization mass spectrometric and liquid chromatographic-mass spectrometric studies on the metabolism of synthetic dynorphin A peptides in brain tissue in vitro and in vivo. J Chromatogr A 800 (1): 59-68. (Pubitemid 28154864)
    • (1998) Journal of Chromatography A , vol.800 , Issue.1 , pp. 59-68
    • Prokai, L.1    Kim, H.-S.2    Zharikova, A.3    Roboz, J.4    Ma, L.5    Deng, L.6    Simonsick Jr., W.J.7
  • 110
    • 34447563924 scopus 로고    scopus 로고
    • The Nobel trail of Vincent du Vigneaud
    • DOI 10.1002/psc.864
    • Ragnarsson U,. 2007. The Nobel trail of Vincent du Vigneaud. J Pept Sci 13: 431-433. (Pubitemid 47082892)
    • (2007) Journal of Peptide Science , vol.13 , Issue.7 , pp. 431-433
    • Ragnarsson, U.1
  • 111
    • 33644794292 scopus 로고    scopus 로고
    • Study of bradykinin metabolism by rat lung tissue membranes and rat kidney brush border membranes by HPLC with inductively coupled plasma - Mass spectrometry and orthogonal acceleration time-of-flight mass spectrometry
    • DOI 10.1002/psc.712
    • Ramírez-Molina C, Heudi O, Pullen M, Marshall PS,. 2006. Study of bradykinin metabolism by rat lung tissue membranes and rat kidney brush border membranes by HPLC with inductively coupled plasma-mass spectrometry and orthogonal acceleration time-of-flight mass spectrometry. J Pept Sci 12 (3): 220-226. (Pubitemid 43349363)
    • (2006) Journal of Peptide Science , vol.12 , Issue.3 , pp. 220-226
    • Ramirez-Molina, C.1    Heudi, O.2    Pullen, M.3    Marshall, P.S.4
  • 112
    • 34248389627 scopus 로고    scopus 로고
    • Simultaneous quantification of ghrelin and desacyl-ghrelin by liquid chromatography-tandem mass spectrometry in plasma, serum, and cell supernatants
    • DOI 10.1373/clinchem.2006.078956
    • Rauh M, Groschl M, Rascher W,. 2007. Simultaneous quantification of ghrelin and desacyl-ghrelin by liquid chromatography tandem mass spectrometry in plasma, serum and cell supernatants. Clin Chem 53: 902-910. (Pubitemid 46744247)
    • (2007) Clinical Chemistry , vol.53 , Issue.5 , pp. 902-910
    • Rauh, M.1    Groschl, M.2    Rascher, W.3
  • 113
    • 0041730472 scopus 로고    scopus 로고
    • Dynorphin A(1-17) biotransformation in striatum of freely moving rats using microdialysis and matrix-assisted laser desorption/ionization mass spectrometry
    • DOI 10.1046/j.1471-4159.2003.01859.x
    • Reed B, Zhang Y, Chait BT, Kreek MJ,. 2003. Dynorphin A(1-17) biotransformation in striatum of freely moving rats using microdialysis and matrix-assisted laser desorption/ionization mass spectrometry. J Neurochem 86 (4): 815-823. (Pubitemid 36988794)
    • (2003) Journal of Neurochemistry , vol.86 , Issue.4 , pp. 815-823
    • Reed, B.1    Zhang, Y.2    Chait, B.T.3    Kreek, M.J.4
  • 114
    • 0034463924 scopus 로고    scopus 로고
    • Definition and measurement of follicle stimulating hormone
    • DOI 10.1210/er.21.1.5
    • Rose MP, Gaines Das RE, Balen AH,. 2000. Definition and measurement of follicle stimulating hormone. Endocr Rev 21 (1): 5-22. Review. (Pubitemid 32260393)
    • (2000) Endocrine Reviews , vol.21 , Issue.1 , pp. 5-22
    • Rose, M.P.1    Gaines Das, R.E.2    Balen, A.H.3
  • 115
    • 33947587274 scopus 로고    scopus 로고
    • Simulation and prediction of in vivo drug metabolism in human populations from in vitro data
    • DOI 10.1038/nrd2173, PII NRD2173
    • Rostami-Hodjegan A, Tucker GT,. 2007. Simulation and prediction of in vivo drug metabolism in human populations from in vitro data. Nat Rev Drug Discov 6: 140-148. (Pubitemid 46745341)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.2 , pp. 140-148
    • Rostami-Hodjegan, A.1    Tucker, G.T.2
  • 116
    • 33751218547 scopus 로고    scopus 로고
    • Therapeutic peptides: Technological advances driving peptides into development
    • DOI 10.1016/j.copbio.2006.10.002, PII S0958166906001467
    • Sato AK, Viswanathan M, Kent RB, Wood R,. 2006. Therapeutic peptides: Technological advances driving peptides into development. Curr Opin Biotechnol 17: 638-642. (Pubitemid 44791908)
    • (2006) Current Opinion in Biotechnology , vol.17 , Issue.6 , pp. 638-642
    • Sato, A.K.1    Viswanathan, M.2    Kent, R.B.3    Wood, C.R.4
  • 117
    • 77957266562 scopus 로고    scopus 로고
    • Identification and characterization of acyl-protein thioesterase 1/lysophospholipase i as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium
    • Satou M, Nishi Y, Yoh J, Hattori Y, Sugimoto H,. 2010. Identification and characterization of acyl-protein thioesterase 1/lysophospholipase I as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium. Endocrinology 151 (10): 4765-4775.
    • (2010) Endocrinology , vol.151 , Issue.10 , pp. 4765-4775
    • Satou, M.1    Nishi, Y.2    Yoh, J.3    Hattori, Y.4    Sugimoto, H.5
  • 118
    • 0023709846 scopus 로고
    • Identification by fast atom bombardment mass spectrometry of insulin fragments produced by insulin proteinase
    • Savoy LA, Jones RML, Pochon S, Davies JG, Muir AV, Offord RE, Rose K,. 1988. Identification by fast atom bombardment mass spectrometry of insulin fragments produced by insulin proteinase. Biochem J 249: 215-222.
    • (1988) Biochem J , vol.249 , pp. 215-222
    • Savoy, L.A.1    Jones, R.M.L.2    Pochon, S.3    Davies, J.G.4    Muir, A.V.5    Offord, R.E.6    Rose, K.7
  • 119
    • 0034033915 scopus 로고    scopus 로고
    • Identification of peptide oxidation by tandem mass spectrometry
    • Schey KL, Finley EL,. 2000. Identification of peptide oxidation by tandem mass spectrometry. Acc Chem Res 33: 299-306.
    • (2000) Acc Chem Res , vol.33 , pp. 299-306
    • Schey, K.L.1    Finley, E.L.2
  • 120
    • 0030277396 scopus 로고    scopus 로고
    • First steps in peptide science
    • Schwyzer R,. 1996. First steps in peptide science. Protein Sci 5: 2358-2363.
    • (1996) Protein Sci , vol.5 , pp. 2358-2363
    • Schwyzer, R.1
  • 121
    • 67650360365 scopus 로고    scopus 로고
    • Simultaneous absolute quantification of the glucose-dependent insulinotropic polypeptides GIP1-42 and GIP3-42 in mouse plasma by LC/ESI-MS/MS: Preclinical evaluation of DP-IV inhibitors
    • Siskos AP, Katsila T, Balafas E, Kostomitsopoulos N, Tamvakopoulos C,. 2009. Simultaneous absolute quantification of the glucose-dependent insulinotropic polypeptides GIP1-42 and GIP3-42 in mouse plasma by LC/ESI-MS/MS: Preclinical evaluation of DP-IV inhibitors. J Proteome Res 8: 3487-3496.
    • (2009) J Proteome Res , vol.8 , pp. 3487-3496
    • Siskos, A.P.1    Katsila, T.2    Balafas, E.3    Kostomitsopoulos, N.4    Tamvakopoulos, C.5
  • 122
    • 55249127332 scopus 로고    scopus 로고
    • In vivo evaluation and in vitro metabolism of leuprolide in mice-Mass spectrometry based biomarker measurement for efficacy and toxicity
    • Sofianos ZD, Katsila T, Kostomitsopoulos N, Balafas V, Matsoukas J, Tselios T, Tamvakopoulos C,. 2008. In vivo evaluation and in vitro metabolism of leuprolide in mice-Mass spectrometry based biomarker measurement for efficacy and toxicity. J Mass Spectrom 43: 1381-1392.
    • (2008) J Mass Spectrom , vol.43 , pp. 1381-1392
    • Sofianos, Z.D.1    Katsila, T.2    Kostomitsopoulos, N.3    Balafas, V.4    Matsoukas, J.5    Tselios, T.6    Tamvakopoulos, C.7
  • 123
    • 34248545256 scopus 로고    scopus 로고
    • Mass spectrometry for the quantification of bioactive peptides in biological fluids
    • DOI 10.1002/mas.20120
    • Tamvakopoulos C,. 2007. Mass spectrometry for the quantification of bioactive peptides in biological fluids. Mass Spectrom Rev 26: 389-402. (Pubitemid 46750376)
    • (2007) Mass Spectrometry Reviews , vol.26 , Issue.3 , pp. 389-402
    • Tamvakopoulos, C.1
  • 124
    • 0042318496 scopus 로고    scopus 로고
    • The origin of macromolecule ionization by laser irradiation (Nobel lecture)
    • Tanaka K,. 2003. The origin of macromolecule ionization by laser irradiation (Nobel lecture). Angew Chem Int Ed Engl 42: 3860-3870.
    • (2003) Angew Chem Int Ed Engl , vol.42 , pp. 3860-3870
    • Tanaka, K.1
  • 125
    • 4344634877 scopus 로고    scopus 로고
    • Pharmacokinetic aspects of biotechnology products
    • Tang L, Persky AM, Hochhaus G, Meibohm B,. 2004. Pharmacokinetic aspects of biotechnology products. J Pharm Sci 93: 2184-2198.
    • (2004) J Pharm Sci , vol.93 , pp. 2184-2198
    • Tang, L.1    Persky, A.M.2    Hochhaus, G.3    Meibohm, B.4
  • 126
    • 33947693366 scopus 로고    scopus 로고
    • Mass spectrometric identification of peptide hormones in doping-control analysis
    • DOI 10.1039/b618748j
    • Thevis M, Schanzer W,. 2007. Mass spectrometric identification of peptide hormones in doping control analysis. Analyst 132: 287-291. (Pubitemid 46494497)
    • (2007) Analyst , vol.132 , Issue.4 , pp. 287-291
    • Thevis, M.1    Schanzer, W.2
  • 127
    • 37249011308 scopus 로고    scopus 로고
    • Mass spectrometric determination of insulins and their degradation products in sports drug testing
    • DOI 10.1002/mas.20154
    • Thevis M, Thomas A, Schanzer W,. 2008. Mass spectrometric determination of insulins and their degradation products in sports drug testing. Mass Spectrom Rev 27: 35-50. (Pubitemid 350279865)
    • (2008) Mass Spectrometry Reviews , vol.27 , Issue.1 , pp. 35-50
    • Thevis, M.1    Thomas, A.2    Schanzer, W.3
  • 129
    • 33947390452 scopus 로고    scopus 로고
    • Mass spectrometric identification of degradation products of insulin and its long-acting analogues in human urine for doping control purposes
    • DOI 10.1021/ac062037t
    • Thomas A, Thevis M, Delahaut P, Bosseloir A, Schänzer W,. 2007. Mass spectrometric identification of degradation products of insulin and its long-acting analogues in human urine for doping control purposes. Anal Chem 79 (6): 2518-2524. (Pubitemid 46449034)
    • (2007) Analytical Chemistry , vol.79 , Issue.6 , pp. 2518-2524
    • Thomas, A.1    Thevis, M.2    Delahaut, P.3    Bosseloir, A.4    Schanzer, W.5
  • 130
    • 0032604318 scopus 로고    scopus 로고
    • Bioassays for the characterization and control of therapeutic cytokines: Determination of potency
    • Thorpe R, Wadhwa M, Page C, Mire-Sluis A,. 1999. Bioassays for the characterization and control of therapeutic cytokines: Determination of potency. Dev Biol Stand 97: 61-71.
    • (1999) Dev Biol Stand , vol.97 , pp. 61-71
    • Thorpe, R.1    Wadhwa, M.2    Page, C.3    Mire-Sluis, A.4
  • 131
    • 0030017103 scopus 로고    scopus 로고
    • The relevance of pharmacokinetics in the development of biotechnology products
    • Toon S,. 1996. The relevance of pharmacokinetics in the development of biotechnology products. Eur J Drug Metab Pharmacokinet 21: 93-103. (Pubitemid 26246152)
    • (1996) European Journal of Drug Metabolism and Pharmacokinetics , vol.21 , Issue.2 , pp. 93-103
    • Toon, S.1
  • 132
    • 0033635054 scopus 로고    scopus 로고
    • Protein instability in poly(lactic-co-glycolic acid) microparticles
    • van de Weert M, Hennink WE, Jiskoot W,. 2000. Protein instability in poly(lactic-co-glycolic acid) microparticles. Pharm Res 17: 1159-1167.
    • (2000) Pharm Res , vol.17 , pp. 1159-1167
    • Van De Weert, M.1    Hennink, W.E.2    Jiskoot, W.3
  • 133
    • 33744502918 scopus 로고    scopus 로고
    • Development and validation of a quantitative assay for the measurement of two HIV-fusion inhibitors, enfuvirtide and tifuvirtide, and one metabolite of enfuvirtide (M-20) in human plasma by liquid chromatography-tandem mass spectrometry
    • DOI 10.1016/j.jchromb.2006.03.059, PII S1570023206002959
    • van den Broek I, Sparidans RW, Huitema AD, Schellens JH, Beijnen JH,. 2006. Development and validation of a quantitative assay for the measurement of two HIV-fusion inhibitors, enfuvirtide and tifuvirtide, and one metabolite of enfuvirtide (M-20) in human plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 837 (1-2): 49-58. (Pubitemid 43796292)
    • (2006) Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences , vol.837 , Issue.1-2 , pp. 49-58
    • Van Den Broek, I.1    Sparidans, R.W.2    Huitema, A.D.R.3    Schellens, J.H.M.4    Beijnen, J.H.5
  • 134
    • 34250863316 scopus 로고    scopus 로고
    • Enzymatic digestion as a tool for the LC-MS/MS quantification of large peptides in biological matrices: Measurement of chymotryptic fragments from the HIV-1 fusion inhibitor enfuvirtide and its metabolite M-20 in human plasma
    • DOI 10.1016/j.jchromb.2007.04.026, PII S1570023207003236
    • van den Broek I, Sparidans RW, Schellens JHM, Beijnen JH,. 2007. Enzymatic digestion as a tool for the LC-MS/MS quantification of large peptides in biological matrices: Measurement of chymotryptic fragments from the HIV-1 fusion inhibitor enfuvirtide and its metabolite M-20 in human plasma. J Chromatogr B 854: 245-259. (Pubitemid 46970742)
    • (2007) Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences , vol.854 , Issue.1-2 , pp. 245-259
    • Van Den Broek, I.1    Sparidans, R.W.2    Schellens, J.H.M.3    Beijnen, J.H.4
  • 136
    • 52049107373 scopus 로고    scopus 로고
    • In vitro metabolic stability of obestatin: Kinetics and identification of cleavage products
    • Vergote V, Van Dorpe S, Peremans K, Burvenich C, De Spiegeleer B,. 2008. In vitro metabolic stability of obestatin: Kinetics and identification of cleavage products. Peptides 29 (10): 1740-1748.
    • (2008) Peptides , vol.29 , Issue.10 , pp. 1740-1748
    • Vergote, V.1    Van Dorpe, S.2    Peremans, K.3    Burvenich, C.4    De Spiegeleer, B.5
  • 138
    • 0004053611 scopus 로고
    • New York: John Wiley & Sons. p.
    • Voet D, Voet JG,. 1995. Biochemistry. New York: John Wiley & Sons. p. 71.
    • (1995) Biochemistry , pp. 71
    • Voet, D.1    Voet, J.G.2
  • 139
    • 0031765907 scopus 로고    scopus 로고
    • Role of p-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics
    • Wacher VJ, Silverman JA, Zhang Y, Benet LZ,. 1998. Role of p-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics. J Pharm Sci 87: 1322-1330.
    • (1998) J Pharm Sci , vol.87 , pp. 1322-1330
    • Wacher, V.J.1    Silverman, J.A.2    Zhang, Y.3    Benet, L.Z.4
  • 141
    • 33746163862 scopus 로고    scopus 로고
    • Biopharmaceutical benchmarks 2006
    • DOI 10.1038/nbt0706-769, PII NBT0706769
    • Walsh G,. 2006. Biopharmaceutical benchmarks 2006. Nat Biotechnol 24 (7): 769-776. (Pubitemid 44086612)
    • (2006) Nature Biotechnology , vol.24 , Issue.7 , pp. 769-776
    • Walsh, G.1
  • 142
    • 0041324818 scopus 로고    scopus 로고
    • Review role of liquid chromatography-mass spectrometry in the analysis of oxidation products and antioxidants in biological systems
    • DOI 10.1016/S0003-2670(03)00467-7
    • Watson DG, Atsriku C, Oliveira EJ,. 2003. Review role of liquid chromatography-mass spectrometry in analysis of oxidation products and antioxidants in biological systems. Anal Chim Acta 492: 17-47. (Pubitemid 37101389)
    • (2003) Analytica Chimica Acta , vol.492 , Issue.1-2 , pp. 17-47
    • Watson, D.G.1    Atsriku, C.2    Oliveira, E.J.3
  • 143
    • 32344448382 scopus 로고    scopus 로고
    • Screening for peptide drugs from the natural repertoire of biodiverse protein folds
    • DOI 10.1038/nbt1190, PII NBT1190
    • Watt PM,. 2006. Screening for peptide drugs from the natural repertoire of biodiverse protein folds. Nat Biotechnol 24: 177-183. (Pubitemid 43221700)
    • (2006) Nature Biotechnology , vol.24 , Issue.2 , pp. 177-183
    • Watt, P.M.1
  • 146
    • 1942534029 scopus 로고    scopus 로고
    • Major method-specific differences in the measurement of intact parathyroid hormone: Studies in patients with and without chronic renal failure
    • DOI 10.1258/000456304322880050
    • Worth GK, Vasikaran SD, Retallack RW, Musk AA, Gutteridge DH,. 2004. Major method-specific differences in the measurement of intact parathyroid hormone: Studies in patients with and without chronic renal failure. Ann Clin Biochem 41: 149-154. (Pubitemid 38523602)
    • (2004) Annals of Clinical Biochemistry , vol.41 , Issue.2 , pp. 149-154
    • Worth, G.K.1    Vasikaran, S.D.2    Retallackl, R.W.3    Musk, A.A.4    Gutteridge, D.H.5
  • 147
    • 46149121257 scopus 로고    scopus 로고
    • Recent development in application of high performance liquid chromatography-tandem mass spectrometry in therapeutic drug monitoring of immunosuppressants
    • Yang Z, Wang S,. 2008. Recent development in application of high performance liquid chromatography-tandem mass spectrometry in therapeutic drug monitoring of immunosuppressants. J Immunol Methods 336 (2): 98-103.
    • (2008) J Immunol Methods , vol.336 , Issue.2 , pp. 98-103
    • Yang, Z.1    Wang, S.2
  • 148
    • 0037175451 scopus 로고    scopus 로고
    • Quantitative analysis of a model opioid peptide and its cyclic prodrugs in rat plasma using high-performance liquid chromatography with fluorescence and tandem mass spectrometric detection
    • DOI 10.1016/S1570-0232(02)00536-6, PII S1570023202005366
    • Yang JZ, Bastiab KC, Moore RD, Stobaugh JF, Borchardt RT,. 2002. Quantitative analysis of a model opioid peptide and its cyclic prodrugs in rat plasma using high-performance liquid chromatography with fluorescence and tandem mass spectrometric detection. J Chromatogr B 780: 269-281. (Pubitemid 35223562)
    • (2002) Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences , vol.780 , Issue.2 , pp. 269-281
    • Yang, J.Z.1    Bastian, K.C.2    Moore, R.D.3    Stobaugh, J.F.4    Borchardt, R.T.5
  • 149
    • 33748151944 scopus 로고    scopus 로고
    • 18-amine specific PEGylation: Stability, permeability, pharmacokinetic behavior and in vivo hypocalcemic efficacy
    • DOI 10.1016/j.jconrel.2006.06.007, PII S016836590600280X
    • Youn YS, Jung JY, Oh SH, Yoo SD, Lee KC,. 2006. Improved intestinal delivery of salmon calcitonin by Lys18-amine specific PEGylation: Stability, permeability, pharmacokinetic behavior and in vivo hypocalcemic efficacy. J Control Release 114: 334-342. (Pubitemid 44310815)
    • (2006) Journal of Controlled Release , vol.114 , Issue.3 , pp. 334-342
    • Youn, Y.S.1    Jung, J.Y.2    Oh, S.H.3    Yoo, S.D.4    Lee, K.C.5
  • 150
    • 33845207048 scopus 로고    scopus 로고
    • Evaluation of therapeutic potentials of site-specific PEGylated glucagon-like peptide-1 isomers as a type 2 anti-diabetic treatment: Insulinotropic activity, glucose-stabilizing capability, and proteolytic stability
    • DOI 10.1016/j.bcp.2006.09.013, PII S0006295206005788
    • Youn YS, Chae SY, Lee S, Jeon JE, Shin HG, Lee KC,. 2007. Evaluation of therapeutic potentials of site-specific PEGylated glucagon-like peptide-1 isomers as a type 2 anti-diabetic treatment, insulinotropic activity, glucose-stabilizing capability and proteolytic stability. Biochem Pharmacol 73: 84-93. (Pubitemid 44853930)
    • (2007) Biochemical Pharmacology , vol.73 , Issue.1 , pp. 84-93
    • Youn, Y.S.1    Chae, S.Y.2    Lee, S.3    Jeon, J.E.4    Shin, H.G.5    Lee, K.C.6
  • 151
    • 44649125389 scopus 로고    scopus 로고
    • Lipidization of human interferon-alpha: A new approach toward improving delivery of protein drugs
    • Yuan L, Wang J, Shen WC,. 2008. Lipidization of human interferon-alpha: A new approach toward improving delivery of protein drugs. J Control Release 129: 11-17.
    • (2008) J Control Release , vol.129 , pp. 11-17
    • Yuan, L.1    Wang, J.2    Shen, W.C.3
  • 152
    • 0037165196 scopus 로고    scopus 로고
    • Antimicrobial peptides of multicellular organisms
    • DOI 10.1038/415389a
    • Zasloff M,. 2002. Antimicrobial peptides of multicellular organisms. Nature 415: 389-395. (Pubitemid 34100944)
    • (2002) Nature , vol.415 , Issue.6870 , pp. 389-395
    • Zasloff, M.1
  • 153
    • 33644781735 scopus 로고    scopus 로고
    • Identification of carboxyl-terminal peptide fragments of parathyroid hormone in human plasma at low-picomolar levels by mass spectrometry
    • DOI 10.1021/ac051711o
    • Zhang CX, Weber BV, Thammavong J, Grover TA, Wells DS,. 2006. Identification of carboxyl-terminal peptide fragments of parathyroid hormone in human plasma at low picomolar levels by mass spectrometry. Anal Chem 78: 1636-1643. (Pubitemid 43346303)
    • (2006) Analytical Chemistry , vol.78 , Issue.5 , pp. 1636-1643
    • Zhang, C.-X.1    Weber, B.V.2    Thammavong, J.3    Grover, T.A.4    Wells, D.S.5
  • 154
    • 0033964101 scopus 로고    scopus 로고
    • Elucidation of peptide metabolism by on-line immunoaffinity liquid chromatography mass spectrometry
    • DOI 10.1002/(SICI)1097-0231(2000 0229)14:4<261::AID-R CM868>3.0.CO;2-X
    • Zheng K, Lubman DM, Rossi DT, Nordblom GD, Barksdale CM,. 2000. Elucidation of peptide metabolism by on-line immunoaffinity liquid chromatography mass spectrometry. Rapid Commun Mass Spectrom 14 (4): 261-269. (Pubitemid 30100852)
    • (2000) Rapid Communications in Mass Spectrometry , vol.14 , Issue.4 , pp. 261-269
    • Zheng, K.1    Lubman, D.M.2    Rossi, D.T.3    Nordblom, G.D.4    Barksdale, C.M.5


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