Presystemic metabolism of orally administered peptide drugs and strategies to overcome it

Current Drug Metabolism

Volumn 8, Issue 5, 2007, Pages 509-517

  Bernkop Schnürch, Andreas ^a   Schmitz, T ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Oral absorption; Peptide drugs; Presystemic metabolism

Indexed keywords

AMASTATIN; ANTIPAIN; ANTOCIN; BESTATIN; CELL ENZYME; CHYMOSTATIN; DESMOPRESSIN; DISULFIDE; ELASTATINAL; ENZYME INHIBITOR; INSULIN; LEUPEPTIN; LIPOSOME; NANOCARRIER; NANOPARTICLE; OXYTOCIN; OXYTOCIN DERIVATIVE; PEPSTATIN; PEPTIDASE; PEPTIDE; PHOSPHINATE INHIBITOR VI; PHOSPHORAMIDON; POLYELECTROLYTE; PRODRUG; PUROMYCIN; THIOL; UNCLASSIFIED DRUG; VASOPRESSIN; DRUG; PEPTIDE HYDROLASE;

DERIVATIZATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG METABOLISM; DRUG PENETRATION; DRUG STABILITY; DRUG STRUCTURE; ENZYME RELEASE; GASTROINTESTINAL SECRETION; HUMAN; INTESTINE BRUSH BORDER; NONHUMAN; PHARMACEUTICAL ENGINEERING; REVIEW; TABLET MATRIX; BIOAVAILABILITY; CHEMISTRY; METABOLISM; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; BIOLOGICAL AVAILABILITY; HUMANS; PEPTIDE HYDROLASES; PEPTIDES; PHARMACEUTICAL PREPARATIONS;

EID: 34548803860     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920007780866834     Document Type: Review

References (78)

1. Yu, Y.; Jawa, A.; Pan, W.K.A. (2004) Peptides, 25(12), 2257-2289.
2. Turker, S.; Onur, E.; Ozer, Y. (2004) Pharm. World Sci., 26(3), 137-142.
3. Katsura, T.; Inui, K. (2003) Drug Metab. Pharmacokinet., 181(1), 1-15.
4. Aungst, B.J. (1993) J Pharm. Sci., 82(10), 979-987.
5. Schmitz, T.; Huck, C.W.; Bernkop-Schnürch, A. (2006) Amino Acids, 30(1), 35-42.
6. Wilkinson, G.R. (1997) Adv. Drug Deliv. Rev., 27(2-3), 129-159.
7. Mahato, R.I.; Narang, A.S.; Thoma, L.; Miller, D.D. (2003) Crit. Rev. Ther. Drug Carrier Syst., 20(2&3), 153-214.
8. Martinez, M.N.; Amidon, G.L. (2002) J. Clin. Pharmacol., 42(6), 620-643.
9. Testa, B. (2004) Biochem. Pharmacol., 68(11), 2097-2106.
10. Borchardt, R.T. (1999) J. Control. Rel., 62(1-2), 231-238.
11. Han, H.K. (2000) AAPS Pharm. Sci., 2(1), 1-11.
12. Zhang, K.; Wu, X.Y. (2004) Biomaterials, 25(22), 5281-5291.
13. Simoes, S.; Moreira, J.N.; Fonseca, C.; Duzgunes, N.; de Lima, M.C. (2004) Adv. Drug Deliv. Rev., 56(7), 947-965.
14. Jung, T.; Kamm, W.; Breitenbach, A.; Kaiserling, E.; Xiao, J.X.; Kissel, T. (2000) Eur. J. Pharm. Biopharm., 50(1), 147-150
15. Bernkop-Schnürch, A.; Walker, G. (2001) Crit. Rev. Ther. Drug Carrier Syst., 18(5), 459-501.
16. Johnson, L.R.; Alpers, D.H.; Christensen, J.; Jacobson, E.D.; Walsh, J.H.; Eds. (1994) Physiology of the gastrointestinal tract. New York: Raven Press.
17. Langner, J.; Ansorge, S. Eds. (2000) Kluwer Academic/Plenum Publishers, 241-254.
18. Walsh, K.A. (1970) Methods Enzymol., 19, 41-63.
19. Perona, J.J.; Craik, C.S. (1995) Protein Sci., 4(3), 337-360.
20. Rick, W. (1970) Internist, 11(3), 110-117.
21. Woodley, J.F. (1994) Crit. Rev. Ther. Drug Carrier Syst., 11(2-3), 61-95.
22. Sanderink, G.-J.; Artur, Y.; Siest, G. (1988) J. Clin. Chem. Clin. Biochem., 26(12), 795-807.
23. Davenport, H.W. (1982) Physiology of the Digestive Tract, 5th Edition. Year Book Medical Publishers, Inc. Chicago, Illinois.
24. Kim, Y.S.; Brophy, E.J.; Nicholson J.A. (1976) Biol. Chem., 251(11), 3206-3212.
25. Holzer, H.; Heinrich, P.C. (1980) Annu. Rev. Biochem., 49, 63-91.
26. Caspary, W.F. (1992) Am. J. Clin. Nutr., 55 (Suppl. 1), 299S-308S.
27. Hershko, A.; Ciechanover, A. (1982) Annu. Rev. Biochem., 51, 335-364.
28. Goldberg, A.L.; St John, A.C. (1976) Annu. Rev. Biochem., 45, 747-804.
29. Hershko, A.; Ciechanover, A. (1998) Annu. Rev. Biochem., 67, 425-479.
30. Snyder, G.H.; Cennerazzo, M.J.; Karalis, A.J.; Field, D. (1981) Biochemistry, 20(23), 6509-6519.
31. Flagg, E.W.; Coates, R.J.; Eley, J.W.; Jones, D.P.; Gunter, E.W.; Byers, T.E.; Block, G.S.; Greenberg, R.S. (1994) Nutr. Cancer, 21(1), 33-46.
32. Wierzbicka, G.T.; Hagen, T.M.; Jones, D.P. (1989) J. Food Compos. Anal., 2(4), 327-337.
33. Hagen, T.M.; Wierzbicka, G.T.; Bowman, B.B.; Awit, Y.; Jones, D.P. (1990) Am. J. Physiol., 259(4P+1), G530-G535.
34. Snyder, G.H.; Reddy, M.K.; Cennerazzo, M.J.; Field, D. (1983) Bichim. Biophys. Acta, 749(3), 219-226.
35. Svensson, L.A.; Tunek, A. (1988) Drug Metab. Rev., 19(2), 165-194.
36. Oliyai, R.; Stella, V.J. (1993) Annu. Rev. Pharmacol. Toxicol., 33, 521-544.
37. Bai, J.P.; Chang, L.L.; Guo, J.H. (1995) Crit. Rev. Ther. Drug Carrier Syst., 12(4), 339-371.
38. Wang, W.; Jiang, J.; Ballard, C.E.; Wang, B. (1999) Curr. Pharm. Des., 5(4), 265-287.
39. Sewald, N.; Jakubke, H.D. (2002) Wiley: Peptides: Chemistry and Biology. 1st Edition.
40. Lee, V.H.L.; Yamamoto, A. (1990) Adv. Drug Deliv. Rev., 4(2), 171-207.
41. Gudmundsson, O.S.; Nimkar, K.; Gangwar, S.; Siahaan, T.J.; Borchardt, R.T. (1999) Pharm. Res., 16(1), 16-23.
42. Borchardt, R.T. (1999) J. Control. Release, 62(1-2), 231-238.
43. Manning, M.; Lowbridge, J.; Haldar, J.; Sawyer, W.H. (1977) Fed. Proc., 36(6), 1848-1852.
44. Fjellestad-Paulsen, A.; Söderberg-Ahlm, C.; Lundin, S. (1995) Peptides, 16(6), 1141-1147.
45. Kahns, A.H.; Moss J.; Bundgaard, H. (1992) Acta Pharm. Nord., 4(3), 187-188.
46. Mattiasson, A.; Abrams, P.; Van Kerrebroeck, P.; Walter, S.; Weiss, J. (2002) BJU Int., 89(9), 855-862.
47. Reseland, J.E.; Holm, H.; Jacobsen, M.B.; Jenssen, T.G.; Hanssen, L.E.; (1996) Hum. Clin. Nutr., 126(3), 634-642.
48. Bernkop-Schnürch, A. (1998) J. Control. Release, 52(1-2), 1-16.
49. Ohtani, S.; Shirasu, K.; Ogawara, K.; Higaki, K.; Kimura, T. (2003) Pharm. Res., 20(4), 611-617.
50. Ohtani, S.; Ogawara, K.; Higaki, K.; Kimura, T. (2003) Pharm. Res., 20(11), 1746-1751.
51. Ponchel, G. (1997) Eur. J. Pharm. Biopharm., 44(1), 25-31.
52. Khalil, S.A.; Nixon, J.R.; Carless, J.E. (1968) J. Pharm. Pharmacol., 20(3), 215-225.
53. Luzzi, L.A.; Gerraughty, R.J. (1967) J. Pharm. Sci., 56(5), 634-638.
54. Phares, R.E. Jr.; Sperandio, G.J. (1964) J. Pharm. Sci., 53, 515-518.
55. Lamprecht, A.; Yamamoto, H.; Takeuchi, H.; Kawashima, Y. (2004) J. Control. Release, 23(98), 1-9.
56. Birrenbach, G.; Speiser, P.P. (1976) J. Pharm. Sci., 65(12), 1763-1766.
57. Moghimi, S.M.; Hunter, A.C.; Murray, J.C. (2005) FASEB J., 19(3), 311-330.
58. Damge, C.; Michel, M.; Aprahamian, M.; Couvreur, P. (1988) Diabetes, 37(2), 246-251.
59. Mesiha, M.S.; Sidhom, M.B.; Fasipe, B. (2005) Int. J. Pharm., 288(2), 289-293.
60. Sang Yoo, H.; Gwan Park, T. (2004) J. Pharm. Sci., 93(2), 488-495.
61. Li, J.K.; Wang, N.; Wu, X.S. (1997) J. Pharm. Sci., 86(8), 891-895.
62. Patel, H.M.; Ryman, B.E. (1976) FEBs Lett., 62(1), 60-63.
63. Dapergolas, G.; Gregoriadis, G. (1976) Lancet, 2(7990), 824-827.
64. Zhang, N.; Ping, Q.N.; Xu, W.F. (2004) Yao Xue Xue Bao, 39(5), 380-384.
65. Chen, H.; Langer, R. (1998) Adv. Drug Deliv. Rev., 34(2-3), 339-350.
66. Larionova, N.V.; Ponchel, G.; Duchêne, D.; Larionova, N.I. (1999) Int. J. Pharm., 189(2), 171-175
67. Bernkop-Schnürch, A.; Krauland, A.; Valenta, C. (1998) J. Drug Target, 6(3), 207-214.
68. Birk, Y. (1985) Int. J. Pept. Protein Res., 25(2), 113-131.
69. Marschütz, M.K.; Bernkop-Schnürch, A. (2000) Biomaterials, 21(14), 1499-1507.
70. Jaulent, A.M.; Leatherbarrow, R.J. (2004) Protein Eng. Des. Sel., 17(9), 681-687.
71. Guggi, D.; Krauland, A.H.; Bernkop-Schnürch, A. (2003) J. Control. Release, 92(1-2), 125-135.
72. Bernkop-Schnürch, A.; Krauland, A.H.; Leitner, V.M.; Palmberger, T. (2004) Eur. J. Pharm. Biopharm., 58(2), 253-263.
73. Bromberg, L. (2003) Curr. Pharm. Biotechnol., 4(5), 339-349.
74. van der Merwe, S.M.; Verhoef, J.C.; Verheijden, J.H.; Kotze, A.F.; Junginger, H.E. (2004) Eur. J. Pharm. Biopharm., 58(2), 225-235.
75. Hussain, A.; Arnold, J.J.; Khan, M.A.; Ahsan, F. (2004) J. Control. Release, 94(1), 15-24.
76. Thanou, M.; Verhoef, J.C.; Junginger, H.E. (2001) Adv. Drug Deliv. Rev., 50(Suppl. 1), 91-101.
77. Aungst, B.J. (2000) J. Pharm. Sci., 89(4), 429-442.
78. Clausen, A.E.; Kast, C.E.; Bernkop-Schnürch, A. (2002) Pharm. Res., 19(5), 602-608.