Investigation of exenatide elimination and its in vivo and in vitro degradation

Current Drug Metabolism

Volumn 7, Issue 4, 2006, Pages 367-374

  Copley, Kathrin ^a   McCowen, Kevin ^a   Hiles, Richard ^a   Nielsen, Loretta L ^a   Young, Andrew ^a   Parkes, David G ^a  

^a AMYLIN PHARMACEUTICALS INC   (United States)

Author keywords

AC2993; Exenatide; Exendin 4; GLP 1; Renal clearance; Type 2 diabetes

Indexed keywords

AMINO ACID; EXENDIN 4;

AMINO ACID ANALYSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DEGRADATION; DRUG ELIMINATION; DRUG EXCRETION; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; IN VITRO STUDY; IN VIVO STUDY; KIDNEY PARENCHYMA; LIVER DYSFUNCTION; MALE; MEAN RESIDENCE TIME; MONKEY; MOUSE; NONHUMAN; RABBIT; RAT; REVIEW;

ANIMALS; CHROMATOGRAPHY, LIQUID; GALACTOSAMINE; HEPATITIS, TOXIC; KIDNEY; LIVER CIRRHOSIS; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED STRAINS; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; THIOACETAMIDE; VENOMS;

EID: 33646497453     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920006776873490     Document Type: Review

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