General pharmacokinetic model for drugs exhibiting target-mediated drug disposition

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 28, Issue 6, 2001, Pages 507-532

  Mager, Donald E ^a   Jusko, William J ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Bosentan; Human; Imirestat; Interferon ; Mathematical modeling; Nonlinear pharmacokinetics; Receptor binding; Receptor mediated endocytosis; Target mediated drug disposition

Indexed keywords

ALDOSE REDUCTASE INHIBITOR; BOSENTAN; ENDOTHELIN RECEPTOR ANTAGONIST; IMIRESTAT; RECOMBINANT BETA INTERFERON;

ARTICLE; BINDING AFFINITY; CLINICAL TRIAL; COMPUTER SIMULATION; DISTRIBUTION VOLUME; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; ENDOCYTOSIS; HUMAN; MALE; MODEL; PHARMACOKINETICS; PRIORITY JOURNAL;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; FLUORENES; HUMANS; HYDANTOINS; INTERFERON-BETA; MALE; MODELS, CHEMICAL; NONLINEAR DYNAMICS; PHARMACOKINETICS; SULFONAMIDES;

EID: 0035730322     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1014414520282     Document Type: Article

References (42)

1. Pharmacologic target-mediated drug disposition
2. Pharmacokinetics of repeated single oral doses of enalapril maleate (MK-421) in normal volunteers
3. Pharmacokinetics of an ACE inhibitor, S-9780, in man: Evidence of tissue binding
4. Studies with low dose intravenous diacid ACE inhibitor (perindoprilat) infusions in normotensive male volunteers
5. Mathematical modeling of receptor-mediated endocytosis
6. Intracellular pathways and mechanisms of sorting in receptor-mediated endocytosis
7. Receptor-mediated transport of peptide hormones and its importance in the overall hormone disposition in the body
8. Recycling receptors: The round-trip itinerary of migrant membrane proteins
9. The pathway of endocytosis
10. Protein sorting by transport vesicles
11. Phase I study of recombinant tumor necrosis factor in cancer patients
12. Single pass mean residence time in peripheral tissues: A distribution parameter intrinsic to the tissue affinity of a drug
13. Dose-dependent pharmacokinetics of the aldose reductase inhibitor imirestat in man
14. Pharmacokinetics and pharmacodynamics of the endothelin-receptor antagonist bosentan in healthy human subjects
15. Pharmacokinetics and pharmacodynamics of IFN-β 1a in healthy volunteers
16. Effect of saturable binding on the pharmacokinetics of drugs: A simulation
17. Dose-dependent pharmacokinetics: Experimental observations and theoretical considerations
18. Guidelines for collection and analysis of pharmacokinetic data
19. A new generalized nonlinear pharmacokinetic model and its implications
20. Mean residence time concepts for pharmacokinetic systems with nonlinear drug elimination described by the Michaelis-Menten equation
21. Saturable tissue binding and imirestat pharmacokinetics in rats
22. Endothelin receptor antagonists: Current status and perspectives
23. Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist
24. Absorption, excretion, and metabolism of the endothelin receptor antagonist bosentan in healthy male subjects
25. Multiple-dose pharmacokinetics, safety, and tolerability of bosentan, an endothelin receptor antagonist, in healthy male volunteers
26. Multiple Sclerosis
27. Pharmacokinetics of recombinant human interferon-β ser in healthy volunteers and its effect on serum neopterin
28. Pharmacokinetics and pharmacodynamics of recombinant human interferon-β in healthy male volunteers
29. Clinical pharmacokinetics of interferons
30. Comparative pharmacokinetics and pharmacodynamics of two recombinant human interferon-β 1a (IFN-β 1a) products administered intramuscularly in healthy male and female volunteers
31. Pharmacokinetics and metabolism of therapeutic cytokines
32. Interferons and their actions
33. Pharmacokinetics of capacity-limited tissue distribution of methicillin in rabbits
34. A combined specific target site binding and pharmacokinetic model to explore the non-linear disposition of draflazine
35. Nonlinear pharmacokinetics and metabolism of paclitaxel and its pharmacokinetic/pharmacodynamic relationships in humans
36. Operational models of pharmacological agonism
37. Comparison of four basic models of indirect pharmacodynamic responses
38. Precursor-dependent indirect pharmacodynamic response model for tolerance and rebound phenomena
39. Transit compartments versus gamma distribution function to model signal transduction processes in pharmacodynamics
40. Pharmacodynamic modeling of time-dependent transduction systems