Analysis of cyclosporine A and its metabolites in rat urine and feces by liquid chromatography-tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 15-16, 2010, Pages 1153-1162

  Fang, Zhi gang ^a   You, Ben gang ^a   Chen, Ya gen ^a   Zhang, Jian kang ^a   Liu, Yue qing ^a   Zhang, Xue nong ^a   Zhang, Qiang ^b  

^a SOOCHOW UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Cyclosporine A; LC MS MS; Metabolites

Indexed keywords

ANALYTES; CONCENTRATION RANGES; CYCLOSPORINE A; EUDRAGIT; EXTRACTION RECOVERY; FRAGMENTATION BEHAVIOR; IN-VIVO; INTERNAL STANDARDS; LC-MS/MS; LINEAR CALIBRATION CURVE; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID-LIQUID EXTRACTION; METABOLIC PATHWAYS; MULTIPLE REACTIONS MONITORING; NANOPARTICLE SYSTEMS; ORAL ADMINISTRATION; POSITIVE ION MODE; RAPID DETERMINATION; RAT URINE; RELATIVE STANDARD DEVIATIONS; RETENTION TIME; TURBOIONSPRAY; WASTE SAMPLES;

BIOMOLECULES; BODY FLUIDS; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; METABOLITES; NANOPARTICLES; PHYSIOLOGY; SOLVENT EXTRACTION;

METABOLISM;

CYCLOSPORIN A; CYCLOSPORIN A DERIVATIVE; CYCLOSPORIN D; DIHYDROXYCYCLOSPORIN A; DIMETHYLCYCLOSPORIN A; DRUG METABOLITE; EUDRAGIT; HYDROXYCYCLOSPORIN A; NANOPARTICLE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIHYDROXYLATION; DRUG DETERMINATION; DRUG EXCRETION; DRUG FECES LEVEL; DRUG METABOLISM; DRUG RETENTION; DRUG STRUCTURE; DRUG URINE LEVEL; FRAGMENTATION REACTION; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REACTION ANALYSIS; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STRUCTURE ANALYSIS; TANDEM MASS SPECTROMETRY;

ANIMALS; CHROMATOGRAPHY, LIQUID; CYCLOSPORINE; DRUG STABILITY; FECES; LINEAR MODELS; MALE; NANOPARTICLES; POLYMETHACRYLIC ACIDS; RATS; RATS, SPRAGUE-DAWLEY; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 77950933847     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.03.032     Document Type: Article

References (36)

1. Kaufman D.B., Shapiro R., Lucey M.R., Cherikh W.S., Bustami R.T., and Dyke D.B. Am. J. Transplant. 4 Suppl. 9 (2004) 38
2. Shaw L.M., Bowers L., Demers L., Freeman D., Moyer T., Sanghvi A., Seltman H., and Venkataramanan R. Clin. Chem. 33 (1987) 1269
3. Jorga A., Holt D.W., and Johnston A. Transplant. Proc. 36 Suppl. 2S (2004) 396S
4. Dusci L.J., Hackett P., Chiswell G.M., and Ilett K.F. Ther. Drug Monit. 14 (1992) 327
5. Chimalakonda A.P., Shah R.B., and Mehvar R. J. Chromatogr. B 772 (2002) 107
6. Amini H., and Ahmadiani A. J. Chromatogr. B 795 (2003) 209
7. Khoschsorur G., Erwa W., Fruehwirth F., Stettin M., Meinitzer A., Hoebarth G., Zelzer S., and Halwachs-Baumann G. Talanta 65 (2005) 638
8. Vollenbroeker B., Koch J.-H., Fobker M., Suwelack B., Hohage H., and Müller U. Transplant. Proc. 37 (2005) 1741
9. Ansermot N., Fathi M., Veuthey J.-L., Desmeules J., Hochstrasser D., and Rudaz S. J. Chromatogr. B 857 (2007) 92
10. Mendonza A., Gohh R., and Akhlaghi F. Ther. Drug Monit. 26 (2004) 569
11. Wilhelm A.J., den Burger J.C.G., Vos R.M., Chahbouni A., and Sinjewel A. J. Chromatogr. B 877 (2009) 1595
12. Streit F., Christians U., Schiebel H.M., Napoli K.L., Ernst L., Linck A., Kahan B.D., and Sewing K.Fr. Clin. Chem. 42 (1996) 1417
13. Taylor P.J., Jones C.E., Martin P.T., Lynch S.V., Johnson A.G., and Pond S.M. J. Chromatogr. B 705 (1998) 289
14. Christians U., and Sewing K.F. Pharmacol. Ther. 57 (1993) 291
15. Lensmeyer G.L., Wiebe D.A., and Carlson I.H. Clin. Chem. 33 (1987) 1841
16. Gmur D.J., Meier P., and Yee G.C. J. Chromatogr. 425 (1988) 343
17. Falck P., Guldseth H., Åsberg A., Midtvedt K., and Reubsaet J.L.E. J. Chromatogr. B 852 (2007) 345
18. Vékey K. J. Chromatogr. A 921 (2001) 227
19. McClean S., Prosser E., Meehan E., O'Malley D., Clarke N., Ramtoola Z., and Brayden D. Eur. J. Pharm. Sci. 6 (1998) 153
20. Dai J.D., Nagai T., Wang X.Q., Zhang T., Meng M., and Zhang Q. Int. J. Pharm. 280 (2004) 229
21. Yang Z.Q., Xu J., Pan P., and Zhang X.N. Pharmazie 64 (2009) 26
22. Wang X.Q., Dai J.D., Zhang H., Zhang X., Wang J.C., and Zhang Q. J. Nanosci. Nanotechnol. 8 (2008) 2422
23. Zhang W.S., and Li A.L. Medicinal Chemistry (1999), Higher Education Press, China p. 67
24. Christians U., Zimmer K.O., Wonigeit K., Maurer G., and Sewing K.F. Clin. Chem. 34 (1988) 34
25. Havlicek V., Jegorov A., Sedmera P., and Ryska M. Org. Mass Spectrom. 28 (1993) 1440
26. Dai Y., Iwanaga K., Lin Y.S., Hebert M.F., Davis C.L., Huang W., Kharasch E.D., and Thummel K.E. Biochem. Pharmacol. 68 (2004) 1889
27. Christians U., and Sewing K.-F. Clin. Biochem. 28 (1995) 547
28. Maurer G., and Lemaier M. Transplant. Proc. 18 (1986) 25
29. Venkataramanan R., Wang C.P., Habacky K., Patchcinski R.J., Burckart G.J., Koneru B., Baker R., Toclo S., and Starzl T.E. Transplant. Proc. 20 (1988) 680
30. Schwinghammer T.L., Przepiorka D., Venkataramanan R., Wang C.P., Burckart G.J., Rosenfeld C.S., and Shadduck R.K. Br. J. Clin. Pharmacol. 32 (1991) 323
31. Fahr A., Hiestand P., and Ryffel B. Transplant. Proc. 22 (1990) 1116
32. Fidelus R.K., and Ferguson R.M. Transplant. Proc. 15 (1983) 1921
33. Dindzans V.J., Wong P.Y., Mee A.V., Cheung F., Abecassis M., Cole E.H., Cohen Z., and Levy G.A. Transplant. Proc. 19 (1987) 3490
34. Zeevi A., Venkataramanan R., Burckart G., Wang C.P., Murase N., Van Thiel D.H., Starzl T.E., Makowka L., and Duquesnoy R.J. Human Immunol. 21 (1988) 143
35. Abecassis M., Wong P.Y., Mason N., Cheung F., Mee A.V., Cole E.H., Langer B., Cohen Z., and Levy G.A. Can. J. Surg. 31 (1988) 145
36. Hartmann N.R., and Jardine I. Drug Metab. Dispos. 15 (1987) 661