Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase

Nature Immunology

Volumn 6, Issue 3, 2005, Pages 253-260

  Van Vliet, Catherine ^a   Bukczynska, Patricia E ^a   Puryer, Michelle A ^a,c   Sadek, Christine M ^a   Shields, Benjamin J ^a   Tremblay, Michel L ^b   Tiganis, Tony ^a  

^a MONASH UNIVERSITY   (Australia)

^b MCGILL UNIVERSITY   (Canada)

^c MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; T CELL PROTEIN TYROSINE PHOSPHATASE; T-CELL PROTEIN TYROSINE PHOSPHATASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; FIBROBLAST; HEMATOPOIESIS; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; ANIMAL; ENZYMOLOGY; HUMAN; IMMUNOLOGY; METABOLISM; UPREGULATION;

ANIMALS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INTERLEUKIN-6; MAP KINASE KINASE KINASES; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 3; PROTEIN-TYROSINE-PHOSPHATASE; SRC-FAMILY KINASES; T-LYMPHOCYTES; TNF RECEPTOR-ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 14944349510     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1169     Document Type: Article

References (54)

1. Baud, V. & Karin, M. Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol. 11, 372-377 (2001).
2. Kyriakis, J.M. Life-or-death decisions. Nature 414, 265-266 (2001).
3. Chang, L. & Karin, M. Mammalian MAP kinase signalling cascades. Nature 410, 37-40 (2001).
4. Devin, A., Lin, Y. & Liu, Z.G. The role of the death-domain kinase RIP in tumour-necrosis-factor-induced activation of mitogen-activated protein kinases. EMBO Rep. 4, 623-627 (2003).
5. Chadee, D.N., Yuasa, T. & Kyriakis, J.M. Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2. Mol. Cell. Biol. 22, 737-749 (2002).
6. Ibarra-Sanchez, M. et al. The T-cell protein tyrosine phosphatase. Semin. Immunol. 12, 379-386 (2000).
7. Shc are specific substrates of T-cell protein tyrosine phosphatase. Mol. Cell. Biol. 18, 1622-1634 (1998).
8. Galic, S. et al. Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP. Mol. Cell. Biol. 23, 2096-2108 (2003).
9. Simoncic, P.D., Lee-Loy, A., Barber, D.L., Tremblay, M.L. & McGlade, C.J. The T-cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. Curr. Biol. 12, 446-453 (2002).
10. ten Hoeve, J. et al. Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol. Cell. Biol. 22, 5662-5668 (2002).
11. Ibarra-Sanchez, M.J., Wagner, J., Ong, M.T., Lampron, C. & Tremblay, M.L. Murine embryonic fibroblasts lacking TC-PTP display delayed G1 phase through defective NFκB activation. Oncogene 20, 4728-4739 (2001).
12. Tiganis, T., Kemp, B.E. & Tonks, N.K. The protein tyrosine phosphatase TCPTP regulates epidermal growth factor receptor-mediated and phosphatidylinositol 3-kinase-dependent signalling. J. Biol. Chem. 274, 27768-27775 (1999).
13. Galic, S. et al. Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP. Mol. Cell. Biol. 25, 819-829 (2005).
14. You-Ten, K.E. et al. Impaired bone marrow microenvironment and immune function in T-cell protein tyrosine phosphatase-deficient mice. J. Exp. Med. 186, 683-693 (1997).
15. Heinonen, K.M. et al. T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease. Blood 103, 3457-3464 (2004).
16. Rosette, C. & Karin, M. Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science 274, 1194-1197 (1996).
17. Tobin, D., van Hogerlinden, M. & Toftgard, R. UVB-induced association of tumor necrosis factor (TNF) receptor 1/TNF receptor-associated factor-2 mediates activation of Rel proteins. Proc. Natl. Acad. Sci. USA 95, 565-569 (1998).
18. 1-mediated activation of protein tyrosine phosphatase TCPTP. Nat. Cell Biol. 7, 78-85 (2005).
19. Flint, A.J., Tiganis, T., Barford, D. & Tonks, N.K. Development of 'substrate-trapping' mutants to identify physiological substrates of protein tyrosine phosphatases. Proc. Natl. Acad. Sci. USA 94, 1680-1685 (1997).
20. Elchebly, M. et al. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 283, 1544-1548 (1999).
21. Zabolotny, J.M. et al. PTP1B regulates leptin signal transduction in vivo. Dev. Cell 2, 489-495 (2002).
22. Myers, M.P. et al. TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B. J. Biol. Chem. 276, 47771-47774 (2001).
23. Frangioni, J.V., Beahm, P.H., Shifrin, V., Jost, C.A. & Neel, B.G. The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence. Cell 68, 545-560 (1992).
24. Lam, M.H. et al. Cellular stress regulates the nucleocytoplasmic distribution of the protein tyrosine phosphatase TCPTP. J. Biol. Chem. 276, 37700-37707 (2001).
25. Naka, T., Nishimoto, N. & Kishimoto, T. The paradigm of IL6: from basic science to medicine. Arthritis Res. 4 (Suppl. 3), S233-S242 (2002).
26. You, M., Flick, L.M., Yu, D. & Feng, G.S. Modulation of the nuclear factor κB pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor. J. Exp. Med. 193, 101-110 (2001).
27. Wysk, M., Yang, D.D., Lu, H.T., Flavell, R.A. & Davis, R.J. Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression. Proc. Natl. Acad. Sci. USA 96, 3763-3768 (1999).
28. Yeatman, T.J. A renaissance for SRC. Nat. Rev. Cancer 4, 470-480 (2004).
29. Taylor, S.J., Anafi, M., Pawson, T. & Shalloway, D. Functional interaction between c-Src and its mitotic target, Sam 68. J. Biol. Chem. 270, 10120-10124 (1995).
30. Bivona, T.G. et al. Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1. Nature 424, 694-698 (2003).
31. Silva, C.M. Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis. Oncogene 23, 8017-8023 (2004).
32. Ponniah, S., Wang, D.Z., Lim, K.L. & Pallen, C.J. Targeted disruption of the tyrosine phosphatase PTPα leads to constitutive downregulation of the kinases Src and Fyn. Curr. Biol. 9, 535-538 (1999).
33. Gil-Henn, H. & Elson, A. Tyrosine phosphatase-ε activates Src and supports the transformed phenotype of Neu-induced mammary tumor cells. J. Biol. Chem. 278, 15579-15586 (2003).
34. Hermiston, M.L., Xu, Z., Majeti, R. & Weiss, A. Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases. J. Clin. Invest. 109, 9-14 (2002).
35. Zhang, S.Q. et al. Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment. Mol. Cell 13, 341-355 (2004).
36. Lorenz, U., Ravichandran, K.S., Burakoff, S.J. & Neel, B.G. Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness. Proc. Natl. Acad. Sci. USA 93, 9624-9629 (1996).
37. Bjorge, J.D., Pang, A. & Fujita, D.J. Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines. J. Biol. Chem. 275, 41439-41446 (2000).
38. Dube, N., Cheng, A. & Tremblay, M.L. The role of protein tyrosine phosphatase 1B in Ras signaling. Proc. Natl. Acad. Sci. USA 101, 1834-1839 (2004).
39. Galbiati, F., Razani, B. & Lisanti, M.P. Emerging themes in lipid rafts and caveolae. Cell 106, 403-411 (2001).
40. Arron, J.R., Pewzner-Jung, Y., Walsh, M.C., Kobayashi, T. & Choi, Y. Regulation of the subcellular localization of tumor necrosis factor receptor-associated factor (TRAF)2 by TRAF1 reveals mechanisms of TRAF2 signaling. J. Exp. Med. 196, 923-934 (2002).
41. Doan, J.E., Windmiller, D.A. & Riches, D.W. Differential regulation of TNF-R1 signaling: lipid raft dependency of p42mapk/erk2 activation, but not NFκB activation. J. Immunol. 172, 7654-7660 (2004).
42. Muppidi, J.R., Tschopp, J. & Siegel, R.M. Life and death decisions; Secondary complexes and lipid rafts in TNF receptor family signal transduction. Immunity 21, 461-465 (2004).
43. Legler, D.F., Micheau, O., Doucey, M.A., Tschopp, J. & Bron, C. Recruitment of TNF receptor 1 to lipid rafts is essential for TNFα-mediated NF-κB activation. Immunity 18, 655-664 (2003).
44. Wong, B.R. et al. TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src. Mol. Cell 4, 1041-1049 (1999).
45. Mukundan, L. et al. TNF receptor-associated factor 6 is an essential mediator of CD40-activated proinflammatory pathways in monocytes and macrophages. J. Immunol. 174, 1081-1090 (2005).
46. Chiu, V.K. et al. Ras signalling on the endoplasmic reticulum and the Golgi. Nat. Cell Biol. 4, 343-350 (2002).
47. Thomas, R.M. et al. C-terminal SRC kinase controls acute inflammation and granulocyte adhesion. Immunity 20, 181-191 (2004).
48. Shultz, L.D. et al. Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell 73, 1445-1454 (1993).
49. Tsui, H.W., Siminovitch, K.A., de Souza, L. & Tsui, F.W. Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene. Nat. Genet. 4, 124-129 (1993).
50. Lowell, C.A., Fumagalli, L. & Berton, G. Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. J. Cell Biol. 133, 895-910 (1996).
51. Abu-Amer, Y. et al. Tumor necrosis factor-α activation of nuclear transcription factor-κB in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Iκ Bα. J. Biol. Chem. 273, 29417-29423 (1998).
52. Huang, S. et al. Defective activation of c-Src in cystic fibrosis airway epithelial cells results in loss of tumor necrosis factor-α-induced gap junction regulation. J. Biol. Chem. 278, 8326-8332 (2003).
53. Huang, W.C., Chen, J.J. & Chen, C.C. c-Src-dependent tyrosine phosphorylation of IKKβ is involved in tumor necrosis factor-α- induced intercellular adhesion molecule-1 expression. J. Biol. Chem. 278, 9944-9952 (2003).
54. Saijo, K. et al. Essential role of Src-family protein tyrosine kinases in NF-κB activation during B cell development. Nat. Immunol. 4, 274-279 (2003).