Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog

Molecular and Biochemical Parasitology

Volumn 91, Issue 2, 1998, Pages

  Xu, Ming ^a   Molento, Marcelo ^a   Blackhall, William ^a   Ribeiro, Paula ^a   Beech, Robin ^a   Prichard, Roger ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Drug resistance; Haemonchus contortus; Ivermectin; P glycoprotein

Indexed keywords

GLYCOPROTEIN P; IVERMECTIN; MOXIDECTIN; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG EFFICACY; FEMALE; GENE SEQUENCE; HAEMONCHUS CONTORTUS; MAMMAL; NEMATODIASIS; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SHEEP; SUBCUTANEOUS DRUG ADMINISTRATION;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; ANTINEMATODAL AGENTS; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; CLONING, MOLECULAR; DNA, COMPLEMENTARY; DRUG RESISTANCE, MULTIPLE; FEMALE; GENES, HELMINTH; GERBILLINAE; HAEMONCHIASIS; HAEMONCHUS; HUMANS; IVERMECTIN; MACROLIDES; MOLECULAR SEQUENCE DATA; P-GLYCOPROTEIN; SEQUENCE ALIGNMENT; VERAPAMIL;

CAENORHABDITIS ELEGANS; HAEMONCHUS CONTORTUS; MERIONES UNGUICULATUS; NEMATODA; OVIS ARIES;

EID: 0032520963     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(97)00215-6     Document Type: Article

References (36)

1. [1] Schoop WL. Ivermectin resistance. Parasitol Today 1993;9:154-9.
2. [2] Prichard RK. Anthelmintic resistance. Vet Parasitol 1994;54:259-68.
3. [3] Cully DF, Vassilatis DK, Liu KK, Paress PS, Van der Ploeg LHT, Schaeffer JM, Arena JP. Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. Nature 1994;371:707-11.
4. [4] Arena JP, Liu KK, Paress PS, Frazier EG, Cully DF, Mrozik H, Schaeffer JM. The mechanism of action of avermectins in Caenorhabditis elegans: correlation between activation of glutamate-sensitive chloride current, membrane binding, and biological activity. J Parasitol 1995;81:286-94.
5. [5] Rohrer SP, Birzin ET, Eary CH, Schaeffer JM, Shoop WL. Ivermectin binding sites in sensitive and resistant Haemonchus contortus. J Parasitol 1994;80:493-7.
6. [6] Gottesman MN, Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Ann Rev Biochem 1993;62:385-427.
7. [7] Juliano RL, Ling V. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 1976;455:152-62.
8. [8] Ouellette M, Fase-Fowler F, Borst P. The amplified H circle of methotrexate resistant Leishmania tarentolae contains a novel P-glycoprotein gene. EMBO J 1990;9:1027-33.
9. [9] Ouellet M, Hettema E, Wust D, Fase-Fowler F, Borst P. Direct and inverted DNA repeats associated with P-glycoprotein gene amplification in drug resistant Leishmania. EMBO J 1991;10:1009-61.
10. [10] Hendrickson N, Sifri DC, Henderson DM, Allen T, Wirth DF, Ullman B. Molecular characterization of the ldmdr1 multidrug resistance gene from Leishmania donovani. Mol Biochem Parasitol 1993;60:53-64.
11. [11] Legare D, Hettema E, Ouellette M. The P-glycoprotein-related gene family in Leishmania. Mol Biochem Parasitol 1994;68:81-91.
12. [12] Foote JA, Cowman AF. The mode of action and mechanism of resistance to antimalarial drugs. Acta Trop 1994;56:157-71.
13. [13] Pussard E, Verdier F. Antimalarial 4-aminoquinolines: mode of action and pharmacokinetics. Fund Clin Pharmacol 1994;8:1-17.
14. [14] Broeks A, Janssen HWRM, Calafat J, Plasterk RHA. A P-glycoprotein protects Caenorhabditis elegans against natural toxins. EMBO J 1995;14:1858-66.
15. [15] Broeks A, Gerrard B, Allikmets R, Dean M, Plasterk RHA. Homologue of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans. EMBO J 1996;15:6132-43.
16. [16] Schinkel AH, Smit JJM, Van Tellingen O, Beijnen JH, Wanenaar EE, Van Deemter E, Mol CAAM, Van der Valk MA, Robanus-Maandag EC, Te Riele HPJ, Berns AJM, Borst P. Disruption of the mouse mdr-1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 1995;77:491-502.
17. [17] Didier A, Loor F. The abamectin derivative ivermectin is a potent P-glycoprotein inhibitor. Anti-Cancer Drugs 1996;7:745-51.
18. [18] Pouliot J-F, L'heureux F, Liu Z, Prichard RK, Georges E. Reversal of P-glycoprotein-associated multidrug resistance by ivermectin. Biochem Pharmacol 1997;53:17-25.
19. [19] Wang GT, Berger H, Simkins K, Rock D. The rate of resistance development by H. contortus to endectocides. Proceedings of the XV International Conference of the World Association for the Advancement of Veterinary Parasitology, Yokohama, Japan, 1995:104.
20. [20] Linke CRI, The CR, Van Groenigen M, Borst P. The P-glycoprotein gene family of Caenorhabditis elegans. Cloning and characterization of genomic and complementary DNA sequences. J Mol Biol 1992;228:701-11.
21. [21] Higgins DG, Sharp PM. Clustal: a package for performing multiple sequence alignment on a microcomputer. Gene 1988;73:237-44.
22. [22] Ausubel F, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K. Northern hybridization of RNA fractionated by agarose-formaldehyde gel electrophoresis. Curr Protoc Mol Biol 1987;1:491-8.
23. [23] Sambrook J, Fritsch EF, Maniatis T. Analysis and cloning of eukaryotic genomic DNA. Molecular Cloning A Laboratory Manual 2, 2nd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1989:916-9.
24. [24] Blackhall WJ, Liu HY, Xu M, Prichard RK, Beech R. Selection at a P-glycoprotein gene in ivermectin- and moxidectin-selected strains of Haemonchus contortus. Submitted 1997.
25. [25] Conder GA, Jen L-W, Marbury KS, Johnson SS, Guimond PM, Thomas EM, Lee BL. A novel anthelmintic model utilizing jirds, Meriones unguiculatus, infected with Haemonchus contortus. J Parasitol 1990;76:168-70.
26. [26] Sangster NC. P-glycoprotein in nematodes. Parasitol Today 1994;10:310-22.
27. [27] Rubio JP, Cowman AF. The ATP-binding cassette (ABC) gene family of Plasmodium falciparum. Parasitol Today 1996;12:135-40.
28. [28] Zalis MG, Wilson GM, Zhang Y, Wirth DF. Characterization of the pfmdr2 gene for Plasmodium falciparum. Mol Biochem Parasitol 1993;62:83-92.
29. [29] Rubio JP, Cowman AF. Plasmodium falciparum: the pfmdr2 protein is not overexpressed in chloroquine-resistant isolates of malaria parasites. Exp Parasitol 1994;79:137-47.
30. [30] Ghosh SK, Lohia A, Kumar A, Samuelson J. Overexpression of P-glycoprotein gene 1 by transfected Entamoeba histolytica confers emetine-resistance. Mol Biochem Parasitol 1996;82:257-60.
31. [31] Ince TA, Scotto KW. A conserved downstream element defines a new class of RNA polymerase II promoters. J Biol Chem 1995;270:30249-52.
32. [32] Yusa K, Tsuruo T. Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells. Cancer Res 1989;49:5002-6.
33. [33] Watanabe T, Tsuge H, Oh-Hara T, Naito M, Tsuruo T. Comparative study on reversal efficacy of SDZ PSC 833, cyclosporin A and verapamil on multidrug resistance in vitro and in vivo. Acta Oncol 1995;34:235-41.
34. [34] Conder GA, Thompson DP, Johnson SS. Demonstration of co-resistance of Haemonchus contortus to ivermectin and moxidectin. Vet Rec 1993;132:651-2.
35. [35] Chen CJ, Chin JE, Ueda K, Clark DP, Pastan I, Gotteman MM, Roninson IB. Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell 1986;47:381-9.
36. [36] Hsu SI-H, Cohen D, Kirschner LS, Lothstein L, Hartstein M, Horwitz SB. Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells. Mol Cell Biol 1990;10:3596-606.