Decreased ABCB1 mRNA expression induced by atorvastatin results from enhanced mRNA degradation in HepG2 cells

European Journal of Pharmaceutical Sciences

Volumn 37, Issue 3-4, 2009, Pages 486-491

  Rodrigues, Alice Cristina ^a   Curi, Rui ^a   Hirata, Mario Hiroyuki ^a   Hirata, Rosario Dominguez Crespo ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

ABCB1 mRNA; Atorvastatin; HepG2 cells; mRNA stability

Indexed keywords

ATORVASTATIN; CHOLESTEROL; DNA FRAGMENT; FARNESYL DIPHOSPHATE; GERANYLGERANYL PYROPHOSPHATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR SP1;

ARTICLE; BINDING AFFINITY; CELL STRAIN HEPG2; CLINICAL EVALUATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DNA PROBE; DRUG EFFECT; DRUG EXPOSURE; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HALF LIFE TIME; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; RNA DEGRADATION; RNA STABILITY; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; CHOLESTEROL; CULTURE MEDIA, SERUM-FREE; DOWN-REGULATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HALF-LIFE; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; P-GLYCOPROTEIN; PYRROLES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 66049103757     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2009.04.006     Document Type: Article

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