메뉴 건너뛰기




Volumn 62, Issue 5, 2010, Pages 426-431

Characterization of PXR mediated P-glycoprotein regulation in intestinal LS174T cells

Author keywords

Function; Induction; Intestinal P glycoprotein; Localization; LS174T; Rifampicin

Indexed keywords

GLYCOPROTEIN P; KETOCONAZOLE; PREGNANE X RECEPTOR; RHODAMINE 123; RIFAMPICIN;

EID: 77956944501     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2010.07.001     Document Type: Article
Times cited : (33)

References (37)
  • 1
    • 0026621245 scopus 로고
    • ABC transporters: from microorganisms to man
    • Higgins C.F. ABC transporters: from microorganisms to man. Annu Rev Cell Biol 1992, 8:67-113.
    • (1992) Annu Rev Cell Biol , vol.8 , pp. 67-113
    • Higgins, C.F.1
  • 2
    • 33644840984 scopus 로고    scopus 로고
    • The power of the pump: mechanisms of action of P-glycoprotein (ABCB1)
    • Ambudkar S.V., Kim I.W., Sauna Z.E. The power of the pump: mechanisms of action of P-glycoprotein (ABCB1). Eur J Pharm Sci 2006, 27:392-400.
    • (2006) Eur J Pharm Sci , vol.27 , pp. 392-400
    • Ambudkar, S.V.1    Kim, I.W.2    Sauna, Z.E.3
  • 3
    • 0037229942 scopus 로고    scopus 로고
    • Role of P-glycoprotein in pharmacokinetics: clinical implications
    • Lin J.H., Yamazaki M. Role of P-glycoprotein in pharmacokinetics: clinical implications. Clin Pharmacokinet 2003, 42:59-98.
    • (2003) Clin Pharmacokinet , vol.42 , pp. 59-98
    • Lin, J.H.1    Yamazaki, M.2
  • 6
    • 0026500180 scopus 로고
    • The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa
    • Hsing S., Gatmaitan Z., Arias I.M. The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa. Gastroenterology 1992, 102:879-885.
    • (1992) Gastroenterology , vol.102 , pp. 879-885
    • Hsing, S.1    Gatmaitan, Z.2    Arias, I.M.3
  • 7
    • 0033007704 scopus 로고    scopus 로고
    • Effects of intestinal CYP3A4 and P-glycoprotein on oral drug absorption-theoretical approach
    • Ito K., Kusuhara H., Sugiyama Y. Effects of intestinal CYP3A4 and P-glycoprotein on oral drug absorption-theoretical approach. Pharm Res 1999, 16:225-231.
    • (1999) Pharm Res , vol.16 , pp. 225-231
    • Ito, K.1    Kusuhara, H.2    Sugiyama, Y.3
  • 8
    • 0032101275 scopus 로고    scopus 로고
    • The pharmacological role of P-glycoprotein in the intestinal epithelium
    • Van Asperen J., Van Tellingen O., Beijnen J.H. The pharmacological role of P-glycoprotein in the intestinal epithelium. Pharmacol Res 1998, 37:429-435.
    • (1998) Pharmacol Res , vol.37 , pp. 429-435
    • Van Asperen, J.1    Van Tellingen, O.2    Beijnen, J.H.3
  • 9
    • 0035805536 scopus 로고    scopus 로고
    • Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
    • Geick A., Eichelbaum M., Burk O. Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem 2001, 276:14581-14587.
    • (2001) J Biol Chem , vol.276 , pp. 14581-14587
    • Geick, A.1    Eichelbaum, M.2    Burk, O.3
  • 11
    • 0030990079 scopus 로고    scopus 로고
    • In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man-fact or myth
    • Yee S. In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man-fact or myth. Pharm Res 1997, 14:763-766.
    • (1997) Pharm Res , vol.14 , pp. 763-766
    • Yee, S.1
  • 12
    • 0035286778 scopus 로고    scopus 로고
    • Caco-2 monolayers in experimental and theoretical predictions of drug transport
    • Artursson P., Palm K., Luthman K. Caco-2 monolayers in experimental and theoretical predictions of drug transport. Adv Drug Deliv Rev 2001, 46:27-43.
    • (2001) Adv Drug Deliv Rev , vol.46 , pp. 27-43
    • Artursson, P.1    Palm, K.2    Luthman, K.3
  • 13
    • 0037252475 scopus 로고    scopus 로고
    • Gene expression of CYP3A4, ABC-transporters (MDR1 and MRP1-MRP5) and hPXR in three different human colon carcinoma cell lines
    • Pfrunder A., Gutmann H., Beglinger C., Drewe J. Gene expression of CYP3A4, ABC-transporters (MDR1 and MRP1-MRP5) and hPXR in three different human colon carcinoma cell lines. J Pharm Pharmacol 2003, 55:59-66.
    • (2003) J Pharm Pharmacol , vol.55 , pp. 59-66
    • Pfrunder, A.1    Gutmann, H.2    Beglinger, C.3    Drewe, J.4
  • 14
    • 0038343630 scopus 로고    scopus 로고
    • Decreased expression of P-glycoprotein during differentiation in the human intestinal cell line Caco-2
    • Goto M., Masuda S., Saito H., Inui K. Decreased expression of P-glycoprotein during differentiation in the human intestinal cell line Caco-2. Biochem Pharmacol 2003, 66:163-170.
    • (2003) Biochem Pharmacol , vol.66 , pp. 163-170
    • Goto, M.1    Masuda, S.2    Saito, H.3    Inui, K.4
  • 15
    • 0031834404 scopus 로고    scopus 로고
    • P-Glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels
    • Anderle P., Niederer E., Rubas W., Hilgendorf C., Spahn-Langguth H., Wunderli-Allenspach H., et al. P-Glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels. J Pharm Sci 1998, 87:757-762.
    • (1998) J Pharm Sci , vol.87 , pp. 757-762
    • Anderle, P.1    Niederer, E.2    Rubas, W.3    Hilgendorf, C.4    Spahn-Langguth, H.5    Wunderli-Allenspach, H.6
  • 16
    • 51449120063 scopus 로고    scopus 로고
    • Induction of P-glycoprotein expression and function in human intestinal epithelial cells (T84)
    • Haslam I.S., Jones K., Coleman T., Simmons N.L. Induction of P-glycoprotein expression and function in human intestinal epithelial cells (T84). Biochem Pharmacol 2008, 76:850-861.
    • (2008) Biochem Pharmacol , vol.76 , pp. 850-861
    • Haslam, I.S.1    Jones, K.2    Coleman, T.3    Simmons, N.L.4
  • 17
    • 42949127617 scopus 로고    scopus 로고
    • Rifampin and digoxin induction of MDR1 expression and function in human intestinal (T84) epithelial cells
    • Haslam I.S., Jones K., Coleman T., Simmons N.L. Rifampin and digoxin induction of MDR1 expression and function in human intestinal (T84) epithelial cells. Br J Pharmacol 2008, 154:246-255.
    • (2008) Br J Pharmacol , vol.154 , pp. 246-255
    • Haslam, I.S.1    Jones, K.2    Coleman, T.3    Simmons, N.L.4
  • 18
    • 3242686014 scopus 로고    scopus 로고
    • Rapid induction of P-glycoprotein expression by high permeability compounds in colonic cells in vitro: a possible source of transporter mediated drug interactions?
    • Collett A., Tanianis-Hughes J., Warhurst G. Rapid induction of P-glycoprotein expression by high permeability compounds in colonic cells in vitro: a possible source of transporter mediated drug interactions?. Biochem Pharmacol 2004, 68:783-790.
    • (2004) Biochem Pharmacol , vol.68 , pp. 783-790
    • Collett, A.1    Tanianis-Hughes, J.2    Warhurst, G.3
  • 19
    • 33846892518 scopus 로고    scopus 로고
    • Effects of budesonide on P-glycoprotein expression in intestinal cell lines
    • Maier A., Zimmermann C., Beglinger C., Drewe J., Gutmann H. Effects of budesonide on P-glycoprotein expression in intestinal cell lines. Br J Pharmacol 2007, 150:361-368.
    • (2007) Br J Pharmacol , vol.150 , pp. 361-368
    • Maier, A.1    Zimmermann, C.2    Beglinger, C.3    Drewe, J.4    Gutmann, H.5
  • 20
    • 44149109915 scopus 로고    scopus 로고
    • Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors
    • Gupta A., Mugundu G.M., Desai P.B., Thummel K.E., Unadkat J.D. Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors. Drug Metab Dispos 2008, 36:1172-1180.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1172-1180
    • Gupta, A.1    Mugundu, G.M.2    Desai, P.B.3    Thummel, K.E.4    Unadkat, J.D.5
  • 21
    • 0018869204 scopus 로고
    • Longitudinal karyotype and genetic signature analysis of cultured human colon adenocarcinoma cell lines LS180 and LS174T
    • Rutzky L.P., Kaye C.I., Siciliano M.J., Chao M., Kahan B.D. Longitudinal karyotype and genetic signature analysis of cultured human colon adenocarcinoma cell lines LS180 and LS174T. Cancer Res 1980, 40:1443-1448.
    • (1980) Cancer Res , vol.40 , pp. 1443-1448
    • Rutzky, L.P.1    Kaye, C.I.2    Siciliano, M.J.3    Chao, M.4    Kahan, B.D.5
  • 22
    • 0017064628 scopus 로고
    • Human colonic adenocarcinoma cells. I. Establishment and description of a new line
    • Tom B.H., Rutzky L.P., Jakstys M.M., Oyasu R., Kaye C.I., Kahan B.D. Human colonic adenocarcinoma cells. I. Establishment and description of a new line. In Vitro 1976, 12:180-191.
    • (1976) In Vitro , vol.12 , pp. 180-191
    • Tom, B.H.1    Rutzky, L.P.2    Jakstys, M.M.3    Oyasu, R.4    Kaye, C.I.5    Kahan, B.D.6
  • 25
    • 0034777488 scopus 로고    scopus 로고
    • Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4
    • Hustert E., Zibat A., Presecan-Siedel E., Eiselt R., Mueller R., Fuss C., et al. Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4. Drug Metab Dispos 2001, 29:1454-1459.
    • (2001) Drug Metab Dispos , vol.29 , pp. 1454-1459
    • Hustert, E.1    Zibat, A.2    Presecan-Siedel, E.3    Eiselt, R.4    Mueller, R.5    Fuss, C.6
  • 26
    • 33644810414 scopus 로고    scopus 로고
    • Lack of interactions between breast cancer resistance protein (bcrp/abcg2) and selected antiepileptic agents
    • Cerveny L., Pavek P., Malakova J., Staud F., Fendrich Z. Lack of interactions between breast cancer resistance protein (bcrp/abcg2) and selected antiepileptic agents. Epilepsia 2006, 47:461-468.
    • (2006) Epilepsia , vol.47 , pp. 461-468
    • Cerveny, L.1    Pavek, P.2    Malakova, J.3    Staud, F.4    Fendrich, Z.5
  • 27
    • 21744451835 scopus 로고    scopus 로고
    • Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor
    • Burk O., Arnold K.A., Nussler A.K., Schaeffeler E., Efimova E., Avery B.A., et al. Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor. Mol Pharmacol 2005, 67:1954-1965.
    • (2005) Mol Pharmacol , vol.67 , pp. 1954-1965
    • Burk, O.1    Arnold, K.A.2    Nussler, A.K.3    Schaeffeler, E.4    Efimova, E.5    Avery, B.A.6
  • 28
    • 38749114272 scopus 로고    scopus 로고
    • Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression
    • Svecova L., Vrzal R., Burysek L., Anzenbacherova E., Cerveny L., Grim J., et al. Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression. Drug Metab Dispos 2008, 36:339-348.
    • (2008) Drug Metab Dispos , vol.36 , pp. 339-348
    • Svecova, L.1    Vrzal, R.2    Burysek, L.3    Anzenbacherova, E.4    Cerveny, L.5    Grim, J.6
  • 29
    • 0037031809 scopus 로고    scopus 로고
    • Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics
    • Takeshita A., Taguchi M., Koibuchi N., Ozawa Y. Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics. J Biol Chem 2002, 277:32453-32458.
    • (2002) J Biol Chem , vol.277 , pp. 32453-32458
    • Takeshita, A.1    Taguchi, M.2    Koibuchi, N.3    Ozawa, Y.4
  • 30
    • 33846230463 scopus 로고    scopus 로고
    • Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole
    • Huang H., Wang H., Sinz M., Zoeckler M., Staudinger J., Redinbo M.R., et al. Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole. Oncogene 2007, 26:258-268.
    • (2007) Oncogene , vol.26 , pp. 258-268
    • Huang, H.1    Wang, H.2    Sinz, M.3    Zoeckler, M.4    Staudinger, J.5    Redinbo, M.R.6
  • 31
    • 0037457793 scopus 로고    scopus 로고
    • Drug-drug interaction mediated by inhibition and induction of P-glycoprotein
    • Lin J.H. Drug-drug interaction mediated by inhibition and induction of P-glycoprotein. Adv Drug Deliv Rev 2003, 55:53-81.
    • (2003) Adv Drug Deliv Rev , vol.55 , pp. 53-81
    • Lin, J.H.1
  • 32
    • 0033514320 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein-mediated drug transport: a unifying mechanism to explain the interaction between digoxin and quinidine
    • Fromm M.F., Kim R.B., Stein C.M., Wilkinson G.R., Roden D.M. Inhibition of P-glycoprotein-mediated drug transport: a unifying mechanism to explain the interaction between digoxin and quinidine. Circulation 1999, 99:552-557.
    • (1999) Circulation , vol.99 , pp. 552-557
    • Fromm, M.F.1    Kim, R.B.2    Stein, C.M.3    Wilkinson, G.R.4    Roden, D.M.5
  • 33
    • 0032500849 scopus 로고    scopus 로고
    • Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells
    • Takano M., Hasegawa R., Fukuda T., Yumoto R., Nagai J., Murakami T. Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells. Eur J Pharmacol 1998, 358:289-294.
    • (1998) Eur J Pharmacol , vol.358 , pp. 289-294
    • Takano, M.1    Hasegawa, R.2    Fukuda, T.3    Yumoto, R.4    Nagai, J.5    Murakami, T.6
  • 34
    • 45849091909 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein in Caco-2 cells: effects of herbal remedies frequently used by cancer patients
    • Engdal S., Nilsen O.G. Inhibition of P-glycoprotein in Caco-2 cells: effects of herbal remedies frequently used by cancer patients. Xenobiotica 2008, 38:559-573.
    • (2008) Xenobiotica , vol.38 , pp. 559-573
    • Engdal, S.1    Nilsen, O.G.2
  • 35
    • 0036175307 scopus 로고    scopus 로고
    • Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4
    • Cummins C.L., Jacobsen W., Benet L.Z. Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002, 300:1036-1045.
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 1036-1045
    • Cummins, C.L.1    Jacobsen, W.2    Benet, L.Z.3
  • 36
    • 70350407482 scopus 로고    scopus 로고
    • Association of pregnane X receptor with multidrug resistance-related protein 3 and its role in human colon cancer chemoresistance
    • Jiang H., Chen K., He J., Pan F., Li J., Chen J., et al. Association of pregnane X receptor with multidrug resistance-related protein 3 and its role in human colon cancer chemoresistance. J Gastrointest Surg 2009, 13:1831-1838.
    • (2009) J Gastrointest Surg , vol.13 , pp. 1831-1838
    • Jiang, H.1    Chen, K.2    He, J.3    Pan, F.4    Li, J.5    Chen, J.6
  • 37
    • 1242274510 scopus 로고    scopus 로고
    • Dynamic and intracellular trafficking of P-glycoprotein-EGFP fusion protein: implications in multidrug resistance in cancer
    • Fu D., Bebawy M., Kable E.P., Roufogalis B.D. Dynamic and intracellular trafficking of P-glycoprotein-EGFP fusion protein: implications in multidrug resistance in cancer. Int J Cancer 2004, 109:174-181.
    • (2004) Int J Cancer , vol.109 , pp. 174-181
    • Fu, D.1    Bebawy, M.2    Kable, E.P.3    Roufogalis, B.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.