miR-126 inhibits non-small cell lung cancer cells proliferation by targeting EGFL7

Biochemical and Biophysical Research Communications

Volumn 391, Issue 3, 2010, Pages 1483-1489

  Sun, Yanqin ^a   Bai, Yifeng ^a   Zhang, Fan ^a   Wang, Yu ^a   Guo, Ying ^a   Guo, Linlang ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

EGFL7; MicroRNAs (miRNAs); NSCLC; Proliferation

Indexed keywords

EPIDERMAL GROWTH FACTOR LIKE DOMAIN 7; GROWTH FACTOR; MICRORNA; MICRORNA 26; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL PROLIFERATION; CELL STRAIN A549; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE OVEREXPRESSION; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LUNG NON SMALL CELL CANCER; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR GROWTH; WESTERN BLOTTING;

3' UNTRANSLATED REGIONS; ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; ENDOTHELIAL GROWTH FACTORS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; MICRORNAS; TRANSFECTION;

EID: 73949116135     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.12.098     Document Type: Article

References (38)

1. Lee R.C., Feinbaum R.L., and Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarily to lin-14. Cell 5 (1993) 843-854
2. Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116 (2004) 281-297
3. Sotiropoulou G., Pampalakis G., Lianidou E., and Mourelatos Z. Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell. RNA 15 (2009) 1443-1461
4. Alvarez-Garcia I., and Miska E.A. MicroRNA functions in animal development and human disease. Development 132 (2005) 4653-4662
5. Esquela-Kerscher A., and Slack F.J. Oncomirs-microRNAs with a role in cancer. Nat. Rev. 6 (2006) 259-269
6. Tavazoie S.F., Alarcón C., Oskarsson T., Padua D., Wang Q., Bos P.D., Gerald W.L., and Massagué J. Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451 (2008) 145-152
7. Sonoki T., Iwanaga E., Mitsuya H., and Asou N. Insertion of microRNA-125b-1, a human homologue of lin-4, into a rearranged immunoglobulin heavy chain gene locus in a patient with precursor B-cell acute lymphoblastic leukemia. Leukemia 19 (2005) 2009-2010
8. Michael M.Z., O'Connor S.M., van Holst Pellekaan N.G., Young G.P., and James R.J. Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol. Cancer Res. 1 (2003) 882-891
9. Calin G.A., Dumitru C.D., Shimizu M., Bichi R., Zupo S., Noch E., Aldler H., Rattan S., Keating M., Rai K., Rassenti L., Kipps T., Negrini M., Bullrich F., and Croce C.M. Frequent deletions and downregulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc. Natl. Acad. Sci. USA 99 (2002) 15524-15529
10. Li Z., Lu J., Sun M., Mi S., Zhang H., Luo R.T., Chen P., Wang Y., Yan M., Qian Z., Neilly M.B., Jin J., Zhang Y., Bohlander S.K., Zhang D.E., Larson R.A., Le Beau M.M., Thirman M.J., Golub T.R., Rowley J.D., and Chen J. Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proc. Natl. Acad. Sci. USA 105 (2008) 15535-15540
11. Shen W.F., Hu Y.L., Uttarwar L., Passegue E., and Largman C. MicroRNA-126 regulates HOXA9 by binding to the homeobox. Mol. Cell. Biol. 28 (2008) 4609-4619
12. Wang X., Tang S., Le S.Y., Lu R., Rader J.S., Meyers C., and Zheng Z.M. Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth. PLoS ONE 3 (2008) 2557-2567
13. Bartel D.P., and Chen C.Z. Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat. Rev. Genet. 5 (2004) 396-400
14. Rajewsky N. MicroRNA target predictions in animals. Nat. Genet. Suppl. (2006) S8-S13
15. Lim L.P., Lau N.C., Garrett-Engele P., Grimson A., Schelter J.M., Castle J., Bartel D.P., Linsley P.S., and Johnson J.M. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433 (2005) 769-773
16. Krek A., Grün D., Poy M.N., Wolf R., Rosenberg L., Epstein E.J., MacMenamin P., da Piedade I., Gunsalus K.C., Stoffel M., and Rajewsky N. Combinatorial microRNA target predictions. Nat. Genet. 37 (2005) 495-500
17. Lewis B.P., Burge C.B., and Bartel D.P. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120 (2005) 15-20
18. Xie X., Lu J., Kulbokas E.J., Golub T.R., Mootha V., Lindblad-Toh K., Lander E.S., and Kellis M. Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature 434 (2005) 338-345
19. Tzur G., Israel A., Levy A., Benjamin H., Meiri E., Shufaro Y., Meir K., Khvalevsky E., Spector Y., Rojansky N., Bentwich Z., Reubinoff B.E., and Galun E. Comprehensive gene and microRNA expression profiling reveals a role for microRNAs in human liver development. PLoS ONE 4 (2009) e7511
20. Zhang J., Du Y.Y., Lin Y.F., Chen Y.T., Yang L., Wang H.J., and Ma D. The cell growth suppressor, mir-126, targets IRS-1. Biochem. Biophys. Res. Commun. 377 (2008) 136-140
21. Saito Y., Friedman J.M., Chihara Y., Egger G., Chuang J.C., and Liang G. Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells. Biochem. Biophys. Res. Commun. 379 (2009) 726-731
22. Parker L.H., Schmidt M., Jin S.W., Gray A.M., Beis D., Pham T., Frantz G., Palmieri S., Hillan K., Stainier D.Y., De Sauvage F.J., and Ye W. The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation. Nature 428 (2004) 754-758
23. Fitch M.J., Campagnolo L., Kuhnert F., and Stuhlmann H. Egfl7, a novel epidermal growth factor-domain gene expressed in endothelial cells. Dev. Dyn. 230 (2004) 316-324
24. Campagnolo L., Leahy A., Chitnis S., Koschnick S., Fitch M.J., Fallon J.T., Loskutoff D., Taubman M.B., and Stuhlmann H. EGFL7 is a chemoattractant for endothelial cells and is up-regulated in angiogenesis and arterial injury. Am. J. Pathol. 167 (2005) 275-284
25. Schmidt M.H., Bicker F., Nikolic I., Meister J., Babuke T., Picuric S., Müller-Esterl W., Plate K.H., and Dikic I. Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal. Nat. Cell Biol. 11 (2009) 873-880
26. Lewis B.P., Shih I.H., Jones-Rhoades M.W., Bartel D.P., and Burge C.B. Prediction of mammalian microRNA targets. Cell 115 (2003) 787-798
27. John B., Enright A.J., Aravin A., Tuschl T., Sander C., and Marks D.S. Human microRNA targets. PLoS Biol. 2 (2004) 1163-1179
28. Song Y., Fullerton D.A., Mauchley D., Su X., Ao L., Yang X., Cleveland J.C., and Meng X. Microfilaments facilitate TLR4-mediated ICAM-1 expression in human aortic valve interstitial cells. J. Surg. Res. (2009) 1-7
29. Lee Y.S., Kim H.K., Chung S., Kim K.S., and Dutta A. Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the downregulation of putative targets during differentiation. J. Biol. Chem. 280 (2005) 16635-16641
30. Takamizawa J., Konishi H., Yanagisawa K., Tomida S., Osada H., Endoh H., Harano T., Yatabe Y., Nagino M., Nimura Y., Mitsudomi T., and Takahashi T. Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res. 64 (2004) 3753-3756
31. Johnson S.M., Grosshans H., Shingara J., Byrom M., Jarvis R., Cheng A., Labourier E., Reinert K.L., Brown D., and Slack F.J. RAS is regulated by the let-7 microRNA family. Cell 120 (2005) 635-647
32. Calin G.A., Sevignani C., Dumitru C.D., Hyslop T., Noch E., Yendamuri S., Shimizu M., Rattan S., Bullrich F., Negrini M., and Croce C.M. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc. Natl. Acad. Sci. USA 101 (2004) 2999-3004
33. Iorio M.V., Ferracin M., Liu C.G., Veronese A., Spizzo R., Sabbioni S., Magri E., Pedriali M., Fabbri M., Campiglio M., Ménard S., Palazzo J.P., Rosenberg A., Musiani P., Volinia S., Nenci I., Calin G.A., Querzoli P., Negrini M., and Croce C.M. MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 65 (2005) 7065-7070
34. Crawford M., Brawner E., Batte K., Yu L., Hunter M.G., Otterson G.A., Nuovo G., Marsh C.B., and Nana-Sinkam S.P. MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. Biochem. Biophys. Res. Commun. 373 (2008) 607-612
35. Díaz R., Silva J., García J.M., Lorenzo Y., García V., Peña C., Rodríguez R., Muñoz C., García F., Bonilla F., and Domínguez G. Deregulated expression of miR-106a predicts survival in human colon cancer patients. Genes Chromosomes Cancer 47 (2008) 794-802
36. Manikandan J., Aarthi J.J., Kumar S.D., and Pushparaj P.N. Oncomirs: the potential role of non-coding microRNAs in understanding cancer. Bioinformation 2 (2008) 330-334
37. Guo C., Sah J.F., Beard L., Willson J.K., Markowitz S.D., and Guda K. The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Genes Chromosomes Cancer 47 (2008) 939-946
38. Wu F., Yang L.Y., Li Y.F., Ou D.P., Chen D.P., and Fan C. Novel role for epidermal growth factor-like domain 7 in metastasis of human hepatocellular carcinoma. Hepatology 50 (2009) 1839-1850