Cancer therapy via modulation of micro RNA levels: A promising future

Drug Discovery Today

Volumn 15, Issue 17-18, 2010, Pages 733-740

  Kota, Satya K ^a   Balasubramanian, Savithri ^b  

^a CNRS   (France)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA;

CANCER THERAPY; GENE EXPRESSION REGULATION; HUMAN; PROGNOSIS; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG DELIVERY SYSTEMS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICRORNAS; MODELS, GENETIC; NEOPLASMS; OLIGONUCLEOTIDES, ANTISENSE;

EID: 77956453939     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2010.07.003     Document Type: Review

References (85)

1. Farazi T.A., et al. The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members. Development 2008, 135:1201-1214.
2. Lee R.C., et al. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993, 75:843-854.
3. Pasquinelli A.E., et al. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature 2000, 408:86-89.
4. Fire A., et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998, 391:806-811.
5. Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116:281-297.
6. Olsen P.H., Ambros V. The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev. Biol. 1999, 216:671-680.
7. Lim L.P., et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 2005, 433:769-773.
8. Kim D.H., et al. MicroRNA-directed transcriptional gene silencing in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:16230-16235.
9. Lee Y., et al. MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 2004, 23:4051-4060.
10. Lee Y., et al. The nuclear RNase III Drosha initiates microRNA processing. Nature 2003, 425:415-419.
11. Bohnsack M.T., et al. Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA 2004, 10:185-191.
12. Bernstein E., et al. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 2001, 409:363-366.
13. Chendrimada T.P., et al. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 2005, 436:740-744.
14. Tomari Y., et al. A protein sensor for siRNA asymmetry. Science 2004, 306:1377-1380.
15. Carthew R.W., Sontheimer E.J. Origins and mechanisms of miRNAs and siRNAs. Cell 2009, 136:642-655.
16. Wightman B., et al. Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development. Genes Dev. 1991, 5:1813-1824.
17. Tay Y., et al. MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature 2008, 455:1124-1128.
18. Forman J.J., et al. A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:14879-14884.
19. Lewis B.P., et al. Prediction of mammalian microRNA targets. Cell 2003, 115:787-798.
20. Kai Z.S., Pasquinelli A.E. MicroRNA assassins: factors that regulate the disappearance of miRNAs. Nat. Struct. Mol. Biol. 2010, 17:5-10.
21. Hornstein E., et al. The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development. Nature 2005, 438:671-674.
22. Brennecke J., et al. bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell 2003, 113:25-36.
23. Ambros V. MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing. Cell 2003, 113:673-676.
24. Landgraf P., et al. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 2007, 129:1401-1414.
25. Lu J., et al. MicroRNA expression profiles classify human cancers. Nature 2005, 435:834-838.
26. Hernando E. microRNAs and cancer: role in tumorigenesis, patient classification and therapy. Clin. Transl. Oncol. 2007, 9:155-160.
27. Kashyap V., et al. Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs. Stem Cells Dev. 2009, 18:1093-1108.
28. Esquela-Kerscher A., Slack F.J. Oncomirs-microRNAs with a role in cancer. Nat. Rev. Cancer 2006, 6:259-269.
29. Morris J.P., McManus M.T. Slowing down the Ras lane: miRNAs as tumor suppressors?. Sci. STKE 2005, 297:pe41.
30. He L., et al. A microRNA component of the p53 tumour suppressor network. Nature 2007, 447:1130-1134.
31. Hammond S.M. MicroRNAs as oncogenes. Curr. Opin. Genet. Dev. 2006, 16:4-9.
32. He L., et al. A microRNA polycistron as a potential human oncogene. Nature 2005, 435:828-833.
33. Hayashita Y., et al. A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res. 2005, 65:9628-9632.
34. Volinia S., et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:2257-2261.
35. Yu S.L., et al. MicroRNA signature predicts survival and relapse in lung cancer. Cancer Cell 2008, 13:48-57.
36. Lawrie C.H., et al. Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br. J. Haematol. 2008, 141:672-675.
37. Hanke, M. et al.: A robust methodology to study urine microRNA as tumor marker: microRNA-126 and microRNA-182 are related to urinary bladder cancer. Urol. Oncol. (in press).
38. Gallardo E., et al. miR-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer. Carcinogenesis 2009, 30:1903-1909.
39. Ji J., et al. MicroRNA expression, survival, and response to interferon in liver cancer. N. Engl. J. Med. 2009, 361:1437-1447.
40. Merritt W.M., et al. Dicer, Drosha, and outcomes in patients with ovarian cancer. N. Engl. J. Med. 2008, 359:2641-2650.
41. Karube Y., et al. Reduced expression of Dicer associated with poor prognosis in lung cancer patients. Cancer Sci. 2005, 96:111-115.
42. He H., et al. The role of microRNA genes in papillary thyroid carcinoma. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:19075-19080.
43. Chin L.J., et al. A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. Cancer Res. 2008, 68:8535-8540.
44. Yang R., et al. A genetic variant in the pre-miR-27a oncogene is associated with a reduced familial breast cancer risk. Breast Cancer Res. Treat. 2010, 121:693-702.
45. Hu Z., et al. Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women. Hum. Mutat. 2009, 30:79-84.
46. Matsubara H., et al. Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92. Oncogene 2007, 26:6099-6105.
47. Sylvestre Y., et al. An E2F/miR-20a autoregulatory feedback loop. J. Biol. Chem. 2007, 282:2135-2143.
48. Si M.L., et al. miR-21-mediated tumor growth. Oncogene 2007, 26:2799-2803.
49. Segura M.F., et al. Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:1814-1819.
50. Ebert M.S., et al. MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat. Methods 2007, 4:721-726.
51. Ma L., et al. miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat. Cell Biol. 2010, 12:209-211.
52. Trang P., et al. Regression of murine lung tumors by the let-7 microRNA. Oncogene 2009, 29:1580-1587.
53. Kumar M.S., et al. Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:3903-3908.
54. Li Y., et al. MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes. Cancer Res. 2009, 69:7569-7576.
55. Ji Q., et al. Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumor spheres. BMC Cancer 2008, 8:266.
56. Kota J., et al. Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 2009, 137:1005-1017.
57. Takeshita F., et al. Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes. Mol. Ther. 2010, 18:181-187.
58. Suzuki T., et al. miR-122a-regulated expression of a suicide gene prevents hepatotoxicity without altering antitumor effects in suicide gene therapy. Mol. Ther. 2008, 16:1719-1726.
59. Kelly E.J., et al. Engineering microRNA responsiveness to decrease virus pathogenicity. Nat. Med. 2008, 14:1278-1283.
60. Lee C.Y., et al. MicroRNA regulation of oncolytic herpes simplex virus-1 for selective killing of prostate cancer cells. Clin. Cancer Res. 2009, 15:5126-5135.
61. Krutzfeldt J., et al. Silencing of microRNAs in vivo with 'antagomirs'. Nature 2005, 438:685-689.
62. Elmen J., et al. LNA-mediated microRNA silencing in non-human primates. Nature 2008, 452:896-899.
63. Sepp-Lorenzino L., Ruddy M. Challenges and opportunities for local and systemic delivery of siRNA and antisense oligonucleotides. Clin. Pharmacol. Ther. 2008, 84:628-632.
64. Li W., Szoka F.C. Lipid-based nanoparticles for nucleic acid delivery. Pharm. Res. 2007, 24:438-449.
65. Li S.D., Huang L. Targeted delivery of siRNA by nonviral vectors: lessons learned from recent advances. Curr. Opin. Invest. Drugs 2008, 9:1317-1323.
66. Sibley C.R., et al. Novel RNA-based strategies for therapeutic gene silencing. Mol. Ther. 2010, 18:466-476.
67. Garofalo M., et al. miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation. Cancer Cell 2009, 16:498-509.
68. Meng F., et al. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007, 133:647-658.
69. Gramantieri L., et al. Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma. Cancer Res. 2007, 67:6092-6099.
70. Huse J.T., et al. The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. Genes Dev. 2009, 23:1327-1337.
71. Chan J.A., et al. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res. 2005, 65:6029-6033.
72. Zhang C., et al. Co-suppression of miR-221/222 cluster suppresses human glioma cell growth by targeting p27kip1 in vitro and in vivo. Int. J. Oncol. 2009, 34:1653-1660.
73. Kefas B., et al. The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors. J. Neurosci. 2009, 29:15161-15168.
74. Saydam O., et al. Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt/beta-catenin signaling pathway. Mol. Cell. Biol. 2009, 29:5923-5940.
75. Yu F., et al. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 2007, 131:1109-1123.
76. Gregory P.A., et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat. Cell Biol. 2008, 10:593-601.
77. Tavazoie S.F., et al. Endogenous human microRNAs that suppress breast cancer metastasis. Nature 2008, 451:147-152.
78. Ribas J., Lupold S.E. The transcriptional regulation of miR-21, its multiple transcripts, and their implication in prostate cancer. Cell Cycle 2010, 9:923-929.
79. Hagman, Z. et al., miR-34c is down regulated in prostate cancer and exerts tumor suppressive functions. Int. J. Cancer. (in press).
80. Gandellini P., et al. miR-205 Exerts tumor-suppressive functions in human prostate through down-regulation of protein kinase Cepsilon. Cancer Res. 2009, 69:2287-2295.
81. Eis P.S., et al. Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:3627-3632.
82. Mavrakis K.J., et al. Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia. Nat. Cell Biol. 2010, 12:372-379.
83. Mu P., et al. Genetic dissection of the miR-17∼92 cluster of microRNAs in Myc-induced B-cell lymphomas. Genes Dev. 2009, 23:2806-2811.
84. Calin G.A., et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:15524-15529.
85. Garzon R., et al. MicroRNA 29b functions in acute myeloid leukemia. Blood 2009, 114:5331-5341.