메뉴 건너뛰기




Volumn 2, Issue 4, 2011, Pages 556-574

Vascular Pathology as a Potential Therapeutic Target in SCI

Author keywords

Angiogenesis; Blood spinal cord barrier; EC protection; Microvascular; Permeability

Indexed keywords

SCLEROPROTEIN;

EID: 83355162673     PISSN: 18684483     EISSN: 1868601X     Source Type: Journal    
DOI: 10.1007/s12975-011-0128-7     Document Type: Review
Times cited : (14)

References (183)
  • 2
    • 84943442523 scopus 로고
    • Surgery of experimental lesion of spinal cord equivalent to crush injury of fracture dislocation of spinal column. A preliminary report
    • Allen A. Surgery of experimental lesion of spinal cord equivalent to crush injury of fracture dislocation of spinal column. A preliminary report. JAMA. 1911; 57: 878-80.
    • (1911) Jama , vol.57 , pp. 878-880
    • Allen, A.1
  • 3
    • 84939076147 scopus 로고
    • Remarks on the histopathological changes in the spinal cord due to impact. An experimental study
    • Allen AR. Remarks on the histopathological changes in the spinal cord due to impact. An experimental study. J Nerv Ment Dis. 1914; 41: 141-7.
    • (1914) J Nerv Ment Dis , vol.41 , pp. 141-147
    • Allen, A.R.1
  • 4
    • 0029840675 scopus 로고    scopus 로고
    • Ultrastructural evidence for arteriolar vasospasm after spinal cord trauma
    • Anthes DL, Theriault E, Tator CH. Ultrastructural evidence for arteriolar vasospasm after spinal cord trauma. Neurosurgery. 1996; 39: 804-14.
    • (1996) Neurosurgery , vol.39 , pp. 804-814
    • Anthes, D.L.1    Theriault, E.2    Tator, C.H.3
  • 5
    • 0031803957 scopus 로고    scopus 로고
    • Production of urokinase-type plasminogen activator (u-PA) and plasminogen activator inhibitor-1(PAI-1) in human brain tumors
    • Arai Y, Kubota T, Nakagawa T, Kabuto M, Sato K, Kobayashi H. Production of urokinase-type plasminogen activator (u-PA) and plasminogen activator inhibitor-1(PAI-1) in human brain tumors. Acta Neurochir (Wien). 1998; 140: 377-85.
    • (1998) Acta Neurochir (Wien) , vol.140 , pp. 377-385
    • Arai, Y.1    Kubota, T.2    Nakagawa, T.3    Kabuto, M.4    Sato, K.5    Kobayashi, H.6
  • 6
    • 33846025825 scopus 로고    scopus 로고
    • Developmental and injury-induced expression of alpha1beta1 and alpha6beta1 integins in the rat spinal cord
    • Baker KA, Hagg T. Developmental and injury-induced expression of alpha1beta1 and alpha6beta1 integins in the rat spinal cord. Brain Res. 2007; 1130(1): 54-66.
    • (2007) Brain Res , vol.1130 , Issue.1 , pp. 54-66
    • Baker, K.A.1    Hagg, T.2
  • 7
    • 77953421054 scopus 로고    scopus 로고
    • Transcriptional activation of endothelial cells by TGFbeta coincides with acute microvascular plasticity following focal spinal cord ischaemia/reperfusion injury
    • Benton RL, Maddie MA, Dincman TA, Hagg T, Whittemore SR. Transcriptional activation of endothelial cells by TGFbeta coincides with acute microvascular plasticity following focal spinal cord ischaemia/reperfusion injury. ASN Neuro. 2009; 1.
    • (2009) ASN Neuro , vol.1
    • Benton, R.L.1    Maddie, M.A.2    Dincman, T.A.3    Hagg, T.4    Whittemore, S.R.5
  • 8
    • 65749108276 scopus 로고    scopus 로고
    • Neutralizing endogenous VEGF following traumatic spinal cord injury modulates microvascular plasticity but not tissue sparing or functional recovery
    • Benton RL, Maddie MA, Gruenthal MJ, Hagg T, Whittemore SR. Neutralizing endogenous VEGF following traumatic spinal cord injury modulates microvascular plasticity but not tissue sparing or functional recovery. Curr Neurovasc Res. 2009; 6(2): 124-31.
    • (2009) Curr Neurovasc Res , vol.6 , Issue.2 , pp. 124-131
    • Benton, R.L.1    Maddie, M.A.2    Gruenthal, M.J.3    Hagg, T.4    Whittemore, S.R.5
  • 9
    • 38949158421 scopus 로고    scopus 로고
    • Griffonia simplicifolia isolectin B4 identifies a specific subpopulation of angiogenic blood vessels following contusive spinal cord injury in the adult mouse
    • Benton RL, Maddie MA, Minnillo DR, Hagg T, Whittemore SR. Griffonia simplicifolia isolectin B4 identifies a specific subpopulation of angiogenic blood vessels following contusive spinal cord injury in the adult mouse. J Comp Neurol. 2008; 507: 1031-52.
    • (2008) J Comp Neurol , vol.507 , pp. 1031-1052
    • Benton, R.L.1    Maddie, M.A.2    Minnillo, D.R.3    Hagg, T.4    Whittemore, S.R.5
  • 10
    • 54949153088 scopus 로고    scopus 로고
    • Transcriptomic screening of microvascular endothelial cells implicates novel molecular regulators of vascular dysfunction after spinal cord injury
    • Benton RL, Maddie MA, Worth CA, Mahoney ET, Hagg T, Whittemore SR. Transcriptomic screening of microvascular endothelial cells implicates novel molecular regulators of vascular dysfunction after spinal cord injury. J Cereb Blood Flow Metab. 2008; 28: 1771-85.
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 1771-1785
    • Benton, R.L.1    Maddie, M.A.2    Worth, C.A.3    Mahoney, E.T.4    Hagg, T.5    Whittemore, S.R.6
  • 11
    • 0142116387 scopus 로고    scopus 로고
    • VEGF165 therapy exacerbates secondary damage following spinal cord injury
    • Benton RL, Whittemore SR. VEGF165 therapy exacerbates secondary damage following spinal cord injury. Neurochem Res. 2003; 28(11): 1693-703.
    • (2003) Neurochem Res , vol.28 , Issue.11 , pp. 1693-1703
    • Benton, R.L.1    Whittemore, S.R.2
  • 12
    • 26244466229 scopus 로고    scopus 로고
    • Intraspinal application of endothelin results in focal ischemic injury of spinal gray matter and restricts the differentiation of engrafted neural stem cells
    • Benton RL, Woock JP, Gozal E, Heman M, Whittemore SR. Intraspinal application of endothelin results in focal ischemic injury of spinal gray matter and restricts the differentiation of engrafted neural stem cells. Neurochem Res. 2005; 30(6-7): 809-23.
    • (2005) Neurochem Res , vol.30 , Issue.6-7 , pp. 809-823
    • Benton, R.L.1    Woock, J.P.2    Gozal, E.3    Heman, M.4    Whittemore, S.R.5
  • 13
    • 34249339783 scopus 로고    scopus 로고
    • Longitudinal magnetic resonance imaging of spinal cord injury in mouse: changes in signal patterns associated with the inflammatory response
    • Bilgen M, Al-Hafez B, Alrefae T, He YY, Smirnova IV, Aldur MM, et al. Longitudinal magnetic resonance imaging of spinal cord injury in mouse: changes in signal patterns associated with the inflammatory response. Magn Reson Imaging. 2007; 25: 657-64.
    • (2007) Magn Reson Imaging , vol.25 , pp. 657-664
    • Bilgen, M.1    Al-Hafez, B.2    Alrefae, T.3    He, Y.Y.4    Smirnova, I.V.5    Aldur, M.M.6
  • 14
    • 77951883821 scopus 로고    scopus 로고
    • The urokinase receptor: focused cell surface proteolysis, cell adhesion and signaling
    • Blasi F, Sidenius N. The urokinase receptor: focused cell surface proteolysis, cell adhesion and signaling. FEBS Lett. 2010; 584(9): 1923-30.
    • (2010) FEBS Lett , vol.584 , Issue.9 , pp. 1923-1930
    • Blasi, F.1    Sidenius, N.2
  • 15
    • 79961050726 scopus 로고    scopus 로고
    • Reversal of lysosomal storage in brain of adult MPS-1 mice with intravenous trojan horse-iduronidase fusion protein
    • Boado RJ, Hui EK, Lu JZ, Zhou QH, Pardridge WM. Reversal of lysosomal storage in brain of adult MPS-1 mice with intravenous trojan horse-iduronidase fusion protein. Mol Pharm. 2011; 8(4): 1342-50.
    • (2011) Mol Pharm , vol.8 , Issue.4 , pp. 1342-1350
    • Boado, R.J.1    Hui, E.K.2    Lu, J.Z.3    Zhou, Q.H.4    Pardridge, W.M.5
  • 16
    • 0027280530 scopus 로고
    • Glucose deprivation causes post-transcriptional enhancement of brain capillary endothelial glucose transporter gene expression via GLUT1 mRNA stabilization
    • Boado RJ, Pardridge. Glucose deprivation causes post-transcriptional enhancement of brain capillary endothelial glucose transporter gene expression via GLUT1 mRNA stabilization. J Neurochem. 1993; 60: 2290-6.
    • (1993) J Neurochem , vol.60 , pp. 2290-2296
    • Boado, R.J.1    Pardridge2
  • 17
    • 71049162181 scopus 로고    scopus 로고
    • Comparison of blood-brain barrier transport of glial-derived neurotrophic factor (GDNF) and an IgG-GDNF fusion protein in the rhesus monkey
    • Boado RJ, Pardridge WM. Comparison of blood-brain barrier transport of glial-derived neurotrophic factor (GDNF) and an IgG-GDNF fusion protein in the rhesus monkey. Drug Metab Dispos. 2009; 37(12): 2299-304.
    • (2009) Drug Metab Dispos , vol.37 , Issue.12 , pp. 2299-2304
    • Boado, R.J.1    Pardridge, W.M.2
  • 18
    • 33846897981 scopus 로고    scopus 로고
    • Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier
    • Boado RJ, Zhang Y, Zhang Y, Pardridge WM. Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier. Biotechnol Bioeng. 2007; 96(2): 381-91.
    • (2007) Biotechnol Bioeng , vol.96 , Issue.2 , pp. 381-391
    • Boado, R.J.1    Zhang, Y.2    Zhang, Y.3    Pardridge, W.M.4
  • 19
    • 77953165954 scopus 로고    scopus 로고
    • Laser speckle contrast imaging in biomedical optics
    • Boas DA, Dunn AK. Laser speckle contrast imaging in biomedical optics. J Biomed Opt. 2010; 15: 011109.
    • (2010) J Biomed Opt , vol.15 , pp. 011109
    • Boas, D.A.1    Dunn, A.K.2
  • 20
    • 0034731560 scopus 로고    scopus 로고
    • Neurochemical changes and laser Doppler flowmetry in the endothelin-1 rat model for focal cerebral ischemia
    • Bogaert L, Scheller D, Monnen J, Sarre S, Smolders I, Ebinger G, et al. Neurochemical changes and laser Doppler flowmetry in the endothelin-1 rat model for focal cerebral ischemia. Brain Res. 2000; 887(2): 266-75.
    • (2000) Brain Res , vol.887 , Issue.2 , pp. 266-275
    • Bogaert, L.1    Scheller, D.2    Monnen, J.3    Sarre, S.4    Smolders, I.5    Ebinger, G.6
  • 21
    • 0036968150 scopus 로고    scopus 로고
    • Fiblast (trafermin) in acute stroke: results of the European-Australian phase II/III safety and efficacy trial
    • Bogousslavsky J, Victor SJ, Salinas EO, Pallay A, Donnan GA, Fieschi C, et al. Fiblast (trafermin) in acute stroke: results of the European-Australian phase II/III safety and efficacy trial. Cerebrovasc Dis. 2002; 14(3-4): 239-51.
    • (2002) Cerebrovasc Dis , vol.14 , Issue.3-4 , pp. 239-251
    • Bogousslavsky, J.1    Victor, S.J.2    Salinas, E.O.3    Pallay, A.4    Donnan, G.A.5    Fieschi, C.6
  • 22
    • 34347356395 scopus 로고    scopus 로고
    • Progressive damage after brain and spinal cord injury: pathomechanisms and treatment strategies
    • Bramlett HM, Dietrich WD. Progressive damage after brain and spinal cord injury: pathomechanisms and treatment strategies. Prog Brain Res. 2007; 161: 125-41.
    • (2007) Prog Brain Res , vol.161 , pp. 125-141
    • Bramlett, H.M.1    Dietrich, W.D.2
  • 23
    • 63849246613 scopus 로고    scopus 로고
    • Axial diffusivity is the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord: a quantitative pixelwise analysis
    • Budde MD, Xie M, Cross AH, Song SK. Axial diffusivity is the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord: a quantitative pixelwise analysis. J Neurosci. 2009; 29: 2805-13.
    • (2009) J Neurosci , vol.29 , pp. 2805-2813
    • Budde, M.D.1    Xie, M.2    Cross, A.H.3    Song, S.K.4
  • 24
    • 79952197662 scopus 로고    scopus 로고
    • Neuropathological differences between rats and mice after spinal cord injury
    • Byrnes KR, Fricke ST, Faden AI. Neuropathological differences between rats and mice after spinal cord injury. J Magn Reson Imaging. 2010; 32: 836-46.
    • (2010) J Magn Reson Imaging , vol.32 , pp. 836-846
    • Byrnes, K.R.1    Fricke, S.T.2    Faden, A.I.3
  • 25
    • 33644509823 scopus 로고    scopus 로고
    • Expression of two temporally distinct microglia-related gene clusters after spinal cord injury
    • Byrnes KR, Garay J, Di Giovanni S, De Biase A, Knoblach SM, Hoffman EP, et al. Expression of two temporally distinct microglia-related gene clusters after spinal cord injury. Glia. 2006; 53: 420-33.
    • (2006) Glia , vol.53 , pp. 420-433
    • Byrnes, K.R.1    Garay, J.2    Di Giovanni, S.3    de Biase, A.4    Knoblach, S.M.5    Hoffman, E.P.6
  • 26
    • 33748429148 scopus 로고    scopus 로고
    • Endothelial cell loss is not a major cause of neuronal and glial cell death following contusion injury of the spinal cord
    • Casella GT, Bunge MB, Wood PM. Endothelial cell loss is not a major cause of neuronal and glial cell death following contusion injury of the spinal cord. Exp Neurol. 2006; 202: 8-20.
    • (2006) Exp Neurol , vol.202 , pp. 8-20
    • Casella, G.T.1    Bunge, M.B.2    Wood, P.M.3
  • 27
    • 0036144964 scopus 로고    scopus 로고
    • New vascular tissue rapidly replaces neural parenchyma and vessels destroyed by a contusion injury to the rat spinal cord
    • Casella GT, Marcillo A, Bunge MB, Wood PM. New vascular tissue rapidly replaces neural parenchyma and vessels destroyed by a contusion injury to the rat spinal cord. Exp Neurol. 2002; 173: 63-76.
    • (2002) Exp Neurol , vol.173 , pp. 63-76
    • Casella, G.T.1    Marcillo, A.2    Bunge, M.B.3    Wood, P.M.4
  • 28
    • 77449121168 scopus 로고    scopus 로고
    • Neuroproteomic methods in spinal cord injury
    • Chen A, Springer JE. Neuroproteomic methods in spinal cord injury. Mehods Mol Biol. 2009; 566: 57-67.
    • (2009) Mehods Mol Biol , vol.566 , pp. 57-67
    • Chen, A.1    Springer, J.E.2
  • 29
    • 0141456728 scopus 로고    scopus 로고
    • Functional coupling between sulfonylurea receptor type 1 and a nonselective cation channel in reactive astrocytes from adult rat brain
    • Chen M, Dong Y, Simard JM. Functional coupling between sulfonylurea receptor type 1 and a nonselective cation channel in reactive astrocytes from adult rat brain. J Neurosci. 2003; 23(24): 8568-77.
    • (2003) J Neurosci , vol.23 , Issue.24 , pp. 8568-8577
    • Chen, M.1    Dong, Y.2    Simard, J.M.3
  • 30
    • 79958252534 scopus 로고    scopus 로고
    • Preclinical use of longitudinal MRI for screening the efficacy of S-nitrosoglutathione in treating spinal cord injury
    • Chou PC, Shunmugavel A, El Sayed H, Desouki MM, Nguyen SA, Khan M, et al. Preclinical use of longitudinal MRI for screening the efficacy of S-nitrosoglutathione in treating spinal cord injury. J Magn Reson Imaging. 2011; 33: 1301-11.
    • (2011) J Magn Reson Imaging , vol.33 , pp. 1301-1311
    • Chou, P.C.1    Shunmugavel, A.2    El Sayed, H.3    Desouki, M.M.4    Nguyen, S.A.5    Khan, M.6
  • 31
    • 0022466364 scopus 로고
    • Three-dimensional reconstruction of vesicles in endothelium of blood-brain barrier versus highly permeable microvessels
    • Coomber BL, Stewart PA. Three-dimensional reconstruction of vesicles in endothelium of blood-brain barrier versus highly permeable microvessels. Anat Rec. 1986; 215(3): 256-61.
    • (1986) Anat Rec , vol.215 , Issue.3 , pp. 256-261
    • Coomber, B.L.1    Stewart, P.A.2
  • 32
    • 0036682484 scopus 로고    scopus 로고
    • A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability
    • Corada M, Zanetta L, Orsenigo F, Breviario F, Lampugnani MG, Bernasconi S, et al. A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability. Blood. 2002; 100(3): 905-11.
    • (2002) Blood , vol.100 , Issue.3 , pp. 905-911
    • Corada, M.1    Zanetta, L.2    Orsenigo, F.3    Breviario, F.4    Lampugnani, M.G.5    Bernasconi, S.6
  • 33
    • 39749169771 scopus 로고    scopus 로고
    • Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy
    • Davalos D, Lee JK, Smith WB, Brinkman B, Ellisman MH, Zheng B, et al. Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy. J Neurosci Methods. 2008; 169: 1-7.
    • (2008) J Neurosci Methods , vol.169 , pp. 1-7
    • Davalos, D.1    Lee, J.K.2    Smith, W.B.3    Brinkman, B.4    Ellisman, M.H.5    Zheng, B.6
  • 34
    • 0034830757 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 regulates cell adhesion by binding to the somatomedin B domain of vitronectin
    • Deng G, Curriden SA, Hu G, Czekay RP, Loskutoff DJ. Plasminogen activator inhibitor-1 regulates cell adhesion by binding to the somatomedin B domain of vitronectin. J Cell Physiol. 2001; 189(1): 23-33.
    • (2001) J Cell Physiol , vol.189 , Issue.1 , pp. 23-33
    • Deng, G.1    Curriden, S.A.2    Hu, G.3    Czekay, R.P.4    Loskutoff, D.J.5
  • 35
    • 25144506952 scopus 로고    scopus 로고
    • Gene expression profiling of experimental traumatic spinal cord injury as a function of distance from impact site and injury severity
    • De Biase A, Knoblach SM, Di Giovanni S, Fan C, Molon A, Hoffman EP, et al. Gene expression profiling of experimental traumatic spinal cord injury as a function of distance from impact site and injury severity. Physiol Genomics. 2005; 22: 368-81.
    • (2005) Physiol Genomics , vol.22 , pp. 368-381
    • de Biase, A.1    Knoblach, S.M.2    Di Giovanni, S.3    Fan, C.4    Molon, A.5    Hoffman, E.P.6
  • 37
    • 0016711822 scopus 로고
    • Microcirculation of traumatized spinal cord. A correlation of microangiography and blood flow patterns in transitory and permanent paraplegia
    • Dohrmann GJ, Allen WE. Microcirculation of traumatized spinal cord. A correlation of microangiography and blood flow patterns in transitory and permanent paraplegia. J Trauma. 1975; 15: 1003-13.
    • (1975) J Trauma , vol.15 , pp. 1003-1013
    • Dohrmann, G.J.1    Allen, W.E.2
  • 38
    • 84907133445 scopus 로고
    • Demonstration of the microvasculature of the spinal cord by intravenous injection of the fluorescent dye, thioflavine S
    • Dohrmann GJ, Wick KM. Demonstration of the microvasculature of the spinal cord by intravenous injection of the fluorescent dye, thioflavine S. Stain Technol. 1971; 46: 321-2.
    • (1971) Stain Technol , vol.46 , pp. 321-322
    • Dohrmann, G.J.1    Wick, K.M.2
  • 39
    • 67249128891 scopus 로고    scopus 로고
    • Quantitative analysis by in vivo imaging of the dynamics of vascular and axonal networks in injured mouse spinal cord
    • Dray C, Rougon G, Debarbieux F. Quantitative analysis by in vivo imaging of the dynamics of vascular and axonal networks in injured mouse spinal cord. Proc Natl Acad Sci U S A. 2009; 106: 9459-64.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 9459-9464
    • Dray, C.1    Rougon, G.2    Debarbieux, F.3
  • 41
    • 73449115641 scopus 로고    scopus 로고
    • The blood-brain and the blood-cerebrospinal barriers: function and dysfunction
    • Engelhardt B, Sorokin L. The blood-brain and the blood-cerebrospinal barriers: function and dysfunction. Semin Immunopathology. 2009; 31(4): 497-511.
    • (2009) Semin Immunopathology , vol.31 , Issue.4 , pp. 497-511
    • Engelhardt, B.1    Sorokin, L.2
  • 42
    • 24744445996 scopus 로고    scopus 로고
    • Consequences of noggin expression by neural stem, glial, and neuronal precursor cells engrafted into the injured spinal cord
    • Enzmann GU, Benton RL, Woock JP, Howard RM, Tsoulfas P, Whittemore SR. Consequences of noggin expression by neural stem, glial, and neuronal precursor cells engrafted into the injured spinal cord. Exp Neurol. 2005; 195(2): 293-304.
    • (2005) Exp Neurol , vol.195 , Issue.2 , pp. 293-304
    • Enzmann, G.U.1    Benton, R.L.2    Woock, J.P.3    Howard, R.M.4    Tsoulfas, P.5    Whittemore, S.R.6
  • 45
    • 78651430456 scopus 로고    scopus 로고
    • Activating Notch signaling post-SCI modulates angiogenesis in penumbral vascular beds but does not improve hindlimb locomotor recovery
    • Fassbender JM, Myers SA, Whittemore SR. Activating Notch signaling post-SCI modulates angiogenesis in penumbral vascular beds but does not improve hindlimb locomotor recovery. Exp Neurol. 2011; 227: 302-13.
    • (2011) Exp Neurol , vol.227 , pp. 302-313
    • Fassbender, J.M.1    Myers, S.A.2    Whittemore, S.R.3
  • 46
    • 79955063410 scopus 로고    scopus 로고
    • Targeting microvasculature for neuroprotection after SCI
    • Fassbender JM, Whittemore SR, Hagg T. Targeting microvasculature for neuroprotection after SCI. Neurotherapeutics. 2011; 8: 240-51.
    • (2011) Neurotherapeutics , vol.8 , pp. 240-251
    • Fassbender, J.M.1    Whittemore, S.R.2    Hagg, T.3
  • 47
    • 0024326071 scopus 로고
    • The effect of nimodipine and dextran on axonal function and blood flow following experimental spinal cord injury
    • Fehlings MG, Tator CH, Linden RD. The effect of nimodipine and dextran on axonal function and blood flow following experimental spinal cord injury. J Neurosurg. 1989; 71: 403-16.
    • (1989) J Neurosurg , vol.71 , pp. 403-416
    • Fehlings, M.G.1    Tator, C.H.2    Linden, R.D.3
  • 48
    • 0028791689 scopus 로고
    • Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats
    • Fisher M, Meadows ME, Do T, Weise J, Trubetskoy V, Charette M, et al. Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 1995; 15(6): 953-9.
    • (1995) J Cereb Blood Flow Metab , vol.15 , Issue.6 , pp. 953-959
    • Fisher, M.1    Meadows, M.E.2    Do, T.3    Weise, J.4    Trubetskoy, V.5
  • 50
    • 77957944896 scopus 로고    scopus 로고
    • Neuroprotection in experimental stroke in the rat with an IgG-erythropoietin fusion protein
    • Fu A, Hui EK, Lu JZ, Boado RJ, Pardridge WM. Neuroprotection in experimental stroke in the rat with an IgG-erythropoietin fusion protein. Brain Res. 2010; 1360: 193-7.
    • (2010) Brain Res , vol.1360 , pp. 193-197
    • Fu, A.1    Hui, E.K.2    Lu, J.Z.3    Boado, R.J.4    Pardridge, W.M.5
  • 51
    • 77950279550 scopus 로고    scopus 로고
    • Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models
    • Fukumura D, Duda DG, Munn LL, Jain RK. Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models. Microcirculation. 2010; 17: 206-25.
    • (2010) Microcirculation , vol.17 , pp. 206-225
    • Fukumura, D.1    Duda, D.G.2    Munn, L.L.3    Jain, R.K.4
  • 53
    • 0026777715 scopus 로고
    • Importance of charge on transvascular albumin transport in skin and skeletal muscle
    • Gandhi RR, Bell DR. Importance of charge on transvascular albumin transport in skin and skeletal muscle. Am J Physiol. 1992; 262(4pt2): H999-H1008.
    • (1992) Am J Physiol , vol.262 , Issue.4 pt2
    • Gandhi, R.R.1    Bell, D.R.2
  • 54
    • 59649105028 scopus 로고    scopus 로고
    • De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury
    • Gerzanich V, Woo SK, Vennekens R, Tsymbalyuk O, Ivanova S, Ivanov A, et al. De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury. Nat Med. 2009; 15: 185-91.
    • (2009) Nat Med , vol.15 , pp. 185-191
    • Gerzanich, V.1    Woo, S.K.2    Vennekens, R.3    Tsymbalyuk, O.4    Ivanova, S.5    Ivanov, A.6
  • 55
    • 55849129973 scopus 로고    scopus 로고
    • Genes involved in the balance between neuronal survival and death during inflammation
    • Glezer I, Chernomoretz A, David S, Plante MM, Rivest S. Genes involved in the balance between neuronal survival and death during inflammation. PLoS One. 2007; 2: e310.
    • (2007) PLoS One , vol.2
    • Glezer, I.1    Chernomoretz, A.2    David, S.3    Plante, M.M.4    Rivest, S.5
  • 57
    • 77951667019 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 is an aggregate response factor with pleiotropic effects on cell signaling in vascular disease and the tumor microenvironment
    • Gramling MW, Church FC. Plasminogen activator inhibitor-1 is an aggregate response factor with pleiotropic effects on cell signaling in vascular disease and the tumor microenvironment. Thromb Res. 2010; 125(5): 377-81.
    • (2010) Thromb Res , vol.125 , Issue.5 , pp. 377-381
    • Gramling, M.W.1    Church, F.C.2
  • 58
    • 2142821430 scopus 로고    scopus 로고
    • Transient blockade of the CD11d/CD18 integrin reduces secondary damage after spinal cord injury, improving sensory, autonomic, and motor function
    • Gris D, Marsh DR, Oatway MA, Chen Y, Hamilton EF, Dekaban GA, et al. Transient blockade of the CD11d/CD18 integrin reduces secondary damage after spinal cord injury, improving sensory, autonomic, and motor function. J Neurosci. 2004; 24(16): 4043-51.
    • (2004) J Neurosci , vol.24 , Issue.16 , pp. 4043-4051
    • Gris, D.1    Marsh, D.R.2    Oatway, M.A.3    Chen, Y.4    Hamilton, E.F.5    Dekaban, G.A.6
  • 59
    • 0026768692 scopus 로고
    • Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids
    • Grobelny D, Poncz L, Galardy RE. Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry. 1992; 31: 7152-4.
    • (1992) Biochemistry , vol.31 , pp. 7152-7154
    • Grobelny, D.1    Poncz, L.2    Galardy, R.E.3
  • 60
    • 0024436784 scopus 로고
    • Improvement in post-traumatic spinal cord blood flow with a combination of a calcium channel blocker and a vasopressor
    • Guha A, Tator CH, Smith CR, Piper I. Improvement in post-traumatic spinal cord blood flow with a combination of a calcium channel blocker and a vasopressor. J Trauma. 1989; 29: 1440-7.
    • (1989) J Trauma , vol.29 , pp. 1440-1447
    • Guha, A.1    Tator, C.H.2    Smith, C.R.3    Piper, I.4
  • 61
    • 0033428065 scopus 로고    scopus 로고
    • The unique histopathological responses of the injured spinal cord. Implications for neuroprotective therapy
    • Guth L, Zhang Z, Steward O. The unique histopathological responses of the injured spinal cord. Implications for neuroprotective therapy. Ann N Y Acad Sci. 1999; 890: 366-84.
    • (1999) Ann N Y Acad Sci , vol.890 , pp. 366-384
    • Guth, L.1    Zhang, Z.2    Steward, O.3
  • 62
    • 33646577436 scopus 로고    scopus 로고
    • Degenerative and spontaneous regenerative processes after spinal cord injury
    • Hagg T, Oudega M. Degenerative and spontaneous regenerative processes after spinal cord injury. J Neurotrauma. 2006; 23: 264-80.
    • (2006) J Neurotrauma , vol.23 , pp. 264-280
    • Hagg, T.1    Oudega, M.2
  • 63
    • 17444392322 scopus 로고    scopus 로고
    • Neuroprotection and acute spinal cord injury: a reappraisal
    • Hall ED, Springer JE. Neuroprotection and acute spinal cord injury: a reappraisal. NeuroRx. 2004; 1: 80-100.
    • (2004) NeuroRx , vol.1 , pp. 80-100
    • Hall, E.D.1    Springer, J.E.2
  • 64
    • 1442299254 scopus 로고    scopus 로고
    • Mild to moderate hypothermia prevents microvascular basal lamina antigen loss in experimental focal cerebral ischemia
    • Hamann GF, Burggraf D, Martens HK, Liebetrau M, Jager G, Wunderlich N, et al. Mild to moderate hypothermia prevents microvascular basal lamina antigen loss in experimental focal cerebral ischemia. Stroke. 2004; 35: 764-9.
    • (2004) Stroke , vol.35 , pp. 764-769
    • Hamann, G.F.1    Burggraf, D.2    Martens, H.K.3    Liebetrau, M.4    Jager, G.5    Wunderlich, N.6
  • 65
    • 77950810539 scopus 로고    scopus 로고
    • Rescuing vasculature with intravenous angiopoietin-1 and alpha v beta 3 integrin peptide is protective after spinal cord injury
    • Han S, Arnold SA, Sithu SD, Mahoney ET, Geralds JT, Tran P, et al. Rescuing vasculature with intravenous angiopoietin-1 and alpha v beta 3 integrin peptide is protective after spinal cord injury. Brain. 2010; 133: 1026-42.
    • (2010) Brain , vol.133 , pp. 1026-1042
    • Han, S.1    Arnold, S.A.2    Sithu, S.D.3    Mahoney, E.T.4    Geralds, J.T.5    Tran, P.6
  • 66
    • 0022365637 scopus 로고
    • Endothelial negative surface charge areas and blood-brain barrier function
    • Hardebo JE, Kahrstom J. Endothelial negative surface charge areas and blood-brain barrier function. Acta Physiol Scand Suppl. 1985; 125(3): 495-9.
    • (1985) Acta Physiol Scand Suppl , vol.125 , Issue.3 , pp. 495-499
    • Hardebo, J.E.1    Kahrstom, J.2
  • 67
    • 78649346412 scopus 로고    scopus 로고
    • Sustained expression of vascular endothelial growth factor and angiopoietin-1 improves blood-spinal cord barrier integrity and functional recovery after spinal cord injury
    • Herrera JJ, Sundberg LM, Zentilin L, Giacca M, Narayana PA. Sustained expression of vascular endothelial growth factor and angiopoietin-1 improves blood-spinal cord barrier integrity and functional recovery after spinal cord injury. J Neurotrauma. 2010; 27: 2067-76.
    • (2010) J Neurotrauma , vol.27 , pp. 2067-2076
    • Herrera, J.J.1    Sundberg, L.M.2    Zentilin, L.3    Giacca, M.4    Narayana, P.A.5
  • 70
    • 6344250448 scopus 로고    scopus 로고
    • Neuropathology: the foundation for new treatments in spinal cord injury
    • Kakulas BA. Neuropathology: the foundation for new treatments in spinal cord injury. Spinal Cord. 2004; 42(10): 549-63.
    • (2004) Spinal Cord , vol.42 , Issue.10 , pp. 549-563
    • Kakulas, B.A.1
  • 71
    • 59849125389 scopus 로고    scopus 로고
    • Genetic ablation of transcription repressor Bach1 reduces neural tissue damage and improves locomotor function after spinal cord injury in mice
    • Kanno H, Ozawa H, Dohi Y, Sekiguchi A, Igarashi K, Itoi E. Genetic ablation of transcription repressor Bach1 reduces neural tissue damage and improves locomotor function after spinal cord injury in mice. J Neurotrauma. 2009; 26: 31-9.
    • (2009) J Neurotrauma , vol.26 , pp. 31-39
    • Kanno, H.1    Ozawa, H.2    Dohi, Y.3    Sekiguchi, A.4    Igarashi, K.5    Itoi, E.6
  • 72
    • 77950931419 scopus 로고    scopus 로고
    • Matrix metalloproteinases: regulators of the tumor microenvironment
    • Kessenbrock K, Plaks V, Werb Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell. 2010; 141: 52-67.
    • (2010) Cell , vol.141 , pp. 52-67
    • Kessenbrock, K.1    Plaks, V.2    Werb, Z.3
  • 73
    • 77950612951 scopus 로고    scopus 로고
    • Diffusion tensor imaging at 3 h after traumatic spinal cord injury predicts long-term locomotor recovery
    • Kim JH, Loy DN, Wang Q, Budde MD, Schmidt RE, Trinkaus K, et al. Diffusion tensor imaging at 3 h after traumatic spinal cord injury predicts long-term locomotor recovery. J Neurotrauma. 2010; 27: 587-98.
    • (2010) J Neurotrauma , vol.27 , pp. 587-598
    • Kim, J.H.1    Loy, D.N.2    Wang, Q.3    Budde, M.D.4    Schmidt, R.E.5    Trinkaus, K.6
  • 74
    • 77952911900 scopus 로고    scopus 로고
    • Protective role of aquaporin-4 water channels after contusion spinal cord injury
    • Kimura A, Hsu M, Seldin M, Verkman AS, Scharfman HE, Binder DK. Protective role of aquaporin-4 water channels after contusion spinal cord injury. Ann Neurol. 2010; 67(6): 794-801.
    • (2010) Ann Neurol , vol.67 , Issue.6 , pp. 794-801
    • Kimura, A.1    Hsu, M.2    Seldin, M.3    Verkman, A.S.4    Scharfman, H.E.5    Binder, D.K.6
  • 75
    • 0029942399 scopus 로고    scopus 로고
    • Pathophysiology of the aquaporin water channels
    • King LS, Agre P. Pathophysiology of the aquaporin water channels. Annu Rev Physiol. 1996; 58: 619-48.
    • (1996) Annu Rev Physiol , vol.58 , pp. 619-648
    • King, L.S.1    Agre, P.2
  • 76
    • 79951519159 scopus 로고    scopus 로고
    • Active metalloproteases of the A Disintegrin and Metalloprotease (ADAM) family: biological function and structure
    • Klein T, Bischoff R. Active metalloproteases of the A Disintegrin and Metalloprotease (ADAM) family: biological function and structure. J Proteome Res. 2011; 10: 17-33.
    • (2011) J Proteome Res , vol.10 , pp. 17-33
    • Klein, T.1    Bischoff, R.2
  • 77
    • 79952798014 scopus 로고    scopus 로고
    • Inflammatory and structural biomarkers in acute traumatic spinal cord injury
    • Kwon BK, Casha S, Hurlbert RJ, Yong VW. Inflammatory and structural biomarkers in acute traumatic spinal cord injury. Clin Chem Lab Med. 2011; 49(3): 425-33.
    • (2011) Clin Chem Lab Med , vol.49 , Issue.3 , pp. 425-433
    • Kwon, B.K.1    Casha, S.2    Hurlbert, R.J.3    Yong, V.W.4
  • 78
    • 77951287743 scopus 로고    scopus 로고
    • Cerebrospinal fluid inflammatory cytokines and biomarkers of injury severity in acute human spinal cord injury
    • Kwon BK, Stammers AM, Belanger LM, Bernardo A, Chan D, Bishop CM, et al. Cerebrospinal fluid inflammatory cytokines and biomarkers of injury severity in acute human spinal cord injury. J Neurotrauma. 2010; 27(4): 669-82.
    • (2010) J Neurotrauma , vol.27 , Issue.4 , pp. 669-682
    • Kwon, B.K.1    Stammers, A.M.2    Belanger, L.M.3    Bernardo, A.4    Chan, D.5    Bishop, C.M.6
  • 79
    • 4444353257 scopus 로고    scopus 로고
    • Tumor progression: the effects of thrombospondin-1 and-2
    • Lawler J, Detmar M. Tumor progression: the effects of thrombospondin-1 and-2. Int J Biochem Cell Biol. 2004; 36(6): 1038-45.
    • (2004) Int J Biochem Cell Biol , vol.36 , Issue.6 , pp. 1038-1045
    • Lawler, J.1    Detmar, M.2
  • 80
    • 0030955124 scopus 로고    scopus 로고
    • Molecular characteristics of pial microvessels of the rat optic nerve. Can pial microvessels be used as a model for the blood-brain barrier?
    • Lawrenson JG, Reid AR, Allt G. Molecular characteristics of pial microvessels of the rat optic nerve. Can pial microvessels be used as a model for the blood-brain barrier? Cell Tissue Res. 1997; 288(2): 259-65.
    • (1997) Cell Tissue Res , vol.288 , Issue.2 , pp. 259-265
    • Lawrenson, J.G.1    Reid, A.R.2    Allt, G.3
  • 81
    • 0025372848 scopus 로고
    • Functional analysis of the endothelin-1 gene promoter. Evidence for an endothelial cell-specific cis-acting sequence
    • Lee ME, Bloch KD, Clifford JA, Quertermous T. Functional analysis of the endothelin-1 gene promoter. Evidence for an endothelial cell-specific cis-acting sequence. J Biol Chem. 1990; 265(18): 10446-50.
    • (1990) J Biol Chem , vol.265 , Issue.18 , pp. 10446-10450
    • Lee, M.E.1    Bloch, K.D.2    Clifford, J.A.3    Quertermous, T.4
  • 82
    • 34247495046 scopus 로고    scopus 로고
    • Heme oxygenase-1 stabilizes the blood-spinal cord barrier and limits oxidative stress and white matter damage in the acutely injured murine spinal cord
    • Lin Y, Vreman HJ, Wong RJ, Tjoa T, Yamauchi T, Noble-Haeusslein LJ. Heme oxygenase-1 stabilizes the blood-spinal cord barrier and limits oxidative stress and white matter damage in the acutely injured murine spinal cord. J Cereb Blood Flow Metab. 2007; 27: 1010-21.
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 1010-1021
    • Lin, Y.1    Vreman, H.J.2    Wong, R.J.3    Tjoa, T.4    Yamauchi, T.5    Noble-Haeusslein, L.J.6
  • 83
    • 0037089824 scopus 로고    scopus 로고
    • Temporal progression of angiogenesis and basal lamina deposition after contusive spinal cord injury in the adult rat
    • Loy DN, Crawford CH, Darnall JB, Burke DA, Onifer SM, Whittemore SR. Temporal progression of angiogenesis and basal lamina deposition after contusive spinal cord injury in the adult rat. J Comp Neurol. 2002; 445: 308-24.
    • (2002) J Comp Neurol , vol.445 , pp. 308-324
    • Loy, D.N.1    Crawford, C.H.2    Darnall, J.B.3    Burke, D.A.4    Onifer, S.M.5    Whittemore, S.R.6
  • 84
    • 13444311774 scopus 로고    scopus 로고
    • Serum biomarkers for experimental acute spinal cord injury: rapid elevation of neuron-specific enolase and S-100beta
    • Loy DN, Sroufe AE, Pelt JL, Burke DA, Cao QL, Talbott JF, et al. Serum biomarkers for experimental acute spinal cord injury: rapid elevation of neuron-specific enolase and S-100beta. Neurosurgery. 2005; 56(2): 391-7.
    • (2005) Neurosurgery , vol.56 , Issue.2 , pp. 391-397
    • Loy, D.N.1    Sroufe, A.E.2    Pelt, J.L.3    Burke, D.A.4    Cao, Q.L.5    Talbott, J.F.6
  • 85
    • 79955771644 scopus 로고    scopus 로고
    • Biomarkers for severity of spinal cord injury in the cerebrospinal fluid of rats
    • Lubieniecka JM, Streijger F, Lee JH, Stoynov N, Liu J, Mottus R, et al. Biomarkers for severity of spinal cord injury in the cerebrospinal fluid of rats. PLoS One. 2011; 6(4): e19247.
    • (2011) PLoS One , vol.6 , Issue.4
    • Lubieniecka, J.M.1    Streijger, F.2    Lee, J.H.3    Stoynov, N.4    Liu, J.5    Mottus, R.6
  • 86
    • 0034982490 scopus 로고    scopus 로고
    • Behavioral and histological outcomes following graded spinal cord contusion injury in the C57Bl/6 mouse
    • Ma M, Basso DM, Walters P, Stokes BT, Jakeman LB. Behavioral and histological outcomes following graded spinal cord contusion injury in the C57Bl/6 mouse. Exp Neurol. 2001; 169(2): 239-54.
    • (2001) Exp Neurol , vol.169 , Issue.2 , pp. 239-254
    • Ma, M.1    Basso, D.M.2    Walters, P.3    Stokes, B.T.4    Jakeman, L.B.5
  • 87
    • 0027399173 scopus 로고
    • Endothelin-1-induced reductions in cerebral blood flow: dose dependency, time course, and neuropathological consequences
    • Macrae IM, Robinson MJ, Graham DI, Reid JL, McCulloch J. Endothelin-1-induced reductions in cerebral blood flow: dose dependency, time course, and neuropathological consequences. J Cereb Blood Flow Metab. 1993; 13(2): 276-84.
    • (1993) J Cereb Blood Flow Metab , vol.13 , Issue.2 , pp. 276-284
    • Macrae, I.M.1    Robinson, M.J.2    Graham, D.I.3    Reid, J.L.4    McCulloch, J.5
  • 88
    • 58249084386 scopus 로고    scopus 로고
    • ADAM8 is selectively up-regulated in endothelial cells and is associated with angiogenesis after spinal cord injury in adult mice
    • Mahoney ET, Benton RL, Maddie MA, Whittemore SR, Hagg T. ADAM8 is selectively up-regulated in endothelial cells and is associated with angiogenesis after spinal cord injury in adult mice. J Comp Neurol. 2009; 512: 243-55.
    • (2009) J Comp Neurol , vol.512 , pp. 243-255
    • Mahoney, E.T.1    Benton, R.L.2    Maddie, M.A.3    Whittemore, S.R.4    Hagg, T.5
  • 89
    • 0029868298 scopus 로고    scopus 로고
    • Heme-oxygenase-1 induction in glia throughout rat brain following experimental subarachnoid hemorrhage
    • Matz P, Turner C, Weinstein PR, Massa SM, Panter SS, Sharp FR. Heme-oxygenase-1 induction in glia throughout rat brain following experimental subarachnoid hemorrhage. Brain Res. 1996; 713: 211-22.
    • (1996) Brain Res , vol.713 , pp. 211-222
    • Matz, P.1    Turner, C.2    Weinstein, P.R.3    Massa, S.M.4    Panter, S.S.5    Sharp, F.R.6
  • 90
    • 0034628969 scopus 로고    scopus 로고
    • Subarachnoid hemolysate produces DNA fragmentation in a pattern similar to apoptosis in mouse brain
    • Matz PG, Fujimura M, Chan PH. Subarachnoid hemolysate produces DNA fragmentation in a pattern similar to apoptosis in mouse brain. Brain Res. 2000; 858: 312-9.
    • (2000) Brain Res , vol.858 , pp. 312-319
    • Matz, P.G.1    Fujimura, M.2    Chan, P.H.3
  • 91
    • 0032496750 scopus 로고    scopus 로고
    • Induction of heme oxygenase-1 (HO-1) in the contused spinal cord of the rat
    • Mautes AE, Kim DH, Sharp FR, Panter S, Sato M, Maida N, et al. Induction of heme oxygenase-1 (HO-1) in the contused spinal cord of the rat. Brain Res. 1998; 795: 17-24.
    • (1998) Brain Res , vol.795 , pp. 17-24
    • Mautes, A.E.1    Kim, D.H.2    Sharp, F.R.3    Panter, S.4    Sato, M.5    Maida, N.6
  • 92
    • 0033920448 scopus 로고    scopus 로고
    • Vascular events after spinal cord injury: contribution to secondary pathogenesis
    • Mautes AE, Weinzierl MR, Donovan F, Noble LJ. Vascular events after spinal cord injury: contribution to secondary pathogenesis. Phys Ther. 2000; 80: 673-87.
    • (2000) Phys Ther , vol.80 , pp. 673-687
    • Mautes, A.E.1    Weinzierl, M.R.2    Donovan, F.3    Noble, L.J.4
  • 93
    • 0038376001 scopus 로고    scopus 로고
    • Imaging of angiogenesis: from microscope to clinic
    • McDonald DM, Choyke PL. Imaging of angiogenesis: from microscope to clinic. Nat Med. 2003; 9: 713-25.
    • (2003) Nat Med , vol.9 , pp. 713-725
    • McDonald, D.M.1    Choyke, P.L.2
  • 94
    • 0029133863 scopus 로고
    • Immunolocalization of endothelin in the traumatized spinal cord: relationship to blood-spinal cord barrier breakdown
    • McKenzie AL, Hall JJ, Aihara N, Fukuda K, Noble LJ. Immunolocalization of endothelin in the traumatized spinal cord: relationship to blood-spinal cord barrier breakdown. J Neurotrauma. 1995; 12(3): 257-68.
    • (1995) J Neurotrauma , vol.12 , Issue.3 , pp. 257-268
    • McKenzie, A.L.1    Hall, J.J.2    Aihara, N.3    Fukuda, K.4    Noble, L.J.5
  • 96
    • 0013660775 scopus 로고    scopus 로고
    • Fat and carbohydrate metabolism
    • P. D. Glukman and M. A. Heyman (Eds.), London: Arnold
    • Milner RDG. Fat and carbohydrate metabolism. In: Glukman PD, Heyman MA, editors. Pediatrics and perinatology, the scientific basis. London: Arnold; 1996. p. 447-50.
    • (1996) Pediatrics and Perinatology, the Scientific Basis , pp. 447-450
    • Milner, R.D.G.1
  • 97
    • 80055117408 scopus 로고    scopus 로고
    • A method for 2-photon imaging of blood flow in the neocortex through a cranial window
    • doi: 10. 3791/678
    • Mostany R, Portera-Cailliau C. A method for 2-photon imaging of blood flow in the neocortex through a cranial window. J Vis Exp. 2008; 678. doi: 10. 3791/678.
    • (2008) J Vis Exp , vol.678
    • Mostany, R.1    Portera-Cailliau, C.2
  • 98
    • 77956500289 scopus 로고    scopus 로고
    • Spinal expression of PV-1 is associated with inflammation, perivascular astrocyte loss, and diminished EC glucose transport potential in acute SCI
    • Mozer AB, Whittemore SR, Benton RL. Spinal expression of PV-1 is associated with inflammation, perivascular astrocyte loss, and diminished EC glucose transport potential in acute SCI. Curr Microvasc Res. 2010; 7(3): 238-50.
    • (2010) Curr Microvasc Res , vol.7 , Issue.3 , pp. 238-250
    • Mozer, A.B.1    Whittemore, S.R.2    Benton, R.L.3
  • 101
    • 38749101585 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator receptor (uPAR) augments brain damage in a murine model of ischemic stroke
    • Nagai N, Okada K, Kawao N, Ishida C, Ueshima S, Collen D, et al. Urokinase-type plasminogen activator receptor (uPAR) augments brain damage in a murine model of ischemic stroke. Neurosci Lett. 2008; 432: 46-9.
    • (2008) Neurosci Lett , vol.432 , pp. 46-49
    • Nagai, N.1    Okada, K.2    Kawao, N.3    Ishida, C.4    Ueshima, S.5    Collen, D.6
  • 102
    • 0017386018 scopus 로고
    • Spinal cord injury. The role of vascular damage in the pathogenesis of central hemorrhagic necrosis
    • Nelson E, Gertz SD, Rennels ML, Ducker TB, Blaumanis OR. Spinal cord injury. The role of vascular damage in the pathogenesis of central hemorrhagic necrosis. Arch Neurol. 1977; 34: 332-3.
    • (1977) Arch Neurol , vol.34 , pp. 332-333
    • Nelson, E.1    Gertz, S.D.2    Rennels, M.L.3    Ducker, T.B.4    Blaumanis, O.R.5
  • 104
    • 28244448575 scopus 로고    scopus 로고
    • Transcriptional profiling of spinal cord injury-induced central neuropathic pain
    • Nesic O, Lee J, Johnson KM, Ye Z, Xu GY, Unabia GC, et al. Transcriptional profiling of spinal cord injury-induced central neuropathic pain. J Neurochem. 2005; 95: 998-1014.
    • (2005) J Neurochem , vol.95 , pp. 998-1014
    • Nesic, O.1    Lee, J.2    Johnson, K.M.3    Ye, Z.4    Xu, G.Y.5    Unabia, G.C.6
  • 105
    • 33751021655 scopus 로고    scopus 로고
    • Acute and chronic changes in aquaporin 4 expression after spinal cord injury
    • Nesic O, Lee J, Ye Z, Unabia GC, Rafati D, Hulsebosch CE, et al. Acute and chronic changes in aquaporin 4 expression after spinal cord injury. Neuroscience. 2006; 143(3): 779-92.
    • (2006) Neuroscience , vol.143 , Issue.3 , pp. 779-792
    • Nesic, O.1    Lee, J.2    Ye, Z.3    Unabia, G.C.4    Rafati, D.5    Hulsebosch, C.E.6
  • 106
    • 0038407772 scopus 로고    scopus 로고
    • Severe alterations of endothelial and glial cells in the blood-brain barrier of dystrophic mdx mice
    • Nico B, Frigeri A, Nicchia GP, Corsi P, Ribatti D, Quondamatteo F, et al. Severe alterations of endothelial and glial cells in the blood-brain barrier of dystrophic mdx mice. Glia. 2003; 42(3): 235-51.
    • (2003) Glia , vol.42 , Issue.3 , pp. 235-251
    • Nico, B.1    Frigeri, A.2    Nicchia, G.P.3    Corsi, P.4    Ribatti, D.5    Quondamatteo, F.6
  • 107
    • 0037648580 scopus 로고    scopus 로고
    • Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice
    • Nitta T, Hata M, Gotoh S, Seo Y, Sasaki H, Hashimoto N, et al. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol. 2003; 161(3): 653-60.
    • (2003) J Cell Biol , vol.161 , Issue.3 , pp. 653-660
    • Nitta, T.1    Hata, M.2    Gotoh, S.3    Seo, Y.4    Sasaki, H.5    Hashimoto, N.6
  • 108
    • 0026550656 scopus 로고
    • Specific binding sites for 125I-endothelin-1 in the porcine and human spinal cord
    • Niwa M, Kawaguchi T, Himeno A, Fujimoto M, Kurihara M, Yamashita K, et al. Specific binding sites for 125I-endothelin-1 in the porcine and human spinal cord. Eur J Pharmacol. 1992; 225(4): 281-9.
    • (1992) Eur J Pharmacol , vol.225 , Issue.4 , pp. 281-289
    • Niwa, M.1    Kawaguchi, T.2    Himeno, A.3    Fujimoto, M.4    Kurihara, M.5    Yamashita, K.6
  • 109
    • 0025303054 scopus 로고
    • Endogenous peroxidatic activity in astrocytes after spinal cord injury
    • Noble LJ, Cortez SC, Ellison JA. Endogenous peroxidatic activity in astrocytes after spinal cord injury. J Comp Neurol. 1990; 296: 674-85.
    • (1990) J Comp Neurol , vol.296 , pp. 674-685
    • Noble, L.J.1    Cortez, S.C.2    Ellison, J.A.3
  • 110
    • 0036758650 scopus 로고    scopus 로고
    • Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events
    • Noble LJ, Donovan F, Igarashi T, Goussev S, Werb Z. Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events. J Neurosci. 2002; 22: 7526-35.
    • (2002) J Neurosci , vol.22 , pp. 7526-7535
    • Noble, L.J.1    Donovan, F.2    Igarashi, T.3    Goussev, S.4    Werb, Z.5
  • 111
    • 0030479488 scopus 로고    scopus 로고
    • Characterization of the microvascular glycocalyx in normal and injured spinal cord in the rat
    • Noble LJ, Mautes AE, Hall JJ. Characterization of the microvascular glycocalyx in normal and injured spinal cord in the rat. J Comp Neurol. 1996; 376: 542-56.
    • (1996) J Comp Neurol , vol.376 , pp. 542-556
    • Noble, L.J.1    Mautes, A.E.2    Hall, J.J.3
  • 112
    • 0021981613 scopus 로고
    • Spinal cord contusion in the rat: morphometric analyses of alterations in the spinal cord
    • Noble LJ, Wrathall JR. Spinal cord contusion in the rat: morphometric analyses of alterations in the spinal cord. Exp Neurol. 1985; 88(1): 135-49.
    • (1985) Exp Neurol , vol.88 , Issue.1 , pp. 135-149
    • Noble, L.J.1    Wrathall, J.R.2
  • 113
    • 0023928642 scopus 로고
    • Blood-spinal cord barrier disruption proximal to a spinal cord transection in the rat: time course and pathways associated with protein leakage
    • Noble LJ, Wrathall JR. Blood-spinal cord barrier disruption proximal to a spinal cord transection in the rat: time course and pathways associated with protein leakage. Exp Neurol. 1988; 99(3): 567-78.
    • (1988) Exp Neurol , vol.99 , Issue.3 , pp. 567-578
    • Noble, L.J.1    Wrathall, J.R.2
  • 114
    • 0024595411 scopus 로고
    • Correlative analyses of lesion development and functional status after graded spinal cord contusive injuries in the rat
    • Noble LJ, Wrathall JR. Correlative analyses of lesion development and functional status after graded spinal cord contusive injuries in the rat. Exp Neurol. 1989; 103: 34-40.
    • (1989) Exp Neurol , vol.103 , pp. 34-40
    • Noble, L.J.1    Wrathall, J.R.2
  • 115
    • 0024515595 scopus 로고
    • Distribution and time course of protein extravasation in the rat spinal cord after contusive injury
    • Noble LJ, Wrathall JR. Distribution and time course of protein extravasation in the rat spinal cord after contusive injury. Brain Res. 1989; 482: 57-66.
    • (1989) Brain Res , vol.482 , pp. 57-66
    • Noble, L.J.1    Wrathall, J.R.2
  • 116
    • 1942425481 scopus 로고    scopus 로고
    • The pathology of human spinal cord injury: defining the problems
    • Norenberg MD, Smith J, Marcillo A. The pathology of human spinal cord injury: defining the problems. J Neurotrauma. 2004; 21: 429-40.
    • (2004) J Neurotrauma , vol.21 , pp. 429-440
    • Norenberg, M.D.1    Smith, J.2    Marcillo, A.3
  • 117
    • 78649424873 scopus 로고    scopus 로고
    • Angiogenic potential of microvessel fragments is independent of the tissue of origin and can be influenced by the cellular composition of the implants
    • Nunes SS, Krishnan L, Gerard CS, Dale JR, Maddie MA, Benton RL, et al. Angiogenic potential of microvessel fragments is independent of the tissue of origin and can be influenced by the cellular composition of the implants. Microcirculation. 2010; 17(7): 557-67.
    • (2010) Microcirculation , vol.17 , Issue.7 , pp. 557-567
    • Nunes, S.S.1    Krishnan, L.2    Gerard, C.S.3    Dale, J.R.4    Maddie, M.A.5    Benton, R.L.6
  • 118
    • 80455155163 scopus 로고    scopus 로고
    • Protein therapy using heme-oxygenase-1 fused to a polyarginine transduction domain attenuates cerebral vasospasm after experimental subarachnoid hemorrhage
    • doi: 10. 1038/jcbfm. 2011. 87
    • Ogawa T, Hanggi D, Wu Y, Michiue H, Tomizawa K, Ono S, et al. Protein therapy using heme-oxygenase-1 fused to a polyarginine transduction domain attenuates cerebral vasospasm after experimental subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2011. doi: 10. 1038/jcbfm. 2011. 87.
    • (2011) J Cereb Blood Flow Metab
    • Ogawa, T.1    Hanggi, D.2    Wu, Y.3    Michiue, H.4    Tomizawa, K.5    Ono, S.6
  • 119
    • 34547632714 scopus 로고    scopus 로고
    • Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain: importance for CNS drug discovery and development
    • Ohtsuki S, Terasaki T. Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain: importance for CNS drug discovery and development. Pharm Res. 2007; 24(9): 1745-58.
    • (2007) Pharm Res , vol.24 , Issue.9 , pp. 1745-1758
    • Ohtsuki, S.1    Terasaki, T.2
  • 120
    • 34547633657 scopus 로고    scopus 로고
    • Brain drug development and brain drug targeting
    • Pardridge WM. Brain drug development and brain drug targeting. Pharm Res. 2007; 24(9): 1729-32.
    • (2007) Pharm Res , vol.24 , Issue.9 , pp. 1729-1732
    • Pardridge, W.M.1
  • 121
    • 0029009048 scopus 로고
    • Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate
    • Pardridge WM, Kang YS, Buciak JL, Yang J. Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate. Pharm Res. 1995; 12(6): 807-16.
    • (1995) Pharm Res , vol.12 , Issue.6 , pp. 807-816
    • Pardridge, W.M.1    Kang, Y.S.2    Buciak, J.L.3    Yang, J.4
  • 122
    • 0018762960 scopus 로고
    • The use of fluorescein-conjugated Bandeiraea simplicifolia B4-isolectin as a histochemical reagent for the detection of alpha-D-galactopyranosyl groups. Their occurrence in basement membranes
    • Peters BP, Goldstein IJ. The use of fluorescein-conjugated Bandeiraea simplicifolia B4-isolectin as a histochemical reagent for the detection of alpha-D-galactopyranosyl groups. Their occurrence in basement membranes. Exp Cell Res. 1979; 120(2): 321-34.
    • (1979) Exp Cell Res , vol.120 , Issue.2 , pp. 321-334
    • Peters, B.P.1    Goldstein, I.J.2
  • 124
    • 0032838089 scopus 로고    scopus 로고
    • Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury
    • Popovich PG, Guan Z, Wei P, Huitinga I, van Rooijen N, Stokes BT. Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury. Exp Neurol. 1999; 158: 351-65.
    • (1999) Exp Neurol , vol.158 , pp. 351-365
    • Popovich, P.G.1    Guan, Z.2    Wei, P.3    Huitinga, I.4    van Rooijen, N.5    Stokes, B.T.6
  • 125
    • 84856531948 scopus 로고    scopus 로고
    • Independent evaluation of the effects of glibenclamide on reducing progressive hemorrhagic necrosis after cervical spinal cord injury
    • doi: 10. 1016/j. expneurol. 2010. 11. 016 (PMID 21145891)
    • Popovich PG, Lemeshow S, Gensel JC, Tovar CA. Independent evaluation of the effects of glibenclamide on reducing progressive hemorrhagic necrosis after cervical spinal cord injury. Exp Neurol. 2010. doi: 10. 1016/j. expneurol. 2010. 11. 016 (PMID 21145891).
    • (2010) Exp Neurol
    • Popovich, P.G.1    Lemeshow, S.2    Gensel, J.C.3    Tovar, C.A.4
  • 126
    • 77950617581 scopus 로고    scopus 로고
    • Neuronal and axonal degeneration in experimental spinal cord injury: in vivo proton magnetic resonance spectroscopy and histology
    • Qian J, Herrera JJ, Narayana PA. Neuronal and axonal degeneration in experimental spinal cord injury: in vivo proton magnetic resonance spectroscopy and histology. J Neurotrauma. 2010; 27: 599-610.
    • (2010) J Neurotrauma , vol.27 , pp. 599-610
    • Qian, J.1    Herrera, J.J.2    Narayana, P.A.3
  • 127
  • 128
    • 63649141727 scopus 로고    scopus 로고
    • The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions
    • Reiss K, Saftig P. The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions. Semin Cell Dev Biol. 2009; 20: 126-37.
    • (2009) Semin Cell Dev Biol , vol.20 , pp. 126-137
    • Reiss, K.1    Saftig, P.2
  • 129
    • 0027374595 scopus 로고
    • Effect of nimodipine or methylprednisolone on recovery from acute experimental spinal cord injury in rats
    • Ross IB, Tator CH, Theriault E. Effect of nimodipine or methylprednisolone on recovery from acute experimental spinal cord injury in rats. Surg Neurol. 1993; 40: 461-70.
    • (1993) Surg Neurol , vol.40 , pp. 461-470
    • Ross, I.B.1    Tator, C.H.2    Theriault, E.3
  • 130
    • 41849108753 scopus 로고    scopus 로고
    • Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice
    • Saadoun S, Bell BA, Verkman AS, Papadopoulos MC. Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice. Brain. 2008; 131(4): 1087-98.
    • (2008) Brain , vol.131 , Issue.4 , pp. 1087-1098
    • Saadoun, S.1    Bell, B.A.2    Verkman, A.S.3    Papadopoulos, M.C.4
  • 132
    • 0033635344 scopus 로고    scopus 로고
    • Complex phenotype of mice lacking occludin, a component of tight junction strands
    • Saitou M, Furuse M, Sasaki H, Schulzke JD, Fromm M, Takano H, et al. Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol Ciol Cell. 2000; 11(12): 4131-42.
    • (2000) Mol Ciol Cell , vol.11 , Issue.12 , pp. 4131-4142
    • Saitou, M.1    Furuse, M.2    Sasaki, H.3    Schulzke, J.D.4    Fromm, M.5    Takano, H.6
  • 133
    • 0029944443 scopus 로고    scopus 로고
    • Spinal endothelin content is elevated after moderate local trauma in the rat to levels associated with locomotor dysfunction after intrathecal injection
    • Salzman SK, Acosta R, Beck G, Madden J, Boxer B, Ohlstein EH. Spinal endothelin content is elevated after moderate local trauma in the rat to levels associated with locomotor dysfunction after intrathecal injection. J Neurotrauma. 1996; 13(2): 93-101.
    • (1996) J Neurotrauma , vol.13 , Issue.2 , pp. 93-101
    • Salzman, S.K.1    Acosta, R.2    Beck, G.3    Madden, J.4    Boxer, B.5    Ohlstein, E.H.6
  • 134
  • 135
    • 0034867539 scopus 로고    scopus 로고
    • Evaluation of the neuroprotective effects of sodium channel blockers after spinal cord injury: improved behavioral and neuroanatomical recovery with riluzole
    • Schwartz G, Fehlings MG. Evaluation of the neuroprotective effects of sodium channel blockers after spinal cord injury: improved behavioral and neuroanatomical recovery with riluzole. J Neurosurg. 2001; 94: 245-56.
    • (2001) J Neurosurg , vol.94 , pp. 245-256
    • Schwartz, G.1    Fehlings, M.G.2
  • 136
    • 85052609477 scopus 로고    scopus 로고
    • Early micro vascular changes after subarachnoid hemorrhage
    • Sehba FA, Friedrich V. Early micro vascular changes after subarachnoid hemorrhage. Acta Neurochir Suppl. 2011; 110: 49-55.
    • (2011) Acta Neurochir Suppl , vol.110 , pp. 49-55
    • Sehba, F.A.1    Friedrich, V.2
  • 137
    • 33645733773 scopus 로고    scopus 로고
    • Newly expressed SUR1-regulated NC(Ca-ATP) channel mediates cerebral edema after ischemic stroke
    • Simard JM, Chen M, Tarasov KV, Bhatta S, Ivanova S, Melnitchenko L, et al. Newly expressed SUR1-regulated NC(Ca-ATP) channel mediates cerebral edema after ischemic stroke. Nat Med. 2006; 12(4): 433-0.
    • (2006) Nat Med , vol.12 , Issue.4 , pp. 430-433
    • Simard, J.M.1    Chen, M.2    Tarasov, K.V.3    Bhatta, S.4    Ivanova, S.5    Melnitchenko, L.6
  • 138
    • 59149087488 scopus 로고    scopus 로고
    • Glibenclamide reduces inflammation, vasogenic edema, and caspase-3 activation after subarachnoid hemorrhage
    • Simard JM, Geng Z, Woo SK, Ivanova S, Tosun C, Melnichenko L, et al. Glibenclamide reduces inflammation, vasogenic edema, and caspase-3 activation after subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2009; 29: 317-30.
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 317-330
    • Simard, J.M.1    Geng, Z.2    Woo, S.K.3    Ivanova, S.4    Tosun, C.5    Melnichenko, L.6
  • 139
    • 34547691350 scopus 로고    scopus 로고
    • Endothelial sulfonylurea receptor 1-regulated NC Ca-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury
    • Simard JM, Tsymbalyuk O, Ivanov A, Ivanova S, Bhatta S, Geng Z, et al. Endothelial sulfonylurea receptor 1-regulated NC Ca-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury. J Clin Invest. 2007; 117: 2105-13.
    • (2007) J Clin Invest , vol.117 , pp. 2105-2113
    • Simard, J.M.1    Tsymbalyuk, O.2    Ivanov, A.3    Ivanova, S.4    Bhatta, S.5    Geng, Z.6
  • 141
    • 1942452552 scopus 로고    scopus 로고
    • Peptide and peptide analog transport systems at the blood-CSF barrier
    • Smith DE, Johanson CE, Keep RF. Peptide and peptide analog transport systems at the blood-CSF barrier. Adv Drug Deliv Rev. 2004; 56(12): 1765-91.
    • (2004) Adv Drug Deliv Rev , vol.56 , Issue.12 , pp. 1765-1791
    • Smith, D.E.1    Johanson, C.E.2    Keep, R.F.3
  • 142
    • 0036228917 scopus 로고    scopus 로고
    • Enhanced neuroprotective effects of basic fibroblast growth factor in regional brain ischemia after conjugation to a blood-brain barrier delivery vector
    • Song BW, Vinters HV, Wu D, Pardridge WM. Enhanced neuroprotective effects of basic fibroblast growth factor in regional brain ischemia after conjugation to a blood-brain barrier delivery vector. J Pharmacol Exp Ther. 2002; 301(2): 605-10.
    • (2002) J Pharmacol Exp Ther , vol.301 , Issue.2 , pp. 605-610
    • Song, B.W.1    Vinters, H.V.2    Wu, D.3    Pardridge, W.M.4
  • 143
    • 0037665153 scopus 로고    scopus 로고
    • Rats and mice exhibit distinct inflammatory reactions after spinal cord injury
    • Sroga JM, Jones TB, Kigerl KA, McGaughy VM, Popovich PG. Rats and mice exhibit distinct inflammatory reactions after spinal cord injury. J Comp Neurol. 2003; 462(2): 223-40.
    • (2003) J Comp Neurol , vol.462 , Issue.2 , pp. 223-240
    • Sroga, J.M.1    Jones, T.B.2    Kigerl, K.A.3    McGaughy, V.M.4    Popovich, P.G.5
  • 144
    • 0034016152 scopus 로고    scopus 로고
    • Developmental and lesion-induced changes in the distribution of the glucose transporter Glut-1 in the central and peripheral nervous system
    • Stark B, Carlstedt T, Cullheim S, Risling M. Developmental and lesion-induced changes in the distribution of the glucose transporter Glut-1 in the central and peripheral nervous system. Exp Brain Res. 2000; 131: 74-84.
    • (2000) Exp Brain Res , vol.131 , pp. 74-84
    • Stark, B.1    Carlstedt, T.2    Cullheim, S.3    Risling, M.4
  • 145
    • 0035188727 scopus 로고    scopus 로고
    • How matrix metalloproteinases regulate cell behavior
    • Sternlicht MD, Werb Z. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol. 2001; 17: 463-516.
    • (2001) Annu Rev Cell Dev Biol , vol.17 , pp. 463-516
    • Sternlicht, M.D.1    Werb, Z.2
  • 146
    • 79953829608 scopus 로고    scopus 로고
    • Effect of vascular endothelial growth factor treatment in experimental traumatic spinal cord injury: in vivo longitudinal assessment
    • Sundberg LM, Herrera JJ, Narayana PA. Effect of vascular endothelial growth factor treatment in experimental traumatic spinal cord injury: in vivo longitudinal assessment. J Neurotrauma. 2011; 28: 565-78.
    • (2011) J Neurotrauma , vol.28 , pp. 565-578
    • Sundberg, L.M.1    Herrera, J.J.2    Narayana, P.A.3
  • 147
    • 0026755699 scopus 로고
    • The role of endothelin-1 in the origin of cerebral vasospasm in patients with aneurismal subarachnoid hemorrhage
    • Suzuki R, Masaoka H, Hirata Y, Marumo F, Isotani E, Hirakawa K. The role of endothelin-1 in the origin of cerebral vasospasm in patients with aneurismal subarachnoid hemorrhage. J Neurosurg. 1992; 77(1): 96-100.
    • (1992) J Neurosurg , vol.77 , Issue.1 , pp. 96-100
    • Suzuki, R.1    Masaoka, H.2    Hirata, Y.3    Marumo, F.4    Isotani, E.5    Hirakawa, K.6
  • 148
    • 0028303208 scopus 로고
    • Characterization of pulmonary endothelial charge barrier
    • Swanson JA, Kern DF. Characterization of pulmonary endothelial charge barrier. Am J Physiol. 1994; 266(4 pt 2): H1300-3.
    • (1994) Am J Physiol , vol.266 , Issue.4 pt 2
    • Swanson, J.A.1    Kern, D.F.2
  • 149
    • 48649101326 scopus 로고    scopus 로고
    • Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5
    • Taddei A, Giampietro C, Conti A, Orsenigo F, Breviario F, Pirazzoli V, et al. Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5. Nat Cell Biol. 2008; 10(8): 923-34.
    • (2008) Nat Cell Biol , vol.10 , Issue.8 , pp. 923-934
    • Taddei, A.1    Giampietro, C.2    Conti, A.3    Orsenigo, F.4    Breviario, F.5    Pirazzoli, V.6
  • 150
    • 0025684646 scopus 로고
    • Erythrocyte/HepG2-type glucose transporter is concentrated in cells of blood-tissue barriers
    • Takata K, Kasahara T, Kasahara M, Ezaki O, Hirano H. Erythrocyte/HepG2-type glucose transporter is concentrated in cells of blood-tissue barriers. Biochem Biophys Res Commun. 1990; 173: 67-73.
    • (1990) Biochem Biophys Res Commun , vol.173 , pp. 67-73
    • Takata, K.1    Kasahara, T.2    Kasahara, M.3    Ezaki, O.4    Hirano, H.5
  • 151
    • 68249144440 scopus 로고    scopus 로고
    • Evaluating regional blood spinal cord barrier dysfunction following spinal cord injury using longitudinal dynamic contrast-enhanced MRI
    • Tatar I, Chou PC, Desouki MM, El Sayed H, Bilgen M. Evaluating regional blood spinal cord barrier dysfunction following spinal cord injury using longitudinal dynamic contrast-enhanced MRI. BMC Med Imaging. 2009; 9: 10.
    • (2009) BMC Med Imaging , vol.9 , pp. 10
    • Tatar, I.1    Chou, P.C.2    Desouki, M.M.3    El Sayed, H.4    Bilgen, M.5
  • 152
    • 0026326449 scopus 로고
    • Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms
    • Tator CH, Fehlings MG. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg. 1991; 75: 15-26.
    • (1991) J Neurosurg , vol.75 , pp. 15-26
    • Tator, C.H.1    Fehlings, M.G.2
  • 153
    • 0030605824 scopus 로고    scopus 로고
    • Endogenous endothelin-1 initiates astrocytic growth after spinal cord injury
    • Uesugi M, Kasuya Y, Hama H, Yamamoto M, Hayashi K, Masaki T, et al. Endogenous endothelin-1 initiates astrocytic growth after spinal cord injury. Brain Res. 1996; 728(2): 255-9.
    • (1996) Brain Res , vol.728 , Issue.2 , pp. 255-259
    • Uesugi, M.1    Kasuya, Y.2    Hama, H.3    Yamamoto, M.4    Hayashi, K.5    Masaki, T.6
  • 154
    • 0032498889 scopus 로고    scopus 로고
    • SB209670, a potent endothelin receptor antagonist, prevents or delays axonal degeneration after spinal cord injury
    • Uesugi M, Kasuya Y, Hayashi K, Goto K. SB209670, a potent endothelin receptor antagonist, prevents or delays axonal degeneration after spinal cord injury. Brain Res. 1998; 786(1-2): 235-9.
    • (1998) Brain Res , vol.786 , Issue.1-2 , pp. 235-239
    • Uesugi, M.1    Kasuya, Y.2    Hayashi, K.3    Goto, K.4
  • 155
    • 70350565505 scopus 로고    scopus 로고
    • Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging
    • Vakoc BJ, Lanning RM, Tyrrell JA, Padera TP, Bartlett LA, Stylianopoulos T, et al. Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging. Nat Med. 2009; 15: 1219-23.
    • (2009) Nat Med , vol.15 , pp. 1219-1223
    • Vakoc, B.J.1    Lanning, R.M.2    Tyrrell, J.A.3    Padera, T.P.4    Bartlett, L.A.5    Stylianopoulos, T.6
  • 156
    • 39549111237 scopus 로고    scopus 로고
    • Brain perfusion territory imaging: methods and clinical applications of selective arterial spin-labeling MR imaging
    • van Laar PJ, van der Grond J, Hendrikse J. Brain perfusion territory imaging: methods and clinical applications of selective arterial spin-labeling MR imaging. Radiology. 2008; 246: 354-64.
    • (2008) Radiology , vol.246 , pp. 354-364
    • van Laar, P.J.1    van der Grond, J.2    Hendrikse, J.3
  • 157
    • 4644231090 scopus 로고    scopus 로고
    • Biopharmaceutic classification system: a scientific framework for pharmacokinetic optimization in drug research
    • Varma MV, Khandavilli S, Ashokraj Y, Jain A, Dhanikula A, Sood A, et al. Biopharmaceutic classification system: a scientific framework for pharmacokinetic optimization in drug research. Curr Drug Metab. 2004; 5(5): 375-88.
    • (2004) Curr Drug Metab , vol.5 , Issue.5 , pp. 375-388
    • Varma, M.V.1    Khandavilli, S.2    Ashokraj, Y.3    Jain, A.4    Dhanikula, A.5    Sood, A.6
  • 158
    • 85052609356 scopus 로고    scopus 로고
    • Endothelin related pathophysiology in cerebral vasospasm: what happens to the cerebral vessels?
    • Vatter H, Konczalla J, Seifert V. Endothelin related pathophysiology in cerebral vasospasm: what happens to the cerebral vessels? Acta Neurochir Suppl. 2011; 110: 177-80.
    • (2011) Acta Neurochir Suppl , vol.110 , pp. 177-180
    • Vatter, H.1    Konczalla, J.2    Seifert, V.3
  • 159
    • 69749088023 scopus 로고    scopus 로고
    • Human umbilical cord blood stem cells upregulate matrix metalloproteinase-2 in rats after spinal cord injury
    • Veeravalli KK, Dasari VR, Tsung AJ, Dinh DH, Gujrati M, Fassett D, et al. Human umbilical cord blood stem cells upregulate matrix metalloproteinase-2 in rats after spinal cord injury. Neruobiol Dis. 2009; 36(1): 200-12.
    • (2009) Neruobiol Dis , vol.36 , Issue.1 , pp. 200-212
    • Veeravalli, K.K.1    Dasari, V.R.2    Tsung, A.J.3    Dinh, D.H.4    Gujrati, M.5    Fassett, D.6
  • 160
    • 0024390069 scopus 로고
    • Ultracytochemical characterization of anionic sites in the wall of brain capillaries
    • Vorbrodt AW. Ultracytochemical characterization of anionic sites in the wall of brain capillaries. J Neurocytology. 1989; 18(3): 359-68.
    • (1989) J Neurocytology , vol.18 , Issue.3 , pp. 359-368
    • Vorbrodt, A.W.1
  • 161
    • 0037011911 scopus 로고    scopus 로고
    • Phenoxyphenyl sulfone N-formylhydroxylamines (retrohydroxamates) as potent, selective, orally bioavailable matrix metalloproteinase inhibitors
    • Wada CK, Holms JH, Curtin ML, Dai Y, Florjancic AS, Garland RB, et al. Phenoxyphenyl sulfone N-formylhydroxylamines (retrohydroxamates) as potent, selective, orally bioavailable matrix metalloproteinase inhibitors. J Med Chem. 2002; 45(1): 219-32.
    • (2002) J Med Chem , vol.45 , Issue.1 , pp. 219-232
    • Wada, C.K.1    Holms, J.H.2    Curtin, M.L.3    Dai, Y.4    Florjancic, A.S.5    Garland, R.B.6
  • 162
    • 0017333585 scopus 로고
    • The development of intramedullary cavitation following spinal cord injury: an experimental pathological study
    • Wagner Jr FC, van Gilder JC, Dohrmann GJ. The development of intramedullary cavitation following spinal cord injury: an experimental pathological study. Paraplegia. 1977; 14: 245-50.
    • (1977) Paraplegia , vol.14 , pp. 245-250
    • Wagner Jr., F.C.1    van Gilder, J.C.2    Dohrmann, G.J.3
  • 163
    • 31044456582 scopus 로고    scopus 로고
    • Methylprednisolone causes minimal improvement after spinal cord injury in rats, contrasting with benefits of an anti-integrin treatment
    • Weaver LC, Gris D, Saville LR, Oatway MA, Chen Y, Marsh DR, et al. Methylprednisolone causes minimal improvement after spinal cord injury in rats, contrasting with benefits of an anti-integrin treatment. J Neurotrauma. 2005; 22: 1375-87.
    • (2005) J Neurotrauma , vol.22 , pp. 1375-1387
    • Weaver, L.C.1    Gris, D.2    Saville, L.R.3    Oatway, M.A.4    Chen, Y.5    Marsh, D.R.6
  • 164
    • 0242442568 scopus 로고    scopus 로고
    • An adverse role for matrix metalloproteinase 12 after spinal cord injury in mice
    • Wells JE, Rice TK, Nuttall RK, Edwards DR, Zekki H, Rivest S, et al. An adverse role for matrix metalloproteinase 12 after spinal cord injury in mice. J Neurosci. 2003; 23(31): 10107-15.
    • (2003) J Neurosci , vol.23 , Issue.31 , pp. 10107-10115
    • Wells, J.E.1    Rice, T.K.2    Nuttall, R.K.3    Edwards, D.R.4    Zekki, H.5    Rivest, S.6
  • 165
    • 0141705210 scopus 로고    scopus 로고
    • Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing
    • Whetstone WD, Hsu JY, Eisenberg M, Werb Z, Noble-Haeusslein LJ. Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing. J Neurosci Res. 2003; 74(2): 227-39.
    • (2003) J Neurosci Res , vol.74 , Issue.2 , pp. 227-239
    • Whetstone, W.D.1    Hsu, J.Y.2    Eisenberg, M.3    Werb, Z.4    Noble-Haeusslein, L.J.5
  • 166
    • 0344352501 scopus 로고    scopus 로고
    • Pharmacokinetics and blood-brain barrier transport of an anti-transferrin receptor monoclonal antibody (OX26) in rats after chronic treatment with the antibody
    • Wu D, Pardridge WM. Pharmacokinetics and blood-brain barrier transport of an anti-transferrin receptor monoclonal antibody (OX26) in rats after chronic treatment with the antibody. Drug Metab Dispos. 1998; 26(9): 937-9.
    • (1998) Drug Metab Dispos , vol.26 , Issue.9 , pp. 937-939
    • Wu, D.1    Pardridge, W.M.2
  • 168
    • 70349242264 scopus 로고    scopus 로고
    • Neurovascular effects of CD47 signaling: promotion of cell death, inflammation, and suppression of angiogenesis in brain endothelial cell in vitro
    • Xing C, Lee S, Kim WJ, Wnag H, Yang YG, Ning M, et al. Neurovascular effects of CD47 signaling: promotion of cell death, inflammation, and suppression of angiogenesis in brain endothelial cell in vitro. J Neurosci Res. 2009; 87(11): 2571-7.
    • (2009) J Neurosci Res , vol.87 , Issue.11 , pp. 2571-2577
    • Xing, C.1    Lee, S.2    Kim, W.J.3    Wnag, H.4    Yang, Y.G.5    Ning, M.6
  • 169
    • 4143064639 scopus 로고    scopus 로고
    • Hemin induces heme oxygenase-1 in spinal cord vasculature and attenuates barrier disruption and neutrophil infiltration in the injured murine spinal cord
    • Yamauchi T, Lin Y, Sharp FR, Noble-Haeusslein LJ. Hemin induces heme oxygenase-1 in spinal cord vasculature and attenuates barrier disruption and neutrophil infiltration in the injured murine spinal cord. J Neurotrauma. 2004; 21: 1017-30.
    • (2004) J Neurotrauma , vol.21 , pp. 1017-1030
    • Yamauchi, T.1    Lin, Y.2    Sharp, F.R.3    Noble-Haeusslein, L.J.4
  • 170
    • 79960348242 scopus 로고    scopus 로고
    • Immunolocalization of aquaporins in rat brain
    • doi:10.1111/j.1439-0264.2011.01070.x
    • Yang M, Gao F, Liu H, Yu WH, He GQ, Zhuo F, et al. Immunolocalization of aquaporins in rat brain. Anat Histol Embryol. 2011; 40(4): 299-306. doi: 10. 1111/j. 1439-0264. 2011. 01070. x.
    • (2011) Anat Histol Embryol , vol.40 , Issue.4 , pp. 299-306
    • Yang, M.1    Gao, F.2    Liu, H.3    Yu, W.H.4    He, G.Q.5    Zhuo, F.6
  • 171
    • 33747341626 scopus 로고    scopus 로고
    • The ADAMs family: coordinators of nervous system development, plasticity and repair
    • Yang P, Baker KA, Hagg T. The ADAMs family: coordinators of nervous system development, plasticity and repair. Prog Neurobiol. 2006; 79: 73-94.
    • (2006) Prog Neurobiol , vol.79 , pp. 73-94
    • Yang, P.1    Baker, K.A.2    Hagg, T.3
  • 172
    • 33745021587 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality
    • Yano K, Liaw PC, Mullington JM, Shih SC, Okada H, Bodyak N, et al. Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. J Exp Med. 2006; 203(6): 1447-58.
    • (2006) J Exp Med , vol.203 , Issue.6 , pp. 1447-1458
    • Yano, K.1    Liaw, P.C.2    Mullington, J.M.3    Shih, S.C.4    Okada, H.5    Bodyak, N.6
  • 173
    • 34848923138 scopus 로고    scopus 로고
    • Targeting MMPs in acute and chronic neurological conditions
    • Yong VW, Agrawal SM, Stirling DP. Targeting MMPs in acute and chronic neurological conditions. Neurotherapeutics. 2007; 4: 580-9.
    • (2007) Neurotherapeutics , vol.4 , pp. 580-589
    • Yong, V.W.1    Agrawal, S.M.2    Stirling, D.P.3
  • 174
    • 40949153084 scopus 로고    scopus 로고
    • Induction of mmp-9 expression and endothelial injury by oxidative stress after spinal cord injury
    • Yu F, Kamada H, Miizuma K, Endo H, Chan PH. Induction of mmp-9 expression and endothelial injury by oxidative stress after spinal cord injury. J Neurotrauma. 2008; 25: 184-95.
    • (2008) J Neurotrauma , vol.25 , pp. 184-195
    • Yu, F.1    Kamada, H.2    Miizuma, K.3    Endo, H.4    Chan, P.H.5
  • 175
    • 77951137392 scopus 로고    scopus 로고
    • Matrix metalloproteinases and neurotrauma: evolving roles in injury and reparative processes
    • Zhang H, Adwanikar H, Werb Z, Noble-Haeusslein LJ. Matrix metalloproteinases and neurotrauma: evolving roles in injury and reparative processes. Neuroscientist. 2010; 16: 156-70.
    • (2010) Neuroscientist , vol.16 , pp. 156-170
    • Zhang, H.1    Adwanikar, H.2    Werb, Z.3    Noble-Haeusslein, L.J.4
  • 176
    • 79955071242 scopus 로고    scopus 로고
    • Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury
    • Zhang H, Chang M, Hansen CN, Basso DM, Noble-Haeusslein LJ. Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury. Neurotherapeutics. 2011; 8: 206-20.
    • (2011) Neurotherapeutics , vol.8 , pp. 206-220
    • Zhang, H.1    Chang, M.2    Hansen, C.N.3    Basso, D.M.4    Noble-Haeusslein, L.J.5
  • 177
    • 4444317633 scopus 로고    scopus 로고
    • Differential gene expression after complete spinal cord transection in adult rats: an analysis focused on a subchronic post-injury stage
    • Zhang KH, Xiao HS, Lu PH, Shi J, Li GD, Wang YT, et al. Differential gene expression after complete spinal cord transection in adult rats: an analysis focused on a subchronic post-injury stage. Neuroscience. 2004; 128: 375-88.
    • (2004) Neuroscience , vol.128 , pp. 375-388
    • Zhang, K.H.1    Xiao, H.S.2    Lu, P.H.3    Shi, J.4    Li, G.D.5    Wang, Y.T.6
  • 178
    • 79952026900 scopus 로고    scopus 로고
    • Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric adenocarcinoma
    • Zhang M, Zhu GY, Gao HY, Zhao SP, Xue Y. Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric adenocarcinoma. J Surg Oncol. 2011; 103: 243-7.
    • (2011) J Surg Oncol , vol.103 , pp. 243-247
    • Zhang, M.1    Zhu, G.Y.2    Gao, H.Y.3    Zhao, S.P.4    Xue, Y.5
  • 179
    • 34548821303 scopus 로고    scopus 로고
    • Thrombospondin-based antiangiogenic therapy
    • Zhang X, Lawler J. Thrombospondin-based antiangiogenic therapy. Microvasc Res. 2007; 74(2-3): 90-9.
    • (2007) Microvasc Res , vol.74 , Issue.2-3 , pp. 90-99
    • Zhang, X.1    Lawler, J.2
  • 180
    • 0034988984 scopus 로고    scopus 로고
    • Neuroprotection in transient focal brain ischemia after delayed intravenous administration of brain-derived neurotrophic factor conjugated to a blood-brain barrier drug targeting system
    • Zhang Y, Pardridge WM. Neuroprotection in transient focal brain ischemia after delayed intravenous administration of brain-derived neurotrophic factor conjugated to a blood-brain barrier drug targeting system. Stroke. 2001; 32(6): 1378-84.
    • (2001) Stroke , vol.32 , Issue.6 , pp. 1378-1384
    • Zhang, Y.1    Pardridge, W.M.2
  • 181
    • 0033573539 scopus 로고    scopus 로고
    • Cerebral microvascular obstruction by fibrin is associated with upregulation of PAI-1 acutely after onset of focal embolic ischemia in rats
    • Zhang ZG, Chopp M, Goussev A, Lu D, Morris D, Tsang W, et al. Cerebral microvascular obstruction by fibrin is associated with upregulation of PAI-1 acutely after onset of focal embolic ischemia in rats. J Neurosci. 1999; 19: 10898-907.
    • (1999) J Neurosci , vol.19 , pp. 10898-10907
    • Zhang, Z.G.1    Chopp, M.2    Goussev, A.3    Lu, D.4    Morris, D.5    Tsang, W.6
  • 182
    • 42449126419 scopus 로고    scopus 로고
    • Review of noninvasive methods for skin blood flow imaging in microcirculation
    • Zhao H, Webb RH, Ortel B. Review of noninvasive methods for skin blood flow imaging in microcirculation. J Clin Eng. 2002; 27: 40-7.
    • (2002) J Clin Eng , vol.27 , pp. 40-47
    • Zhao, H.1    Webb, R.H.2    Ortel, B.3
  • 183
    • 85052608852 scopus 로고    scopus 로고
    • Advances in experimental subarachnoid hemorrhage
    • Zhou Y, Martin RD, Zhang JH. Advances in experimental subarachnoid hemorrhage. Acta Neurochir Suppl. 2011; 110: 15-21.
    • (2011) Acta Neurochir Suppl , vol.110 , pp. 15-21
    • Zhou, Y.1    Martin, R.D.2    Zhang, J.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.