Subarachnoid hemolysate produces DNA fragmentation in a pattern similar to apoptosis in mouse brain

Brain Research

Volumn 858, Issue 2, 2000, Pages 312-319

  Matz, Paul G ^a,b   Fujimura, Miki ^a   Chan, Pak H ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Surgical Service   (United States)

Author keywords

Apoptosis; Hemoglobin; Oxidative injury; Stroke; Subarachnoid hemorrhage

Indexed keywords

DNA FRAGMENT; HEME OXYGENASE;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN HEMORRHAGE; CONTROLLED STUDY; DNA DETERMINATION; HEMOLYSATE; IMMUNOREACTIVITY; MALE; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; SUBARACHNOID HEMORRHAGE;

ANIMALS; APOPTOSIS; BRAIN; CEREBROVASCULAR ACCIDENT; CYTOCHROME C GROUP; DNA FRAGMENTATION; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HEMOGLOBINS; HEMOLYSIS; IN SITU NICK-END LABELING; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED STRAINS; OXIDATIVE STRESS; SUBARACHNOID HEMORRHAGE; SUBARACHNOID SPACE;

EID: 0034628969     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)02454-3     Document Type: Article

References (24)

1. Balla J., Jacob H., Balla G., Nath K., Eaton J., Vercellotti G. Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage. Proc. Natl. Acad. Sci. U. S. A. 90:1993;9285-9289.
2. Bonita R., Thomson S. Subarachnoid hemorrhage: epidemiology, diagnosis, management and outcome. Stroke. 16:1995;591-594.
3. Braughler J., Duncan L., Chase R. The involvement of iron in lipid peroxidation. J. Biol. Chem. 261:1986;10282-10289.
4. Chan P., Epstein C., Li Y., Huang T., Carlson E., Kinouchi H., Yang G., Kamii H., Mikawa S., Kondo T., Copin J.-C., Chen S., Chan T., Gafni J., Gobbel G., Reola F. Transgenic mice and knockout mutants in the study of oxidative stress in brain injury. J. Neurotrauma. 12:1995;815-824.
5. Charriaut-Marlangue C., Ben-Ari Y. A cautionary note on the use of the TUNEL stain to determine apoptosis. NeuroReport. 7:1995;61-64.
6. Delgado T., Brismar J., Svendgaard N. Subarachnoid hemorrhage in the rat: angiography and fluorescent microscopy of the major cerebral arteries. Stroke. 16:1985;595-602.
7. + is increased in the subarachnoid space. J. Cereb. Blood Flow Metab. 18:1998;978-990.
8. Fujimura M., Morita-Fujimura Y., Kawase M., Copin J.-C., Calagui B., Epstein C., Chan P. Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome c and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice. J. Neurosci. 19:1999;3414-3422.
9. Fujimura M., Morita-Fujimura Y., Murakami K., Kawase M., Chan P. Cytosolic redistribution of cytochrome c after transient focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 18:1999;1239-1247.
10. Gutteridge J. The antioxidant activity of haptoglobin towards haemoglobin-stimulated lipid peroxidation. Biochim. Biophys. Acta. 917:1987;219-223.
11. Imlay J., Chin S., Linn S. Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro. Science. 240:1988;640-642.
12. Kondo T., Reaume A., Huang T., Carlson E., Murakami K., Chen S., Hoffman E., Scott R., Epstein C., Chan P. Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia. J. Neurosci. 17:1997;4180-4189.
13. Li Y., Chopp M., Jiang N., Yao F., Zaloga C. Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat. J. Cereb. Blood Flow Metab. 15:1995;389-397.
14. Liu X., Kim C., Yang J., Jemmerson R., Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell. 86:1996;147-157.
15. MacDonald R., Weir B. A review of hemoglobin and the pathogenesis of cerebral vasospasm. Stroke. 22:1991;971-982.
16. MacManus J., Fliss H., Preston E., Rasquinha I., Tuor U. Cerebral ischemia produces laddered DNA fragments distinct from cardiac ischemia and archetypal apoptosis. J. Cereb. Blood Flow Metab. 19:1999;502-510.
17. Maines M. Hemeoxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J. 2:1988;2557-2568.
18. Matz P., Massa S., Weinstein P., Turner C., Panter S., Sharp F. Focal expression of hemeoxygenase-1 protein and messenger RNA in rat brain caused by cellular stress following subarachnoid injections of lysed blood. J. Neurosurg. 85:1996;892-900.
19. Matz P., Turner C., Weinstein P., Massa S., Panter S., Sharp F. Hemeoxygenase-1 induction in glia throughout rat brain following experimental subarachnoid hemorrhage. Brain Res. 713:1996;211-222.
20. Morita-Fujimura Y., Fujimura M., Kawase M., Chen S., Chan P. Release of mitochondrial cytochrome c and DNA fragmentation after cold injury-induced brain trauma in mice: possible role in neuronal apoptosis. Neurosci. Lett. 267:1999;201-205.
21. Regan R., Panter S. Neurotoxicity of hemoglobin in cortical cell culture. Neurosci. Lett. 153:1993;219-222.
22. Rosen A., Frumin N. Focal epileptogenesis after intracortical hemoglobin injection. Exp. Neurol. 66:1979;277-284.
23. Turner C., Bergeron M., Matz P., Zegna A., Noble L., Panter S., Sharp F. Hemeoxygenase-1 is induced in glia throughout brain by subarachnoid hemoglobin. J. Cereb. Blood Flow Metab. 18:1998;257-273.
24. Turner C., Panter S., Sharp F. Antioxidants prevent focal rat brain injury as assessed by induction of heat shock proteins (HSP70, HO-1/HSP32, HSP47) following subarachnoid injections of lysed blood. Mol. Brain Res. 65:1999;87-102.