Longitudinal magnetic resonance imaging of spinal cord injury in mouse: changes in signal patterns associated with the inflammatory response

Magnetic Resonance Imaging

Volumn 25, Issue 5, 2007, Pages 657-664

  Bilgen, Mehmet ^a,b   Al Hafez, Baraa ^a   Alrefae, Tareq ^a   He, Yong Yu ^a   Smirnova, Irina V ^a   Aldur, M Mustafa ^c   Festoff, Barry W ^b,d  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c HACETTEPE UNIVERSITY   (Turkey)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Inflammation response; Magnetic resonance imaging; Mouse; Neuroinflammation; Spinal cord injury

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; APPARATUS; ARTICLE; C57BL 6 MOUSE; COGNITION; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DISEASE MODEL; GRAY MATTER; HISTOLOGY; IMAGE ANALYSIS; INFLAMMATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SIGNAL DETECTION; SPINAL CORD INJURY; WHITE MATTER;

ANIMALS; ARTIFACTS; DISEASE MODELS, ANIMAL; INFLAMMATION; MAGNETIC RESONANCE IMAGING; MALE; MICE; MICE, INBRED C57BL; NEUROPSYCHOLOGICAL TESTS; SPINAL CORD; SPINAL CORD INJURIES;

MUS;

EID: 34249339783     PISSN: 0730725X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mri.2006.10.009     Document Type: Article

References (39)

1. Kwon B.K., Oxland T.R., and Tetzlaff W. Animal models used in spinal cord regeneration research. Spine 27 14 (2002) 1504-1510
2. Steward O., Schauwecker P.E., Guth L., Zhang Z., Fujiki M., Inman D., et al. Genetic approaches to neurotrauma research: opportunities and potential pitfalls of murine models. Exp Neurol 157 1 (1999) 19-42
3. Rosenzweig E.S., and McDonald J.W. Rodent models for treatment of spinal cord injury: research trends and progress toward useful repair. Curr Opin Neurol 17 2 (2004) 121-131
4. Guertin P.A. Paraplegic mice are leading to new advances in spinal cord injury research. Spinal Cord 43 8 (2005) 459-461
5. Sroga J.M., Jones T.B., Kigerl K.A., McGaughy V.M., and Popovich P.G. Rats and mice exhibit distinct inflammatory reactions after spinal cord injury. J Comp Neurol 462 2 (2003) 223-240
6. Metz G.A., Curt A., van de Meent H., Klusman I., Schwab M.E., and Dietz V. Validation of the weight-drop contusion model in rats: a comparative study of human spinal cord injury. J Neurotrauma 17 1 (2000) 1-17
7. Zhang Z., Fujiki M., Guth L., and Steward O. Genetic influences on cellular reactions to spinal cord injury: a wound-healing response present in normal mice is impaired in mice carrying a mutation (WldS) that causes delayed Wallerian degeneration. J Comp Neurol 371 3 (1996) 485-495
8. Inman D.M., and Steward O. Physical size does not determine the unique histopathological response seen in the injured mouse spinal cord. J Neurotrauma 20 1 (2003) 33-42
9. Inman D., Guth L., and Steward O. Genetic influences on secondary degeneration and wound healing following spinal cord injury in various strains of mice. J Comp Neurol 451 3 (2002) 225-235
10. Kigerl K.A., McGaughy V.M., and Popovich P.G. Comparative analysis of lesion development and intraspinal inflammation in four strains of mice following spinal contusion injury. J Comp Neurol 494 4 (2006) 578-594
11. Gonzalez R., Glaser J., Liu M.T., Lane T.E., and Keirstead H.S. Reducing inflammation decreases secondary degeneration and functional deficit after spinal cord injury. Exp Neurol 184 1 (2003) 456-463
12. Popovich P.G., and Jones T.B. Manipulating neuroinflammatory reactions in the injured spinal cord: back to basics. Trends Pharmacol Sci 24 1 (2003) 13-17
13. Beattie M.S. Inflammation and apoptosis: linked therapeutic targets in spinal cord injury. Trends Mol Med 10 12 (2004) 580-583
14. Bloom F.E., Reilly J.F., Redwine J.M., Wu C.C., Young W.G., and Morrison J.H. Mouse models of human neurodegenerative disorders: requirements for medication development. Arch Neurol 62 2 (2005) 185-187
15. Bilgen M., Al-Hafez B., He Y.Y., and Brooks W.M. Magnetic resonance angiography of rat spinal cord at 9.4 T: a feasibility study. Magn Reson Med 53 6 (2005) 1459-1461
16. Bilgen M., Al-Hafez B., Malone T.M., and Smirnova I.V. Ex vivo magnetic resonance imaging of rat spinal cord at 9.4 T. Magn Reson Imaging 23 4 (2005) 601-605
17. Bilgen M., Dancause N., Al-Hafez B., He Y.Y., and Malone T.M. Manganese-enhanced MRI of rat spinal cord injury. Magn Reson Imaging 23 7 (2005) 829-832
18. Berens S.A., Colvin D.C., Yu C.G., Yezierski R.P., and Mareci T.H. Evaluation of the pathologic characteristics of excitotoxic spinal cord injury with MR imaging. AJNR Am J Neuroradiol 26 7 (2005) 1612-1622
19. Schwartz E.D. MRI and the evaluation of the blood-spinal cord barrier following injury. AJNR Am J Neuroradiol 26 7 (2005) 1609-1610
20. Ahrens E.T., Laidlaw D.H., Readhead C., Brosnan C.F., Fraser S.E., and Jacobs R.E. MR microscopy of transgenic mice that spontaneously acquire experimental allergic encephalomyelitis. Magn Reson Med 40 1 (1998) 119-132
21. Wamil A.W., Wamil B.D., and Hellerqvist C.G. CM101-mediated recovery of walking ability in adult mice paralyzed by spinal cord injury. Proc Natl Acad Sci U S A 95 22 (1998) 13188-13193
22. Bonny J.M., Gaviria M., Donnat J.P., Jean B., Privat A., and Renou J.P. Nuclear magnetic resonance microimaging of mouse spinal cord in vivo. Neurobiol Dis 15 3 (2004) 474-482
23. Bilgen M., Al-Hafez B., Berman N.E., and Festoff B.W. Magnetic resonance imaging of mouse spinal cord. Magn Reson Med 54 5 (2005) 1226-1231
24. Kim J.H., Budde M.D., Liang H.F., Klein R.S., Russell J.H., Cross A.H., et al. Detecting axon damage in spinal cord from a mouse model of multiple sclerosis. Neurobiol Dis 21 3 (2006) 626-632
25. Bilgen M., Al-Hafez B., Farooque M., Arnold P., Berman N.E.J., and Festoff B.W. Magnetic resonance imaging of mouse spinal cord injury. 23rd Annual Symposium of National Neurotrauma Society, Washington, DC (2005)
26. Bilgen M., and Al-Hafez B. Comparison of spinal vasculature in mouse and rat: investigations using MR angiography. Neuroanatomy 5 (2006) 12-18
27. Bilgen M. Evaluation of spinal cord injury in mouse using longitudinal magnetic resonance imaging. 24th Annual Symposium of National Neurotrauma Society, St. Louis, MO (2006)
28. Beattie M.S., Bresnahan J.C., Komon J., Tovar C.A., Van Meter M., Anderson D.K., et al. Endogenous repair after spinal cord contusion injuries in the rat. Exp Neurol 148 2 (1997) 453-463
29. Bilgen M. A new device for experimental modeling of central nervous system injuries. Neurorehabil Neural Repair 19 3 (2005) 219-226
30. Bilgen M. Simple, low-cost multipurpose RF coil for MR microscopy at 9.4 T. Magn Reson Med 52 4 (2004) 937-940
31. Basso D.M., Beattie M.S., Bresnahan J.C., Anderson D.K., Faden A.I., Gruner J.A., et al. MASCIS evaluation of open field locomotor scores: effects of experience and teamwork on reliability. Multicenter Animal Spinal Cord Injury Study. J Neurotrauma 13 7 (1996) 343-359
32. Jakeman L.B., Guan Z., Wei P., Ponnappan R., Dzwonczyk R., Popovich P.G., et al. Traumatic spinal cord injury produced by controlled contusion in mouse. J Neurotrauma 17 4 (2000) 299-319
33. Ma M., Basso D.M., Walters P., Stokes B.T., and Jakeman L.B. Behavioral and histological outcomes following graded spinal cord contusion injury in the C57Bl/6 mouse. Exp Neurol 169 2 (2001) 239-254
34. Farooque M., Suo Z., Arnold P.M., Wulser M.J., Chou C.T., Vancura R.W., et al. Gender-related differences in recovery of locomotor function after spinal cord injury in mice. Spinal Cord 44 3 (2005) 182-187
35. Whetstone W.D., Hsu J.Y., Eisenberg M., Werb Z., and Noble-Haeusslein L.J. Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing. J Neurosci Res 74 2 (2003) 227-239
36. Bilgen M., Abbe R., Liu S.J., and Narayana P.A. Spatial and temporal evolution of hemorrhage in the hyperacute phase of experimental spinal cord injury: in vivo magnetic resonance imaging. Magn Reson Med 43 4 (2000) 594-600
37. Ma M., Wei P., Wei T., Ransohoff R.M., and Jakeman L.B. Enhanced axonal growth into a spinal cord contusion injury site in a strain of mouse (129X1/SvJ) with a diminished inflammatory response. J Comp Neurol 474 4 (2004) 469-486
38. Bilgen M. Inductively-overcoupled coil design for high resolution magnetic resonance imaging. Biomed Eng Online 5 1 (2006) 3
39. Bilgen M. Magnetic resonance microscopy of spinal cord injury in mouse using a miniaturized implantable RF coil. J Neurosci Methods (2006) In press, 10.1016/j.jneumeth.2006.06.024